-
1
-
-
0032779351
-
Molecular mechanism of metabolic syndrome X: Contribution of adipocytokines adipocyte-derived bioactive substances
-
Matsuzawa Y, Funahashi T, Nakamura T (1999) Molecular mechanism of metabolic syndrome X: contribution of adipocytokines adipocyte-derived bioactive substances. Ann N Y Acad Sci 892: 146-154.
-
(1999)
Ann N Y Acad Sci
, vol.892
, pp. 146-154
-
-
Matsuzawa, Y.1
Funahashi, T.2
Nakamura, T.3
-
2
-
-
33745834319
-
Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
-
Kadowaki T, Yamauchi T, Kubota N, Hara K, Ueki K, et al. (2006) Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J Clin Invest 116: 1784-1792.
-
(2006)
J Clin Invest
, vol.116
, pp. 1784-1792
-
-
Kadowaki, T.1
Yamauchi, T.2
Kubota, N.3
Hara, K.4
Ueki, K.5
-
3
-
-
19044393872
-
Adipose tissue, inflammation, and cardiovascular disease
-
Berg AH, Scherer PE (2005) Adipose tissue, inflammation, and cardiovascular disease. Circ Res 96: 939-949.
-
(2005)
Circ Res
, vol.96
, pp. 939-949
-
-
Berg, A.H.1
Scherer, P.E.2
-
4
-
-
51349156218
-
Insulin sensitivity: Modulation by nutrients and inflammation
-
Schenk S, Saberi M, Olefsky JM (2008) Insulin sensitivity: modulation by nutrients and inflammation. J Clin Invest 118: 2992-3002.
-
(2008)
J Clin Invest
, vol.118
, pp. 2992-3002
-
-
Schenk, S.1
Saberi, M.2
Olefsky, J.M.3
-
5
-
-
33845866857
-
Inflammation and metabolic disorders
-
Hotamisligil GS (2006) Inflammation and metabolic disorders. Nature 444: 860-867.
-
(2006)
Nature
, vol.444
, pp. 860-867
-
-
Hotamisligil, G.S.1
-
6
-
-
69249205739
-
Obesity, inflammation, and atherosclerosis
-
Rocha VZ, Libby P (2009) Obesity, inflammation, and atherosclerosis. Nat Rev Cardiol 6: 399-409.
-
(2009)
Nat Rev Cardiol
, vol.6
, pp. 399-409
-
-
Rocha, V.Z.1
Libby, P.2
-
7
-
-
0348230958
-
Obesity is associated with macrophage accumulation in adipose tissue
-
Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL, et al. (2003) Obesity is associated with macrophage accumulation in adipose tissue. J Clin Invest 112: 1796-1808.
-
(2003)
J Clin Invest
, vol.112
, pp. 1796-1808
-
-
Weisberg, S.P.1
McCann, D.2
Desai, M.3
Rosenbaum, M.4
Leibel, R.L.5
-
8
-
-
9144223683
-
Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance
-
Xu H, Barnes GT, Yang Q, Tan G, Yang D, et al. (2003) Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. J Clin Invest 112: 1821-1830.
-
(2003)
J Clin Invest
, vol.112
, pp. 1821-1830
-
-
Xu, H.1
Barnes, G.T.2
Yang, Q.3
Tan, G.4
Yang, D.5
-
9
-
-
7744226149
-
Weight loss regulates inflammation-related genes in white adipose tissue of obese subjects
-
Clement K, Viguerie N, Poitou C, Carette C, Pelloux V, et al. (2004) Weight loss regulates inflammation-related genes in white adipose tissue of obese subjects. FASEB J 18: 1657-1669.
-
(2004)
FASEB J
, vol.18
, pp. 1657-1669
-
-
Clement, K.1
Viguerie, N.2
Poitou, C.3
Carette, C.4
Pelloux, V.5
-
11
-
-
77951918926
-
Macrophages, inflammation, and insulin resistance
-
Olefsky JM, Glass CK (2010) Macrophages, inflammation, and insulin resistance. Annu Rev Physiol 72: 219-246
-
(2010)
Annu Rev Physiol
, vol.72
, pp. 219-246
-
-
Olefsky, J.M.1
Glass, C.K.2
-
12
-
-
3042710511
-
-
American Physiology Society, Washington, D. C
-
Wasserman F (1965) Handbook of Physiology. American Physiology Society, Washington, D. C.
