Dendritic cells in antifungal immunity and vaccine design

Cell Host and Microbe

Volumn 11, Issue 5, 2012, Pages 436-446

  Roy, René M ^a   Klein, Bruce S ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIFUNGAL VACCINE; DECTIN 1; DECTIN 2; DENDRITIC CELL VACCINE; MANNOSE RECEPTOR; MINCLE; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 9; UNCLASSIFIED DRUG; VACCINE;

ADAPTIVE IMMUNITY; ANTIFUNGAL ACTIVITY; ANTIFUNGAL IMMUNITY; BLASTOMYCES DERMATITIDIS; CELL MIGRATION; DENDRITIC CELL; FUNGUS; IMMUNE RESPONSE; IMMUNITY; INNATE IMMUNITY; INTESTINE; LUNG; MONOCYTE; MYCOSIS; NONHUMAN; PLASMACYTOID DENDRITIC CELL; PRIORITY JOURNAL; REVIEW; SKIN; T LYMPHOCYTE; TARGET CELL;

DENDRITIC CELLS; FUNGAL VACCINES; FUNGI; HUMANS; IMMUNOTHERAPY; MYCOSES;

FUNGI;

EID: 84861142106     PISSN: 19313128     EISSN: 19346069     Source Type: Journal    
DOI: 10.1016/j.chom.2012.04.005     Document Type: Review

References (82)

1. U.M. Abdel-Motal, L. Berg, A. Rosén, M. Bengtsson, C.J. Thorpe, J. Kihlberg, J. Dahmén, G. Magnusson, K.A. Karlsson, and M. Jondal Immunization with glycosylated Kb-binding peptides generates carbohydrate-specific, unrestricted cytotoxic T cells Eur. J. Immunol. 26 1996 544 551
2. R.S. Allan, J. Waithman, S. Bedoui, C.M. Jones, J.A. Villadangos, Y. Zhan, A.M. Lew, K. Shortman, W.R. Heath, and F.R. Carbone Migratory dendritic cells transfer antigen to a lymph node-resident dendritic cell population for efficient CTL priming Immunity 25 2006 153 162
3. F.Y. Avci, X. Li, M. Tsuji, and D.L. Kasper A mechanism for glycoconjugate vaccine activation of the adaptive immune system and its implications for vaccine design Nat. Med. 17 2011 1602 1609
4. R. Backer, F. van Leeuwen, G. Kraal, and J.M. den Haan CD8- dendritic cells preferentially cross-present Saccharomyces cerevisiae antigens Eur. J. Immunol. 38 2008 370 380
5. J. Banchereau, and R.M. Steinman Dendritic cells and the control of immunity Nature 392 1998 245 252
6. S.R. Beaty, C.E.J. Rose Jr., and S.S. Sung Diverse and potent chemokine production by lung CD11bhigh dendritic cells in homeostasis and in allergic lung inflammation J. Immunol. 178 2007 1882 1895
7. R.B. Belshe, F.K. Newman, J. Cannon, C. Duane, J. Treanor, C. Van Hoecke, B.J. Howe, and G. Dubin Serum antibody responses after intradermal vaccination against influenza N. Engl. J. Med. 351 2004 2286 2294
8. D.K.J. Benjamin Jr., B.J. Stoll, M.G. Gantz, M.C. Walsh, P.J. Sánchez, A. Das, S. Shankaran, R.D. Higgins, K.J. Auten, N.A. Miller Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network Neonatal candidiasis: epidemiology, risk factors, and clinical judgment Pediatrics 126 2010 e865 e873
9. D. Bitar, D. Van Cauteren, F. Lanternier, E. Dannaoui, D. Che, F. Dromer, J.C. Desenclos, and O. Lortholary Increasing incidence of zygomycosis (mucormycosis), France, 1997-2006 Emerg. Infect. Dis. 15 2009 1395 1401
10. C. Bourgeois, O. Majer, I.E. Frohner, I. Lesiak-Markowicz, K.S. Hildering, W. Glaser, S. Stockinger, T. Decker, S. Akira, M. Müller, and K. Kuchler Conventional dendritic cells mount a type I IFN response against Candida spp. requiring novel phagosomal TLR7-mediated IFN-β signaling J. Immunol. 186 2011 3104 3112
