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Volumn 92, Issue 4, 2014, Pages 304-313

Caspases and inflammasomes in metabolic inflammation

Author keywords

Caspases; diabetes; inflammasome; metabolism; microbiota; obesity

Indexed keywords

CASPASE; CHOLESTEROL; INFLAMMASOME; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; CYTOKINE;

EID: 84899414605     PISSN: 08189641     EISSN: 14401711     Source Type: Journal    
DOI: 10.1038/icb.2014.5     Document Type: Review
Times cited : (51)

References (95)
  • 1
    • 62649139025 scopus 로고    scopus 로고
    • Immunological and inflammatory functions of the interleukin-1 family
    • Dinarello CA. Immunological and inflammatory functions of the interleukin-1 family. Annu Rev Immunol 2009; 27: 519-550.
    • (2009) Annu Rev Immunol , vol.27 , pp. 519-550
    • Dinarello, C.A.1
  • 2
    • 79957920754 scopus 로고    scopus 로고
    • Inflammatory links between obesity and metabolic disease
    • Lumeng CN, Saltiel AR. Inflammatory links between obesity and metabolic disease. J Clin Invest 2011; 121: 2111-2117.
    • (2011) J Clin Invest , vol.121 , pp. 2111-2117
    • Lumeng, C.N.1    Saltiel, A.R.2
  • 3
    • 84867191669 scopus 로고    scopus 로고
    • Adipose tissue inflammation and ectopic lipid accumulation
    • Suganami T, Tanaka M, Ogawa Y. Adipose tissue inflammation and ectopic lipid accumulation. Endocr J 2012; 59: 849-857.
    • (2012) Endocr J , vol.59 , pp. 849-857
    • Suganami, T.1    Tanaka, M.2    Ogawa, Y.3
  • 4
    • 34948902196 scopus 로고    scopus 로고
    • Visceral and subcutaneous adipose tissue volumes are cross-sectionally related to markers of inflammation and oxidative stress: The Framingham Heart S tudy
    • Pou KM, Massaro JM, Hoffmann U, Vasan RS, Maurovich-Horvat P, Larson MG et al. Visceral and subcutaneous adipose tissue volumes are cross-sectionally related to markers of inflammation and oxidative stress: the Framingham Heart S tudy. Circulation 2007; 116: 1234-1241.
    • (2007) Circulation , vol.116 , pp. 1234-1241
    • Pou, K.M.1    Massaro, J.M.2    Hoffmann, U.3    Vasan, R.S.4    Maurovich-Horvat, P.5    Larson, M.G.6
  • 5
    • 42449097289 scopus 로고    scopus 로고
    • Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes
    • Guilherme A, Virbasius JV, Puri V, Czech MP. Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes. Nat Rev Mol Cell Biol 2008; 9: 367-377.
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 367-377
    • Guilherme, A.1    Virbasius, J.V.2    Puri, V.3    Czech, M.P.4
  • 6
    • 33845866857 scopus 로고    scopus 로고
    • Inflammation and metabolic disorders
    • Hotamisligil GS. Inflammation and metabolic disorders. Nature 2006; 444: 860-867.
    • (2006) Nature , vol.444 , pp. 860-867
    • Hotamisligil, G.S.1
  • 7
    • 0242268894 scopus 로고    scopus 로고
    • Chronic exposure to interleukin-6 causes hepatic insulin resistance in mice
    • Klover PJ, Zimmers TA, Koniaris LG, Mooney RA. Chronic exposure to interleukin-6 causes hepatic insulin resistance in mice. Diabetes 2003; 52: 2784-2789.
    • (2003) Diabetes , vol.52 , pp. 2784-2789
    • Klover, P.J.1    Zimmers, T.A.2    Koniaris, L.G.3    Mooney, R.A.4
  • 8
    • 2342639558 scopus 로고    scopus 로고
    • Diabetes, lipids, and adipocyte secretagogues
    • Faraj M, Lu HL, Cianflone K. Diabetes, lipids, and adipocyte secretagogues. Biochem Cell Biol 2004; 82: 170-190.
    • (2004) Biochem Cell Biol , vol.82 , pp. 170-190
    • Faraj, M.1    Lu Cianflone, H.L.K.2
  • 10
    • 0027299436 scopus 로고
    • Effects of acute hyperins ulinemia on VLDL triglyceride and VLDL apoB production in normal weight and obese individuals
    • Lewis GF, Uffelman KD, Szeto LW, Steiner G. Effects of acute hyperins ulinemia on VLDL triglyceride and VLDL apoB production in normal weight and obese individuals. Diabetes 1993; 42: 833-842.
    • (1993) Diabetes , vol.42 , pp. 833-842
    • Lewis, G.F.1    Uffelman, K.D.2    Szeto, L.W.3    Steiner, G.4
  • 11
    • 17044386953 scopus 로고    scopus 로고
    • Type 2 diabetes: Principles of pathogenesis and therapy
    • Stumvoll M, Goldstein BJ, van Haeften TW. Type 2 diabetes: principles of pathogenesis and therapy. Lancet 2005; 365: 1333-1346.