-
(1965)
Handbook of Physiology
-
-
Wasserman, F.1
-
13
-
-
30044449982
-
Resolution of inflammation: The beginning programs the end
-
Serhan CN, Savill J (2005) Resolution of inflammation: the beginning programs the end. Nat Immunol 6: 1191-1197
-
(2005)
Nat Immunol
, vol.6
, pp. 1191-1197
-
-
Serhan, C.N.1
Savill, J.2
-
14
-
-
47949099098
-
Origin and physiological roles of inflammation
-
Medzhitov R (2008) Origin and physiological roles of inflammation. Nature 454: 428-435.
-
(2008)
Nature
, vol.454
, pp. 428-435
-
-
Medzhitov, R.1
-
15
-
-
34249719581
-
Adipogenesis in obesity requires close interplay between differentiating adipocytes, stromal cells, and blood vessels
-
Nishimura S, Manabe I, Nagasaki M, Hosoya Y, Yamashita H, et al. (2007) Adipogenesis in obesity requires close interplay between differentiating adipocytes, stromal cells, and blood vessels. Diabetes 56: 1517-1526.
-
(2007)
Diabetes
, vol.56
, pp. 1517-1526
-
-
Nishimura, S.1
Manabe, I.2
Nagasaki, M.3
Hosoya, Y.4
Yamashita, H.5
-
16
-
-
38849118568
-
In vivo imaging in mice reveals local cell dynamics and inflammation in obese adipose tissue
-
Nishimura S, Manabe I, Nagasaki M, Seo K, Yamashita H, et al. (2008) In vivo imaging in mice reveals local cell dynamics and inflammation in obese adipose tissue. J Clin Invest 118: 710-721.
-
(2008)
J Clin Invest
, vol.118
, pp. 710-721
-
-
Nishimura, S.1
Manabe, I.2
Nagasaki, M.3
Seo, K.4
Yamashita, H.5
-
17
-
-
84856116245
-
Adipose tissue remodeling as homeostatic inflammation
-
Itoh M, Suganami T, Hachiya R, Ogawa Y (2011) Adipose tissue remodeling as homeostatic inflammation. Int J Inflam 2011: 720926.
-
(2011)
Int J Inflam
, vol.2011
, pp. 720926
-
-
Itoh, M.1
Suganami, T.2
Hachiya, R.3
Ogawa, Y.4
-
18
-
-
77954672503
-
Adipose tissue macrophages: Their role in adipose tissue remodeling
-
Suganami T, Ogawa Y (2010) Adipose tissue macrophages: their role in adipose tissue remodeling. J Leukoc Biol 88: 33-39.
-
(2010)
J Leukoc Biol
, vol.88
, pp. 33-39
-
-
Suganami, T.1
Ogawa, Y.2
-
19
-
-
33846026712
-
Obesity induces a phenotypic switch in adipose tissue macrophage polarization
-
Lumeng CN, Bodzin JL, Saltiel AR (2007) Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest 117: 175-184.
-
(2007)
J Clin Invest
, vol.117
, pp. 175-184
-
-
Lumeng, C.N.1
Bodzin, J.L.2
Saltiel, A.R.3
-
20
-
-
58149347227
-
Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes
-
Lumeng CN, DelProposto JB, Westcott DJ, Saltiel AR (2008) Phenotypic switching of adipose tissue macrophages with obesity is generated by spatiotemporal differences in macrophage subtypes. Diabetes 57: 3239-3246.
-
(2008)
Diabetes
, vol.57
, pp. 3239-3246
-
-
Lumeng, C.N.1
DelProposto, J.B.2
Westcott, D.J.3
Saltiel, A.R.4
-
21
-
-
27444437321
-
Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans
-
Cinti S, Mitchell G, Barbatelli G, Murano I, Ceresi E, et al. (2005) Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J Lipid Res 46: 2347-2355.
