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Volumn 57, Issue 7, 2013, Pages 3182-3193

Molecular mechanisms of drug resistance in clinical Candida species isolated from tunisian hospitals

Author keywords

[No Author keywords available]

Indexed keywords

14ALPHA METHYL ERGOSTA 8,24(28) DIEN 3ALPHA,6BETA DIOL; 14ALPHA METHYL FECOSTEROL; AMPHOTERICIN B; BREFELDIN A; CASPOFUNGIN; ERGOSTEROL; FLUCONAZOLE; MULTIDRUG RESISTANCE PROTEIN 1; NUCLEOTIDE; POLYENE; PROTEIN ERG 11; PYRROLE; STEROL DERIVATIVE; UNCLASSIFIED DRUG; VORICONAZOLE;

EID: 84879018308     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00555-13     Document Type: Article
Times cited : (87)

References (54)
  • 1
    • 0028793725 scopus 로고
    • Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters
    • Sanglard D, Kuchler K, Ischer F, Pagani JL, Monod M, Bille J. 1995. Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters. Antimicrob. Agents Chemother. 39:2378-2386.
    • (1995) Antimicrob. Agents Chemother , vol.39 , pp. 2378-2386
    • Sanglard, D.1    Kuchler, K.2    Ischer, F.3    Pagani, J.L.4    Monod, M.5    Bille, J.6
  • 4
    • 3943093972 scopus 로고    scopus 로고
    • Nosocomial bloodstream infections in US hospitals: Analysis of 24,179 cases from a prospective nationwide surveillance study
    • DOI 10.1086/421946
    • Wisplinghoff H, Bischoff T, Tallent SM, Seifert H, Wenzel RP, Edmond MB. 2004. Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study. Clin. Infect. Dis. 39:309-317. (Pubitemid 39050477)
    • (2004) Clinical Infectious Diseases , vol.39 , Issue.3 , pp. 309-317
    • Wisplinghoff, H.1    Bischoff, T.2    Tallent, S.M.3    Seifert, H.4    Wenzel, R.P.5    Edmond, M.B.6
  • 5
    • 27744433240 scopus 로고    scopus 로고
    • In vitro activities of anidulafungin against more than 2,500 clinical isolates of Candida spp., including 315 isolates resistant to fluconazole
    • DOI 10.1128/JCM.43.11.5425-5427.2005
    • Pfaller MA, Boyken L, Hollis RJ, Messer SA, Tendolkar S, Diekema DJ. 2005. In vitro activities of anidulafungin against more than 2,500 clinical isolates of Candida spp., including 315 isolates resistant to fluconazole. J. Clin. Microbiol. 43:5425-5427. (Pubitemid 41612308)
    • (2005) Journal of Clinical Microbiology , vol.43 , Issue.11 , pp. 5425-5427
    • Pfaller, M.A.1    Boyken, L.2    Hollis, R.J.3    Messer, S.A.4    Tendolkar, S.5    Diekema, D.J.6
  • 6
    • 30744462355 scopus 로고    scopus 로고
    • Results from the ARTEMIS DISK global antifungal surveillance study: A 6.5-year analysis of susceptibilities of Candida and other yeast species to fluconazole and voriconazole by standardized disk diffusion testing
    • DOI 10.1128/JCM.43.12.5848-5859.2005
    • Pfaller MA, Diekema DJ, Rinaldi MG, Barnes R, Hu B, Veselov AV, Tiraboschi N, Nagy E, Gibbs DL. 2005. Results from the ARTEMIS DISK Global Antifungal Surveillance Study: a 6.5-year analysis of susceptibilities of Candida and other yeast species to fluconazole and voriconazole by standardized disk diffusion testing. J. Clin. Microbiol. 43:5848-5859. (Pubitemid 43100628)
    • (2005) Journal of Clinical Microbiology , vol.43 , Issue.12 , pp. 5848-5859
    • Pfaller, M.A.1    Diekema, D.J.2    Rinaldi, M.G.3    Barnes, R.4    Hu, B.5    Veselov, A.V.6    Tiraboschi, N.7    Nagy, E.8    Gibbs, D.L.9
  • 7
    • 77955295116 scopus 로고    scopus 로고
    • Candida tropicalis: Its prevalence, pathogenicity, and increasing resistance to fluconazole
    • Kothavade RJ, Kura MM, Valand AG, Panthaki MH. 2010. Candida tropicalis: its prevalence, pathogenicity, and increasing resistance to fluconazole. J. Med. Microbiol. 59:873-880.