    • (2005) Lancet , vol.365 , pp. 1333-1346
    • Stumvoll, M.1    Goldstein, B.J.2    Van Haeften, T.W.3
  • 12
    • 19944366619 scopus 로고    scopus 로고
    • Regulation of plasma triglycerides in insulin resistance and diabetes
    • Ginsberg HN, Zhang YL, Hernandez-Ono A. Regulation of plasma triglycerides in insulin resistance and diabetes. Arch Med Res 2005; 36: 232-240.
    • (2005) Arch Med Res , vol.36 , pp. 232-240
    • Ginsberg, H.N.1    Zhang, Y.L.2    Hernandez-Ono, A.3
  • 14
    • 80052146101 scopus 로고    scopus 로고
    • The machinery of Nod-like receptors: Refining the paths to immunity and cell death
    • Saleh M. The machinery of Nod-like receptors: refining the paths to immunity and cell death. Immunol Rev 2011; 243: 235-246.
    • (2011) Immunol Rev , vol.243 , pp. 235-246
    • Saleh, M.1
  • 15
    • 77950362382 scopus 로고    scopus 로고
    • The inflammasomes
    • Schroder K, Tscho pp J. The inflammasomes. Cell 2010; 140: 821-832.
    • (2010) Cell , vol.140 , pp. 821-832
    • Schroder, K.1    Tscho Pp, J.2
  • 16
    • 84856957894 scopus 로고    scopus 로고
    • Inflammasomemediated dysbiosis regulates progression of NA FLD and obesity
    • Henao-Mejia J, Elinav E, Jin C, Hao L, Mehal WZ, Strowig T et al. Inflammasomemediated dysbiosis regulates progression of NA FLD and obesity. Nature 2012; 482: 179-185.
    • (2012) Nature , vol.482 , pp. 179-185
    • Henao-Mejia, J.1    Elinav, E.2    Jin, C.3    Hao, L.4    Mehal, W.Z.5    Strowig, T.6
  • 17
    • 79955632319 scopus 로고    scopus 로고
    • Linking lipid metabolism to the innate immune response in macrophages through sterol regulatory element binding protein-1a
    • Im SS, Yousef L, Blaschitz C, Liu JZ, Edwards RA, Young SG et al. Linking lipid metabolism to the innate immune response in macrophages through sterol regulatory element binding protein-1a. Cell Metab 2011; 13: 540-549.
    • (2011) Cell Metab , vol.13 , pp. 540-549
    • Im, S.S.1    Yousef, L.2    Blaschitz, C.3    Liu, J.Z.4    Edwards, R.A.5    Young, S.G.6
  • 19
    • 78649498271 scopus 로고    scopus 로고
    • The inflammasome-mediated cas pase-1 activation controls adipocyte differentiation and insulin sensitivity
    • Stienstra R, Joosten LA, Koenen T, van Tits B, van Diepen JA, van den Berg SA et al. The inflammasome-mediated cas pase-1 activation controls adipocyte differentiation and insulin sensitivity. Cell Metab 2010; 12: 593-605.
    • (2010) Cell Metab , vol.12 , pp. 593-605
    • Stienstra, R.1    Joosten, L.A.2    Koenen, T.3    Van Tits, B.4    Van Diepen, J.A.5    Van Den Berg, S.A.6
  • 23
    • 79955038882 scopus 로고    scopus 로고
    • Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling
    • Wen H, Gris D, Lei Y, Jha S, Zhang L, Huang MT et al. Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling. Nat Immunol 2011; 12: 408-415.
    • (2011) Nat Immunol , vol.12 , pp. 408-415
    • Wen, H.1    Gris, D.2    Lei, Y.3    Jha, S.4    Zhang, L.5    Huang, M.T.6
  • 24
    • 79751512463 scopus 로고    scopus 로고
    • The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
    • Vandanmagsar B, Youm YH, Ravussin A, Galgani JE, Stadler K, Mynatt RL et al. The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance. Nat Med 2011; 17: 179-188.
    • (2011) Nat Med , vol.17 , pp. 179-188
    • Vandanmagsar, B.1    Youm, Y.H.2    Ravussin, A.3    Galgani, J.E.4    Stadler, K.5    Mynatt, R.L.6
  • 25
    • 84866168894 scopus 로고    scopus 로고
    • Functional interactions between the gut microbiota and host metabolism
    • Tremaroli V, Backhed F. Functional interactions between the gut microbiota and host metabolism. Nature 2012; 489: 242-249.
    • (2012) Nature , vol.489 , pp. 242-249
    • Tremaroli, V.1    Backhed, F.2
  • 27
    • 79957576718 scopus 로고    scopus 로고
    • NLRP6 inflammasome regulates coloni c microbial ecology and risk for colitis
    • Elinav E, Strowig T, Kau AL, Henao-Mejia J, Thaiss CA, Booth CJ et al. NLRP6 inflammasome regulates coloni c microbial ecology and risk for colitis. Cell 2011; 145: 745-757.
