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Volumn 9, Issue 4, 2014, Pages 523-542

Elucidating drug resistance in human fungal pathogens

Author keywords

Aspergillus fumigatus; azoles; Candida albicans; Cryptococcus neoformans; drug resistance; echinocandins; polyenes

Indexed keywords

ABC TRANSPORTER; ANTIFUNGAL AGENT; ECHINOCANDIN; LIPID; MULTIDRUG RESISTANCE PROTEIN; POLYENE; PYRROLE DERIVATIVE;

EID: 84900319598     PISSN: 17460913     EISSN: 17460921     Source Type: Journal    
DOI: 10.2217/fmb.14.18     Document Type: Review
Times cited : (58)

References (158)
  • 2
    • 74949107171 scopus 로고    scopus 로고
    • Epidemiology of invasive mycoses in north america
    • Pfaller MA, Diekema DJ. Epidemiology of invasive mycoses in North America. Crit. Rev. Microbiol. 36(1), 1-53 (2010).
    • (2010) Crit. Rev. Microbiol , vol.36 , Issue.1 , pp. 1-53
    • Pfaller, M.A.1    Diekema, D.J.2
  • 3
    • 79958060479 scopus 로고    scopus 로고
    • Regulatory circuitry governing fungal development, drug resistance, and disease
    • Shapiro RS, Robbins N, Cowen LE. Regulatory circuitry governing fungal development, drug resistance, and disease. Microbiol. Mol. Biol. Rev. 75(2), 213-267 (2011).
    • (2011) Microbiol. Mol. Biol. Rev , vol.75 , Issue.2 , pp. 213-267
    • Shapiro, R.S.1    Robbins, N.2    Cowen, L.E.3
  • 4
    • 33750289222 scopus 로고    scopus 로고
    • The biology of the cryptococcus neoformans species complex
    • Lin X, Heitman J. The biology of the Cryptococcus neoformans species complex. Annu. Rev. Microbiol. 60, 69-105 (2006).
    • Annu. Rev. Microbiol , vol.60 , Issue.2006 , pp. 69-105
    • Lin, X.1    Heitman, J.2
  • 5
    • 62349130224 scopus 로고    scopus 로고
    • Estimation of the current global burden of cryptococcal meningitis among persons living with hiv/aids
    • Park BJ, Wannemuehler KA, Marston BJ, Govender N, Pappas PG, Chiller TM. Estimation of the current global burden of cryptococcal meningitis among persons living with HIV/AIDS. AIDS 23(4), 525-530 (2009).
    • (2009) AIDS , vol.23 , Issue.4 , pp. 525-530
    • Park, B.J.1    Wannemuehler, K.A.2    Marston, B.J.3    Govender, N.4    Pappas, P.G.5    Chiller, T.M.6
  • 6
    • 0035109799 scopus 로고    scopus 로고
    • Aspergillosis case-fatality rate: Systematic review of the literature
    • Lin SJ, Schranz J, Teutsch SM. Aspergillosis case-fatality rate: systematic review of the literature. Clin. Infect. Dis. 32(3), 358-366 (2001).
    • (2001) Clin. Infect. Dis , vol.32 , Issue.3 , pp. 358-366
    • Lin, S.J.1    Schranz, J.2    Teutsch, S.M.3
  • 7
    • 84900336786 scopus 로고    scopus 로고
    • CDC
    • US Department of Health and Human Services. CDC, GA, USA (2013).
    • CDC. Antibiotic Resistance Threats in the United States, 2013. US Department of Health and Human Services. CDC, GA, USA (2013).
    • (2013) Antibiotic Resistance Threats in the United States
  • 8
    • 47049090269 scopus 로고    scopus 로고
    • Stress, drugs and evolution: The role of cellular signaling in fungal drug resistance
    • Cowen LE, Steinbach WJ. Stress, drugs and evolution: the role of cellular signaling in fungal drug resistance. Eukaryot. Cell 7(5), 747-764 (2008).
    • (2008) Eukaryot. Cell , vol.7 , Issue.5 , pp. 747-764
    • Cowen, L.E.1    Steinbach, W.J.2
  • 9
    • 39149087719 scopus 로고    scopus 로고
    • The evolution of fungal drug resistance: Modulating the trajectory from genotype to phenotype
    • Cowen LE. The evolution of fungal drug resistance: modulating the trajectory from genotype to phenotype. Nat. Rev. Microbiol. 6(3), 187-198 (2008).
    • (2008) Nat. Rev. Microbiol , vol.6 , Issue.3 , pp. 187-198
    • Cowen, L.E.1
  • 12
    • 0141863188 scopus 로고    scopus 로고
    • Echinocandin antifungal drugs
    • Denning DW. Echinocandin antifungal drugs. Lancet 362(9390), 1142-1151 (2003).
    • (2003) Lancet , vol.362 , Issue.9390 , pp. 1142-1151
    • Denning, D.W.1
  • 13
    • 0038341642 scopus 로고    scopus 로고
    • Antifungal agents: Mechanisms of action
    • Odds FC, Brown AJ, Gow NA. Antifungal agents: mechanisms of action. Trends Microbiol. 11(6), 272-279 (2003).
    • (2003) Trends Microbiol , vol.11 , Issue.6 , pp. 272-279
    • Odds, F.C.1    Brown, A.J.2    Gow, N.A.3
  • 14
  • 16
    • 77149169382 scopus 로고    scopus 로고
    • Acquisition of flucytosine, azole, and caspofungin resistance in candida glabrata bloodstream isolates serially obtained from a hematopoietic stem cell transplant recipient
    • Chapeland-Leclerc F, Hennequin C, Papon N et al. Acquisition of flucytosine, azole, and caspofungin resistance in Candida glabrata bloodstream isolates serially obtained from a hematopoietic stem cell transplant recipient. Antimicrob. Agents Chemother. 54(3), 1360-1362 (2010).
    • (2010) Antimicrob. Agents Chemother , vol.54 , Issue.3 , pp. 1360-1362
    • Chapeland-Leclerc, F.1    Hennequin, C.2    Papon, N.3
  • 17
    • 84866502135 scopus 로고    scopus 로고
    • The potential impact of antifungal drug resistance mechanisms on the host immune response to candida
    • Lewis RE, Viale P, Kontoyiannis DP. The potential impact of antifungal drug resistance mechanisms on the host immune response to Candida. Virulence 3(4), 368-376 (2012).
    • (2012) Virulence , vol.3 , Issue.4 , pp. 368-376
    • Lewis, R.E.1    Viale, P.2    Kontoyiannis, D.P.3
  • 18
    • 84055199809 scopus 로고    scopus 로고
    • Antifungal drug resistance: Mechanisms, epidemiology, and consequences for treatment
    • Pfaller MA. Antifungal drug resistance: mechanisms, epidemiology, and consequences for treatment. Am. J. Med. 125(Suppl. 1), S3-S13 (2012).
    • (2012) Am. J. Med , vol.125 , Issue.SUPPL. 1
    • Pfaller, M.A.1
  • 19
    • 77957241722 scopus 로고    scopus 로고
    • Azole antifungal resistance in aspergillus fumigatus: 2008 and 2009
    • Bueid A, Howard SJ, Moore CB et al. Azole antifungal resistance in Aspergillus fumigatus: 2008 and 2009. J. Antimicrob. Chemother. 65(10), 2116-2118 (2010).
    • (2010) J. Antimicrob. Chemother , vol.65 , Issue.10 , pp. 2116-2118
    • Bueid, A.1    Howard, S.J.2    Moore, C.B.3
  • 20
    • 71549143158 scopus 로고    scopus 로고
    • Azole resistance in aspergillus fumigatus: A side-effect of environmental fungicide use
    • Verweij PE, Snelders E, Kema GH, Mellado E, Melchers WJ. Azole resistance in Aspergillus fumigatus: a side-effect of environmental fungicide use? Lancet Infect. Dis. 9(12), 789-795 (2009).
    • (2009) Lancet infect Dis , vol.9 , Issue.12 , pp. 789-795
    • Verweij, P.E.1    Snelders, E.2    Kema, G.H.3    Mellado, E.4    Melchers, W.J.5
  • 21
    • 38749151566 scopus 로고    scopus 로고
    • Increasing incidence of candida parapsilosis candidemia with caspofungin usage
    • Forrest GN, Weekes E, Johnson JK. Increasing incidence of Candida parapsilosis candidemia with caspofungin usage. J. Infect. 56(2), 126-129 (2008).
    • (2008) J. Infect , vol.56 , Issue.2 , pp. 126-129
    • Forrest, G.N.1    Weekes, E.2    Johnson, J.K.3
  • 22
    • 80052219362 scopus 로고    scopus 로고
    • Diagnostic issues, clinical characteristics, and outcomes for patients with fungemia
    • Arendrup MC, Sulim S, Holm A et al. Diagnostic issues, clinical characteristics, and outcomes for patients with fungemia. J. Clin. Microbiol. 49(9), 3300-3308 (2011).
    • (2011) J. Clin. Microbiol , vol.49 , Issue.9 , pp. 3300-3308
    • Arendrup, M.C.1    Sulim, S.2    Holm, A.3
  • 23
    • 84863666582 scopus 로고    scopus 로고
    • Global analysis of the evolution and mechanism of echinocandin resistance in candida glabrata
    • Singh-Babak SD, Babak T, Diezmann S et al. Global analysis of the evolution and mechanism of echinocandin resistance in Candida glabrata. PLoS Pathog. 8(5), e1002718 (2012).
    • (2012) PLoS Pathog , vol.8 , Issue.5
    • Singh-Babak, S.D.1    Babak, T.2    Diezmann, S.3
  • 24
    • 84858441721 scopus 로고    scopus 로고
    • Breakthrough invasive mould infections in patients treated with caspofungin
    • Pang KA, Godet C, Fekkar A et al. Breakthrough invasive mould infections in patients treated with caspofungin. J. Infect. 64(4), 424-429 (2012).
    • (2012) J. Infect , vol.64 , Issue.4 , pp. 424-429
    • Pang, K.A.1    Godet, C.2    Fekkar, A.3
  • 25
    • 0025776523 scopus 로고
    • Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast
    • Heitman J, Movva NR, Hall MN. Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. Science 253(5022), 905-909 (1991).