    • (2010) J. Med. Microbiol. , vol.59 , pp. 873-880
    • Kothavade, R.J.1    Kura, M.M.2    Valand, A.G.3    Panthaki, M.H.4
  • 8
    • 34547584830 scopus 로고    scopus 로고
    • Predominance of Candida tropicalis bloodstream infections in a Singapore teaching hospital
    • DOI 10.1080/13693780701385868, PII 780831940
    • Chai YA, Wang Y, Khoo AL, Chan FY, Chow C, Kumarasinghe G, Singh K, Tambyah PA. 2007. Predominance of Candida tropicalis bloodstream infections in a Singapore teaching hospital. Med. Mycol. 45:435-439. (Pubitemid 47190129)
    • (2007) Medical Mycology , vol.45 , Issue.5 , pp. 435-439
    • Chai, Y.A.L.1    Wang, Y.2    Khoo, A.L.3    Chan, F.Y.4    Chow, C.5    Kumarasinghe, G.6    Singh, K.7    Tambyah, P.A.8
  • 9
    • 76649099519 scopus 로고    scopus 로고
    • The distribution of species and susceptibility of amphotericin B and fluconazole of yeast pathogens isolated from sterile sites in Taiwan
    • Yang YL, Cheng MF, Wang CW, Wang AH, Cheng WT, Lo HJ, Hospitals T. 2010. The distribution of species and susceptibility of amphotericin B and fluconazole of yeast pathogens isolated from sterile sites in Taiwan. Med. Mycol. 48:328-334.
    • (2010) Med. Mycol. , vol.48 , pp. 328-334
    • Yang, Y.L.1    Cheng, M.F.2    Wang, C.W.3    Wang, A.H.4    Cheng, W.T.5    Lo, H.J.6    Hospitals, T.7
  • 10
    • 0032734512 scopus 로고    scopus 로고
    • The ATP binding cassette transporter gene CgCDR1 from Candida glabrata is involved in the resistance of clinical isolates to azole antifungal agents
    • Sanglard D, Ischer F, Calabrese D, Majcherczyk PA, Bille J. 1999. The ATP binding cassette transporter gene CgCDR1 from Candida glabrata is involved in the resistance of clinical isolates to azole antifungal agents. Antimicrob. Agents Chemother. 43:2753-2765. (Pubitemid 29519560)
    • (1999) Antimicrobial Agents and Chemotherapy , vol.43 , Issue.11 , pp. 2753-2765
    • Sanglard, D.1    Ischer, F.2    Calabrese, D.3    Majcherczyk, P.A.4    Bille, J.5
  • 11
    • 3342910270 scopus 로고    scopus 로고
    • In vitro activities of ravuconazole and four other antifungal agents against fluconazole-resistant or -susceptible clinical yeast isolates
    • DOI 10.1128/AAC.48.8.3107-3111.2004
    • Cuenca-Estrella M, Gomez-Lopez A, Mellado E, Garcia-Effron G, Rodriguez-Tudela JL. 2004. In vitro activities of ravuconazole and four other antifungal agents against fluconazole-resistant or -susceptible clinical yeast isolates. Antimicrob. Agents Chemother. 48:3107-3111. (Pubitemid 38989181)
    • (2004) Antimicrobial Agents and Chemotherapy , vol.48 , Issue.8 , pp. 3107-3111
    • Cuenca-Estrella, M.1    Gomez-Lopez, A.2    Mellado, E.3    Garcia-Effron, G.4    Rodriguez-Tudela, J.L.5
  • 12
    • 0031759244 scopus 로고    scopus 로고
    • Multiple molecular mechanisms contribute to a stepwise development of fluconazole resistance in clinical Candida albicans strains
    • Franz R, Kelly SL, Lamb DC, Kelly DE, Ruhnke M, Morschhauser J. 1998. Multiple molecular mechanisms contribute to a stepwise development of fluconazole resistance in clinical Candida albicans strains. Antimicrob. Agents Chemother. 42:3065-3072. (Pubitemid 28553719)
    • (1998) Antimicrobial Agents and Chemotherapy , vol.42 , Issue.12 , pp. 3065-3072
    • Franz, R.1    Kelly, S.L.2    Lamb, D.C.3    Kelly, D.E.4    Ruhnke, M.5    Morschhauser, J.6
  • 14
    • 11144270183 scopus 로고    scopus 로고
    • TAC1, transcriptional activator of CDR genes, is a new transcription factor involved in the regulation of Candida albicans ABC transporters CDR1 and CDR2
    • DOI 10.1128/EC.3.6.1639-1652.2004