    • (2011) Cell , vol.145 , pp. 745-757
    • Elinav, E.1    Strowig, T.2    Kau, A.L.3    Henao-Mejia, J.4    Thaiss, C.A.5    Booth, C.J.6
  • 28
    • 84866461477 scopus 로고    scopus 로고
    • Familial transmission rather than defective i nnate immunity shapes the distinct intestinal microbiota of TLR-deficient mice
    • Ubeda C, Lipuma L, Gobourne A, Viale A, Leiner I, Equinda M et al. Familial transmission rather than defective i nnate immunity shapes the distinct intestinal microbiota of TLR-deficient mice. J Exp Med 2012; 209: 1445-1456.
    • (2012) J Exp Med , vol.209 , pp. 1445-1456
    • Ubeda, C.1    Lipuma, L.2    Gobourne, A.3    Viale, A.4    Leiner, I.5    Equinda, M.6
  • 31
    • 37549002511 scopus 로고    scopus 로고
    • The caspase-1 digestome identifies the glycolysis pathway as a target during infection and septic shock
    • Shao W, Yeretssian G, Doiron K, Hussain SN, Saleh M. The caspase-1 digestome identifies the glycolysis pathway as a target during infection and septic shock. J Biol Chem 2007; 282: 36321-36329.
    • (2007) J Biol Chem , vol.282 , pp. 36321-36329
    • Shao, W.1    Yeretssian, G.2    Doiron, K.3    Hussain, S.N.4    Saleh, M.5
  • 32
    • 84877329207 scopus 로고    scopus 로고
    • PPARgamma signaling and metabolism: The good, the bad and the future
    • Ahma dian M, Suh JM, Hah N, Liddle C, Atkins AR, Downes M et al. PPARgamma signaling and metabolism: the good, the bad and the future. Nat Med 2013; 19: 557-566.
    • (2013) Nat Med , vol.19 , pp. 557-566
    • Ahmadian, M.1    Suh, J.M.2    Hah, N.3    Liddle, C.4    Atkins, A.R.5    Downes, M.6
  • 33
    • 48749113378 scopus 로고    scopus 로고
    • Caspase-mediated degradation of PPARgamma proteins in adipocytes
    • He F, Doucet JA, Stephens JM. Caspase-mediated degradation of PPARgamma proteins in adipocytes. Obesity (Silver Spring) 2008; 16: 1735-1741.
    • (2008) Obesity (Silver Spring , vol.16 , pp. 1735-1741
    • He, F.1    Doucet, J.A.2    Stephens, J.M.3
  • 34
    • 67650539080 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha induces caspase-mediated cleavage of peroxisome proliferator-activated receptor gamma in adipocytes
    • Guilherme A, Tesz GJ, Guntur KV, Czech MP. Tumor necrosis factor-alpha induces caspase-mediated cleavage of peroxisome proliferator-activated receptor gamma in adipocytes. J Biol Chem 2009; 284: 17082-17091.
    • (2009) J Biol Chem , vol.284 , pp. 17082-17091
    • Guilherme, A.1    Tesz, G.J.2    Guntur, K.V.3    Czech, M.P.4
  • 35
    • 84859977895 scopus 로고    scopus 로고
    • Sirtuins mediate mammalian metabolic responses to nutrient availability
    • Chalkiadaki A, G uarente L. Sirtuins mediate mammalian metabolic responses to nutrient availability. Nat Rev Endocrinol 2012; 8: 287-296.
    • (2012) Nat Rev Endocrinol , vol.8 , pp. 287-296
    • Chalkiadaki, A.1    Uarente, L.G.2
  • 36
    • 84864678390 scopus 로고    scopus 로고
    • High-fat diet triggers inflammation-induced cleavage of SIRT1 in adipose tissue to promote metabolic dysfunction
    • Chalkiadaki A, Guarente L. High-fat diet triggers inflammation-induced cleavage of SIRT1 in adipose tissue to promote metabolic dysfunction. Cell Metab 2012; 16: 180-188.
    • (2012) Cell Metab , vol.16 , pp. 180-188
    • Chalkiadaki, A.1    Guarente, L.2
  • 37
    • 0037073679 scopus 로고    scopus 로고
    • Serine phosphorylation of insulin receptor substrate by inhibitor kappa B kinase complex
    • Gao Z, Hwang D, Bataille F, Lefevre M, York D, Quon MJ et al. Serine phosphorylation of insulin receptor substrate by inhibitor kappa B kinase complex. J Biol Chem2002 277 48115-48121.
    • (2002) J Biol Chem , vol.277 , pp. 48115-48121
    • Gao, Z.1    Hwang, D.2    Bataille, F.3    Lefevre, M.4    York, D.5    Quon, M.J.6
  • 39
    • 0036671894 scopus 로고    scopus 로고
    • The inflammasome: A molecular platform triggering activation of inflamm atory caspases and processing of proIL-beta
    • Martinon F, Burns K, Tschopp J. The inflammasome: a molecular platform triggering activation of inflamm atory caspases and processing of proIL-beta. Mol Cell 2002; 10: 417-426.
