Mutations in the multi-drug resistance regulator MRR1, followed by loss of heterozygosity, are the main cause of MDR1 overexpression in fluconazole-resistant Candida albicans strains

Molecular Microbiology

Volumn 69, Issue 4, 2008, Pages 827-840

  Dunkel, Nico ^a   Blaß, Julia ^a   Rogers, P David ^b   Morschhäuser, Joachim ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b UNIVERSITY OF TENNESSEE COLLEGE OF PHARMACY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLUCONAZOLE; MULTIDRUG RESISTANCE PROTEIN 1; PROTEIN MRR1; REGULATOR PROTEIN;

ALLELE; AMINO ACID SUBSTITUTION; ANTIBIOTIC RESISTANCE; ARTICLE; CANDIDA ALBICANS; CHROMOSOME 3; CHROMOSOME DUPLICATION; CHROMOSOME LOSS; CONTROLLED STUDY; DRUG SENSITIVITY; FUNGAL STRAIN; FUNGUS ISOLATION; GENE MUTATION; HETEROZYGOSITY LOSS; MULTIDRUG RESISTANCE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; UPREGULATION;

ALLELES; ANTIFUNGAL AGENTS; BASE SEQUENCE; CANDIDA ALBICANS; DRUG RESISTANCE, MULTIPLE, FUNGAL; FLUCONAZOLE; FUNGAL PROTEINS; GENE EXPRESSION REGULATION, FUNGAL; GENES, REGULATOR; LOSS OF HETEROZYGOSITY; MOLECULAR SEQUENCE DATA; MUTATION; P-GLYCOPROTEIN; PROMOTER REGIONS (GENETICS); PROTEIN STRUCTURE, TERTIARY; RECOMBINATION, GENETIC; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; UP-REGULATION;

CANDIDA ALBICANS;

EID: 47749142093     PISSN: 0950382X     EISSN: 13652958     Source Type: Journal    
DOI: 10.1111/j.1365-2958.2008.06309.x     Document Type: Article

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