    • Coste AT, Karababa M, Ischer F, Bille J, Sanglard D. 2004. TAC1, transcriptional activator of CDR genes, is a new transcription factor involved in the regulation of Candida albicans ABC transporters CDR1 and CDR2. Eukaryot. Cell 3:1639-1652. (Pubitemid 40025121)
    • (2004) Eukaryotic Cell , vol.3 , Issue.6 , pp. 1639-1652
    • Coste, A.T.1    Karababa, M.2    Ischer, F.3    Bille, J.4    Sanglard, D.5
  • 15
    • 0031938057 scopus 로고    scopus 로고
    • Amino acid substitutions in the cytochrome P-450 lanosterol 14α- demethylase (CYP51A1) from azole-resistant Candida albicans clinical isolates contribute to resistance to azole antifungal agents
    • Sanglard D, Ischer F, Koymans L, Bille J. 1998. Amino acid substitutions in the cytochrome P-450 lanosterol 14α-demethylase (CYP51A1) from azole-resistant Candida albicans clinical isolates contribute to resistance to azole antifungal agents. Antimicrob. Agents Chemother. 42:241-253. (Pubitemid 28114426)
    • (1998) Antimicrobial Agents and Chemotherapy , vol.42 , Issue.2 , pp. 241-253
    • Sanglard, D.1    Ischer, F.2    Koymans, L.3    Bille, J.4
  • 18
    • 37349095258 scopus 로고    scopus 로고
    • The transcription factor Mrr1p controls expression of the MDR1 efflux pump and mediates multidrug resistance in Candida albicans
    • DOI 10.1371/journal.ppat.0030164
    • Morschhauser J, Barker KS, Liu TT, Bla BWJ, Homayouni R, Rogers PD. 2007. The transcription factor Mrr1p controls expression of the MDR1 efflux pump and mediates multidrug resistance in Candida albicans. PLoS Pathog. 3:e164. doi:10.1371/journal.ppat.0030164. (Pubitemid 350291598)
    • (2007) PLoS Pathogens , vol.3 , Issue.11 , pp. 1603-1616
    • Morschhauser, J.1    Barker, K.S.2    Liu, T.T.3    Blass-Warmuth, J.4    Homayouni, R.5    Rogers, P.D.6
  • 19
    • 0029820482 scopus 로고    scopus 로고
    • Susceptibilities of Candida albicans multidrug transporter mutants to various antifungal agents and other metabolic inhibitors
    • Sanglard D, Ischer F, Monod M, Bille J. 1996. Susceptibilities of Candida albicans multidrug transporter mutants to various antifungal agents and other metabolic inhibitors. Antimicrob. Agents Chemother. 40:2300-2305. (Pubitemid 26328036)
    • (1996) Antimicrobial Agents and Chemotherapy , vol.40 , Issue.10 , pp. 2300-2305
    • Sanglard, D.1    Ischer, F.2    Monod, M.3    Bille, J.4
  • 20
    • 47749142093 scopus 로고    scopus 로고
    • Mutations in the multi-drug resistance regulator MRR1, followed by loss of heterozygosity, are the main cause of MDR1 overexpression in fluconazole-resistant Candida albicans strains
    • DOI 10.1111/j.1365-2958.2008.06309.x
    • Dunkel N, Blass J, Rogers PD, Morschhauser J. 2008. Mutations in the multidrug resistance regulator MRR1, followed by loss of heterozygosity, are the main cause of MDR1 overexpression in fluconazole-resistant Candida albicans strains. Mol. Microbiol. 69:827-840. (Pubitemid 352033303)
    • (2008) Molecular Microbiology , vol.69 , Issue.4 , pp. 827-840
    • Dunkel, N.1    Blass, J.2    Rogers, P.D.3    Morschhauser, J.4
  • 21
    • 59249085257 scopus 로고    scopus 로고
    • Gain-of-function mutations in CgPDR1 of Candida glabrata not only mediate antifungal resistance but also enhance virulence
    • doi:10.1371/journal.ppat.1000268
    • Ferrari S, Ischer F, Calabrese D, Posteraro B, Sanguinetti M, Fadda G, Rohde B, Bauser C, Bader O, Sanglard D. 2009. Gain-of-function mutations in CgPDR1 of Candida glabrata not only mediate antifungal resistance but also enhance virulence. PLoS Pathog. 5:e1000268. doi:10.1371/journal.ppat.1000268.