    • (2002) Mol Cell , vol.10 , pp. 417-426
    • Martinon, F.1    Burns, K.2    Tschopp, J.3
  • 40
    • 84857985148 scopus 로고    scopus 로고
    • The cellular and signaling networks linking the immune system and metabolism in disease
    • Osborn O, Olefsky JM. The cellular and signaling networks linking the immune system and metabolism in disease. Nat Med 2012; 18: 363-374.
    • (2012) Nat Med , vol.18 , pp. 363-374
    • Osborn, O.1    Olefsky, J.M.2
  • 42
    • 75649096002 scopus 로고    scopus 로고
    • Thioredoxin-interacting protein links oxidative stress to inflammasome activation
    • Zhou R, Tardivel A, Thorens B, Choi I, Tschopp J. Thioredoxin-interacting protein links oxidative stress to inflammasome activation. Nat Immunol 2010; 11: 136-140.
    • (2010) Nat Immunol , vol.11 , pp. 136-140
    • Zhou, R.1    Tardivel, A.2    Thorens, B.3    Choi, I.4    Tschopp, J.5
  • 43
    • 80054903245 scopus 로고    scopus 로고
    • Elimination of the NLRP3-ASC inflammasome protects against chronic obesity-induced pancreatic damage
    • Youm YH, Adijiang A, Vandanmagsar B, Burk D, Ravussin A, Dixit VD. Elimination of the NLRP3-ASC inflammasome protects against chronic obesity-induced pancreatic damage. Endocrinology 2011; 152: 4039-4045.
    • (2011) Endocrinology , vol.152 , pp. 4039-4045
    • Youm, Y.H.1    Adijiang, A.2    Vandanmagsar, B.3    Burk, D.4    Ravussin, A.5    Dixit, V.D.6
  • 44
    • 84883784100 scopus 로고    scopus 로고
    • Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocanna binoids mediates beta cell loss in type 2 diabetes
    • Jourdan T, Godlewski G, Cinar R, Bertola A, Szanda G, Liu J et al. Activation of the Nlrp3 inflammasome in infiltrating macrophages by endocanna binoids mediates beta cell loss in type 2 diabetes. Nat Med 2013; 19: 1132-1140.
    • (2013) Nat Med , vol.19 , pp. 1132-1140
    • Jourdan, T.1    Godlewski, G.2    Cinar, R.3    Bertola, A.4    Szanda, G.5    Liu, J.6
  • 45
    • 0023579739 scopus 로고
    • Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients
    • Cooper GJ, Willis AC, Clark A, Turner RC, Sim RB, Reid KB. Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients. Proc Natl Acad Sci USA 1987; 84: 8628-8632.
    • (1987) Proc Natl Acad Sci USA , vol.84 , pp. 8628-8632
    • Cooper, G.J.1    Willis, A.C.2    Clark, A.3    Turner, R.C.4    Sim, R.B.5    Reid, K.B.6
  • 46
    • 2542581025 scopus 로고    scopus 로고
    • Diabetes due to a progressive defect in beta-cell mass in rats transgenic for human islet amyloid polypeptide (HIP Rat): A new model for type 2 diabetes
    • Butler AE, Jang J, Gurlo T, Carty MD, Soeller WC, Butler PC. Diabetes due to a progressive defect in beta-cell mass in rats transgenic for human islet amyloid polypeptide (HIP Rat): a new model for type 2 diabetes. Diabetes 2004; 53: 1509-1516.
    • (2004) Diabetes , vol.53 , pp. 1509-1516
    • Butler, A.E.1    Jang, J.2    Gurlo, T.3    Carty, M.D.4    Soeller, W.C.5    Butler, P.C.6
  • 48
    • 77956958947 scopus 로고    scopus 로고
    • Activation of th e NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1beta in type 2 diabetes
    • Masters SL, Dunne A, Subramanian SL, Hull RL, Tannahill GM, Sharp FA et al. Activation of th e NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1beta in type 2 diabetes. Nat Immunol 2010; 11: 897-904.
    • (2010) Nat Immunol , vol.11 , pp. 897-904
    • Masters, S.L.1    Dunne, A.2    Subramanian, S.L.3    Hull, R.L.4    Tannahill, G.M.5    Sharp, F.A.6
  • 49
    • 84864682160 scopus 로고    scopus 로고
    • IRE1alpha induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress
    • Lerner AG, Upton JP, Praveen PV, Ghosh R, Nakaga wa Y, Igbaria A et al. IRE1alpha induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress. Cell Metab 2012; 16: 250-264.
    • (2012) Cell Metab , vol.16 , pp. 250-264
    • Lerner, A.G.1    Upton, J.P.2    Praveen, P.V.3    Ghosh, R.4    Nakaga Wa, Y.5    Igbaria, A.6
  • 50
    • 84864693470 scopus 로고    scopus 로고
    • Thioredoxin-interacting protein mediates ER stress-induced beta cell death through initiation of the inflammasome
    • Oslowski CM, Hara T, O'Sullivan-Murphy B, Kanekura K, Lu S, Hara M et al. Thioredoxin-interacting protein mediates ER stress-induced beta cell death through initiation of the inflammasome. Cell Metab 2012; 16: 265-273.