11. S. Bozza, C. Montagnoli, R. Gaziano, G. Rossi, G. Nkwanyuo, S. Bellocchio, and L. Romani Dendritic cell-based vaccination against opportunistic fungi Vaccine 22 2004 857 864
12. G.D. Brown Innate antifungal immunity: the key role of phagocytes Annu. Rev. Immunol. 29 2011 1 21
13. G.D. Brown, and S. Gordon Immune recognition. A new receptor for beta-glucans Nature 413 2001 36 37
14. A. Casadevall, and L. Pirofski Immunoglobulins in defense, pathogenesis, and therapy of fungal diseases Cell Host Microbe 11 2012 447 456 this issue
15. A. Cassone, and R. Rappuoli Universal vaccines: shifting to one for many MBio 1 2010 e00042-10
16. L. Chorro, A. Sarde, M. Li, K.J. Woollard, P. Chambon, B. Malissen, A. Kissenpfennig, J.B. Barbaroux, R. Groves, and F. Geissmann Langerhans cell (LC) proliferation mediates neonatal development, homeostasis, and inflammation-associated expansion of the epidermal LC network J. Exp. Med. 206 2009 3089 3100
17. J.E. Cutler, G.S.J. Deepe Jr., and B.S. Klein Advances in combating fungal diseases: vaccines on the threshold Nat. Rev. Microbiol. 5 2007 13 28
18. M.L. del Rio, J.I. Rodriguez-Barbosa, E. Kremmer, and R. Förster CD103- and CD103+ bronchial lymph node dendritic cells are specialized in presenting and cross-presenting innocuous antigen to CD4+ and CD8+ T cells J. Immunol. 178 2007 6861 6866
19. J.M. den Haan, S.M. Lehar, and M.J. Bevan CD8(+) but not CD8(-) dendritic cells cross-prime cytotoxic T cells in vivo J. Exp. Med. 192 2000 1685 1696
20. T.L. Denning, B.A. Norris, O. Medina-Contreras, S. Manicassamy, D. Geem, R. Madan, C.L. Karp, and B. Pulendran Functional specializations of intestinal dendritic cell and macrophage subsets that control Th17 and regulatory T cell responses are dependent on the T cell/APC ratio, source of mouse strain, and regional localization J. Immunol. 187 2011 733 747
21. A.N. Desch, G.J. Randolph, K. Murphy, E.L. Gautier, R.M. Kedl, M.H. Lahoud, I. Caminschi, K. Shortman, P.M. Henson, and C.V. Jakubzick CD103+ pulmonary dendritic cells preferentially acquire and present apoptotic cell-associated antigen J. Exp. Med. 208 2011 1789 1797
22. S. Dillon, S. Agrawal, K. Banerjee, J. Letterio, T.L. Denning, K. Oswald-Richter, D.J. Kasprowicz, K. Kellar, J. Pare, and T. van Dyke Yeast zymosan, a stimulus for TLR2 and dectin-1, induces regulatory antigen-presenting cells and immunological tolerance J. Clin. Invest. 116 2006 916 928
23. P.M. Domínguez, and C. Ardavín Differentiation and function of mouse monocyte-derived dendritic cells in steady state and inflammation Immunol. Rev. 234 2010 90 104
24. D. Dudziak, A.O. Kamphorst, G.F. Heidkamp, V.R. Buchholz, C. Trumpfheller, S. Yamazaki, C. Cheong, K. Liu, H.W. Lee, and C.G. Park Differential antigen processing by dendritic cell subsets in vivo Science 315 2007 107 111
25. A.D. Edwards, S.S. Diebold, E.M. Slack, H. Tomizawa, H. Hemmi, T. Kaisho, S. Akira, and C. Reis e Sousa Toll-like receptor expression in murine DC subsets: lack of TLR7 expression by CD8 alpha+ DC correlates with unresponsiveness to imidazoquinolines Eur. J. Immunol. 33 2003 827 833
26. K. Ersland, M. Wüthrich, and B.S. Klein Dynamic interplay among monocyte-derived, dermal, and resident lymph node dendritic cells during the generation of vaccine immunity to fungi Cell Host Microbe 7 2010 474 487