    • (2009) PLoS Pathog. , vol.5
    • Ferrari, S.1    Ischer, F.2    Calabrese, D.3    Posteraro, B.4    Sanguinetti, M.5    Fadda, G.6    Rohde, B.7    Bauser, C.8    Bader, O.9    Sanglard, D.10
  • 22
    • 84867168091 scopus 로고    scopus 로고
    • Gain-of-function mutations in UPC2 are a frequent cause of ERG11 upregulation in azole-resistant clinical isolates of Candida albicans
    • Flowers SA, Barker KS, Berkow EL, Toner G, Chadwick SG, Gygax SE, Morschhauser J, Rogers PD. 2012. Gain-of-function mutations in UPC2 are a frequent cause of ERG11 upregulation in azole-resistant clinical isolates of Candida albicans. Eukaryot. Cell 11:1289-1299.
    • (2012) Eukaryot. Cell , vol.11 , pp. 1289-1299
    • Flowers, S.A.1    Barker, K.S.2    Berkow, E.L.3    Toner, G.4    Chadwick, S.G.5    Gygax, S.E.6    Morschhauser, J.7    Rogers, P.D.8
  • 23
    • 77949344512 scopus 로고    scopus 로고
    • Relationship between antifungal resistance of fluconazole-resistant Candida albicans and mutations in ERG11 gene
    • Feng LJ, Wan Z, Wang XH, Li RY, Liu W. 2010. Relationship between antifungal resistance of fluconazole-resistant Candida albicans and mutations in ERG11 gene. Chin. Med. J. 123:544-548.
    • (2010) Chin. Med. J. , vol.123 , pp. 544-548
    • Feng, L.J.1    Wan, Z.2    Wang, X.H.3    Li, R.Y.4    Liu, W.5
  • 24
    • 0346784897 scopus 로고    scopus 로고
    • Three-Dimensional Models of Wild-Type and Mutated Forms of Cytochrome P450 14α-Sterol Demethylases from Aspergillus fumigatus and Candida albicans Provide Insights into Posaconazole Binding
    • DOI 10.1128/AAC.48.2.568-574.2004
    • Xiao L, Madison V, Chau AS, Loebenberg D, Palermo RE, McNicholas PM. 2004. Three-dimensional models of wild-type and mutated forms of cytochrome P450 14α-sterol demethylases from Aspergillus fumigatus and Candida albicans provide insights into posaconazole binding. Antimicrob. Agents Chemother. 48:568-574. (Pubitemid 38141718)
    • (2004) Antimicrobial Agents and Chemotherapy , vol.48 , Issue.2 , pp. 568-574
    • Xiao, L.1    Madison, V.2    Chau, A.S.3    Loebenberg, D.4    Palermo, R.E.5    McNicholas, P.M.6
  • 25
    • 0028883458 scopus 로고
    • Deletion of the Candida glabrata ERG3 and ERG11 genes: Effect on cell viability, cell growth, sterol composition, and antifungal susceptibility
    • Geber A, Hitchcock CA, Swartz JE, Pullen FS, Marsden KE, Kwon-Chung KJ, Bennett JE. 1995. Deletion of the Candida glabrata ERG3 and ERG11 genes: effect on cell viability, cell growth, sterol composition, and antifungal susceptibility. Antimicrob. Agents Chemother. 39:2708-2717.