    • (1991) Science , vol.253 , Issue.5022 , pp. 905-909
    • Heitman, J.1    Movva, N.R.2    Hall, M.N.3
  • 26
    • 0027959267 scopus 로고
    • A saccharomyces cerevisiae mutant with echinocandin-resistant 1,3-beta-d-glucan synthase
    • Douglas CM, Marrinan JA, Li W, Kurtz MB. A Saccharomyces cerevisiae mutant with echinocandin-resistant 1,3-beta-D-glucan synthase. J. Bacteriol. 176(18), 5686-5696 (1994).
    • (1994) J. Bacteriol , vol.176 , Issue.18 , pp. 5686-5696
    • Douglas, C.M.1    Marrinan, J.A.2    Li, W.3    Kurtz, M.B.4
  • 27
    • 0036840642 scopus 로고    scopus 로고
    • Melanization of cryptococcus neoformans and histoplasma capsulatum reduces their susceptibilities to amphotericin b and caspofungin
    • Van Duin D, Casadevall A, Nosanchuk JD. Melanization of Cryptococcus neoformans and Histoplasma capsulatum reduces their susceptibilities to amphotericin B and caspofungin. Antimicrob. Agents Chemother. 46(11), 3394-3400 (2002).
    • (2002) Antimicrob. Agents Chemother , vol.46 , Issue.11 , pp. 3394-3400
    • Van Duin, D.1    Casadevall, A.2    Nosanchuk, J.D.3
  • 28
    • 84874263762 scopus 로고    scopus 로고
    • A functional variomics tool for discovering drug-resistance genes and drug targets
    • Huang Z, Chen K, Zhang J et al. A functional variomics tool for discovering drug-resistance genes and drug targets. Cell Rep. 3(2), 577-585 (2013).
    • (2013) Cell Rep , vol.3 , Issue.2 , pp. 577-585
    • Huang, Z.1    Chen, K.2    Zhang, J.3
  • 29
    • 84876834080 scopus 로고    scopus 로고
    • Genetic and genomic architecture of the evolution of resistance to antifungal drug combinations
    • Hill JA, Ammar R, Torti D, Nislow C, Cowen LE. Genetic and genomic architecture of the evolution of resistance to antifungal drug combinations. PLoS Genet. 9(4), e1003390 (2013).
    • (2013) PLoS Genet , vol.9 , Issue.4
    • Hill, J.A.1    Ammar, R.2    Torti, D.3    Nislow, C.4    Cowen, L.E.5
  • 30
    • 70049109583 scopus 로고    scopus 로고
    • Hsp90 governs echinocandin resistance in the pathogenic yeast candida albicans via calcineurin
    • Singh SD, Robbins N, Zaas AK, Schell WA, Perfect JR, Cowen LE. Hsp90 governs echinocandin resistance in the pathogenic yeast Candida albicans via calcineurin. PLoS Pathog. 5(7), e1000532 (2009).
    • (2009) PLoS Pathog , vol.5 , Issue.7
    • Singh, S.D.1    Robbins, N.2    Zaas, A.K.3    Schell, W.A.4    Perfect, J.R.5    Cowen, L.E.6
  • 31
    • 2942620604 scopus 로고    scopus 로고
    • Analysis of beta-1,3- glucan assembly in saccharomyces cerevisiae using a synthetic interaction network and altered sensitivity to caspofungin
    • Lesage G, Sdicu AM, Menard P, Shapiro J, Hussein S, Bussey H. Analysis of beta-1,3- glucan assembly in Saccharomyces cerevisiae using a synthetic interaction network and altered sensitivity to caspofungin. Genetics 167(1), 35-49 (2004).
    • (2004) Genetics , vol.167 , Issue.1 , pp. 35-49
    • Lesage, G.1    Sdicu, A.M.2    Menard, P.3    Shapiro, J.4    Hussein, S.5    Bussey, H.6
  • 32
    • 2142647837 scopus 로고    scopus 로고
    • Functional genomic analysis of fluconazole susceptibility in the pathogenic yeast candida glabrata: Roles of calcium signaling and mitochondria
    • Kaur R, Castano I, Cormack BP. Functional genomic analysis of fluconazole susceptibility in the pathogenic yeast Candida glabrata: roles of calcium signaling and mitochondria. Antimicrob. Agents Chemother. 48(5), 1600-1613 (2004).
    • (2004) Antimicrob. Agents Chemother , vol.48 , Issue.5 , pp. 1600-1613
    • Kaur, R.1    Castano, I.2    Cormack, B.P.3
  • 33
    • 77958121046 scopus 로고    scopus 로고
    • PKC signaling regulates drug resistance of the fungal pathogen candida albicans via circuitry comprised of mkc1, calcineurin, and hsp90
    • Lafayette SL, Collins C, Zaas AK et al. PKC signaling regulates drug resistance of the fungal pathogen Candida albicans via circuitry comprised of Mkc1, calcineurin, and Hsp90. PLoS Pathog. 6(8), e1001069 (2010).
    • (2010) PLoS Pathog , vol.6 , Issue.8
    • Lafayette, S.L.1    Collins, C.2    Zaas, A.K.3
  • 34
    • 0033048778 scopus 로고    scopus 로고
    • Genomic profiling of drug sensitivities via induced haploinsufficiency
    • Giaever G, Shoemaker DD, Jones TW et al. Genomic profiling of drug sensitivities via induced haploinsufficiency. Nat. Genet. 21(3), 278-283 (1999).
    • (1999) Nat. Genet , vol.21 , Issue.3 , pp. 278-283
    • Giaever, G.1    Shoemaker, D.D.2    Jones, T.W.3
  • 35
    • 47649093352 scopus 로고    scopus 로고
    • An integrated platform of genomic assays reveals small-molecule bioactivities
    • Hoon S, Smith AA, Wallace IM et al. An integrated platform of genomic assays reveals small-molecule bioactivities. Nat. Chem. Biol. 4(8), 498-506 (2008).
    • (2008) Nat. Chem. Biol , vol.4 , Issue.8 , pp. 498-506
    • Hoon, S.1    Smith, A.A.2    Wallace, I.M.3
  • 36
    • 84907123977 scopus 로고
    • The lipid composition and permeability to azole of an azole- and polyene-resistant mutant of candida albicans
    • Hitchcock CA, Barrett-Bee KJ, Russell NJ. The lipid composition and permeability to azole of an azole- and polyene-resistant mutant of Candida albicans. J. Med. Vet. Mycol. 25(1), 29-37 (1987).
    • (1987) J. Med. Vet. Mycol , vol.25 , Issue.1 , pp. 29-37
    • Hitchcock, C.A.1    Barrett-Bee, K.J.2    Russell, N.J.3
  • 37
    • 0028793725 scopus 로고
    • Mechanisms of resistance to azole antifungal agents in candida albicans isolates from aids patients involve specific multidrug transporters
    • Sanglard D, Kuchler K, Ischer F, Pagani JL, Monod M, Bille J. Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters. Antimicrob. Agents Chemother. 39(11), 2378-2386 (1995).
    • (1995) Antimicrob. Agents Chemother , vol.39 , Issue.11 , pp. 2378-2386
    • Sanglard, D.1    Kuchler, K.2    Ischer, F.3    Pagani, J.L.4    Monod, M.5    Bille, J.6
  • 38
    • 0029146207 scopus 로고
    • Resistance to fluconazole in candida albicans from aids patients correlated with reduced intracellular accumulation of drug
    • Venkateswarlu K, Denning DW, Manning NJ, Kelly SL. Resistance to fluconazole in Candida albicans from AIDS patients correlated with reduced intracellular accumulation of drug. FEMS Microbiol. Lett. 131(3), 337-341 (1995).
    • (1995) FEMS Microbiol. Lett , vol.131 , Issue.3 , pp. 337-341
    • Venkateswarlu, K.1    Denning, D.W.2    Manning, N.J.3    Kelly, S.L.4
  • 39
    • 0025189969 scopus 로고
    • Mutation in cytochrome p-450-dependent 14 alpha-demethylase results in decreased affinity for azole antifungals
    • Vanden Bossche H, Marichal P, Gorrens J, Bellens D, Moereels H, Janssen PA. Mutation in cytochrome P-450-dependent 14 alpha-demethylase results in decreased affinity for azole antifungals. Biochem. Soc. Trans. 18(1), 56-59 (1990).
    • (1990) Biochem. Soc. Trans , vol.18 , Issue.1 , pp. 56-59
    • Vanden Bossche, H.1    Marichal, P.2    Gorrens, J.3    Bellens, D.4    Moereels, H.5    Janssen, P.A.6
  • 41
    • 84455161690 scopus 로고    scopus 로고
    • Elevated cell wall chitin in candida albicans confers echinocandin resistance in vivo
    • Lee KK, Maccallum DM, Jacobsen MD et al. Elevated cell wall chitin in Candida albicans confers echinocandin resistance in vivo. Antimicrob. Agents Chemother. 56(1), 208-217 (2012).
    • (2012) Antimicrob. Agents Chemother , vol.56 , Issue.1 , pp. 208-217
    • Lee, K.K.1    Maccallum, D.M.2    Jacobsen, M.D.3
  • 42
    • 0346433839 scopus 로고    scopus 로고
    • The yeast protein kinase c cell integrity pathway mediates tolerance to the antifungal drug caspofungin through activation of slt2p mitogen-activated protein kinase signaling
    • Reinoso-Martin C, Schuller C, Schuetzer- Muehlbauer M, Kuchler K. The yeast protein kinase C cell integrity pathway mediates tolerance to the antifungal drug caspofungin through activation of Slt2p mitogen-activated protein kinase signaling. Eukaryot. Cell 2(6), 1200-1210 (2003).
    • (2003) Eukaryot. Cell , vol.2 , Issue.6 , pp. 1200-1210
    • Reinoso-Martin, C.1    Schuller, C.2    Schuetzer-Muehlbauer, M.3    Kuchler, K.4
  • 43
    • 77951243670 scopus 로고    scopus 로고
    • Changes in the proteome of candida albicans in response to azole, polyene, and echinocandin antifungal agents
    • Hoehamer CF, Cummings ED, Hilliard GM, Rogers PD. Changes in the proteome of Candida albicans in response to azole, polyene, and echinocandin antifungal agents. Antimicrob. Agents Chemother. 54(5), 1655-1664 (2010).
