Obesity phenotype is related to NLRP3 inflammasome activity and immunological profile of visceral adipose tissue

Diabetologia

Volumn 56, Issue 11, 2013, Pages 2487-2497

  Esser, Nathalie ^a,b   L'Homme, Laurent ^a   De Roover, Arnaud ^b   Kohnen, Laurent ^b   Scheen, André J ^b   Moutschen, Michel ^a   Piette, Jacques ^a   Legrand Poels, Sylvie ^a   Paquot, Nicolas ^a,b  

^a UNIVERSITY OF LIÈGE   (Belgium)

^b UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

Adipose tissue; Inflammatory cytokines; Macrophages; Metabolic disorders; NLRP3 inflammasome; Obesity

Indexed keywords

CELL PROTEIN; CRYOPYRIN; GLYCOPROTEIN P 15095; INFLAMMASOME; INSULIN; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; PROTEIN CD206; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CELL COMPOSITION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE ASSOCIATION; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IL1B GENE; IMMUNE SYSTEM; INTRAABDOMINAL FAT; LEAN BODY WEIGHT; LYMPHOCYTE COUNT; MACROPHAGE; MALE; METABOLIC SYNDROME X; NLRP3 GENE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; REGULATORY T LYMPHOCYTE; SUBCUTANEOUS FAT;

ADULT; CARRIER PROTEINS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; INFLAMMASOMES; INTERLEUKIN-18; INTERLEUKIN-1BETA; INTRA-ABDOMINAL FAT; MALE; MIDDLE AGED; OBESITY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 84885863093     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-013-3023-9     Document Type: Article

References (47)

