Structures of Cryptococcus neoformans protein farnesyltransferase reveal strategies for developing inhibitors that target fungal pathogens

Journal of Biological Chemistry

Volumn 286, Issue 40, 2011, Pages 35149-35162

  Hast, Michael A ^a   Nichols, Connie B ^a   Armstrong, Stephanie M ^a   Kelly, Shannon M ^a   Hellinga, Homme W ^a   Alspaugh, J Andrew ^a   Beese, Lorena S ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; ANTIFUNGALS; CONFORMATIONAL CHANGE; CRYPTOCOCCUS NEOFORMANS; DEVELOPMENT STRATEGIES; DRUG RESISTANCE; DRUG TARGETS; ENZYMATIC REACTION CYCLE; ESSENTIAL ELEMENTS; FTASE INHIBITORS; FUNGAL ENZYMES; FUNGAL INFECTION; FUNGAL PATHOGEN; LIFE-THREATENING INFECTIONS; LIPIDATION; NEOFORMANS; ORTHOLOGS; PROTEIN FARNESYLTRANSFERASE; REACTION CYCLES; STRUCTURAL STUDIES;

ENZYMES; FUNCTIONAL GROUPS; OPTIMIZATION; PATHOGENS; PROTEINS; SIGNAL TRANSDUCTION; SITE SELECTION;

FUNGI;

HYBRID PROTEIN; L 778123; PROTEIN CNRAS 1; PROTEIN FARNESYLTRANSFERASE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; TIPIFARNIB; UNCLASSIFIED DRUG;

ANTIFUNGAL ACTIVITY; ARTICLE; BINDING SITE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CRYPTOCOCCUS NEOFORMANS; CRYSTAL STRUCTURE; DRUG PROTEIN BINDING; DRUG TARGETING; ENZYME MECHANISM; FUNGAL CELL; FUNGAL STRAIN; FUNGUS GROWTH; GROWTH INHIBITION; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN STRUCTURE;

ALKYL AND ARYL TRANSFERASES; ANTIFUNGAL AGENTS; CLONING, MOLECULAR; CRYPTOCOCCUS NEOFORMANS; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; HUMANS; LIGANDS; MODELS, CHEMICAL; PRENYLATION; PROTEIN CONFORMATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; SIGNAL TRANSDUCTION; SUBSTRATE SPECIFICITY;

FILOBASIDIELLA NEOFORMANS;

EID: 80053400607     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.250506     Document Type: Article

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