    • (2010) Antimicrob. Agents Chemother , vol.54 , Issue.5 , pp. 1655-1664
    • Hoehamer, C.F.1    Cummings, E.D.2    Hilliard, G.M.3    Rogers, P.D.4
  • 44
    • 84863001304 scopus 로고    scopus 로고
    • Comparative lipidomics in clinical isolates of candida albicans reveal crosstalk between mitochondria, cell wall integrity and azole resistance
    • Singh A, Yadav V, Prasad R. Comparative lipidomics in clinical isolates of Candida albicans reveal crosstalk between mitochondria, cell wall integrity and azole resistance. PLoS ONE 7(6), e39812 (2012).
    • (2012) PLoS ONE , vol.7 , Issue.6
    • Singh, A.1    Yadav, V.2    Prasad, R.3
  • 45
    • 33845244538 scopus 로고    scopus 로고
    • Antifungal effects on metabolite profiles of medically important yeast species measured by nuclear magnetic resonance spectroscopy
    • Coen M, Bodkin J, Power D et al. Antifungal effects on metabolite profiles of medically important yeast species measured by nuclear magnetic resonance spectroscopy. Antimicrob. Agents Chemother. 50(12), 4018-4026 (2006).
    • (2006) Antimicrob. Agents Chemother , vol.50 , Issue.12 , pp. 4018-4026
    • Coen, M.1    Bodkin, J.2    Power, D.3
  • 46
    • 0037079054 scopus 로고    scopus 로고
    • Computational systems biology
    • Kitano H. Computational systems biology. Nature 420(6912), 206-210 (2002).
    • (2002) Nature , vol.420 , Issue.6912 , pp. 206-210
    • Kitano, H.1
  • 47
    • 75949116834 scopus 로고    scopus 로고
    • Gene expression analysis, proteomics, and network discovery
    • Baginsky S, Hennig L, Zimmermann P, Gruissem W. Gene expression analysis, proteomics, and network discovery. Plant Physiol. 152(2), 402-410 (2010).
    • (2010) Plant Physiol , vol.152 , Issue.2 , pp. 402-410
    • Baginsky, S.1    Hennig, L.2    Zimmermann, P.3    Gruissem, W.4
  • 48
    • 0032826408 scopus 로고    scopus 로고
    • Contribution of mutations in the cytochrome p450 14alpha-demethylase (erg11p, cyp51p) to azole resistance in candida albicans
    • Marichal P, Koymans L, Willemsens S et al. Contribution of mutations in the cytochrome P450 14alpha-demethylase (Erg11p, Cyp51p) to azole resistance in Candida albicans. Microbiology 145 (Pt 10), 2701-2713 (1999).
    • (1999) Microbiology , vol.145 PART , Issue.10 , pp. 2701-2713
    • Marichal, P.1    Koymans, L.2    Willemsens, S.3
  • 49
    • 0033986849 scopus 로고    scopus 로고
    • The r467k amino acid substitution in candida albicans sterol 14alpha-demethylase causes drug resistance through reduced affinity
    • Lamb DC, Kelly DE, White TC, Kelly SL. The R467K amino acid substitution in Candida albicans sterol 14alpha-demethylase causes drug resistance through reduced affinity. Antimicrob. Agents Chemother. 44(1), 63-67 (2000).
    • (2000) Antimicrob. Agents Chemother , vol.44 , Issue.1 , pp. 63-67
    • Lamb, D.C.1    Kelly, D.E.2    White, T.C.3    Kelly, S.L.4
  • 50
    • 84877642562 scopus 로고    scopus 로고
    • Erg11 mutations associated with azole resistance in clinical isolates of candida albicans
    • Xiang MJ, Liu JY, Ni PH et al. Erg11 mutations associated with azole resistance in clinical isolates of Candida albicans. FEMS Yeast Res. 13(4), 386-393 (2013).
    • (2013) FEMS Yeast Res , vol.13 , Issue.4 , pp. 386-393
    • Xiang, M.J.1    Liu, J.Y.2    Ni, P.H.3
  • 51
    • 0034729667 scopus 로고    scopus 로고
    • A three-dimensional model of lanosterol 14alpha-demethylase of candida albicans and its interaction with azole antifungals
    • Ji H, Zhang W, Zhou Y et al. A three-dimensional model of lanosterol 14alpha-demethylase of Candida albicans and its interaction with azole antifungals. J. Med. Chem. 43(13), 2493-2505 (2000).
    • (2000) J. Med. Chem , vol.43 , Issue.13 , pp. 2493-2505
    • Ji, H.1    Zhang, W.2    Zhou, Y.3
  • 52
    • 3042771191 scopus 로고    scopus 로고
    • Shuttle vectors for candida albicans: Control of plasmid copy number and elevated expression of cloned genes
    • Du W, Coaker M, Sobel JD, Akins RA. Shuttle vectors for Candida albicans: control of plasmid copy number and elevated expression of cloned genes. Curr. Genet. 45(6), 390-398 (2004).
    • (2004) Curr. Genet , vol.45 , Issue.6 , pp. 390-398
    • Du, W.1    Coaker, M.2    Sobel, J.D.3    Akins, R.A.4
  • 53
    • 0031969879 scopus 로고    scopus 로고
    • Clinical, cellular, and molecular factors that contribute to antifungal drug resistance
    • White TC, Marr KA, Bowden RA. Clinical, cellular, and molecular factors that contribute to antifungal drug resistance. Clin. Microbiol. Rev. 11(2), 382-402 (1998).
    • (1998) Clin. Microbiol. Rev , vol.11 , Issue.2 , pp. 382-402
    • White, T.C.1    Marr, K.A.2    Bowden, R.A.3
  • 54
    • 11144308844 scopus 로고    scopus 로고
    • Role of candida albicans transcription factor upc2p in drug resistance and sterol metabolism
    • Silver PM, Oliver BG, White TC. Role of Candida albicans transcription factor Upc2p in drug resistance and sterol metabolism. Eukaryot. Cell 3(6), 1391-1397 (2004).
    • (2004) Eukaryot. Cell , vol.3 , Issue.6 , pp. 1391-1397
    • Silver, P.M.1    Oliver, B.G.2    White, T.C.3
  • 55
    • 84867168091 scopus 로고    scopus 로고
    • Gain-of-function mutations in upc2 are a frequent cause of erg11 upregulation in azole-resistant clinical isolates of candida albicans
    • Flowers SA, Barker KS, Berkow EL et al. Gain-of-function mutations in UPC2 are a frequent cause of ERG11 upregulation in azole-resistant clinical isolates of Candida albicans. Eukaryot. Cell 11(10), 1289-1299 (2012).
    • (2012) Eukaryot. Cell , vol.11 , Issue.10 , pp. 1289-1299
    • Flowers, S.A.1    Barker, K.S.2    Berkow, E.L.3
  • 56
    • 0242290930 scopus 로고    scopus 로고
    • G484S amino acid substitution in lanosterol 14-alpha demethylase (erg11) is related to fluconazole resistance in a recurrent cryptococcus neoformans clinical isolate
    • Rodero L, Mellado E, Rodriguez AC et al. G484S amino acid substitution in lanosterol 14-alpha demethylase (ERG11) is related to fluconazole resistance in a recurrent Cryptococcus neoformans clinical isolate. Antimicrob. Agents Chemother. 47(11), 3653-3656 (2003).
    • (2003) Antimicrob. Agents Chemother , vol.47 , Issue.11 , pp. 3653-3656
    • Rodero, L.1    Mellado, E.2    Rodriguez, A.C.3
  • 57
    • 0037310145 scopus 로고    scopus 로고
    • Mutations in aspergillus fumigatus resulting in reduced susceptibility to posaconazole appear to be restricted to a single amino acid in the cytochrome p450 14alpha-demethylase
    • Mann PA, Parmegiani RM, Wei SQ et al. Mutations in Aspergillus fumigatus resulting in reduced susceptibility to posaconazole appear to be restricted to a single amino acid in the cytochrome P450 14alpha-demethylase. Antimicrob. Agents Chemother. 47, 577-581 (2003).
    • Antimicrob. Agents Chemother , vol.47 , Issue.2003 , pp. 577-581
    • Mann, P.A.1    Parmegiani, R.M.2    Wei, S.Q.3
  • 58
    • 0037417050 scopus 로고    scopus 로고
    • A point mutation in the 14alpha-sterol demethylase gene cyp51a contributes to itraconazole resistance in aspergillus fumigatus
    • Diaz-Guerra TM, Mellado E, Cuenca-Estrella M, Rodriguez-Tudela JL. A point mutation in the 14alpha-sterol demethylase gene cyp51A contributes to itraconazole resistance in Aspergillus fumigatus. Antimicrob. Agents Chemother. 47, 1120-1124 (2003).
    • (2003) Antimicrob. Agents Chemother , vol.47 , pp. 1120-1124
    • Diaz-Guerra, T.M.1    Mellado, E.2    Cuenca-Estrella, M.3    Rodriguez-Tudela, J.L.4
  • 59
    • 0346784897 scopus 로고    scopus 로고
    • Three-dimensional models of wild-type and mutated forms of cytochrome p450 14alpha-sterol demethylases from aspergillus fumigatus and candida albicans provide insights into posaconazole binding
    • Xiao L, Madison V, Chau AS, Loebenberg D, Palermo RE, Mcnicholas PM. Three-dimensional models of wild-type and mutated forms of cytochrome P450 14alpha-sterol demethylases from Aspergillus fumigatus and Candida albicans provide insights into posaconazole binding. Antimicrob. Agents Chemother. 48(2), 568-574 (2004).
    • (2004) Antimicrob. Agents Chemother , vol.48 , Issue.2 , pp. 568-574
    • Xiao, L.1    Madison, V.2    Chau, A.S.3    Loebenberg, D.4    Palermo, R.E.5    McNicholas, P.M.6
  • 60
    • 11844274704 scopus 로고    scopus 로고
    • Rapid, high-throughput, multiplex, real-time pcr for identification of mutations in the cyp51a gene of aspergillus fumigatus that confer resistance to itraconazole
    • Balashov SV, Gardiner R, Park S, Perlin DS. Rapid, high-throughput, multiplex, real-time PCR for identification of mutations in the cyp51A gene of Aspergillus fumigatus that confer resistance to itraconazole. J. Clin. Microbiol. 43, 214-222 (2005).