    • (1995) Antimicrob. Agents Chemother , vol.39 , pp. 2708-2717
    • Geber, A.1    Hitchcock, C.A.2    Swartz, J.E.3    Pullen, F.S.4    Marsden, K.E.5    Kwon-Chung, K.J.6    Bennett, J.E.7
  • 26
    • 40549126935 scopus 로고    scopus 로고
    • The ATP-binding cassette transporter-encoding gene CgSNQ2 is contributing to the CgPDR1-dependent azole resistance of Candida glabrata
    • DOI 10.1111/j.1365-2958.2008.06143.x
    • Torelli R, Posteraro B, Ferrari S, La Sorda M, Fadda G, Sanglard D, Sanguinetti M. 2008. The ATP-binding cassette transporter-encoding gene CgSNQ2 is contributing to the CgPDR1-dependent azole resistance of Candida glabrata. Mol. Microbiol. 68:186-201. (Pubitemid 351363785)
    • (2008) Molecular Microbiology , vol.68 , Issue.1 , pp. 186-201
    • Torelli, R.1    Posteraro, B.2    Ferrari, S.3    La Sorda, M.4    Fadda, G.5    Sanglard, D.6    Sanguinetti, M.7
  • 28
    • 57049159416 scopus 로고    scopus 로고
    • Gain-of-function mutations in the transcription factor MRR1 are responsible for overexpression of the MDR1 efflux pump in fluconazole-resistant Candida dubliniensis strains
    • Schubert S, Rogers PD, Morschhauser J. 2008. Gain-of-function mutations in the transcription factor MRR1 are responsible for overexpression of the MDR1 efflux pump in fluconazole-resistant Candida dubliniensis strains. Antimicrob. Agents Chemother. 52:4274-4280.
    • (2008) Antimicrob. Agents Chemother , vol.52 , pp. 4274-4280
    • Schubert, S.1    Rogers, P.D.2    Morschhauser, J.3
  • 29
    • 84879029784 scopus 로고    scopus 로고
    • Identification and antifungal susceptibility of a large collection of yeast strains isolated in Tunisian Hospitals
    • in press
    • Eddouzi J, Lohberger A, Vogne C, Manai M, Sanglard D. Identification and antifungal susceptibility of a large collection of yeast strains isolated in Tunisian Hospitals. Med. Mycol., in press.
    • Med. Mycol.
    • Eddouzi, J.1    Lohberger, A.2    Vogne, C.3    Manai, M.4    Sanglard, D.5
  • 30
    • 0027192868 scopus 로고
    • Isogenic strain construction and gene mapping in Candida albicans
    • Fonzi WA, Irwin MY. 1993. Isogenic strain construction and gene mapping in Candida albicans. Genetics 134:717-728. (Pubitemid 23193572)
    • (1993) Genetics , vol.134 , Issue.3 , pp. 717-728
    • Fonzi, W.A.1    Irwin, M.Y.2
  • 31
    • 3342996550 scopus 로고    scopus 로고
    • Comparison of gene expression profiles of Candida albicans azole-resistant clinical isolates and laboratory strains exposed to drugs inducing multidrug transporters
    • DOI 10.1128/AAC.48.8.3064-3079.2004
    • Karababa M, Coste AT, Rognon B, Bille J, Sanglard D. 2004. Comparison of gene expression profiles of Candida albicans azole-resistant clinical isolates and laboratory strains exposed to drugs inducing multidrug transporters. Antimicrob. Agents Chemother. 48:3064-3079. (Pubitemid 38989176)
    • (2004) Antimicrobial Agents and Chemotherapy , vol.48 , Issue.8 , pp. 3064-3079
    • Karababa, M.1    Coste, A.T.2    Rognon, B.3    Bille, J.4    Sanglard, D.5
  • 33
    • 33646171879 scopus 로고    scopus 로고
    • A mutation in Tac1p, a transcription factor regulating CDR1 and CDR2, is coupled with loss of heterozygosity at chromosome 5 to mediate antifungal resistance in Candida albicans
    • Coste A, Turner V, Ischer F, Morschhauser J, Forche A, Selmecki A, Berman J, Bille J, Sanglard D. 2006. A mutation in Tac1p, a transcription factor regulating CDR1 and CDR2, is coupled with loss of heterozygosity at chromosome 5 to mediate antifungal resistance in Candida albicans. Genetics 172:2139-2156.
    • (2006) Genetics , vol.172 , pp. 2139-2156
    • Coste, A.1    Turner, V.2    Ischer, F.3    Morschhauser, J.4    Forche, A.5    Selmecki, A.6    Berman, J.7    Bille, J.8    Sanglard, D.9
  • 34
    • 0043270593 scopus 로고    scopus 로고
    • Candida albicans mutations in the ergosterol biosynthetic pathway and resistance to several antifungal agents
    • DOI 10.1128/AAC.47.8.2404-2412.2003
    • Sanglard D, Ischer F, Parkinson T, Falconer D, Bille J. 2003. Candida albicans mutations in the ergosterol biosynthetic pathway and resistance to several antifungal agents. Antimicrob. Agents Chemother. 47:2404-2412. (Pubitemid 36919437)
    • (2003) Antimicrobial Agents and Chemotherapy , vol.47 , Issue.8 , pp. 2404-2412
    • Sanglard, D.1    Ischer, F.2    Parkinson, T.3    Falconer, D.4    Bille, J.5
  • 35
    • 79952646882 scopus 로고    scopus 로고
    • Probing the role of point mutations in the cyp51A gene from Aspergillus fumigatus in the model yeast Saccharomyces cerevisiae
    • Alcazar-Fuoli L, Mellado E, Cuenca-Estrella M, Sanglard D. 2011. Probing the role of point mutations in the cyp51A gene from Aspergillus fumigatus in the model yeast Saccharomyces cerevisiae. Med. Mycol. 49: 276-284.
