Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity

Cell

Volumn 101, Issue 4, 2000, Pages 413-424

  Plotnikov, Alexander N ^a   Hubbard, Stevan R ^a   Schlessinger, Joseph ^a   Mohammadi, Moosa ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR RECEPTOR;

ALTERNATIVE RNA SPLICING; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING SITE; COMPLEX FORMATION; CRYSTAL STRUCTURE; LIGAND BINDING; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; RECEPTOR BINDING; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS;

EID: 0034640103     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)80851-X     Document Type: Article

References (44)

1. Apert syndrome mutations in fibrobtast growth factor receptor 2 exhibit increased affinity for FGF ligand
2. The FGF family of growth factors and oncogenes
3. X-ray crystal structure of human acidic fibroblast growth factor
4. A keratinocyte growth factor receptor-derived peptide antagonist identifies part of the ligand binding site
5. Crystallography and NMR system: A new software suite for macromolecular structure determination
6. The heparin-binding (fibroblast) growth factor family of proteins
7. Fibroblast growth factor receptors: Lessons from the genes
8. Mapping ligand binding domains in chimeric fibroblast growth factor receptor molecules. Multiple regions determine ligand binding specificity
9. A novel form of fibroblast growth factor receptor 2. Alternative splicing of the third immunoglobulin-like domain confers ligand binding specificity
10. Three-dimensional structure of human basic fibroblast growth factor
11. Diversity does make a difference: Fibroblast growth factor-heparin interactions
12. Molecular modeling based mutagenesis defines ligand binding and specificity determining regions of fibroblast growth factor receptors
13. Asparagine-344 is a key residue for ligand binding in keratinocyte growth factor receptor
14. X-ray structure determination of telokin, the C-terminal domain of myosin light chain kinase, at 2.8 Å resolution
15. Recovery of mitogenic activity of a growth factor mutant with a nuclear translocation sequence
16. Fibroblast growth factor receptor tyrosine kinases: Molecular analysis and signal transduction
17. Structural and functional diversity in the FGF receptor multigene family
18. Improved methods for binding protein models in electron density maps and the location of errors in these models
19. MOLSCRIPT: A program to produce both detailed and schematic plots of protein structures
20. PROCHECK: A program to check the stereochemical quality of protein structures
21. Raster3D: Photorealistic molecular graphics
22. Determination of ligand-binding specificity by alternative splicing: Two distinct growth factor receptors encoded by a single gene
23. FGF signaling in skeletal development
24. AMoRe: An automated package for molecular replacement
25. Heparin is required for cell-free binding of βFGF to a soluble receptor and for mitogenesis in whole cells
26. Receptor specificity of the fibroblast growth factor family
27. Oscillation data reduction program
28. Structural basis for FGF receptor dimerization and activation
29. Chimeric molecules between keratinocyte growth factor and basic fibroblast growth factor define domains that confer receptor binding specificities
30. Fibroblast growth factor receptor 4 is a high affinity receptor for both acidic and basic fibroblast growth factor but not for keratinocyte growth factor
31. Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation
32. Identification and concerted function of two receptor binding surfaces on basic fibroblast growth factor required for mitogenesis
33. Structural interactions of fibroblast growth factor receptor with its ligands
34. CLUSTAL W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
35. Fibroblast growth factor receptor-4 shows novel features in genomic structure, ligand binding and signal transduction
36. Ligand-specific structural domains in the fibroblast growth factor receptor
37. Common and specific determinants for fibroblast growth factors in the ectodomain of the receptor kinase complex
38. Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor
39. A confined variable region confers ligand specificity on fibroblast growth factor receptors: Implications for the origin of the immunoglobulin fold
40. Isolation of peptides that inhibit binding of basic fibroblast growth factor to its receptor from a random phage-epitope library
41. Glu-96 of basic fibroblast growth factor is essential for high affinity receptor binding. Identification by structure-based site-directed mutagenesis
42. Analysis of high-affinity binding determinants in the receptor binding epitope of basic fibroblast growth factor
43. Identification of two new hydrophobic residues on basic fibroblast growth factor important for fibroblast growth factor receptor binding