    • J. Clin. Microbiol , vol.43 , Issue.2005 , pp. 214-222
    • Balashov, S.V.1    Gardiner, R.2    Park, S.3    Perlin, D.S.4
  • 61
    • 34250223076 scopus 로고    scopus 로고
    • A new aspergillus fumigatus resistance mechanism conferring in vitro cross-resistance to azole antifungals involves a combination of cyp51a alterations
    • Mellado E, Garcia-Effron G, Alczar-Fuoli L et al. A new Aspergillus fumigatus resistance mechanism conferring in vitro cross-resistance to azole antifungals involves a combination of cyp51A alterations. Antimicrob. Agents Chemother. 51, 1897-1904 (2007).
    • (2007) Antimicrob. Agents Chemother , vol.51 , pp. 1897-1904
    • Mellado, E.1    Garcia-Effron, G.2    Alczar-Fuoli, L.3
  • 62
    • 56749159784 scopus 로고    scopus 로고
    • Emergence of azole resistance in aspergillus fumigatus and spread of a single resistance mechanism
    • Snelders E, Van Der Lee HA, Kuijpers J et al. Emergence of azole resistance in Aspergillus fumigatus and spread of a single resistance mechanism. PLoS Med. 5(11), e219 (2008).
    • (2008) PLoS Med , vol.5 , Issue.11
    • Snelders, E.1    Van Der Lee, H.A.2    Kuijpers, J.3
  • 64
    • 84930481483 scopus 로고    scopus 로고
    • Clinical implications of azole resistance in aspergillus fumigatus, the netherlands, 2007-2009
    • Van Der Linden JW, Snelders E, Kampinga GA et al. Clinical implications of azole resistance in Aspergillus fumigatus, The Netherlands, 2007-2009. Emerg. Infect. Dis. 17(10), 1846-1854 (2011).
    • (2011) Emerg. Infect. Dis , vol.17 , Issue.10 , pp. 1846-1854
    • Van Der Linden, J.W.1    Snelders, E.2    Kampinga, G.A.3
  • 65
    • 0000612152 scopus 로고    scopus 로고
    • Resistance to amphotericin b: Emerging clinical and microbiological patterns
    • Sterling TR, Merz WG. Resistance to amphotericin B: emerging clinical and microbiological patterns. Drug Resist. Updat. 1(3), 161-165 (1998).
    • (1998) Drug Resist. Updat , vol.1 , Issue.3 , pp. 161-165
    • Sterling, T.R.1    Merz, W.G.2
  • 66
    • 33847611100 scopus 로고    scopus 로고
    • Reduced susceptibility to polyenes associated with a missense mutation in the erg6 gene in a clinical isolate of candida glabrata with pseudohyphal growth
    • Vandeputte P, Tronchin G, Berges T, Hennequin C, Chabasse D, Bouchara JP. Reduced susceptibility to polyenes associated with a missense mutation in the ERG6 gene in a clinical isolate of Candida glabrata with pseudohyphal growth. Antimicrob. Agents Chemother. 51(3), 982-990 (2007).
    • (2007) Antimicrob. Agents Chemother , vol.51 , Issue.3 , pp. 982-990
    • Vandeputte, P.1    Tronchin, G.2    Berges, T.3    Hennequin, C.4    Chabasse, D.5    Bouchara, J.P.6
  • 67
    • 0029818929 scopus 로고    scopus 로고
    • Resistance to fluconazole and amphotericin in candida albicans from aids patients
    • Kelly SL, Lamb DC, Kelly DE, Loeffler J, Einsele H. Resistance to fluconazole and amphotericin in Candida albicans from AIDS patients. Lancet 348(9040), 1523-1524 (1996).
    • (1996) Lancet , vol.348 , Issue.9040 , pp. 1523-1524
    • Kelly, S.L.1    Lamb, D.C.2    Kelly, D.E.3    Loeffler, J.4    Einsele, H.5
  • 68
    • 0031024163 scopus 로고    scopus 로고
    • Resistance to fluconazole and cross-resistance to amphotericin b in candida albicans from aids patients caused by defective sterol delta5,6-desaturation
    • Kelly SL, Lamb DC, Kelly DE et al. Resistance to fluconazole and cross-resistance to amphotericin B in Candida albicans from AIDS patients caused by defective sterol delta5,6-desaturation. FEBS Lett. 400(1), 80-82 (1997).
    • (1997) FEBS Lett , vol.400 , Issue.1 , pp. 80-82
    • Kelly, S.L.1    Lamb, D.C.2    Kelly, D.E.3
  • 69
    • 84879018308 scopus 로고    scopus 로고
    • Molecular mechanisms of drug resistance in clinical candida species isolated from tunisian hospitals
    • Eddouzi J, Parker JE, Vale-Silva LA et al. Molecular mechanisms of drug resistance in clinical Candida species isolated from Tunisian hospitals. Antimicrob. Agents Chemother. 57(7), 3182-3193 (2013).
    • (2013) Antimicrob. Agents Chemother , vol.57 , Issue.7 , pp. 3182-3193
    • Eddouzi, J.1    Parker, J.E.2    Vale-Silva, L.A.3
  • 71
    • 18544384549 scopus 로고    scopus 로고
    • Global trends in the antifungal susceptibility of cryptococcus neoformans (1990 to 2004)
    • Pfaller MA, Messer SA, Boyken L et al. Global trends in the antifungal susceptibility of Cryptococcus neoformans (1990 to 2004). J. Clin. Microbiol. 43(5), 2163-2167 (2005).
    • (2005) J. Clin. Microbiol , vol.43 , Issue.5 , pp. 2163-2167
    • Pfaller, M.A.1    Messer, S.A.2    Boyken, L.3
  • 72
    • 0027956453 scopus 로고
    • Resistance to amphotericin b associated with defective sterol delta 8-7 isomerase in a cryptococcus neoformans strain from an aids patient
    • Kelly SL, Lamb DC, Taylor M, Corran AJ, Baldwin BC, Powderly WG. Resistance to amphotericin B associated with defective sterol delta 8-7 isomerase in a Cryptococcus neoformans strain from an AIDS patient. FEMS Microbiol. Lett. 122(1-2), 39-42 (1994).
    • (1994) FEMS Microbiol. Lett , vol.122 , Issue.1-2 , pp. 39-42
    • Kelly, S.L.1    Lamb, D.C.2    Taylor, M.3    Corran, A.J.4    Baldwin, B.C.5    Powderly, W.G.6
  • 73
    • 68549130732 scopus 로고    scopus 로고
    • Remodeling of global transcription patterns of cryptococcus neoformans genes mediated by the stress-activated hog signaling pathways
    • Ko YJ, Yu YM, Kim GB et al. Remodeling of global transcription patterns of Cryptococcus neoformans genes mediated by the stress-activated HOG signaling pathways. Eukaryot. Cell 8(8), 1197-1217 (2009).
    • (2009) Eukaryot. Cell , vol.8 , Issue.8 , pp. 1197-1217
    • Ko, Y.J.1    Yu, Y.M.2    Kim, G.B.3
  • 74
    • 0033969288 scopus 로고    scopus 로고
    • In vitro activity of the new triazole bms-207147 against aspergillus species in comparison with itraconazole and amphotericin b
    • Moore CB, Walls CM, Denning DW. In vitro activity of the new triazole BMS-207147 against Aspergillus species in comparison with itraconazole and amphotericin B. Antimicrob. Agents Chemother. 44(2), 441-443 (2000).
    • (2000) Antimicrob. Agents Chemother , vol.44 , Issue.2 , pp. 441-443
    • Moore, C.B.1    Walls, C.M.2    Denning, D.W.3
  • 75
    • 42049089497 scopus 로고    scopus 로고
    • Potential basis for amphotericin b resistance in aspergillus terreus
    • Blum G, Perkhofer S, Haas H et al. Potential basis for amphotericin B resistance in Aspergillus terreus. Antimicrob. Agents Chemother. 52(4), 1553-1555 (2008).
    • (2008) Antimicrob. Agents Chemother , vol.52 , Issue.4 , pp. 1553-1555
    • Blum, G.1    Perkhofer, S.2    Haas, H.3
  • 76
    • 34447105864 scopus 로고    scopus 로고
    • Resistance to echinocandin-class antifungal drugs
    • Perlin DS. Resistance to echinocandin-class antifungal drugs. Drug Resist. Updat. 10(3), 121-130 (2007).
    • (2007) Drug Resist. Updat , vol.10 , Issue.3 , pp. 121-130
    • Perlin, D.S.1
  • 77
    • 33744504444 scopus 로고    scopus 로고
    • Assessing resistance to the echinocandin antifungal drug caspofungin in candida albicans by profiling mutations in fks1
    • Balashov SV, Park S, Perlin DS. Assessing resistance to the echinocandin antifungal drug caspofungin in Candida albicans by profiling mutations in FKS1. Antimicrob. Agents Chemother. 50(6), 2058-2063 (2006).
    • (2006) Antimicrob. Agents Chemother , vol.50 , Issue.6 , pp. 2058-2063
    • Balashov, S.V.1    Park, S.2    Perlin, D.S.3
  • 78
    • 23044471740 scopus 로고    scopus 로고
    • Specific substitutions in the echinocandin target fks1p account for reduced susceptibility of rare laboratory and clinical candida sp
    • Park S, Kelly R, Kahn JN et al. Specific substitutions in the echinocandin target Fks1p account for reduced susceptibility of rare laboratory and clinical Candida sp. isolates. Antimicrob. Agents Chemother. 49(8), 3264-3273 (2005).
    • (2005) Isolates. Antimicrob. Agents Chemother , vol.49 , Issue.8 , pp. 3264-3273
    • Park, S.1    Kelly, R.2    Kahn, J.N.3
  • 79
    • 78649671319 scopus 로고    scopus 로고
    • FKS mutations and elevated echinocandin mic values among candida glabrata isolates from us population-based surveillance
    • Zimbeck AJ, Iqbal N, Ahlquist AM et al. FKS mutations and elevated echinocandin MIC values among Candida glabrata isolates from US population-based surveillance. Antimicrob. Agents Chemother. 54(12), 5042-5047 (2010).