27. B. Ferwerda, G. Ferwerda, T.S. Plantinga, J.A. Willment, A.B. van Spriel, H. Venselaar, C.C. Elbers, M.D. Johnson, A. Cambi, and C. Huysamen Human dectin-1 deficiency and mucocutaneous fungal infections N. Engl. J. Med. 361 2009 1760 1767
28. D.K. Fogg, C. Sibon, C. Miled, S. Jung, P. Aucouturier, D.R. Littman, A. Cumano, and F. Geissmann A clonogenic bone marrow progenitor specific for macrophages and dendritic cells Science 311 2006 83 87
29. F. Geissmann, S. Jung, and D.R. Littman Blood monocytes consist of two principal subsets with distinct migratory properties Immunity 19 2003 71 82
30. F. Ginhoux, M.P. Collin, M. Bogunovic, M. Abel, M. Leboeuf, J. Helft, J. Ochando, A. Kissenpfennig, B. Malissen, and M. Grisotto Blood-derived dermal langerin+ dendritic cells survey the skin in the steady state J. Exp. Med. 204 2007 3133 3146
31. S. Henri, M. Guilliams, L.F. Poulin, S. Tamoutounour, L. Ardouin, M. Dalod, and B. Malissen Disentangling the complexity of the skin dendritic cell network Immunol. Cell Biol. 88 2010 366 375
32. S. Henri, L.F. Poulin, S. Tamoutounour, L. Ardouin, M. Guilliams, B. de Bovis, E. Devilard, C. Viret, H. Azukizawa, A. Kissenpfennig, and B. Malissen CD207+ CD103+ dermal dendritic cells cross-present keratinocyte-derived antigens irrespective of the presence of Langerhans cells J. Exp. Med. 207 2010 189 206
33. N. Hernández-Santos, and S.L. Gaffen Th17 Cells in Immunity to Candida albicans Cell Host Microbe 11 2012 425 435 this issue
34. A.G. Hise, J. Tomalka, S. Ganesan, K. Patel, B.A. Hall, G.D. Brown, and K.A. Fitzgerald An essential role for the NLRP3 inflammasome in host defense against the human fungal pathogen Candida albicans Cell Host Microbe 5 2009 487 497
35. T.M. Hohl, A. Rivera, L. Lipuma, A. Gallegos, C. Shi, M. Mack, and E.G. Pamer Inflammatory monocytes facilitate adaptive CD4 T cell responses during respiratory fungal infection Cell Host Microbe 6 2009 470 481
36. S.H. Hsieh, J.S. Lin, J.H. Huang, S.Y. Wu, C.L. Chu, J.T. Kung, and B.A. Wu-Hsieh Immunization with apoptotic phagocytes containing Histoplasma capsulatum activates functional CD8(+) T cells to protect against histoplasmosis Infect. Immun. 79 2011 4493 4502
37. W. Hu, T.D. Troutman, R. Edukulla, and C. Pasare Priming microenvironments dictate cytokine requirements for T helper 17 cell lineage commitment Immunity 35 2011 1010 1022
38. H. Huang, G.R. Ostroff, C.K. Lee, C.A. Specht, and S.M. Levitz Robust stimulation of humoral and cellular immune responses following vaccination with antigen-loaded beta-glucan particles MBio 1 2010 e00164-10
39. L. Huang, A. Cattamanchi, J.L. Davis, S. den Boon, J. Kovacs, S. Meshnick, R.F. Miller, P.D. Walzer, W. Worodria, H. Masur International HIV-associated Opportunistic Pneumonias (IHOP) Study Lung HIV Study HIV-associated Pneumocystis pneumonia Proc. Am. Thorac. Soc. 8 2011 294 300
40. J. Idoyaga, N. Suda, K. Suda, C.G. Park, and R.M. Steinman Antibody to Langerin/CD207 localizes large numbers of CD8alpha+ dendritic cells to the marginal zone of mouse spleen Proc. Natl. Acad. Sci. USA 106 2009 1524 1529