-
(2005)
J Lipid Res
, vol.46
, pp. 2347-2355
-
-
Cinti, S.1
Mitchell, G.2
Barbatelli, G.3
Murano, I.4
Ceresi, E.5
-
22
-
-
33745428666
-
Oxidative metabolism and PGC-1beta attenuate macrophage-mediated inflammation
-
Vats D, Mukundan L, Odegaard JI, Zhang L, Smith KL, et al. (2006) Oxidative metabolism and PGC-1beta attenuate macrophage-mediated inflammation. Cell Metab 4: 13-24.
-
(2006)
Cell Metab
, vol.4
, pp. 13-24
-
-
Vats, D.1
Mukundan, L.2
Odegaard, J.I.3
Zhang, L.4
Smith, K.L.5
-
23
-
-
77956954197
-
The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection
-
Satoh T, Takeuchi O, Vandenbon A, Yasuda K, Tanaka Y, et al. (2010) The Jmjd3-Irf4 axis regulates M2 macrophage polarization and host responses against helminth infection. Nat Immunol 11: 936-944.
-
(2010)
Nat Immunol
, vol.11
, pp. 936-944
-
-
Satoh, T.1
Takeuchi, O.2
Vandenbon, A.3
Yasuda, K.4
Tanaka, Y.5
-
24
-
-
78751483763
-
The interleukin 13 (IL-13) pathway in human macrophages is modulated by microRNA-155 via direct targeting of interleukin 13 receptor alpha1 (IL13Ralpha1)
-
Martinez-Nunez RT, Louafi F, Sanchez-Elsner T (2011) The interleukin 13 (IL-13) pathway in human macrophages is modulated by microRNA-155 via direct targeting of interleukin 13 receptor alpha1 (IL13Ralpha1). J Biol Chem 286: 1786-1794.
-
(2011)
J Biol Chem
, vol.286
, pp. 1786-1794
-
-
Martinez-Nunez, R.T.1
Louafi, F.2
Sanchez-Elsner, T.3
-
25
-
-
33846302361
-
Attenuation of obesity-induced adipose tissue inflammation in C3H/HeJ mice carrying a Toll-like receptor 4 mutation
-
Suganami T, Mieda T, Itoh M, Shimoda Y, Kamei Y, et al. (2007) Attenuation of obesity-induced adipose tissue inflammation in C3H/HeJ mice carrying a Toll-like receptor 4 mutation. Biochem Biophys Res Commun 354: 45-49.
-
(2007)
Biochem Biophys Res Commun
, vol.354
, pp. 45-49
-
-
Suganami, T.1
Mieda, T.2
Itoh, M.3
Shimoda, Y.4
Kamei, Y.5
-
26
-
-
33750584214
-
TLR4 links innate immunity and fatty acid-induced insulin resistance
-
Shi H, Kokoeva MV, Inouye K, Tzameli I, Yin H, et al. (2006) TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest 116: 3015-3025.
-
(2006)
J Clin Invest
, vol.116
, pp. 3015-3025
-
-
Shi, H.1
Kokoeva, M.V.2
Inouye, K.3
Tzameli, I.4
Yin, H.5
-
27
-
-
34547602916
-
Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance
-
Tsukumo DM, Carvalho-Filho MA, Carvalheira JB, Prada PO, Hirabara SM, et al. (2007) Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance. Diabetes 56: 1986-1998.
-
(2007)
Diabetes
, vol.56
, pp. 1986-1998
-
-
Tsukumo, D.M.1
Carvalho-Filho, M.A.2
Carvalheira, J.B.3
Prada, P.O.4
Hirabara, S.M.5
-
28
-
-
34247884376
-
C3H/HeJ mice carrying a toll-like receptor 4 mutation are protected against the development of insulin resistance in white adipose tissue in response to a high-fat diet
-
Poggi M, Bastelica D, Gual P, Iglesias MA, Gremeaux T, et al. (2007) C3H/HeJ mice carrying a toll-like receptor 4 mutation are protected against the development of insulin resistance in white adipose tissue in response to a high-fat diet. Diabetologia 50: 1267-1276.