    • (2010) Antimicrob. Agents Chemother , vol.54 , Issue.12 , pp. 5042-5047
    • Zimbeck, A.J.1    Iqbal, N.2    Ahlquist, A.M.3
  • 80
    • 79960329629 scopus 로고    scopus 로고
    • New fks hot spot for acquired echinocandin resistance in saccharomyces cerevisiae and its contribution to intrinsic resistance of scedosporium species
    • Johnson ME, Katiyar SK, Edlind TD. New Fks hot spot for acquired echinocandin resistance in Saccharomyces cerevisiae and its contribution to intrinsic resistance of Scedosporium species. Antimicrob. Agents Chemother. 55(8), 3774-3781 (2011).
    • (2011) Antimicrob. Agents Chemother , vol.55 , Issue.8 , pp. 3774-3781
    • Johnson, M.E.1    Katiyar, S.K.2    Edlind, T.D.3
  • 81
    • 22844431862 scopus 로고    scopus 로고
    • Characterization of aspergillus fumigatus mutants with reduced susceptibility to caspofungin
    • Gardiner RE, Souteropoulos P, Park S, Perlin DS. Characterization of Aspergillus fumigatus mutants with reduced susceptibility to caspofungin. Med. Mycol. 43(Suppl. 1), 299-305 (2005).
    • (2005) Med. Mycol , vol.43 SUPPL. 1 , pp. 299-305
    • Gardiner, R.E.1    Souteropoulos, P.2    Park, S.3    Perlin, D.S.4
  • 82
    • 35848964834 scopus 로고    scopus 로고
    • A ser678pro substitution in fks1p confers resistance to echinocandin drugs in aspergillus fumigatus
    • Rocha EM, Garcia-Effron G, Park S, Perlin DS. A Ser678Pro substitution in Fks1p confers resistance to echinocandin drugs in Aspergillus fumigatus. Antimicrob. Agents Chemother. 51, 4174-4176 (2007).
    • Antimicrob. Agents Chemother , vol.51 , Issue.2007 , pp. 4174-4176
    • Rocha, E.M.1    Garcia-Effron, G.2    Park, S.3    Perlin, D.S.4
  • 83
    • 0032925368 scopus 로고    scopus 로고
    • A glucan synthase fks1 homolog in cryptococcus neoformans is single copy and encodes an essential function
    • Thompson JR, Douglas CM, Li W et al. A glucan synthase FKS1 homolog in Cryptococcus neoformans is single copy and encodes an essential function. J. Bacteriol. 181(2), 444-453 (1999).
    • (1999) J. Bacteriol , vol.181 , Issue.2 , pp. 444-453
    • Thompson, J.R.1    Douglas, C.M.2    Li, W.3
  • 84
    • 21444455677 scopus 로고    scopus 로고
    • Cryptococcus neoformans resistance to echinocandins: (1,3)beta-glucan synthase activity is sensitive to echinocandins
    • Maligie MA, Selitrennikoff CP. Cryptococcus neoformans resistance to echinocandins: (1,3)beta-glucan synthase activity is sensitive to echinocandins. Antimicrob. Agents Chemother. 49(7), 2851-2856 (2005).
    • (2005) Antimicrob. Agents Chemother , vol.49 , Issue.7 , pp. 2851-2856
    • Maligie, M.A.1    Selitrennikoff, C.P.2
  • 85
    • 66449112829 scopus 로고    scopus 로고
    • Efflux-mediated antifungal drug resistance
    • Cannon RD, Lamping E, Holmes AR et al. Efflux-mediated antifungal drug resistance. Clin. Microbiol. Rev. 22(2), 291-321 (2009).
    • (2009) Clin. Microbiol. Rev , vol.22 , Issue.2 , pp. 291-321
    • Cannon, R.D.1    Lamping, E.2    Holmes, A.R.3
  • 86
    • 0034812585 scopus 로고    scopus 로고
    • Prevalence of molecular mechanisms of resistance to azole antifungal agents in candida albicans strains displaying high-level fluconazole resistance isolated from human immunodeficiency virus-infected patients
    • Perea S, Lopez-Ribot JL, Kirkpatrick WR et al. Prevalence of molecular mechanisms of resistance to azole antifungal agents in Candida albicans strains displaying high-level fluconazole resistance isolated from human immunodeficiency virus-infected patients. Antimicrob. Agents Chemother. 45(10), 2676-2684 (2001).
    • (2001) Antimicrob. Agents Chemother , vol.45 , Issue.10 , pp. 2676-2684
    • Perea, S.1    Lopez-Ribot, J.L.2    Kirkpatrick, W.R.3
  • 87
    • 0031047670 scopus 로고    scopus 로고
    • Cloning of candida albicans genes conferring resistance to azole antifungal agents: Characterization of cdr2, a new multidrug abc transporter gene
    • Sanglard D, Ischer F, Monod M, Bille J. Cloning of Candida albicans genes conferring resistance to azole antifungal agents: characterization of CDR2, a new multidrug ABC transporter gene. Microbiology 143(Pt 2), 405-416 (1997).
    • (1997) Microbiology , vol.143 PART , Issue.2 , pp. 405-416
    • Sanglard, D.1    Ischer, F.2    Monod, M.3    Bille, J.4
  • 88
    • 11144270183 scopus 로고    scopus 로고
    • TAC1, transcriptional activator of cdr genes, is a new transcription factor involved in the regulation of candida albicans abc transporters cdr1 and cdr2
    • Coste AT, Karababa M, Ischer F, Bille J, Sanglard D. TAC1, transcriptional activator of CDR genes, is a new transcription factor involved in the regulation of Candida albicans ABC transporters CDR1 and CDR2. Eukaryot. Cell 3(6), 1639-1652 (2004).
    • (2004) Eukaryot. Cell , vol.3 , Issue.6 , pp. 1639-1652
    • Coste, A.T.1    Karababa, M.2    Ischer, F.3    Bille, J.4    Sanglard, D.5
  • 89
    • 68549128735 scopus 로고    scopus 로고
    • Functional analysis of cis- and trans-acting elements of the candida albicans cdr2 promoter with a novel promoter reporter system
    • Coste AT, Crittin J, Bauser C, Rohde B, Sanglard D. Functional analysis of cis- and trans-acting elements of the Candida albicans CDR2 promoter with a novel promoter reporter system. Eukaryot. Cell 8(8), 1250-1267 (2009).
    • (2009) Eukaryot. Cell , vol.8 , Issue.8 , pp. 1250-1267
    • Coste, A.T.1    Crittin, J.2    Bauser, C.3    Rohde, B.4    Sanglard, D.5
  • 90
    • 78149487663 scopus 로고    scopus 로고
    • Persistent candida albicans colonization and molecular mechanisms of azole resistance in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (apeced) patients
    • Siikala E, Rautemaa R, Richardson M, Saxen H, Bowyer P, Sanglard D. Persistent Candida albicans colonization and molecular mechanisms of azole resistance in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) patients. J. Antimicrob. Chemother. 65(12), 2505-2513 (2010).
    • (2010) J. Antimicrob. Chemother , vol.65 , Issue.12 , pp. 2505-2513
    • Siikala, E.1    Rautemaa, R.2    Richardson, M.3    Saxen, H.4    Bowyer, P.5    Sanglard, D.6
  • 91
    • 84900301613 scopus 로고    scopus 로고
    • Resistance to antifungal drugs
    • Kauffman CA, Pappas PG, Sobel JD, Dismukes WE (Eds). Springer, NY, USA
    • Sanglard D. Resistance to antifungal drugs. In: Essentials of Clinical Mycology, Kauffman CA, Pappas PG, Sobel JD, Dismukes WE (Eds). Springer, NY, USA, 135-151 (2011).
    • (2011) Essentials of Clinical Mycology , pp. 135-151
    • Sanglard, D.1
  • 92
    • 36849055552 scopus 로고    scopus 로고
    • Genome-wide expression and location analyses of the candida albicans tac1p regulon
    • Liu TT, Znaidi S, Barker KS et al. Genome-wide expression and location analyses of the Candida albicans Tac1p regulon. Eukaryot. Cell 6(11), 2122-2138 (2007).
    • (2007) Eukaryot. Cell , vol.6 , Issue.11 , pp. 2122-2138
    • Liu, T.T.1    Znaidi, S.2    Barker, K.S.3
  • 93
    • 84883141533 scopus 로고    scopus 로고
    • Analysis of a fungus-specific transcription factor family, the candida albicans zinc cluster proteins, by artificial activation
    • Schillig R, Morschhauser J. Analysis of a fungus-specific transcription factor family, the Candida albicans zinc cluster proteins, by artificial activation. Mol. Microbiol. 89(5), 1003-1017 (2013).
    • (2013) Mol. Microbiol , vol.89 , Issue.5 , pp. 1003-1017
    • Schillig, R.1    Morschhauser, J.2
  • 94
    • 0037238468 scopus 로고    scopus 로고
    • Identification and characterization of a cryptococcus neoformans atp binding cassette (abc) transporter-encoding gene, cnafr1, involved in the resistance to fluconazole
    • Posteraro B, Sanguinetti M, Sanglard D et al. Identification and characterization of a Cryptococcus neoformans ATP binding cassette (ABC) transporter-encoding gene, CnAFR1, involved in the resistance to fluconazole. Mol. Microbiol. 47(2), 357-371 (2003).
    • (2003) Mol. Microbiol , vol.47 , Issue.2 , pp. 357-371
    • Posteraro, B.1    Sanguinetti, M.2    Sanglard, D.3
  • 95
    • 31844440045 scopus 로고    scopus 로고
    • Role of afr1, an abc transporter-encoding gene, in the in vivo response to fluconazole and virulence of cryptococcus neoformans
    • Sanguinetti M, Posteraro B, La Sorda M et al. Role of AFR1, an ABC transporter-encoding gene, in the in vivo response to fluconazole and virulence of Cryptococcus neoformans. Infect. Immun. 74(2), 1352-1359 (2006).
    • (2006) Infect. Immun , vol.74 , Issue.2 , pp. 1352-1359
    • Sanguinetti, M.1    Posteraro, B.2    La Sorda, M.3
  • 96
    • 0036346165 scopus 로고    scopus 로고
    • Increased expression of a novel aspergillus fumigatus abc transporter gene, atrf, in the presence of itraconazole in an itraconazole resistant clinical isolate
    • Slaven JW, Anderson MJ, Sanglard D et al. Increased expression of a novel Aspergillus fumigatus ABC transporter gene, atrF, in the presence of itraconazole in an itraconazole resistant clinical isolate. Fungal Genet. Biol. 36, 199-206 (2002).