    • (2011) Med. Mycol. , vol.49 , pp. 276-284
    • Alcazar-Fuoli, L.1    Mellado, E.2    Cuenca-Estrella, M.3    Sanglard, D.4
  • 36
    • 40549124325 scopus 로고    scopus 로고
    • EUCAST definitive document EDef 7.1: Method for the determination of broth dilution MICs of antifungal agents for fermentative yeasts
    • Subcommittee on Antifungal Susceptibility Testing of the ESCMID European Committee for Antimicrobial Susceptibility Testing.
    • Subcommittee on Antifungal Susceptibility Testing of the ESCMID European Committee for Antimicrobial Susceptibility Testing. 2008. EUCAST definitive document EDef 7.1: method for the determination of broth dilution MICs of antifungal agents for fermentative yeasts. Clin. Microbiol. Infect. 14:398-405.
    • (2008) Clin. Microbiol. Infect. , vol.14 , pp. 398-405
  • 37
    • 84863335386 scopus 로고    scopus 로고
    • Identification and functional characterization of Rca1, a transcription factor involved in both antifungal susceptibility and host response in Candida albicans
    • Vandeputte P, Pradervand S, Ischer F, Coste AT, Ferrari S, Harshman K, Sanglard D. 2012. Identification and functional characterization of Rca1, a transcription factor involved in both antifungal susceptibility and host response in Candida albicans. Eukaryot. Cell 11:916-931.
    • (2012) Eukaryot. Cell , vol.11 , pp. 916-931
    • Vandeputte, P.1    Pradervand, S.2    Ischer, F.3    Coste, A.T.4    Ferrari, S.5    Harshman, K.6    Sanglard, D.7
  • 38
    • 0028942449 scopus 로고
    • Mode of action and resistance to azole antifungals associated with the formation of 14α-methylergosta-8,24(28)-dien-3β,6a-diol
    • Kelly SL, Lamb DC, Corran AJ, Baldwin BC, Kelly DE. 1995. Mode of action and resistance to azole antifungals associated with the formation of 14α-methylergosta-8,24(28)-dien-3β,6a-diol. Biochem. Biophys. Res. Commun. 207:910-915.
    • (1995) Biochem. Biophys. Res. Commun. , vol.207 , pp. 910-915
    • Kelly, S.L.1    Lamb, D.C.2    Corran, A.J.3    Baldwin, B.C.4    Kelly, D.E.5
  • 39
    • 33645791257 scopus 로고    scopus 로고
    • Overexpression of the MDR1gene is sufficient to confer increased resistance to toxic compounds in Candida albicans
    • Hiller D, Sanglard D, Morschhäuser J. 2006. Overexpression of the MDR1gene is sufficient to confer increased resistance to toxic compounds in Candida albicans. Antimicrob. Agents Chemother. 50:1365-1371.
    • (2006) Antimicrob. Agents Chemother , vol.50 , pp. 1365-1371
    • Hiller, D.1    Sanglard, D.2    Morschhäuser, J.3
  • 40
    • 33749236250 scopus 로고    scopus 로고
    • A fungal family of transcriptional regulators: The zinc cluster proteins
    • DOI 10.1128/MMBR.00015-06
    • MacPherson S, Larochelle M, Turcotte B. 2006. A fungal family of transcriptional regulators: the zinc cluster proteins. Microbiol. Mol. Biol. Rev. 70:583-604. (Pubitemid 44484686)
    • (2006) Microbiology and Molecular Biology Reviews , vol.70 , Issue.3 , pp. 583-604
    • MacPherson, S.1    Larochelle, M.2    Turcotte, B.3
  • 41
    • 77749291956 scopus 로고    scopus 로고
    • Screening for amino acid substitutions in the Candida albicans Erg11 protein of azolesusceptible and azole-resistant clinical isolates: New substitutions and a review of the literature
    • Morio F, Loge C, Besse B, Hennequin C, Pape PL. 2010. Screening for amino acid substitutions in the Candida albicans Erg11 protein of azolesusceptible and azole-resistant clinical isolates: new substitutions and a review of the literature. Diagn. Microbiol. Infect. Dis. 66:373-384.