    • (2012) Cell Metab , Issue.16 , pp. 265-273
    • Oslowski, C.M.1    Hara, T.2    O'Sullivan-Murphy, B.3    Kanekura, K.4    Lu, S.5    Hara, M.6
  • 51
    • 81255188900 scopus 로고    scopus 로고
    • Atherosclerosis: Current pathogenesis and therapeutic options
    • Weber C, Noels H. Atherosclerosis: current pathogenesis and therapeutic options. Nat Med 2011; 17: 1410-1422.
    • (2011) Nat Med , vol.17 , pp. 1410-1422
    • Weber, C.1    Noels, H.2
  • 52
    • 84886797808 scopus 로고    scopus 로고
    • Macrophages in atherosclerosis: A dynamic balance
    • Moore KJ, Sheedy FJ, Fisher EA. Macrophages in atherosclerosis: a dynamic balance. Nat Rev Immunol 2013; 13: 709-721.
    • (2013) Nat Rev Immunol , vol.13 , pp. 709-721
    • Moore, K.J.1    Sheedy, F.J.2    Fisher, E.A.3
  • 53
    • 77951800951 scopus 로고    scopus 로고
    • NLRP3 inflammas omes are required for atherogenesis and activated by cholesterol crystals
    • Duewell P, Kono H, Rayner KJ, Sirois CM, Vladimer G, Bauernfeind FG et al. NLRP3 inflammas omes are required for atherogenesis and activated by cholesterol crystals. Nature 2010; 464: 1357-1361.
    • (2010) Nature , vol.464 , pp. 1357-1361
    • Duewell, P.1    Kono, H.2    Rayner, K.J.3    Sirois, C.M.4    Vladimer, G.5    Bauernfeind, F.G.6
  • 54
    • 77955356552 scopus 로고    scopus 로고
    • Cholesterol crystals activate the NLRP3 inflammasome in human macrophages: A novel link between cholesterol metabolism and inflammation
    • Rajamaki K, Lappalainen J, Oörni K, Välimäki E, Matikainen S, Kovanen PT et al. Ch olesterol crystals activate the NLRP3 inflammasome in human macrophages: a novel link between cholesterol metabolism and inflammation. PLoS One 2010; 5: e11765.
    • (2010) PLoS One , vol.5
    • Rajamaki, K.1    Lappalainen, J.2    Oörni, K.3    Välimäki, E.4    Matikainen, S.5    Kovanen, P.T.6
  • 55
    • 0346037268 scopus 로고    scopus 로고
    • Scavenger receptors class A-I/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages
    • Kunjathoor VV, Febbraio M, Podrez EA, Mo ore KJ, Andersson L, Koehn S et al. Scavenger receptors class A-I/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages. J Biol Chem 2002; 277: 49982-49988.
    • (2002) J Biol Chem , vol.277 , pp. 49982-49988
    • Kunjathoor, V.V.1    Febbraio, M.2    Podrez, E.A.3    Mo Ore, K.J.4    Andersson, L.5    Koehn, S.6
  • 56
    • 75649087741 scopus 로고    scopus 로고
    • CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor and 6 heterodimer
    • Stewart CR, Stuart LM, Wilkinson K, van Gils JM, Deng J, Halle A et al. CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer. Nat Immunol 2010; 11: 155-161.
    • (2010) Nat Immunol , vol.11 , pp. 155-161
    • Stewart, C.R.1    Stuart, L.M.2    Wilkinson, K.3    Van Gils, J.M.4    Deng, J.5    Halle, A.6
  • 57
    • 84880777411 scopus 로고    scopus 로고
    • CD36 coordinates NLRP3 inflammasome activa tion by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation
    • Sheedy FJ Grebe A Rayner KJ Kalantari P Ramkhelawon B Carpenter SB et al. CD36 coordinates NLRP3 inflammasome activa tion by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation Nat Immunol 2013 14 812-820.
    • (2013) Nat Immunol , vol.14 , pp. 812-820
    • Sheedy, F.J.1    Grebe, A.2    Rayner, K.J.3    Kalantari, P.4    Ramkhelawon, B.5    Carpenter, S.B.6
  • 58
    • 0026592806 scopus 로고
    • Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein e
    • Zhang SH, Reddick RL, Piedrahita JA, Maeda N. Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. Science 1992; 258: 468-471.
    • (1992) Science , vol.258 , pp. 468-471
    • Zhang, S.H.1    Reddick, R.L.2    Piedrahita, J.A.3    Maeda, N.4
  • 60
    • 84865389353 scopus 로고    scopus 로고
    • Critical role of caspase-1 in vascular inflammation and development of atherosclerosis in Western diet-fed apolipoprotein E-deficient mice
    • Usui F, Shirasuna K, Kimura H, Tatsumi K, Kawashima A, Karasawa T et al. Critical role of caspase-1 in vascular inflammation and development of atherosclerosis in Western diet-fed apolipoprotein E-deficient mice. B iochem Biophys Res Commun 2012; 425: 162-168.