-
(2007)
Diabetologia
, vol.50
, pp. 1267-1276
-
-
Poggi, M.1
Bastelica, D.2
Gual, P.3
Iglesias, M.A.4
Gremeaux, T.5
-
29
-
-
44349161098
-
Alternative M2 activation of Kupffer cells by PPARdelta ameliorates obesity-induced insulin resistance
-
Odegaard JI, Ricardo-Gonzalez RR, Red Eagle A, Vats D, Morel CR, et al. (2008) Alternative M2 activation of Kupffer cells by PPARdelta ameliorates obesity-induced insulin resistance. Cell Metab 7: 496-507.
-
(2008)
Cell Metab
, vol.7
, pp. 496-507
-
-
Odegaard, J.I.1
Ricardo-Gonzalez, R.R.2
Red Eagle, A.3
Vats, D.4
Morel, C.R.5
-
30
-
-
34347354309
-
Macrophagespecific PPARgamma controls alternative activation and improves insulin resistance
-
Odegaard JI, Ricardo-Gonzalez RR, Goforth MH, Morel CR, Subramanian V, et al. (2007) Macrophagespecific PPARgamma controls alternative activation and improves insulin resistance. Nature 447: 1116-1120.
-
(2007)
Nature
, vol.447
, pp. 1116-1120
-
-
Odegaard, J.I.1
Ricardo-Gonzalez, R.R.2
Goforth, M.H.3
Morel, C.R.4
Subramanian, V.5
-
31
-
-
44349112305
-
Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity
-
Kang K, Reilly SM, Karabacak V, Gangl MR, Fitzgerald K, et al. (2008) Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity. Cell Metab 7: 485-495.
-
(2008)
Cell Metab
, vol.7
, pp. 485-495
-
-
Kang, K.1
Reilly, S.M.2
Karabacak, V.3
Gangl, M.R.4
Fitzgerald, K.5
-
32
-
-
70350560546
-
Regulatory mechanisms for adipose tissue M1 and M2 macrophages in diet-induced obese mice
-
Fujisaka S, Usui I, Bukhari A, Ikutani M, Oya T, et al. (2009) Regulatory mechanisms for adipose tissue M1 and M2 macrophages in diet-induced obese mice. Diabetes 58: 2574-2582.
-
(2009)
Diabetes
, vol.58
, pp. 2574-2582
-
-
Fujisaka, S.1
Usui, I.2
Bukhari, A.3
Ikutani, M.4
Oya, T.5
-
33
-
-
34249907880
-
Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones
-
Hevener AL, Olefsky JM, Reichart D, Nguyen MT, Bandyopadyhay G, et al. (2007) Macrophage PPAR gamma is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidinediones. J Clin Invest 117: 1658-1669.
-
(2007)
J Clin Invest
, vol.117
, pp. 1658-1669
-
-
Hevener, A.L.1
Olefsky, J.M.2
Reichart, D.3
Nguyen, M.T.4
Bandyopadyhay, G.5
-
34
-
-
74249084928
-
Unbalanced M1/M2 phenotype of peripheral blood monocytes in obese diabetic patients: Effect of pioglitazone
-
Satoh N, Shimatsu A, Himeno A, Sasaki Y, Yamakage H, et al. (2010) Unbalanced M1/M2 phenotype of peripheral blood monocytes in obese diabetic patients: effect of pioglitazone. Diabetes Care 33: e7.