41. B.Z. Igyártó, K. Haley, D. Ortner, A. Bobr, M. Gerami-Nejad, B.T. Edelson, S.M. Zurawski, B. Malissen, G. Zurawski, J. Berman, and D.H. Kaplan Skin-resident murine dendritic cell subsets promote distinct and opposing antigen-specific T helper cell responses Immunity 35 2011 260 272
42. F.L. Jahnsen, D.H. Strickland, J.A. Thomas, I.T. Tobagus, S. Napoli, G.R. Zosky, D.J. Turner, P.D. Sly, P.A. Stumbles, and P.G. Holt Accelerated antigen sampling and transport by airway mucosal dendritic cells following inhalation of a bacterial stimulus J. Immunol. 177 2006 5861 5867
43. H. Kumar, Y. Kumagai, T. Tsuchida, P.A. Koenig, T. Satoh, Z. Guo, M.H. Jang, T. Saitoh, S. Akira, and T. Kawai Involvement of the NLRP3 inflammasome in innate and humoral adaptive immune responses to fungal beta-glucan J. Immunol. 183 2009 8061 8067
44. J.S. Lam, H. Huang, and S.M. Levitz Effect of differential N-linked and O-linked mannosylation on recognition of fungal antigens by dendritic cells PLoS ONE 2 2007 e1009
45. S. Leibundgut-Landmann, F. Osorio, G.D. Brown, and C. Reis e Sousa Stimulation of dendritic cells via the dectin-1/Syk pathway allows priming of cytotoxic T-cell responses Blood 112 2008 4971 4980
46. H. Lelouard, M. Fallet, B. de Bovis, S. Méresse, and J.P. Gorvel Peyer's patch dendritic cells sample antigens by extending dendrites through M cell-specific transcellular pores Gastroenterology 142 2012 10.1053/j.gastro. 2011.11.039 592-601.e3. Published online December 8, 2011
47. H.S. Li, A. Gelbard, G.J. Martinez, E. Esashi, H. Zhang, H. Nguyen-Jackson, Y.J. Liu, W.W. Overwijk, and S.S. Watowich Cell-intrinsic role for IFN-α-STAT1 signals in regulating murine Peyer patch plasmacytoid dendritic cells and conditioning an inflammatory response Blood 118 2011 3879 3889
48. J.S. Lin, C.W. Yang, D.W. Wang, and B.A. Wu-Hsieh Dendritic cells cross-present exogenous fungal antigens to stimulate a protective CD8 T cell response in infection by Histoplasma capsulatum J. Immunol. 174 2005 6282 6291
49. K. Liu, and M.C. Nussenzweig Origin and development of dendritic cells Immunol. Rev. 234 2010 45 54
50. K. Liu, G.D. Victora, T.A. Schwickert, P. Guermonprez, M.M. Meredith, K. Yao, F.F. Chu, G.J. Randolph, A.Y. Rudensky, and M. Nussenzweig In vivo analysis of dendritic cell development and homeostasis Science 324 2009 392 397
51. C.A. Luber, J. Cox, H. Lauterbach, B. Fancke, M. Selbach, J. Tschopp, S. Akira, M. Wiegand, H. Hochrein, M. O'Keeffe, and M. Mann Quantitative proteomics reveals subset-specific viral recognition in dendritic cells Immunity 32 2010 279 289
52. T.K. Means, E. Mylonakis, E. Tampakakis, R.A. Colvin, E. Seung, L. Puckett, M.F. Tai, C.R. Stewart, R. Pukkila-Worley, and S.E. Hickman Evolutionarily conserved recognition and innate immunity to fungal pathogens by the scavenger receptors SCARF1 and CD36 J. Exp. Med. 206 2009 637 653
53. S.H. Naik Demystifying the development of dendritic cell subtypes, a little Immunol. Cell Biol. 86 2008 439 452
54. K. Nakamura, A. Miyazato, G. Xiao, M. Hatta, K. Inden, T. Aoyagi, K. Shiratori, K. Takeda, S. Akira, and S. Saijo Deoxynucleic acids from Cryptococcus neoformans activate myeloid dendritic cells via a TLR9-dependent pathway J. Immunol. 180 2008 4067 4074