    • (2012) Biochem Biophys Res Commun , vol.425 , pp. 162-168
    • Usui, F.1    Shirasuna, K.2    Kimura, H.3    Tatsumi, K.4    Kawashima, A.5    Karasawa, T.6
  • 61
    • 0036725464 scopus 로고    scopus 로고
    • Interaction between free fatty acids and glucose metabolism
    • Boden G. Interaction between free fatty acids and glucose metabolism. Curr Opin Clin Nutr Metab Care 2002; 5: 545-549.
    • (2002) Curr Opin Clin Nutr Metab Care , vol.5 , pp. 545-549
    • Boden, G.1
  • 63
    • 84864657351 scopus 로고    scopus 로고
    • Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance
    • Pal D, Dasgupt a S, Kundu R, Maitra S, Das G, Mukhopadhyay S et al. Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance. Nat Med 2012; 18: 1279-1285.
    • (2012) Nat Med , vol.18 , pp. 1279-1285
    • Pal, D.1    Dasgupt, A.S.2    Kundu, R.3    Maitra, S.4    Das, G.5    Mukhopadhyay, S.6
  • 64
    • 84860482342 scopus 로고    scopus 로고
    • A ceramide-centric view of insulin resistance
    • Chavez JA, Summers SA. A ceramide-centric view of insulin resistance. Cell Metab 2012; 15: 585-594.
    • (2012) Cell Metab , vol.15 , pp. 585-594
    • Chavez, J.A.1    Summers, S.A.2
  • 65
    • 79551584144 scopus 로고    scopus 로고
    • Hyperglycemia activates caspase-1 and TXNIP-mediated IL-1beta transcription in human adipose tissue
    • Koenen TB, Stienstra R, van Tits LJ, de Graaf J, Stalenhoef AF, Joosten LA et al. Hyperglycemia activates caspase-1 and TXNIP-mediated IL-1beta transcription in human adipose tissue. Diabetes 2011; 60: 517-524.
    • (2011) Diabetes , vol.60 , pp. 517-524
    • Koenen, T.B.1    Stienstra, R.2    Van Tits, L.J.3    De Graaf, J.4    Stalenhoef, A.F.5    Joosten, L.A.6
  • 67
    • 84861869574 scopus 로고    scopus 로고
    • The ATP-P2-7 signaling ax is is dispensable for obesity-associated inflammasome activation in adipose tissue
    • Sun S, Xia S, Ji Y, Kersten S, Qi L. The ATP-P2-7 signaling ax is is dispensable for obesity-associated inflammasome activation in adipose tissue. Diabetes 2012; 61: 1471-1478.
    • (2012) Diabetes , vol.61 , pp. 1471-1478
    • Sun, S.1    Xia, S.2    Ji, Y.3    Kersten, S.4    Qi, L.5
  • 69
    • 47849097202 scopus 로고    scopus 로고
    • Silica crystal s and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization
    • Hornung V, Bauernfeind F, Halle A, Samstad EO, Kono H, Rock KL et al. Silica crystal s and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. Nat Immunol 2008; 9: 847-856.
    • (2008) Nat Immunol , vol.9 , pp. 847-856
    • Hornung, V.1    Bauernfeind, F.2    Halle, A.3    Samstad, E.O.4    Kono, H.5    Rock, K.L.6
  • 70
    • 32944468985 scopus 로고    scopus 로고
    • Gout-associated uric acid crystals activate the NALP3 inflammasome
    • Martinon F, Petrilli V, Mayor A, Tardivel A, Tschopp J. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 2006; 440: 237-241.
    • (2006) Nature , vol.440 , pp. 237-241
    • Martinon, F.1    Petrilli, V.2    Mayor, A.3    Tardivel, A.4    Tschopp, J.5
  • 71
    • 33845873659 scopus 로고    scopus 로고
    • Interleukin-1betainduced insulin resistan ce in adipocytes through down-regulation of insulin receptor substrate-1 expression
    • Jager J, Gremeaux T, Cormont M, Le Marchand-Brustel Y, Tanti JF. Interleukin-1betainduced insulin resistan ce in adipocytes through down-regulation of insulin receptor substrate-1 expression. Endocrinology 2007; 148: 241-251.
    • (2007) Endocrinology , vol.148 , pp. 241-251
    • Jager, J.1    Gremeaux, T.2    Cormont, M.3    Le Marchand-Brustel, Y.4    Tanti, J.F.5
  • 72
    • 79959438318 scopus 로고    scopus 로고
    • Lack of interleukin-1 receptor i (IL-1RI) protects mice from high-fat diet-induced adipose tissue inflammation coincident with improved glucose homeostasis
    • McGillicuddy FC, Harford KA, Reynolds CM, Oliver E, Claessens M, Mills KH et al. Lack of interleukin-1 receptor I (IL-1RI) protects mice from high-fat diet-induced adipose tissue inflammation coincident with improved glucose homeostasis. Diabetes 2011; 60: 1688-1698.
