메뉴 건너뛰기




Volumn 3, Issue 2, 2013, Pages 577-585

A Functional Variomics Tool for Discovering Drug-Resistance Genes and Drug Targets

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOTERICIN B; CYCLOHEXIMIDE; FILIPIN; MEMBRANE PROTEIN; NATAMYCIN; NYSTATIN; PMP3 PROTEIN; RAPAMYCIN; UNCLASSIFIED DRUG;

EID: 84874263762     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2013.01.019     Document Type: Article
Times cited : (62)

References (49)
  • 2
    • 70350787156 scopus 로고    scopus 로고
    • Amphotericin B and its new derivatives-mode of action
    • Baginski M., Czub J. Amphotericin B and its new derivatives-mode of action. Curr. Drug Metab. 2009, 10:459-469.
    • (2009) Curr. Drug Metab. , vol.10 , pp. 459-469
    • Baginski, M.1    Czub, J.2
  • 3
    • 0021679168 scopus 로고
    • Asparagine-linked glycosylation in Saccharomyces cerevisiae: genetic analysis of an early step
    • Barnes G., Hansen W.J., Holcomb C.L., Rine J. Asparagine-linked glycosylation in Saccharomyces cerevisiae: genetic analysis of an early step. Mol. Cell. Biol. 1984, 4:2381-2388.
    • (1984) Mol. Cell. Biol. , vol.4 , pp. 2381-2388
    • Barnes, G.1    Hansen, W.J.2    Holcomb, C.L.3    Rine, J.4
  • 4
    • 84863234110 scopus 로고    scopus 로고
    • Rapamycin exerts antifungal activity in vitro and in vivo against Mucor circinelloides via FKBP12-dependent inhibition of Tor
    • Bastidas R.J., Shertz C.A., Lee S.C., Heitman J., Cardenas M.E. Rapamycin exerts antifungal activity in vitro and in vivo against Mucor circinelloides via FKBP12-dependent inhibition of Tor. Eukaryot. Cell 2012, 11:270-281.
    • (2012) Eukaryot. Cell , vol.11 , pp. 270-281
    • Bastidas, R.J.1    Shertz, C.A.2    Lee, S.C.3    Heitman, J.4    Cardenas, M.E.5
  • 5
    • 0001677717 scopus 로고
    • Controlling the false discovery rate: a practical and powerful approach to multiple testing
    • Benjamini Y., Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J. R. Stat. Soc. Series B Stat. Methodol. 1995, 57:289-300.
    • (1995) J. R. Stat. Soc. Series B Stat. Methodol. , vol.57 , pp. 289-300
    • Benjamini, Y.1    Hochberg, Y.2
  • 6
    • 0035733108 scopus 로고    scopus 로고
    • The control of the false discovery rate in multiple testing under dependency
    • Benjamini Y., Yekutieli D. The control of the false discovery rate in multiple testing under dependency. Ann. Stat. 2001, 29:1165-1188.
    • (2001) Ann. Stat. , vol.29 , pp. 1165-1188
    • Benjamini, Y.1    Yekutieli, D.2
  • 7
    • 0022862167 scopus 로고
    • How do the polyene macrolide antibiotics affect the cellular membrane properties?
    • Bolard J. How do the polyene macrolide antibiotics affect the cellular membrane properties?. Biochim. Biophys. Acta 1986, 864:257-304.
    • (1986) Biochim. Biophys. Acta , vol.864 , pp. 257-304
    • Bolard, J.1
  • 8
    • 0032579440 scopus 로고    scopus 로고
    • Designer deletion strains derived from Saccharomyces cerevisiae S288C: a useful set of strains and plasmids for PCR-mediated gene disruption and other applications
    • Brachmann C.B., Davies A., Cost G.J., Caputo E., Li J., Hieter P., Boeke J.D. Designer deletion strains derived from Saccharomyces cerevisiae S288C: a useful set of strains and plasmids for PCR-mediated gene disruption and other applications. Yeast 1998, 14:115-132.
    • (1998) Yeast , vol.14 , pp. 115-132
    • Brachmann, C.B.1    Davies, A.2    Cost, G.J.3    Caputo, E.4    Li, J.5    Hieter, P.6    Boeke, J.D.7
  • 9
    • 0025743122 scopus 로고
    • Polyene resistance in ergosterol producing strains of Candida albicans
    • Broughton M.C., Bard M., Lees N.D. Polyene resistance in ergosterol producing strains of Candida albicans. Mycoses 1991, 34:75-83.
