Mutations in Aspergillus fumigatus resulting in reduced susceptibility to posaconazole appear to be restricted to a single amino acid in the cytochrome P450 14α-demethylase

Antimicrobial Agents and Chemotherapy

Volumn 47, Issue 2, 2003, Pages 577-581

  Mann, Paul A ^a   Parmegiani, Raulo M ^a   Wei, Shui Qing ^a   Mendrick, Cara A ^a   Li, Xin ^a   Loebenberg, David ^a   DiDomenico, Beth ^a   Hare, Roberta S ^a   Walker, Scott S ^a   McNicholas, Paul M ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CYTOCHROME P450; CYTOCHROME P450 14ALPHA DEMETHYLASE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; POSACONAZOLE; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; ASPERGILLUS FUMIGATUS; CONTROLLED STUDY; CYP51A GENE; CYP51B GENE; DNA SEQUENCE; FUNGAL GENE; FUNGUS ISOLATION; GENE EXPRESSION; GENE LOCUS; GENE MUTATION; MUTANT; NONHUMAN; PHENOTYPE; POINT MUTATION; PRIORITY JOURNAL; PROMOTER REGION;

ANTIBIOTICS, ANTIFUNGAL; ASPERGILLUS FUMIGATUS; CYTOCHROME P-450 ENZYME SYSTEM; MICROBIAL SENSITIVITY TESTS; OXIDOREDUCTASES; POINT MUTATION; TRIAZOLES;

EID: 0037310145     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.47.2.577-581.2003     Document Type: Article

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