    • (2011) Diabetes , vol.60 , pp. 1688-1698
    • McGillicuddy, F.C.1    Harford, K.A.2    Reynolds, C.M.3    Oliver, E.4    Claessens, M.5    Mills, K.H.6
  • 73
    • 33144466102 scopus 로고    scopus 로고
    • Decreased fat mass in interleukin-1 receptor an tagonist-deficient mice: Impact on adipogenesis, food intake, and energy expenditure
    • Somm E, Henrichot E, Pernin A, Juge-Aubry CE, Muzzin P, Dayer JM et al. Decreased fat mass in interleukin-1 receptor an tagonist-deficient mice: impact on adipogenesis, food intake, and energy expenditure. Diabetes 2005; 54: 3503-3509.
    • (2005) Diabetes , vol.54 , pp. 3503-3509
    • Somm, E.1    Henrichot, E.2    Pernin, A.3    Juge-Aubry, C.E.4    Muzzin, P.5    Dayer, J.M.6
  • 74
    • 0141784866 scopus 로고    scopus 로고
    • IL-1 plays an important role in lipid metabolism by regulating insulin levels under physiological conditions
    • Matsuki T, Horai R, Sudo K, Iwakura Y. IL-1 plays an important role in lipid metabolism by regulating insulin levels under physiological conditions. J Exp Med 2003; 198: 877-888.
    • (2003) J Exp Med , vol.198 , pp. 877-888
    • Matsuki, T.1    Horai, R.2    Sudo, K.3    Iwakura, Y.4
  • 75
    • 33745009509 scopus 로고    scopus 로고
    • Defic iency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance
    • Netea MG, Joosten LA, Lewis E, Jensen DR, Voshol PJ, Kullberg BJ et al. Defic iency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance. Nat Med 2006; 12: 650-656.
    • (2006) Nat Med , vol.12 , pp. 650-656
    • Netea, M.G.1    Joosten, L.A.2    Lewis, E.3    Jensen, D.R.4    Voshol, P.J.5    Kullberg, B.J.6
  • 77
    • 84887338975 scopus 로고    scopus 로고
    • Interleukin-Activates Skeletal Muscle AMPK and Reduces Weight Gain and Insulin Resistance in Mice
    • Lindegaard B, Matthews VB, Brandt C, Hojman P, Allen TL, Estevez E et al. Interleukin-Activates Skeletal Muscle AMPK and Reduces Weight Gain and Insulin Resistance in Mice Diabetes 2013 62 3064-3074.
    • (2013) Diabetes , vol.62 , pp. 3064-3074
    • Lindegaard, B.1    Matthews, V.B.2    Brandt, C.3    Hojman, P.4    Allen, T.L.5    Estevez, E.6
  • 78
    • 0038748305 scopus 로고    scopus 로고
    • Elevated levels of interleukin-18 and tumor necrosis factor-alpha in serum of patients with type 2 diabetes mellitus: Relationship with diabetic nephropathy
    • Moriwak i Y, Yamamoto T, Shibutani Y, Aoki E, Tsutsumi Z, Takahashi S et al. Elevated levels of interleukin-18 and tumor necrosis factor-alpha in serum of patients with type 2 diabetes mellitus: relationship with diabetic nephropathy. Metabolism 2003; 52: 605-608.
    • (2003) Metabolism , vol.52 , pp. 605-608
    • Moriwak, I.Y.1    Yamamoto, T.2    Shibutani, Y.3    Aoki, E.4    Tsutsumi, Z.5    Takahashi, S.6
  • 79
    • 26044457651 scopus 로고    scopus 로고
    • Elevated plasma interleukin-18 is a marker of insulin-resistance in type 2 diabetic and non-diabetic huma ns
    • Fischer CP, Perstrup LB, Berntsen A, Eskildsen P, Pedersen BK. Elevated plasma interleukin-18 is a marker of insulin-resistance in type 2 diabetic and non-diabetic huma ns. Clin Immunol 2005; 117: 152-160.
    • (2005) Clin Immunol , vol.117 , pp. 152-160
    • Fischer, C.P.1    Perstrup, L.B.2    Berntsen, A.3    Eskildsen, P.4    Pedersen, B.K.5
  • 80
    • 20144370398 scopus 로고    scopus 로고
    • Elevated interleukin-levels are associated with the metabolic syndrome independent of obesity and insulin resistance
    • Hung J, McQuillan BM, Chapman CM, Thompson PL, Beilby JP. Elevated interleukin-levels are associated with the metabolic syndrome independent of obesity and insulin resistance. Arterioscler Thromb Vasc Biol 2005; 25: 1268-1273.
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 1268-1273
    • Hung, J.1    McQuillan, B.M.2    Chapman, C.M.3    Thompson, P.L.4    Beilby, J.P.5
  • 81
    • 84866562625 scopus 로고    scopus 로고
    • Metabolic checkpoints in activated T cells
    • Wang R, Green DR. Metabolic checkpoints in activated T cells. Nat Immunol 2012; 13: 907-915.