    • (1991) Mycoses , vol.34 , pp. 75-83
    • Broughton, M.C.1    Bard, M.2    Lees, N.D.3
  • 10
    • 33644899143 scopus 로고    scopus 로고
    • Microarray-based method for monitoring yeast overexpression strains reveals small-molecule targets in TOR pathway
    • Butcher R.A., Bhullar B.S., Perlstein E.O., Marsischky G., LaBaer J., Schreiber S.L. Microarray-based method for monitoring yeast overexpression strains reveals small-molecule targets in TOR pathway. Nat. Chem. Biol. 2006, 2:103-109.
    • (2006) Nat. Chem. Biol. , vol.2 , pp. 103-109
    • Butcher, R.A.1    Bhullar, B.S.2    Perlstein, E.O.3    Marsischky, G.4    LaBaer, J.5    Schreiber, S.L.6
  • 11
    • 0028792326 scopus 로고
    • FKBP12-rapamycin target TOR2 is a vacuolar protein with an associated phosphatidylinositol-4 kinase activity
    • Cardenas M.E., Heitman J. FKBP12-rapamycin target TOR2 is a vacuolar protein with an associated phosphatidylinositol-4 kinase activity. EMBO J. 1995, 14:5892-5907.
    • (1995) EMBO J. , vol.14 , pp. 5892-5907
    • Cardenas, M.E.1    Heitman, J.2
  • 12
    • 84873351389 scopus 로고    scopus 로고
    • DANPOS: Dynamic analysis of nucleosome position and occupancy by sequencing
    • Published online December 20, 2012
    • Chen K., Xi Y., Pan X., Li Z., Kaestner K., Tyler J., Dent S., He X., Li W. DANPOS: Dynamic analysis of nucleosome position and occupancy by sequencing. Genome Res. 2012, Published online December 20, 2012. 10.1101/gr.142067.112.
    • (2012) Genome Res.
    • Chen, K.1    Xi, Y.2    Pan, X.3    Li, Z.4    Kaestner, K.5    Tyler, J.6    Dent, S.7    He, X.8    Li, W.9
  • 13
    • 0028598672 scopus 로고
    • RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex
    • Chiu M.I., Katz H., Berlin V. RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex. Proc. Natl. Acad. Sci. USA 1994, 91:12574-12578.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 12574-12578
    • Chiu, M.I.1    Katz, H.2    Berlin, V.3
  • 14
    • 0029842109 scopus 로고    scopus 로고
    • Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP
    • Choi J., Chen J., Schreiber S.L., Clardy J. Structure of the FKBP12-rapamycin complex interacting with the binding domain of human FRAP. Science 1996, 273:239-242.
    • (1996) Science , vol.273 , pp. 239-242
    • Choi, J.1    Chen, J.2    Schreiber, S.L.3    Clardy, J.4
  • 16
    • 0033043180 scopus 로고    scopus 로고
    • Rapamycin antifungal action is mediated via conserved complexes with FKBP12 and TOR kinase homologs in Cryptococcus neoformans
    • Cruz M.C., Cavallo L.M., Görlach J.M., Cox G., Perfect J.R., Cardenas M.E., Heitman J. Rapamycin antifungal action is mediated via conserved complexes with FKBP12 and TOR kinase homologs in Cryptococcus neoformans. Mol. Cell. Biol. 1999, 19:4101-4112.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 4101-4112
    • Cruz, M.C.1    Cavallo, L.M.2    Görlach, J.M.3    Cox, G.4    Perfect, J.R.5    Cardenas, M.E.6    Heitman, J.7
  • 17
    • 0015980909 scopus 로고
    • Polyene antibiotic-sterol interactions in membranes of Acholeplasma laidlawii cells and lecithin liposomes. 3. Molecular structure of the polyene antibiotic-cholesterol complexes
    • de Kruijff B., Demel R.A. Polyene antibiotic-sterol interactions in membranes of Acholeplasma laidlawii cells and lecithin liposomes. 3. Molecular structure of the polyene antibiotic-cholesterol complexes. Biochim. Biophys. Acta 1974, 339:57-70.
    • (1974) Biochim. Biophys. Acta , vol.339 , pp. 57-70
    • de Kruijff, B.1    Demel, R.A.2
  • 18
    • 0029004755 scopus 로고
    • Dominant mutations confer resistance to the immunosuppressant, rapamycin, in variants of a T cell lymphoma
    • Dumont F.J., Staruch M.J., Grammer T., Blenis J., Kastner C.A., Rupprecht K.M. Dominant mutations confer resistance to the immunosuppressant, rapamycin, in variants of a T cell lymphoma. Cell. Immunol. 1995, 163:70-79.
