Sterol regulatory element binding protein 2 activation of NLRP3 inflammasome in endothelium mediates hemodynamic-induced atherosclerosis susceptibility

Circulation

Volumn 128, Issue 6, 2013, Pages 632-642

  Xiao, Han ^a   Lu, Min ^d   Lin, Ting Yang ^a   Chen, Zhen ^a,d   Chen, Gang ^b   Wang, Wei Chi ^e   Marin, Traci ^a   Shentu, Tzu Pin ^a   Wen, Liang ^a   Gongol, Brendan ^a   Sun, Wei ^a   Liang, Xiao ^c,f   Chen, Ju ^d   Huang, Hsien Da ^e   Pedra, Joao H F ^b,f   Johnson, David A ^a   Shyy, John Y J ^a,d  

^a Division of Biomedical Sciences   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c PEKING UNIVERSITY THIRD HOSPITAL   (China)

^d UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^e NATIONAL CHIAO TUNG UNIVERSITY   (Taiwan)

^f XI'AN JIAOTONG UNIVERSITY   (China)

Author keywords

atherosclerosis; endothelial cell; NLRP3 protein, human; shear stress; sterol regulatory element binding proteins

Indexed keywords

CRYOPYRIN; INFLAMMASOME; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; STEROL REGULATORY ELEMENT BINDING PROTEIN 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROSCLEROSIS; CONTROLLED STUDY; DISEASE PREDISPOSITION; ENDOTHELIUM; ENDOTHELIUM CELL; ENZYME ACTIVATION; HEMODYNAMICS; HUMAN; HUMAN CELL; HYPERLIPIDEMIA; INNATE IMMUNITY; MALE; MOUSE; NONHUMAN; OSCILLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SHEAR FLOW; TISSUE LEVEL; VASCULAR ENDOTHELIUM;

ATHEROSCLEROSIS; ENDOTHELIAL CELL; NLRP3 PROTEIN, HUMAN; SHEAR STRESS; STEROL REGULATORY ELEMENT BINDING PROTEINS;

ANIMALS; APOLIPOPROTEINS E; ATHEROSCLEROSIS; CARRIER PROTEINS; ENDOTHELIAL CELLS; HEMODYNAMICS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; IMMUNITY, INNATE; INFLAMMASOMES; MALE; MEMBRANE GLYCOPROTEINS; MICE; MICE, TRANSGENIC; MICRORNAS; NADPH OXIDASE; RNA, SMALL INTERFERING; STEROL REGULATORY ELEMENT BINDING PROTEIN 2; STRESS, MECHANICAL; VASCULITIS;

EID: 84881131862     PISSN: 00097322     EISSN: 15244539     Source Type: Journal    
DOI: 10.1161/CIRCULATIONAHA.113.002714     Document Type: Article

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