    • (2002) Fungal Genet. Biol , vol.36 , pp. 199-206
    • Slaven, J.W.1    Anderson, M.J.2    Sanglard, D.3
  • 97
    • 47749142093 scopus 로고    scopus 로고
    • Mutations in the multi-drug resistance regulator mrr1, followed by loss of heterozygosity, are the main cause of mdr1 overexpression in fluconazole-resistant candida albicans strains
    • Dunkel N, Blass J, Rogers PD, Morschhauser J. Mutations in the multi-drug resistance regulator MRR1, followed by loss of heterozygosity, are the main cause of MDR1 overexpression in fluconazole-resistant Candida albicans strains. Mol. Microbiol. 69(4), 827-840 (2008).
    • (2008) Mol. Microbiol , vol.69 , Issue.4 , pp. 827-840
    • Dunkel, N.1    Blass, J.2    Rogers, P.D.3    Morschhauser, J.4
  • 98
    • 37349095258 scopus 로고    scopus 로고
    • The transcription factor mrr1p controls expression of the mdr1 efflux pump and mediates multidrug resistance in candida albicans
    • Morschhauser J, Barker KS, Liu TT, Bla BWJ, Homayouni R, Rogers PD. The transcription factor Mrr1p controls expression of the MDR1 efflux pump and mediates multidrug resistance in Candida albicans. PLoS Pathog. 3(11), e164 (2007).
    • (2007) PLoS Pathog , vol.3 , Issue.11
    • Morschhauser, J.1    Barker, K.S.2    Liu, T.T.3    Bla, B.W.J.4    Homayouni, R.5    Rogers, P.D.6
  • 99
    • 79961093145 scopus 로고    scopus 로고
    • Functional dissection of a candida albicans zinc cluster transcription factor, the multidrug resistance regulator mrr1
    • Schubert S, Popp C, Rogers PD, Morschhauser J. Functional dissection of a Candida albicans zinc cluster transcription factor, the multidrug resistance regulator Mrr1. Eukaryot. Cell 10(8), 1110-1121 (2011).
    • (2011) Eukaryot. Cell , vol.10 , Issue.8 , pp. 1110-1121
    • Schubert, S.1    Popp, C.2    Rogers, P.D.3    Morschhauser, J.4
  • 100
    • 0030781143 scopus 로고    scopus 로고
    • Cloning and characterization of cnemdr1: A cryptococcus neoformans gene encoding a protein related to multidrug resistance proteins
    • Thornewell SJ, Peery RB, Skatrud PL. Cloning and characterization of CneMDR1: a Cryptococcus neoformans gene encoding a protein related to multidrug resistance proteins. Gene 201(1-2), 21-29 (1997).
    • (1997) Gene , vol.201 , Issue.1-2 , pp. 21-29
    • Thornewell, S.J.1    Peery, R.B.2    Skatrud, P.L.3
  • 101
    • 7244243917 scopus 로고    scopus 로고
    • In vitro evolution of itraconazole resistance in aspergillus fumigatus involves multiple mechanisms of resistance
    • Da Silva Ferreira ME, Capellaro JL, Dos Reis Marques E et al. In vitro evolution of itraconazole resistance in Aspergillus fumigatus involves multiple mechanisms of resistance. Antimicrob. Agents Chemother. 48(11), 4405-4413 (2004).
    • (2004) Antimicrob. Agents Chemother , vol.48 , Issue.11 , pp. 4405-4413
    • Da Silva Ferreira, M.E.1    Capellaro, J.L.2    Dos Reis Marques, E.3
  • 102
    • 77956858683 scopus 로고    scopus 로고
    • Genomic plasticity of the human fungal pathogen candida albicans
    • Selmecki A, Forche A, Berman J. Genomic plasticity of the human fungal pathogen Candida albicans. Eukaryot. Cell 9(7), 991-1008 (2010).
    • (2010) Eukaryot. Cell , vol.9 , Issue.7 , pp. 991-1008
    • Selmecki, A.1    Forche, A.2    Berman, J.3
  • 103
    • 33746506280 scopus 로고    scopus 로고
    • Aneuploidy and isochromosome formation in drug-resistant candida albicans
    • Selmecki A, Forche A, Berman J. Aneuploidy and isochromosome formation in drug-resistant Candida albicans. Science 313(5785), 367-370 (2006).
    • (2006) Science , vol.313 , Issue.5785 , pp. 367-370
    • Selmecki, A.1    Forche, A.2    Berman, J.3
  • 104
    • 35348903338 scopus 로고    scopus 로고
    • Genotypic evolution of azole resistance mechanisms in sequential candida albicans isolates
    • Coste A, Selmecki A, Forche A et al. Genotypic evolution of azole resistance mechanisms in sequential Candida albicans isolates. Eukaryot. Cell 6(10), 1889-1904 (2007).
    • (2007) Eukaryot. Cell , vol.6 , Issue.10 , pp. 1889-1904
    • Coste, A.1    Selmecki, A.2    Forche, A.3
  • 105
    • 73449107205 scopus 로고    scopus 로고
    • Acquisition of aneuploidy provides increased fitness during the evolution of antifungal drug resistance
    • Selmecki AM, Dulmage K, Cowen LE, Anderson JB, Berman J. Acquisition of aneuploidy provides increased fitness during the evolution of antifungal drug resistance. PLoS Genet. 5(10), e1000705 (2009).
    • (2009) PLoS Genet , vol.5 , Issue.10
    • Selmecki, A.M.1    Dulmage, K.2    Cowen, L.E.3    Anderson, J.B.4    Berman, J.5
  • 106
    • 77954047286 scopus 로고    scopus 로고
    • Cryptococcus neoformans overcomes stress of azole drugs by formation of disomy in specific multiple chromosomes
    • Sionov E, Lee H, Chang YC, Kwon-Chung KJ. Cryptococcus neoformans overcomes stress of azole drugs by formation of disomy in specific multiple chromosomes. PLoS Pathog. 6(4), e1000848 (2010).
    • (2010) PLoS Pathog , vol.6 , Issue.4
    • Sionov, E.1    Lee, H.2    Chang, Y.C.3    Kwon-Chung, K.J.4
  • 107
    • 84863238184 scopus 로고    scopus 로고
    • Characterization of the chromosome 4 genes that affect fluconazole-induced disomy formation in cryptococcus neoformans
    • Ngamskulrungroj P, Chang Y, Hansen B, Bugge C, Fischer E, Kwon-Chung KJ. Characterization of the chromosome 4 genes that affect fluconazole-induced disomy formation in Cryptococcus neoformans. PLoS ONE 7(3), e33022 (2012).
    • (2012) PLoS ONE , vol.7 , Issue.3
    • Ngamskulrungroj, P.1    Chang, Y.2    Hansen, B.3    Bugge, C.4    Fischer, E.5    Kwon-Chung, K.J.6
  • 108
    • 77953710273 scopus 로고    scopus 로고
    • Clinically significant micafungin resistance in candida albicans involves modification of a glucan synthase catalytic subunit gsc1 (fks1) allele followed by loss of heterozygosity
    • Niimi K, Monk BC, Hirai A et al. Clinically significant micafungin resistance in Candida albicans involves modification of a glucan synthase catalytic subunit GSC1 (FKS1) allele followed by loss of heterozygosity. J. Antimicrob. Chemother. 65(5), 842-852 (2010).
    • (2010) J. Antimicrob. Chemother , vol.65 , Issue.5 , pp. 842-852
    • Niimi, K.1    Monk, B.C.2    Hirai, A.3
  • 109
    • 70049108302 scopus 로고    scopus 로고
    • Hsp90 orchestrates stress response signaling governing fungal drug resistance
    • Cowen LE. Hsp90 orchestrates stress response signaling governing fungal drug resistance. PLoS Pathog. 5(8), e1000471 (2009).
    • (2009) PLoS Pathog , vol.5 , Issue.8
    • Cowen, L.E.1
  • 110
    • 25844530060 scopus 로고    scopus 로고
    • Hsp90 potentiates the rapid evolution of new traits: Drug resistance in diverse fungi
    • Cowen LE, Lindquist S. Hsp90 potentiates the rapid evolution of new traits: drug resistance in diverse fungi. Science 309(5744), 2185-2189 (2005).
    • (2005) Science , vol.309 , Issue.5744 , pp. 2185-2189
    • Cowen, L.E.1    Lindquist, S.2
  • 111
    • 62449104891 scopus 로고    scopus 로고
    • Harnessing hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease
    • Cowen LE, Singh SD, Kohler JR et al. Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease. Proc. Natl Acad. Sci. USA 106(8), 2818-2823 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , Issue.8 , pp. 2818-2823
    • Cowen, L.E.1    Singh, S.D.2    Kohler, J.R.3
  • 113
    • 84866114557 scopus 로고    scopus 로고
    • The hsp90 co-chaperone sgt1 governs candida albicans morphogenesis and drug resistance
    • Shapiro RS, Zaas AK, Betancourt-Quiroz M, Perfect JR, Cowen LE. The Hsp90 co-chaperone Sgt1 governs Candida albicans morphogenesis and drug resistance. PLoS ONE 7(9), e44734 (2012).
    • (2012) PLoS ONE , vol.7 , Issue.9
    • Shapiro, R.S.1    Zaas, A.K.2    Betancourt-Quiroz, M.3    Perfect, J.R.4    Cowen, L.E.5
  • 114
    • 84868125083 scopus 로고    scopus 로고
    • Lysine deacetylases hda1 and rpd3 regulate hsp90 function thereby governing fungal drug resistance
    • Robbins N, Leach MD, Cowen LE. Lysine deacetylases Hda1 and Rpd3 regulate Hsp90 function thereby governing fungal drug resistance. Cell Rep. 2(4), 878-888 (2012).