    • (1995) Cell. Immunol. , vol.163 , pp. 70-79
    • Dumont, F.J.1    Staruch, M.J.2    Grammer, T.3    Blenis, J.4    Kastner, C.A.5    Rupprecht, K.M.6
  • 19
    • 0036346444 scopus 로고    scopus 로고
    • Deletions of SKY1 or PTK2 in the Saccharomyces cerevisiae trk1Δtrk2Δ mutant cells exert dual effect on ion homeostasis
    • Erez O., Kahana C. Deletions of SKY1 or PTK2 in the Saccharomyces cerevisiae trk1Δtrk2Δ mutant cells exert dual effect on ion homeostasis. Biochem. Biophys. Res. Commun. 2002, 295:1142-1149.
    • (2002) Biochem. Biophys. Res. Commun. , vol.295 , pp. 1142-1149
    • Erez, O.1    Kahana, C.2
  • 22
    • 0024266139 scopus 로고
    • New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites
    • Gietz R.D., Sugino A. New yeast-Escherichia coli shuttle vectors constructed with in vitro mutagenized yeast genes lacking six-base pair restriction sites. Gene 1988, 74:527-534.
    • (1988) Gene , vol.74 , pp. 527-534
    • Gietz, R.D.1    Sugino, A.2
  • 24
    • 0025776523 scopus 로고
    • Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast
    • Heitman J., Movva N.R., Hall M.N. Targets for cell cycle arrest by the immunosuppressant rapamycin in yeast. Science 1991, 253:905-909.
    • (1991) Science , vol.253 , pp. 905-909
    • Heitman, J.1    Movva, N.R.2    Hall, M.N.3
  • 27
    • 0031959699 scopus 로고    scopus 로고
    • Sequencing, disruption, and characterization of the Candida albicans sterol methyltransferase (ERG6) gene: drug susceptibility studies in erg6 mutants
    • Jensen-Pergakes K.L., Kennedy M.A., Lees N.D., Barbuch R., Koegel C., Bard M. Sequencing, disruption, and characterization of the Candida albicans sterol methyltransferase (ERG6) gene: drug susceptibility studies in erg6 mutants. Antimicrob. Agents Chemother. 1998, 42:1160-1167.
    • (1998) Antimicrob. Agents Chemother. , vol.42 , pp. 1160-1167
    • Jensen-Pergakes, K.L.1    Kennedy, M.A.2    Lees, N.D.3    Barbuch, R.4    Koegel, C.5    Bard, M.6
  • 30
    • 0027956453 scopus 로고
    • Resistance to amphotericin B associated with defective sterol delta 8->7 isomerase in a Cryptococcus neoformans strain from an AIDS patient
    • Kelly S.L., Lamb D.C., Taylor M., Corran A.J., Baldwin B.C., Powderly W.G. Resistance to amphotericin B associated with defective sterol delta 8->7 isomerase in a Cryptococcus neoformans strain from an AIDS patient. FEMS Microbiol. Lett. 1994, 122:39-42.
    • (1994) FEMS Microbiol. Lett. , vol.122 , pp. 39-42
    • Kelly, S.L.1    Lamb, D.C.2    Taylor, M.3    Corran, A.J.4    Baldwin, B.C.5    Powderly, W.G.6
  • 31
    • 0028825698 scopus 로고
    • TOR mutations confer rapamycin resistance by preventing interaction with FKBP12-rapamycin
    • Lorenz M.C., Heitman J. TOR mutations confer rapamycin resistance by preventing interaction with FKBP12-rapamycin. J. Biol. Chem. 1995, 270:27531-27537.
    • (1995) J. Biol. Chem. , vol.270 , pp. 27531-27537
    • Lorenz, M.C.1    Heitman, J.2
  • 32
    • 0026602838 scopus 로고
    • Interaction of the yeast pleiotropic drug resistance genes PDR1 and PDR5
    • Meyers S., Schauer W., Balzi E., Wagner M., Goffeau A., Golin J. Interaction of the yeast pleiotropic drug resistance genes PDR1 and PDR5. Curr. Genet. 1992, 21:431-436.
    • (1992) Curr. Genet. , vol.21 , pp. 431-436
    • Meyers, S.1    Schauer, W.2    Balzi, E.3    Wagner, M.4    Goffeau, A.5    Golin, J.6
  • 33
    • 28244481916 scopus 로고    scopus 로고
    • + and increased salt sensitivity in Arabidopsis thaliana plants
    • + and increased salt sensitivity in Arabidopsis thaliana plants. Planta 2005, 222:1001-1009.