    • (2012) Nat Immunol , vol.13 , pp. 907-915
    • Wang, R.1    Green, D.R.2
  • 82
    • 84859464555 scopus 로고    scopus 로고
    • Orchestration of metabolism by macrophages
    • Biswas SK, Mantovani A. Orchestration of metabolism by macrophages. Cell Metab 2012; 15: 432-437.
    • (2012) Cell Metab , vol.15 , pp. 432-437
    • Biswas, S.K.1    Mantovani, A.2
  • 84
    • 84881131862 scopus 로고    scopus 로고
    • Sterol regulatory element binding protein activation of NLRP3 inflammasome in endothelium mediates hemodynamic-induced atherosclerosis susceptibility
    • Xiao H, Lu M, Lin TY, Chen Z, Chen G, Wang WC et al. Sterol regulatory element binding protein activation of NLRP3 inflammasome in endothelium mediates hemodynamic-induced atherosclerosis susceptibility. Circulation 2013; 128: 632-642.
    • (2013) Circulation , vol.128 , pp. 632-642
    • Xiao, H.1    Lu, M.2    Lin, T.Y.3    Chen, Z.4    Chen, G.5    Wang, W.C.6
  • 85
    • 33748598700 scopus 로고    scopus 로고
    • Caspase-1 activation of lipid metabolic pathways in response to bacterial pore-forming toxins promotes cell survival
    • Gurcel L, Abrami L, Girardin S, Tschopp J, van der Goot FG. Caspase-1 activation of lipid metabolic pathways in response to bacterial pore-forming toxins promotes cell survival. Cell 2006; 126: 1135-1145.
    • (2006) Cell , vol.126 , pp. 1135-1145
    • Gurcel, L.1    Abrami, L.2    Girardin, S.3    Tschopp, J.4    Van Der Goot, F.G.5
  • 86
    • 84872018875 scopus 로고    scopus 로고
    • Upregulated NLRP3 inflammasome activation in patients with type 2 diabetes
    • Lee HM, Kim JJ, Kim HJ, Shong M, Ku BJ, Jo EK. Upregulated NLRP3 inflammasome activation in patients with type 2 diabetes. Diabetes 2013; 62: 194-204.
    • (2013) Diabetes , vol.62 , pp. 194-204
    • Lee, H.M.1    Kim, J.J.2    Kim, H.J.3    Shong, M.4    Ku, B.J.5    Jo, E.K.6
  • 87
    • 84857364150 scopus 로고    scopus 로고
    • Expression of NLRP3 inflammasome and T cell population markers in adipose tissue are associated with insulin resistance and impaired glucose metabolism in h umans
    • Goossens GH, Blaak EE, Theunissen R, Duijvestijn AM, Clément K, Tervaert JW et al. Expression of NLRP3 inflammasome and T cell population markers in adipose tissue are associated with insulin resistance and impaired glucose metabolism in h umans. Mol Immunol 2012; 50: 142-149.
    • (2012) Mol Immunol , vol.50 , pp. 142-149
    • Goossens, G.H.1    Blaak, E.E.2    Theunissen, R.3    Duijvestijn, A.M.4    Clément, K.5    Tervaert, J.W.6
  • 88
    • 84885863093 scopus 로고    scopus 로고
    • Obesity phenotype is related to NLRP3 inflammasome activity and immu nological profile of visceral adipose tissue
    • Esser N, L'homme L, De Roover A, Kohnen L, Scheen AJ, Moutschen M et al. Obesity phenotype is related to NLRP3 inflammasome activity and immu nological profile of visceral adipose tissue. Diabetologia 2013; 56: 2487-2497.
    • (2013) Diabetologia , vol.56 , pp. 2487-2497
    • Esser, N.1    L'Homme, L.2    De Roover, A.3    Kohnen, L.4    Scheen, A.J.5    Moutschen, M.6
  • 92
    • 84864252972 scopus 로고    scopus 로고
    • Resolvins: Anti-inflammatory and proresolving mediators derived from omega-3 polyunsaturated fatty acids
    • Zhang MJ, Spite M. Resolvins: anti-inflammatory and proresolving mediators derived from omega-3 polyunsaturated fatty acids. Annu Rev Nutr 2012; 32: 203-227.
    • (2012) Annu Rev Nutr , vol.32 , pp. 203-227
    • Zhang, M.J.1    Spite, M.2
  • 93
    • 84879582536 scopus 로고    scopus 로고
    • Omega-3 fatty acids prevent inflammation and metabo lic disorder through inhibition of NLRP3 inflammasome activation
    • Yan Y, Jiang W, Spinetti T, Tardivel A, Castillo R, Bourquin C et al. Omega-3 fatty acids prevent inflammation and metabo lic disorder through inhibition of NLRP3 inflammasome activation. Immunity 2013; 38: 1154-1163.
    • (2013) Immunity , vol.38 , pp. 1154-1163
    • Yan, Y.1    Jiang, W.2    Spinetti, T.3    Tardivel, A.4    Castillo, R.5    Bourquin, C.6


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