55. S.G. Nanjappa, E. Heninger, M. Wüthrich, T. Sullivan, and B. Klein Protective antifungal memory CD8(+) T cells are maintained in the absence of CD4(+) T cell help and cognate antigen in mice J. Clin. Invest. 122 2012 987 999
56. M.G. Netea, R. Sutmuller, C. Hermann, C.A. Van der Graaf, J.W. Van der Meer, J.H. van Krieken, T. Hartung, G. Adema, and B.J. Kullberg Toll-like receptor 2 suppresses immunity against Candida albicans through induction of IL-10 and regulatory T cells J. Immunol. 172 2004 3712 3718
57. A.K. Neumann, and K. Jacobson A novel pseudopodial component of the dendritic cell anti-fungal response: the fungipod PLoS Pathog. 6 2010 e1000760
58. J.J. Osterholzer, G.H. Chen, M.A. Olszewski, J.L. Curtis, G.B. Huffnagle, and G.B. Toews Accumulation of CD11b+ lung dendritic cells in response to fungal infection results from the CCR2-mediated recruitment and differentiation of Ly-6Chigh monocytes J. Immunol. 183 2009 8044 8053
59. D. Pappagianis The Valley Fever Vaccine Study Group Evaluation of the protective efficacy of the killed Coccidioides immitis spherule vaccine in humans Am. Rev. Respir. Dis. 148 1993 656 660
60. M.A. Pfaller, and D.J. Diekema Epidemiology of invasive candidiasis: a persistent public health problem Clin. Microbiol. Rev. 20 2007 133 163
61. Z.G. Ramirez-Ortiz, C.A. Specht, J.P. Wang, C.K. Lee, D.C. Bartholomeu, R.T. Gazzinelli, and S.M. Levitz Toll-like receptor 9-dependent immune activation by unmethylated CpG motifs in Aspergillus fumigatus DNA Infect. Immun. 76 2008 2123 2129
62. Z.G. Ramirez-Ortiz, C.K. Lee, J.P. Wang, L. Boon, C.A. Specht, and S.M. Levitz A nonredundant role for plasmacytoid dendritic cells in host defense against the human fungal pathogen Aspergillus fumigatus Cell Host Microbe 9 2011 415 424
63. C.A. Rappleye, L.G. Eissenberg, and W.E. Goldman Histoplasma capsulatum α-(1,3)-glucan blocks innate immune recognition by the β-glucan receptor Proc. Natl. Acad. Sci. USA 104 2007 1366 1370
64. A. Rivera, G. Ro, H.L. Van Epps, T. Simpson, I. Leiner, D.B. Sant'Angelo, and E.G. Pamer Innate immune activation and CD4+ T cell priming during respiratory fungal infection Immunity 25 2006 665 675
65. M.J. Robinson, F. Osorio, M. Rosas, R.P. Freitas, E. Schweighoffer, O. Gross, J.S. Verbeek, J. Ruland, V. Tybulewicz, and G.D. Brown Dectin-2 is a Syk-coupled pattern recognition receptor crucial for Th17 responses to fungal infection J. Exp. Med. 206 2009 2037 2051
66. N. Saïd-Sadier, E. Padilla, G. Langsley, and D.M. Ojcius Aspergillus fumigatus stimulates the NLRP3 inflammasome through a pathway requiring ROS production and the Syk tyrosine kinase PLoS ONE 5 2010 e10008
67. S. Sandini, R. La Valle, S. Deaglio, F. Malavasi, A. Cassone, and F. De Bernardis A highly immunogenic recombinant and truncated protein of the secreted aspartic proteases family (rSap2t) of Candida albicans as a mucosal anticandidal vaccine FEMS Immunol. Med. Microbiol. 62 2011 215 224
68. A. Sczesnak, N. Segata, X. Qin, D. Gevers, J.F. Petrosino, C. Huttenhower, D.R. Littman, and I.I. Ivanov The genome of th17 cell-inducing segmented filamentous bacteria reveals extensive auxotrophy and adaptations to the intestinal environment Cell Host Microbe 10 2011 260 272