    • (2010) Diagn. Microbiol. Infect. Dis. , vol.66 , pp. 373-384
    • Morio, F.1    Loge, C.2    Besse, B.3    Hennequin, C.4    Pape, P.L.5
  • 42
    • 0031047670 scopus 로고    scopus 로고
    • Cloning of Candida albicans genes conferring resistance to azole antifungal agents: Characterization of CDR2, a new multidrug ABC transporter gene
    • Sanglard D, Ischer F, Monod M, Bille J. 1997. Cloning of Candida albicans genes conferring resistance to azole antifungal agents: characterization of CDR2, a new multidrug ABC transporter gene. Microbiology 143(Pt 2):405-416. (Pubitemid 27092176)
    • (1997) Microbiology , vol.143 , Issue.2 , pp. 405-416
    • Sanglard, D.1    Ischer, F.2    Monod, M.3    Bille, J.4
  • 43
    • 0028906887 scopus 로고
    • Cloning of the late genes in the ergosterol biosynthetic pathway of Saccharomyces cerevisiae: A review
    • Lees N, Skaggs B, Kirsch D, Bard M. 1995. Cloning of the late genes in the ergosterol biosynthetic pathway of Saccharomyces cerevisiae: a review. Lipids 30:221-226.
    • (1995) Lipids , vol.30 , pp. 221-226
    • Lees, N.1    Skaggs, B.2    Kirsch, D.3    Bard, M.4
  • 44
    • 0027360859 scopus 로고
    • Sterol synthesis and viability of erg11 (cytochrome P450 lanosterol demethylase) mutations in Saccharomyces cerevisiae and Candida albicans
    • DOI 10.1007/BF02537115
    • Bard M, Lees N, Turi T, Craft D, Cofrin L, Barbuch R, Koegel C, Loper J. 1993. Sterol synthesis and viability of ERG11 (cytochrome P450 lanosterol demethylase) mutations in Saccharomyces cerevisiae and Candida albicans. Lipids 28:963-967. (Pubitemid 23333690)
    • (1993) Lipids , vol.28 , Issue.11 , pp. 963-967
    • Bard, M.1    Lees, N.D.2    Turi, T.3    Craft, D.4    Cofrin, L.5    Barbuch, R.6    Koegel, C.7    Loper, J.C.8
  • 45
    • 77956101405 scopus 로고    scopus 로고
    • A clinical isolate of Candida albicans with mutations in ERG11 (encoding sterol 14α-demethylase) and ERG5 (encoding C22 desaturase) is cross resistant to azoles and amphotericin B
    • Martel CM, Parker JE, Bader O, Weig M, Gross U, Warrilow AG, Kelly DE, Kelly SL. 2010. A clinical isolate of Candida albicans with mutations in ERG11 (encoding sterol 14α-demethylase) and ERG5 (encoding C22 desaturase) is cross resistant to azoles and amphotericin B. Antimicrob. Agents Chemother. 54:3578-3583.
    • (2010) Antimicrob. Agents Chemother , vol.54 , pp. 3578-3583
    • Martel, C.M.1    Parker, J.E.2    Bader, O.3    Weig, M.4    Gross, U.5    Warrilow, A.G.6    Kelly, D.E.7    Kelly, S.L.8
  • 46
    • 79955537321 scopus 로고    scopus 로고
    • Differential requirement of the transcription factor Mcm1 for activation of the Candida albicans multidrug efflux pump MDR1 by its regulators Mrr1 and Cap1
    • Mogavero S, Tavanti A, Senesi S, Rogers PD, Morschhauser J. 2011. Differential requirement of the transcription factor Mcm1 for activation of the Candida albicans multidrug efflux pump MDR1 by its regulators Mrr1 and Cap1. Antimicrob. Agents Chemother. 55:2061-2066.