    • (2012) Cell Rep , vol.2 , Issue.4 , pp. 878-888
    • Robbins, N.1    Leach, M.D.2    Cowen, L.E.3
  • 115
    • 84865368550 scopus 로고    scopus 로고
    • Amino acid substitutions in the candida albicans sterol delta5,6-desaturase (erg3p) confer azole resistance: Characterization of two novel mutants with impaired virulence
    • Morio F, Pagniez F, Lacroix C, Miegeville M, Le Pape P. Amino acid substitutions in the Candida albicans sterol Delta5,6-desaturase (Erg3p) confer azole resistance: characterization of two novel mutants with impaired virulence. J. Antimicrob. Chemother. 67(9), 2131-2138 (2012).
    • (2012) J. Antimicrob. Chemother , vol.67 , Issue.9 , pp. 2131-2138
    • Morio, F.1    Pagniez, F.2    Lacroix, C.3    Miegeville, M.4    Le Pape, P.5
  • 116
    • 84858663078 scopus 로고    scopus 로고
    • Azole resistance by loss of function of the sterol delta(5),(6)- desaturase gene (erg3) in candida albicans does not necessarily decrease virulence
    • Vale-Silva LA, Coste AT, Ischer F et al. Azole resistance by loss of function of the sterol delta(5),(6)-desaturase gene (ERG3) in Candida albicans does not necessarily decrease virulence. Antimicrob. Agents Chemother. 56(4), 1960-1968 (2012).
    • (2012) Antimicrob. Agents Chemother , vol.56 , Issue.4 , pp. 1960-1968
    • Vale-Silva, L.A.1    Coste, A.T.2    Ischer, F.3
  • 117
    • 33846976163 scopus 로고    scopus 로고
    • The pkc, hog and ca2+ signalling pathways co-ordinately regulate chitin synthesis in candida albicans
    • Munro CA, Selvaggini S, De Bruijn I et al. The PKC, HOG and Ca2+ signalling pathways co-ordinately regulate chitin synthesis in Candida albicans. Mol. Microbiol. 63(5), 1399-1413 (2007).
    • (2007) Mol. Microbiol , vol.63 , Issue.5 , pp. 1399-1413
    • Munro, C.A.1    Selvaggini, S.2    De Bruijn, I.3
  • 118
    • 84862805988 scopus 로고    scopus 로고
    • Involvement of PDK1, PKC and TOR signalling pathways in basal fluconazole tolerance in Cryptococcus neoformans
    • Lee H, Khanal Lamichhane A, Garraffo HM, Kwon-Chung KJ, Chang YC, Involvement of PDK1, PKC and TOR signalling pathways in basal fluconazole tolerance in Cryptococcus neoformans. Mol. Microbiol 84(1), 130-146 (2012).
    • (2012) Mol. Microbiol , vol.84 , Issue.1 , pp. 130-146
    • Lee, H.1    Khanal Lamichhane, A.2    Garraffo, H.M.3    Kwon-Chung, K.J.4    Chang, Y.C.5
  • 119
    • 84872031378 scopus 로고    scopus 로고
    • Elevated chitin content reduces the susceptibility of candida species to caspofungin
    • Walker LA, Gow NA, Munro CA. Elevated chitin content reduces the susceptibility of Candida species to caspofungin. Antimicrob. Agents Chemother. 57(1), 146-154 (2013).
    • (2013) Antimicrob. Agents Chemother , vol.57 , Issue.1 , pp. 146-154
    • Walker, L.A.1    Gow, N.A.2    Munro, C.A.3
  • 120
    • 27844588529 scopus 로고    scopus 로고
    • Regulation of sterol metabolism in candida albicans by the upc2 gene
    • White TC, Silver PM. Regulation of sterol metabolism in Candida albicans by the UPC2 gene. Biochem. Soc. Trans. 33(Pt 5), 1215-1218 (2005).
    • (2005) Biochem. Soc. Trans , vol.33 , Issue.PART 5 , pp. 1215-1218
    • White, T.C.1    Silver, P.M.2
  • 121
    • 84891528835 scopus 로고    scopus 로고
    • Novel antifungal drug discovery based on targeting pathways regulating the fungal-conserved upc2 rranscription factor
    • Gallo-Ebert C, Donigan M, Stroke IL et al. Novel antifungal drug discovery based on targeting pathways regulating the fungal-conserved Upc2 rranscription factor. Antimicrob. Agents Chemother. 58(1), 258-266 (2014).
    • (2014) Antimicrob. Agents Chemother , vol.58 , Issue.1 , pp. 258-266
    • Gallo-Ebert, C.1    Donigan, M.2    Stroke, I.L.3
  • 122
    • 84855278233 scopus 로고    scopus 로고
    • SREBP coordinates iron and ergosterol homeostasis to mediate triazole drug and hypoxia responses in the human fungal pathogen aspergillus fumigatus
    • Blatzer M, Barker BM, Willger SD et al. SREBP coordinates iron and ergosterol homeostasis to mediate triazole drug and hypoxia responses in the human fungal pathogen Aspergillus fumigatus. PLoS Genet. 7(12), e1002374 (2011).
    • (2011) PLoS Genet , vol.7 , Issue.12
    • Blatzer, M.1    Barker, B.M.2    Willger, S.D.3
  • 123
    • 72449173927 scopus 로고    scopus 로고
    • Conservation of the sterol regulatory element-binding protein pathway and its pathobiological importance in cryptococcus neoformans
    • Chang YC, Ingavale SS, Bien C, Espenshade P, Kwon-Chung KJ. Conservation of the sterol regulatory element-binding protein pathway and its pathobiological importance in Cryptococcus neoformans. Eukaryot. Cell 8(11), 1770-1779 (2009).
    • (2009) Eukaryot. Cell , vol.8 , Issue.11 , pp. 1770-1779
    • Chang, Y.C.1    Ingavale, S.S.2    Bien, C.3    Espenshade, P.4    Kwon-Chung, K.J.5
  • 124
    • 2142645082 scopus 로고    scopus 로고
    • Membrane sphingolipid-ergosterol interactions are important determinants of multidrug resistance in candida albicans
    • Mukhopadhyay K, Prasad T, Saini P, Pucadyil TJ, Chattopadhyay A, Prasad R. Membrane sphingolipid-ergosterol interactions are important determinants of multidrug resistance in Candida albicans. Antimicrob. Agents Chemother. 48(5), 1778-1787 (2004).
    • (2004) Antimicrob. Agents Chemother , vol.48 , Issue.5 , pp. 1778-1787
    • Mukhopadhyay, K.1    Prasad, T.2    Saini, P.3    Pucadyil, T.J.4    Chattopadhyay, A.5    Prasad, R.6
  • 125
    • 84867469852 scopus 로고    scopus 로고
    • CRS-mis in candida glabrata: Sphingolipids modulate echinocandin-fks interaction
    • Healey KR, Katiyar SK, Raj S, Edlind TD. CRS-MIS in Candida glabrata: sphingolipids modulate echinocandin-Fks interaction. Mol. Microbiol. 86(2), 303-313 (2012).
    • (2012) Mol. Microbiol , vol.86 , Issue.2 , pp. 303-313
    • Healey, K.R.1    Katiyar, S.K.2    Raj, S.3    Edlind, T.D.4
  • 126
    • 79952420944 scopus 로고    scopus 로고
    • Contribution of cgpdr1- regulated genes in enhanced virulence of azole-resistant candida glabrata
    • Ferrari S, Sanguinetti M, Torelli R, Posteraro B, Sanglard D. Contribution of CgPDR1- regulated genes in enhanced virulence of azole-resistant Candida glabrata. PLoS ONE 6(3), e17589 (2011).
    • (2011) PLoS ONE , vol.6 , Issue.3
    • Ferrari, S.1    Sanguinetti, M.2    Torelli, R.3    Posteraro, B.4    Sanglard, D.5
  • 127
    • 84872026338 scopus 로고    scopus 로고
    • Azole susceptibility and transcriptome profiling in candida albicans mitochondrial electron transport chain complex i mutants
    • Sun N, Fonzi W, Chen H, She X, Zhang L, Calderone R. Azole susceptibility and transcriptome profiling in Candida albicans mitochondrial electron transport chain complex I mutants. Antimicrob. Agents Chemother. 57(1), 532-542 (2013).
    • (2013) Antimicrob. Agents Chemother , vol.57 , Issue.1 , pp. 532-542
    • Sun, N.1    Fonzi, W.2    Chen, H.3    She, X.4    Zhang, L.5    Calderone, R.6
  • 128
    • 80055116385 scopus 로고    scopus 로고
    • Mitochondria and fungal pathogenesis: Drug tolerance, virulence, and potential for antifungal therapy
    • Shingu-Vazquez M, Traven A. Mitochondria and fungal pathogenesis: drug tolerance, virulence, and potential for antifungal therapy. Eukaryot. Cell 10(11), 1376-1383 (2011).
    • (2011) Eukaryot. Cell , vol.10 , Issue.11 , pp. 1376-1383
    • Shingu-Vazquez, M.1    Traven, A.2
  • 129
    • 33751235557 scopus 로고    scopus 로고
    • How to build a biofilm: A fungal perspective
    • Blankenship JR, Mitchell AP. How to build a biofilm: a fungal perspective. Curr. Opin. Microbiol. 9(6), 588-594 (2006).
    • (2006) Curr. Opin. Microbiol , vol.9 , Issue.6 , pp. 588-594
    • Blankenship, J.R.1    Mitchell, A.P.2
  • 130
    • 0041764578 scopus 로고    scopus 로고
    • Mechanism of fluconazole resistance in candida albicans biofilms: Phase-specific role of efflux pumps and membrane sterols
    • Mukherjee PK, Chandra J, Kuhn DM, Ghannoum MA. Mechanism of fluconazole resistance in Candida albicans biofilms: phase-specific role of efflux pumps and membrane sterols. Infect. Immun. 71(8), 4333-4340 (2003).
    • (2003) Infect. Immun , vol.71 , Issue.8 , pp. 4333-4340
    • Mukherjee, P.K.1    Chandra, J.2    Kuhn, D.M.3    Ghannoum, M.A.4
  • 132
    • 67649990881 scopus 로고    scopus 로고
    • Biofilm matrix regulation by candida albicans zap1
    • Nobile CJ, Nett JE, Hernday AD et al. Biofilm matrix regulation by Candida albicans Zap1. PLoS Biol. 7(6), e1000133 (2009).