69. M.da G. Sousa, D.M. Reid, E. Schweighoffer, V. Tybulewicz, J. Ruland, J. Langhorne, S. Yamasaki, P.R. Taylor, S.R. Almeida, and G.D. Brown Restoration of pattern recognition receptor costimulation to treat chromoblastomycosis, a chronic fungal infection of the skin Cell Host Microbe 9 2011 436 443
70. R.M. Steinman, and Z.A. Cohn Identification of a novel cell type in peripheral lymphoid organs of mice. I. Morphology, quantitation, tissue distribution J. Exp. Med. 137 1973 1142 1162
71. A.C. Stubbs, K.S. Martin, C. Coeshott, S.V. Skaates, D.R. Kuritzkes, D. Bellgrau, A. Franzusoff, R.C. Duke, and C.C. Wilson Whole recombinant yeast vaccine activates dendritic cells and elicits protective cell-mediated immunity Nat. Med. 7 2001 625 629
72. C. Stuehler, N. Khanna, S. Bozza, T. Zelante, S. Moretti, M. Kruhm, S. Lurati, B. Conrad, E. Worschech, and S. Stevanović Cross-protective TH1 immunity against Aspergillus fumigatus and Candida albicans Blood 117 2011 5881 5891
73. S.S. Sung, S.M. Fu, C.E.J. Rose Jr., F. Gaskin, S.T. Ju, and S.R. Beaty A major lung CD103 (alphaE)-beta7 integrin-positive epithelial dendritic cell population expressing Langerin and tight junction proteins J. Immunol. 176 2006 2161 2172
74. W.A. Szymczak, and G.S.J. Deepe Jr. The CCL7-CCL2-CCR2 axis regulates IL-4 production in lungs and fungal immunity J. Immunol. 183 2009 1964 1974
75. W.A. Szymczak, and G.S.J. Deepe Jr. Antigen-presenting dendritic cells rescue CD4-depleted CCR2-/- mice from lethal Histoplasma capsulatum infection Infect. Immun. 78 2010 2125 2137
76. C.P. Taborda, and A. Casadevall CR3 (CD11b/CD18) and CR4 (CD11c/CD18) are involved in complement-independent antibody-mediated phagocytosis of Cryptococcus neoformans Immunity 16 2002 791 802
77. P.J. Tacken, I.S. Zeelenberg, L.J. Cruz, M.A. van Hout-Kuijer, G. van de Glind, R.G. Fokkink, A.J. Lambeck, and C.G. Figdor Targeted delivery of TLR ligands to human and mouse dendritic cells strongly enhances adjuvanticity Blood 118 2011 6836 6844
78. H. Takagi, T. Fukaya, K. Eizumi, Y. Sato, K. Sato, A. Shibazaki, H. Otsuka, A. Hijikata, T. Watanabe, and O. Ohara Plasmacytoid dendritic cells are crucial for the initiation of inflammation and T cell immunity in vivo Immunity 35 2011 958 971
79. M. Wüthrich, H.I. Filutowicz, and B.S. Klein Mutation of the WI-1 gene yields an attenuated blastomyces dermatitidis strain that induces host resistance J. Clin. Invest. 106 2000 1381 1389
80. M. Wüthrich, B. Gern, C.Y. Hung, K. Ersland, N. Rocco, J. Pick-Jacobs, K. Galles, H. Filutowicz, T. Warner, and M. Evans Vaccine-induced protection against 3 systemic mycoses endemic to North America requires Th17 cells in mice J. Clin. Invest. 121 2011 554 568
81. M. Wüthrich, K. Ersland, T. Sullivan, K. Galles, and B.S. Klein Fungi subvert vaccine T cell priming at the respiratory mucosa by preventing chemokine-induced influx of inflammatory monocytes Immunity 36 2012 680 692
82. T. Zelante, A. De Luca, P. Bonifazi, C. Montagnoli, S. Bozza, S. Moretti, M.L. Belladonna, C. Vacca, C. Conte, and P. Mosci IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistance Eur. J. Immunol. 37 2007 2695 2706