    • (2011) Antimicrob. Agents Chemother , vol.55 , pp. 2061-2066
    • Mogavero, S.1    Tavanti, A.2    Senesi, S.3    Rogers, P.D.4    Morschhauser, J.5
  • 47
    • 11144308844 scopus 로고    scopus 로고
    • Role of Candida albicans transcription factor Upc2p in drug resistance and sterol metabolism
    • DOI 10.1128/EC.3.6.1391-1397.2004
    • Silver PM, Oliver BG, White TC. 2004. Role of Candida albicans transcription factor Upc2p in drug resistance and sterol metabolism. Eukaryot. Cell 3:1391-1397. (Pubitemid 40025098)
    • (2004) Eukaryotic Cell , vol.3 , Issue.6 , pp. 1391-1397
    • Silver, P.M.1    Oliver, B.G.2    White, T.C.3
  • 48
    • 18244396070 scopus 로고    scopus 로고
    • Candida albicans zinc cluster protein Upc2p confers resistance to antifungal drugs and is an activator of ergosterol biosynthetic genes
    • DOI 10.1128/AAC.49.5.1745-1752.2005
    • MacPherson S, Akache B, Weber S, De Deken X, Raymond M, Turcotte B. 2005. Candida albicans zinc cluster protein Upc2p confers resistance to antifungal drugs and is an activator of ergosterol biosynthetic genes. Antimicrob. Agents Chemother. 49:1745-1752. (Pubitemid 40631584)
    • (2005) Antimicrobial Agents and Chemotherapy , vol.49 , Issue.5 , pp. 1745-1752
    • MacPherson, S.1    Akache, B.2    Weber, S.3    De Deken, X.4    Raymond, M.5    Turcotte, B.6
  • 49
    • 70350026151 scopus 로고    scopus 로고
    • Antifungal drug resistance mechanisms in fungal pathogens from the perspective of transcriptional gene regulation
    • Sanglard D, Coste A, Ferrari S. 2009. Antifungal drug resistance mechanisms in fungal pathogens from the perspective of transcriptional gene regulation. FEMS Yeast Res. 9:1029-1050.
    • (2009) FEMS Yeast Res. , vol.9 , pp. 1029-1050
    • Sanglard, D.1    Coste, A.2    Ferrari, S.3
  • 50
    • 79959187026 scopus 로고    scopus 로고
    • Amino acid substitutions at the major insertion loop of Candida albicans sterol 14α-demethylase are involved in fluconazole resistance
    • doi:10.1371/journal.pone.0021239
    • Alvarez-Rueda N, Fleury A, Morio F, Pagniez F, Gastinel L, Le Pape P. 2011. Amino acid substitutions at the major insertion loop of Candida albicans sterol 14α-demethylase are involved in fluconazole resistance. PLoS One 6:e21239. doi:10.1371/journal.pone.0021239.
    • (2011) PLoS One , vol.6
    • Alvarez-Rueda, N.1    Fleury, A.2    Morio, F.3    Pagniez, F.4    Gastinel, L.5    Le Pape, P.6
  • 51
    • 84875276783 scopus 로고    scopus 로고
    • Mechanisms of azole resistance in 52 clinical isolates of Candida tropicalis in China
    • Jiang C, Dong D, Yu B, Cai G, Wang X, Ji Y, Peng Y. 2013. Mechanisms of azole resistance in 52 clinical isolates of Candida tropicalis in China. J. Antimicrob. Chemother. 68:778-785.
    • (2013) J. Antimicrob. Chemother , vol.68 , pp. 778-785
    • Jiang, C.1    Dong, D.2    Yu, B.3    Cai, G.4    Wang, X.5    Ji, Y.6    Peng, Y.7
  • 54
    • 84864389183 scopus 로고    scopus 로고
    • Facultative sterol uptake in an ergosterol-deficient clinical isolate of Candida glabrata harboring a missense mutation in ERG11 and exhibiting cross-resistance to azoles and amphotericin B
    • Hull CM, Parker JE, Bader O, Weig M, Gross U, Warrilow AG, Kelly DE, Kelly SL. 2012. Facultative sterol uptake in an ergosterol-deficient clinical isolate of Candida glabrata harboring a missense mutation in ERG11 and exhibiting cross-resistance to azoles and amphotericin B. Antimicrob. Agents Chemother. 56:4223-4232.
    • (2012) Antimicrob. Agents Chemother , vol.56 , pp. 4223-4232
    • Hull, C.M.1    Parker, J.E.2    Bader, O.3    Weig, M.4    Gross, U.5    Warrilow, A.G.6    Kelly, D.E.7    Kelly, S.L.8


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