    • (2009) PLoS Biol , vol.7 , Issue.6
    • Nobile, C.J.1    Nett, J.E.2    Hernday, A.D.3
  • 133
    • 77953719723 scopus 로고    scopus 로고
    • Genetic basis of candida biofilm resistance due to drug-sequestering matrix glucan
    • Nett JE, Sanchez H, Cain MT, Andes DR. Genetic basis of Candida biofilm resistance due to drug-sequestering matrix glucan. J. Infect. Dis. 202(1), 171-175 (2010).
    • (2010) J. Infect. Dis , vol.202 , Issue.1 , pp. 171-175
    • Nett, J.E.1    Sanchez, H.2    Cain, M.T.3    Andes, D.R.4
  • 134
    • 82555161649 scopus 로고    scopus 로고
    • Interface of candida albicans biofilm matrix-associated drug resistance and cell wall integrity regulation
    • Nett JE, Sanchez H, Cain MT, Ross KM, Andes DR. Interface of Candida albicans biofilm matrix-associated drug resistance and cell wall integrity regulation. Eukaryot. Cell 10(12), 1660-1669 (2011).
    • (2011) Eukaryot. Cell , vol.10 , Issue.12 , pp. 1660-1669
    • Nett, J.E.1    Sanchez, H.2    Cain, M.T.3    Ross, K.M.4    Andes, D.R.5
  • 135
    • 80053455899 scopus 로고    scopus 로고
    • Hsp90 governs dispersion and drug resistance of fungal biofilms
    • Robbins N, Uppuluri P, Nett J et al. Hsp90 governs dispersion and drug resistance of fungal biofilms. PLoS Pathog. 7(9), e1002257 (2011).
    • (2011) PLoS Pathog , vol.7 , Issue.9
    • Robbins, N.1    Uppuluri, P.2    Nett, J.3
  • 136
    • 84880065202 scopus 로고    scopus 로고
    • Regulatory role of glycerol in candida albicans biofilm formation
    • Desai JV, Bruno VM, Ganguly S et al. Regulatory role of glycerol in Candida albicans biofilm formation. MBio 4(2), e00637-e00612 (2013).
    • (2013) MBio , vol.4 , Issue.2
    • Desai, J.V.1    Bruno, V.M.2    Ganguly, S.3
  • 137
    • 84893508246 scopus 로고    scopus 로고
    • An in vitro study of sequential fluconazole/caspofungin treatment against candida albicans biofilms
    • Sarkar S, Uppuluri P, Pierce CG, Lopez-Ribot JL. An in vitro study of sequential fluconazole/caspofungin treatment against Candida albicans biofilms. Antimicrob. Agents Chemother. 58(2), 1183-1186 (2014).
    • (2014) Antimicrob. Agents Chemother , vol.58 , Issue.2 , pp. 1183-1186
    • Sarkar, S.1    Uppuluri, P.2    Pierce, C.G.3    Lopez-Ribot, J.L.4
  • 138
    • 79955544138 scopus 로고    scopus 로고
    • Azole resistance of aspergillus fumigatus biofilms is partly associated with efflux pump activity
    • Rajendran R, Mowat E, Mcculloch E et al. Azole resistance of Aspergillus fumigatus biofilms is partly associated with efflux pump activity. Antimicrob. Agents Chemother. 55(5), 2092-2097 (2011).
    • (2011) Antimicrob. Agents Chemother , vol.55 , Issue.5 , pp. 2092-2097
    • Rajendran, R.1    Mowat, E.2    McCulloch, E.3
  • 139
    • 84874519965 scopus 로고    scopus 로고
    • Extracellular dna release acts as an antifungal resistance mechanism in mature aspergillus fumigatus biofilms
    • Rajendran R, Williams C, Lappin DF, Millington O, Martins M, Ramage G. Extracellular DNA release acts as an antifungal resistance mechanism in mature Aspergillus fumigatus biofilms. Eukaryot. Cell 12(3), 420-429 (2013).
    • (2013) Eukaryot. Cell , vol.12 , Issue.3 , pp. 420-429
    • Rajendran, R.1    Williams, C.2    Lappin, D.F.3    Millington, O.4    Martins, M.5    Ramage, G.6
  • 141
    • 0034896166 scopus 로고    scopus 로고
    • Rationale for combination antifungal therapy
    • Lewis RE, Kontoyiannis DP. Rationale for combination antifungal therapy. Pharmacotherapy 21(8 Pt 2), 149S-164S (2001).
    • (2001) Pharmacotherapy , vol.21 PART 2 , Issue.8
    • Lewis, R.E.1    Kontoyiannis, D.P.2
  • 142
    • 84862765955 scopus 로고    scopus 로고
    • Managing drug resistance in cancer: Lessons from hiv therapy
    • Bock C, Lengauer T. Managing drug resistance in cancer: lessons from HIV therapy. Nat. Rev. Cancer 12(7), 494-501 (2012).
    • (2012) Nat. Rev. Cancer , vol.12 , Issue.7 , pp. 494-501
    • Bock, C.1    Lengauer, T.2
  • 143
    • 70449732094 scopus 로고    scopus 로고
    • Artemisinin-based combination therapies: A vital tool in efforts to eliminate malaria
    • Eastman RT, Fidock DA. Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria. Nat. Rev. Microbiol. 7(12), 864-874 (2009).
    • (2009) Nat. Rev. Microbiol , vol.7 , Issue.12 , pp. 864-874
    • Eastman, R.T.1    Fidock, D.A.2
  • 144
  • 146
    • 77954541309 scopus 로고    scopus 로고
    • Modulation of histone h3 lysine 56 acetylation as an antifungal therapeutic strategy
    • Wurtele H, Tsao S, Lepine G et al. Modulation of histone H3 lysine 56 acetylation as an antifungal therapeutic strategy. Nat. Med. 16(7), 774-780 (2010).
    • (2010) Nat. Med , vol.16 , Issue.7 , pp. 774-780
    • Wurtele, H.1    Tsao, S.2    Lepine, G.3
  • 148
    • 34249069582 scopus 로고    scopus 로고
    • Harnessing calcineurin as a novel anti-infective agent against invasive fungal infections
    • Steinbach WJ, Reedy JL, Cramer RA Jr, Perfect JR, Heitman J. Harnessing calcineurin as a novel anti-infective agent against invasive fungal infections. Nat. Rev. Microbiol. 5(6), 418-430 (2007).
    • (2007) Nat. Rev. Microbiol , vol.5 , Issue.6 , pp. 418-430
    • Steinbach, W.J.1    Reedy, J.L.2    Cramer, Jr.R.A.3    Perfect, J.R.4    Heitman, J.5
  • 149
    • 84887275447 scopus 로고    scopus 로고
    • Exploring the trypanosoma brucei hsp83 potential as a target for structure guided drug design
    • Pizarro JC, Hills T, Senisterra G et al. Exploring the Trypanosoma brucei Hsp83 potential as a target for structure guided drug design. PLoS Negl. Trop. Dis. 7(10), e2492 (2013).
    • (2013) PLoS Negl. Trop. Dis , vol.7 , Issue.10
    • Pizarro, J.C.1    Hills, T.2    Senisterra, G.3
  • 150
    • 80053400607 scopus 로고    scopus 로고
    • Structures of cryptococcus neoformans protein farnesyltransferase reveal strategies for developing inhibitors that target fungal pathogens
    • Hast MA, Nichols CB, Armstrong SM et al. Structures of Cryptococcus neoformans protein farnesyltransferase reveal strategies for developing inhibitors that target fungal pathogens. J. Biol. Chem. 286(40), 35149-35162 (2011).
    • (2011) J. Biol. Chem , vol.286 , Issue.40 , pp. 35149-35162
    • Hast, M.A.1    Nichols, C.B.2    Armstrong, S.M.3
  • 151
    • 84881022393 scopus 로고    scopus 로고
    • Can host receptors for fungi be targeted for treatment of fungal infections
    • Filler SG
    • (2013) Trends Microbiol , vol.21 , Issue.8 , pp. 389-396
    • Filler, S.G.1
  • 152
    • 84865545145 scopus 로고    scopus 로고
    • EGFR and her2 receptor kinase signaling mediate epithelial cell invasion by candida albicans during oropharyngeal infection
    • Zhu W, Phan QT, Boontheung P, Solis NV, Loo JA, Filler SG. EGFR and HER2 receptor kinase signaling mediate epithelial cell invasion by Candida albicans during oropharyngeal infection. Proc. Natl Acad. Sci. USA 109(35), 14194-14199 (2012).
    • (2012) Proc. Natl Acad. Sci. USA , vol.109 , Issue.35 , pp. 14194-14199
    • Zhu, W.1    Phan, Q.T.2    Boontheung, P.3    Solis, N.V.4    Loo, J.A.5    Filler, S.G.6
  • 154
    • 84861168204 scopus 로고    scopus 로고
    • Immunoglobulins in defense, pathogenesis, and therapy of fungal diseases
    • Casadevall A, Pirofski LA. Immunoglobulins in defense, pathogenesis, and therapy of fungal diseases. Cell Host Microbe 11(5), 447-456 (2012).
    • (2012) Cell Host Microbe , vol.11 , Issue.5 , pp. 447-456
    • Casadevall, A.1    Pirofski, L.A.2
  • 156
    • 84861148620 scopus 로고    scopus 로고
    • Exciting developments in the immunology of fungal infections
    • Brown GD, Netea MG. Exciting developments in the immunology of fungal infections. Cell Host Microbe 11(5), 422-424 (2012).
    • (2012) Cell Host Microbe , vol.11 , Issue.5 , pp. 422-424
    • Brown, G.D.1    Netea, M.G.2
  • 157
    • 84861142106 scopus 로고    scopus 로고
    • Dendritic cells in antifungal immunity and vaccine design
    • Roy RM, Klein BS. Dendritic cells in antifungal immunity and vaccine design. Cell Host Microbe 11(5), 436-446 (2012).
    • (2012) Cell Host Microbe , vol.11 , Issue.5 , pp. 436-446
    • Roy, R.M.1    Klein, B.S.2
  • 158
    • 33646242974 scopus 로고    scopus 로고
    • A drug-sensitive genetic network masks fungi from the immune system
    • Wheeler RT, Fink GR. A drug-sensitive genetic network masks fungi from the immune system. PLoS Pathog. 2(4), e35 (2006).
    • (2006) PLoS Pathog , vol.2 , Issue.4
    • Wheeler, R.T.1    Fink, G.R.2


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