Amino acid substitutions in the Candida albicans sterol δ5,6-desaturase (Erg3p) confer azole resistance: Characterization of two novel mutants with impaired virulence

Journal of Antimicrobial Chemotherapy

Volumn 67, Issue 9, 2012, Pages 2131-2138

  Morio, Florent ^a,b   Pagniez, Fabrice ^a   Lacroix, Claire ^c   Miegeville, Michel ^a,b   Le pape, Patrice ^a,b  

^a UNIVERSITÉ DE NANTES   (France)

^b NANTES UNIVERSITY HOSPITAL   (France)

^c Laboratoire de Parasitologie Mycologie   (France)

Author keywords

Amphotericin B; Azole antifungals; C. albicans; ERG3; Ergosterol biosynthesis

Indexed keywords

AMINO ACID; AMPHOTERICIN B; ERG3P; ERGOSTEROL; FLUCONAZOLE; MULTIDRUG RESISTANCE PROTEIN 1; RNA; UNCLASSIFIED DRUG; VORICONAZOLE;

AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIFUNGAL RESISTANCE; ANTIFUNGAL SUSCEPTIBILITY; ARTICLE; BROTH DILUTION; CANDIDA ALBICANS; CONTROLLED STUDY; FEMALE; FUNGAL VIRULENCE; FUNGUS GROWTH; GENE AMPLIFICATION; GENE MUTATION; GENE SEQUENCE; HOSPITAL PATIENT; IN VIVO STUDY; INVASIVE CANDIDIASIS; MASS FRAGMENTOGRAPHY; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADULT; AMINO ACID SUBSTITUTION; ANIMALS; ANTIFUNGAL AGENTS; CANDIDA ALBICANS; CANDIDIASIS; CELL MEMBRANE; CHEMOPREVENTION; DRUG RESISTANCE, FUNGAL; FEMALE; FLUCONAZOLE; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GENE EXPRESSION PROFILING; HUMANS; MICE; MICROBIAL SENSITIVITY TESTS; MIDDLE AGED; MUTANT PROTEINS; OXIDOREDUCTASES; PYRIMIDINES; STEROLS; TRIAZOLES; VIRULENCE;

EID: 84865368550     PISSN: 03057453     EISSN: 14602091     Source Type: Journal    
DOI: 10.1093/jac/dks186     Document Type: Article

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