    • (2005) Planta , vol.222 , pp. 1001-1009
    • Mitsuya, S.1    Taniguchi, M.2    Miyake, H.3    Takabe, T.4
  • 34
    • 0034213888 scopus 로고    scopus 로고
    • Membrane hyperpolarization and salt sensitivity induced by deletion of PMP3, a highly conserved small protein of yeast plasma membrane
    • Navarre C., Goffeau A. Membrane hyperpolarization and salt sensitivity induced by deletion of PMP3, a highly conserved small protein of yeast plasma membrane. EMBO J. 2000, 19:2515-2524.
    • (2000) EMBO J. , vol.19 , pp. 2515-2524
    • Navarre, C.1    Goffeau, A.2
  • 36
    • 33644778778 scopus 로고    scopus 로고
    • A DNA integrity network in the yeast Saccharomyces cerevisiae
    • Pan X., Ye P., Yuan D.S., Wang X., Bader J.S., Boeke J.D. A DNA integrity network in the yeast Saccharomyces cerevisiae. Cell 2006, 124:1069-1081.
    • (2006) Cell , vol.124 , pp. 1069-1081
    • Pan, X.1    Ye, P.2    Yuan, D.S.3    Wang, X.4    Bader, J.S.5    Boeke, J.D.6
  • 38
    • 0003191839 scopus 로고
    • Targeted selection of recombinant clones through gene dosage effects
    • Rine J., Hansen W., Hardeman E., Davis R.W. Targeted selection of recombinant clones through gene dosage effects. Proc. Natl. Acad. Sci. USA 1983, 80:6750-6754.
    • (1983) Proc. Natl. Acad. Sci. USA , vol.80 , pp. 6750-6754
    • Rine, J.1    Hansen, W.2    Hardeman, E.3    Davis, R.W.4
  • 39
    • 0028239893 scopus 로고
    • RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs
    • Sabatini D.M., Erdjument-Bromage H., Lui M., Tempst P., Snyder S.H. RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs. Cell 1994, 78:35-43.
    • (1994) Cell , vol.78 , pp. 35-43
    • Sabatini, D.M.1    Erdjument-Bromage, H.2    Lui, M.3    Tempst, P.4    Snyder, S.H.5
  • 40
    • 0032403058 scopus 로고    scopus 로고
    • The TOR nutrient signalling pathway phosphorylates NPR1 and inhibits turnover of the tryptophan permease
    • Schmidt A., Beck T., Koller A., Kunz J., Hall M.N. The TOR nutrient signalling pathway phosphorylates NPR1 and inhibits turnover of the tryptophan permease. EMBO J. 1998, 17:6924-6931.
    • (1998) EMBO J. , vol.17 , pp. 6924-6931
    • Schmidt, A.1    Beck, T.2    Koller, A.3    Kunz, J.4    Hall, M.N.5
  • 44
    • 84857190127 scopus 로고    scopus 로고
    • Using transcriptome sequencing to identify mechanisms of drug action and resistance
    • Wacker S.A., Houghtaling B.R., Elemento O., Kapoor T.M. Using transcriptome sequencing to identify mechanisms of drug action and resistance. Nat. Chem. Biol. 2012, 8:235-237.
    • (2012) Nat. Chem. Biol. , vol.8 , pp. 235-237
    • Wacker, S.A.1    Houghtaling, B.R.2    Elemento, O.3    Kapoor, T.M.4
  • 45
    • 33646091083 scopus 로고    scopus 로고
    • The fission yeast stress MAPK cascade regulates the pmp3+ gene that encodes a highly conserved plasma membrane protein
    • Wang L.Y., Shiozaki K. The fission yeast stress MAPK cascade regulates the pmp3+ gene that encodes a highly conserved plasma membrane protein. FEBS Lett. 2006, 580:2409-2413.
    • (2006) FEBS Lett. , vol.580 , pp. 2409-2413
    • Wang, L.Y.1    Shiozaki, K.2
  • 48
    • 0042424651 scopus 로고    scopus 로고
    • Disruption of ergosterol biosynthesis confers resistance to amphotericin B in Candida lusitaniae
    • Young L.Y., Hull C.M., Heitman J. Disruption of ergosterol biosynthesis confers resistance to amphotericin B in Candida lusitaniae. Antimicrob. Agents Chemother. 2003, 47:2717-2724.
    • (2003) Antimicrob. Agents Chemother. , vol.47 , pp. 2717-2724
    • Young, L.Y.1    Hull, C.M.2    Heitman, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.