1. Alberti KG, Eckel RH, Grundy SM et al (2009) Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation 120:1640-1645
2. Karelis AD, St-Pierre DH, Conus F, Rabasa-Lhoreth R, Poehlman ET (2004) Metabolic and body composition factors in subgroups of obesity: what do we know? J Clin Endocrinol Metab 89:2569-2575
3. Wildman RP, Muntner P, Reynolds K et al (2008) The obese without cardiometabolic risk factor clustering and the normal weight with cardiometabolic risk factor clustering: prevalence and correlates of 2 phenotypes among the US population (NHANES 1999-2004). Arch Intern Med 168:1617-1624
4. Stefan N, Kantartzis K, Macham J et al (2008) Identification and characterization of metabolically benign obesity in humans. Arch Intern Med 168:1609-1616
5. Bradshaw PT, Monda KL, Stevens J (2013) Metabolic syndrome in healthy obese, overweight, and normal weight individuals: the atherosclerosis risk in communities study. Obesity (Silver Spring) 21:203-209
6. Wajchenberg BL (2000) Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. Endocr Rev 21:697-738
7. Tchernof A, Després JP (2013) Pathophysiology of human visceral obesity: an update. Physiol Rev 93:359-404
8. Koster A, Stenholm S, Alley DE et al (2010) Body fat distribution and inflammation among obese older adults with and without metabolic syndrome. Obesity (Silver Spring) 18:2354-2361
9. Fox CS, Massaro JM, Hoffmann U et al (2007) Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study. Circulation 116:39-48
10. Lundgren M, Svensson M, Lindmark S et al (2007) Fat cell enlargement is an independent marker of insulin resistance and 'hyper-leptinaemia'. Diabetologia 50:625-633
11. Weyer C, Foley JE, Bogardus C et al (2000) Enlarged subcutaneous abdominal adipocyte size but not obesity itself, predicts type II diabetes independent of insulin resistance. Diabetologia 43:1498-1506
12. Gossens GH (2008) The role of adipose tissue dysfunction in the pathogenesis of obesity-related insulin resistance. Physiol Behav 94:206-218
13. Shoelson SE, Lee J (2006) Inflammation and insulin resistance. J Clin Invest 116:1793-1801
14. Hotamisligil GS (2006) Inflammation and metabolic disorders. Nature 444:860-867
15. Donath MT, Shoelson SE (2011) Type 2 diabetes as an inflammatory disease. Nat Rev Immunol 11:98-107
16. Olefsky JM, Glass CK (2010) Macrophages, inflammation, and insulin resistance. Annu Rev Physiol 72:219-246
17. Chawla A, Nguyen KD, Goh YP (2011) Macrophage-mediated inflammation in metabolic disease. Nat Rev Immunol 11:738-749
18. Feve B, Bastard JP (2009) The role of interleukins in insulin resistance and type 2 diabetes mellitus. Nature Rev Endocrinol 5:305-311
19. Osborn O, Olefsky JM (2012) The cellular and signaling networks linking the immune system and metabolism in disease. Nat Med 18:363-374
20. + adipose tissue macrophages are associated with insulin resistance in human obesity. Diabetes 59:1648-1656
21. Fujisaka S, Usui I, Bukhari A et al (2009) Regulatory mechanisms for adipose tissue M1 and M2 macrophages in diet-induced obese mice. Diabetes 58:2574-2582
22. Patsouris D, Li PP, Thapar D et al (2008) Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals. Cell Metab 8:301-309
23. Feuerer M, Herrero L, Cipolletta D et al (2009) Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat Med 15:930-939
24. Nishimura S, Manabe I, Nagasaki M et al (2009) CD8+ effector T cells contribute to macrophages recruitment and adipose tissue inflammation in obesity. Nat Med 15:914-920
25. Winer S, Chan Y, Paltser G et al (2009) Normalization of obesity-associated insulin resistance through immunotherapy. Nat Med 15:921-929
26. Spranger J, Kroke A, Möhlig M et al (2003) Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study. Diabetes 52:812-817
27. Thorand B, Kolb H, Baumert J et al (2005) Elevated levels of interleukin-18 predict the development of type 2 diabetes. Results from the MONICA/KORA Augsburg study, 1984-2002. Diabetes 54:2932-2938
28. Schroder K, Tschopp J (2010) The inflammasomes. Cell 140:821-832
29. Stienstra R, Tack CJ, Kanneganti TD, Joosten LAB, Netea MG (2012) The inflammasome puts obesity in the danger zone. Cell Metab 15:10-18
30. Vandanmagsar B, Youm YH, Ravussin A et al (2011) The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance. Nat Med 17:179-188
31. Lee HM, Kim JJ, Kim HJ et al (2013) Upregulated NLRP3 inflammasome activation in patients with type 2 diabetes. Diabetes 62:194-204
32. Koenen TB, Stienstra R, van Tits LJ et al (2011) The inflammasome and caspase-1 activation: a new mechanism underlying increased inflammatory activity in human visceral adipose tissue. Endocrinology 152:3769-3778
33. Livak KJ, Schmitthen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25:402-408
34. Arend WP, Palmer G, Gabay C (2008) IL-1, IL-18, and IL-33 families of cytokines. Immunol Rev 223:20-38
35. Schertzer JD, Klip A (2011) Give a NOD to insulin resistance. Am J Physiol Endocrinol Metab 301:E585-E586
36. Kim MS, Choi M-S, Han SN (2011) High fat diet-induced obesity leads to proinflammatory response associated with higher expression of NOD2 protein. Nutr Res Pract 5:219-223
37. Deiuliis J, Shah Z, Shah N et al (2011) Visceral adipose inflammation in obesity is associated with critical alterations in T regulatory cell numbers. PLoS One 6:e16376
38. Greenberg AS, Obin MS (2006) Obesity and the role of adipose tissue in inflammation and metabolism. Am J Clin Nutr 83:461S-465S
39. Fried SK, Bunkin DA, Greenberg AS (1998) Omental and subcutaneous adipose tissues of obese subjects release interleukin-6: depot difference and regulation by glucocorticoid. J Clin Endocrinol Metab 83:847-850
40. Membrez M, Ammon-Zufferay C, Philippe D et al (2008) Interleukin-18 protein level is upregulated in adipose tissue of obese mice. Obesity (Silver Spring) 17:393-395
41. Skurk T, Kolb H, Muller-Scholze S et al (2005) The proatherogenic cytokine interleukin-18 is secreted by human adipocytes. Eur J Endocrinol 152:863-868
42. Poulain-Godefroy O, Lecoeur C, Pattou F et al (2008) Inflammation is associated with a decrease of lipogenic factors in omental fat in women. Am J Physiol Regul Integr Comp Physiol 295:R1-R7
43. Lemieux I, Poirier P, Bergeron J et al (2007) Hypertriglyceridemic waist: a useful screening phenotype in preventive cardiology? Can J Cardiol 23(suppl B):23B-31B
44. Shi H, Kokoeva M, Inouye K et al (2006) TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest 116:3015-3025
45. Wen H, Gris D, Lei Y et al (2011) Fatty acid-induced NLRP3-ASC inflammasomes activation interferes with insulin signaling. Nat Immunol 12:408-415
46. Oh DY, Talukdar S, Baz EJ et al (2010) GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin -sensitizing effects. Cell 142:687-698
47. Chatzigeorgiou A, Karalis KP, Bornstein SR, Chavakis T (2012) Lymphocytes in obesity-related adipose tissues inflammation. Diabetologia 55:2583-2592