-
(2010)
Diabetes Care
, vol.33
-
-
Satoh, N.1
Shimatsu, A.2
Himeno, A.3
Sasaki, Y.4
Yamakage, H.5
-
35
-
-
34547492488
-
PPARgamma activation primes human monocytes into alternative M2 macrophages with anti-inflammatory properties
-
Bouhlel MA, Derudas B, Rigamonti E, Dievart R, Brozek J, et al. (2007) PPARgamma activation primes human monocytes into alternative M2 macrophages with anti-inflammatory properties. Cell Metab 6: 137-143
-
(2007)
Cell Metab
, vol.6
, pp. 137-143
-
-
Bouhlel, M.A.1
Derudas, B.2
Rigamonti, E.3
Dievart, R.4
Brozek, J.5
-
36
-
-
26244448904
-
A paracrine loop between adipocytes and macrophages aggravates inflammatory changes: Role of free fatty acids and tumor necrosis factor alpha
-
Suganami T, Nishida J, Ogawa Y (2005) A paracrine loop between adipocytes and macrophages aggravates inflammatory changes: role of free fatty acids and tumor necrosis factor alpha. Arterioscler Thromb Vasc Biol 25: 2062-2068.
-
(2005)
Arterioscler Thromb Vasc Biol
, vol.25
, pp. 2062-2068
-
-
Suganami, T.1
Nishida, J.2
Ogawa, Y.3
-
37
-
-
33846323706
-
Role of the Toll-like receptor 4/ NF-kappaB pathway in saturated fatty acid-induced inflammatory changes in the interaction between adipocytes and macrophages
-
Suganami T, Tanimoto-Koyama K, Nishida J, Itoh M, Yuan X, et al. (2007) Role of the Toll-like receptor 4/ NF-kappaB pathway in saturated fatty acid-induced inflammatory changes in the interaction between adipocytes and macrophages. Arterioscler Thromb Vasc Biol 27: 84-91.
-
(2007)
Arterioscler Thromb Vasc Biol
, vol.27
, pp. 84-91
-
-
Suganami, T.1
Tanimoto-Koyama, K.2
Nishida, J.3
Itoh, M.4
Yuan, X.5
-
38
-
-
0035907302
-
Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Tolllike receptor 4
-
Lee JY, Sohn KH, Rhee SH, Hwang D (2001) Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Tolllike receptor 4. J Biol Chem 276: 16683-16689.
-
(2001)
J Biol Chem
, vol.276
, pp. 16683-16689
-
-
Lee, J.Y.1
Sohn, K.H.2
Rhee, S.H.3
Hwang, D.4
-
39
-
-
70350389389
-
Hematopoietic cell-specific deletion of tolllike receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice
-
Saberi M, Woods NB, de Luca C, Schenk S, Lu JC, et al. (2009) Hematopoietic cell-specific deletion of tolllike receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice. Cell Metab 10: 419-429.
-
(2009)
Cell Metab
, vol.10
, pp. 419-429
-
-
Saberi, M.1
Woods, N.B.2
de Luca, C.3
Schenk, S.4
Lu, J.C.5
-
40
-
-
0030756346
-
Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function
-
Uysal KT, Wiesbrock SM, Marino MW, Hotamisligil GS (1997) Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Nature 389: 610-614.
-
(1997)
Nature
, vol.389
, pp. 610-614
-
-
Uysal, K.T.1
Wiesbrock, S.M.2
Marino, M.W.3
Hotamisligil, G.S.4
-
41
-
-
33748750917
-
Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance
-
Kamei N, Tobe K, Suzuki R, Ohsugi M, Watanabe T, et al. (2006) Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance. J Biol Chem 281: 26602-26614
-
(2006)
J Biol Chem
, vol.281
, pp. 26602-26614
-
-
Kamei, N.1
Tobe, K.2
Suzuki, R.3
Ohsugi, M.4
Watanabe, T.5
-
42
-
-
33745216724
-
MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity
-
Kanda H, Tateya S, Tamori Y, Kotani K, Hiasa K, et al. (2006) MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. J Clin Invest 116: 1494-1505.
-
(2006)
J Clin Invest
, vol.116
, pp. 1494-1505
-
-
Kanda, H.1
Tateya, S.2
Tamori, Y.3
Kotani, K.4
Hiasa, K.5
-
43
-
-
31044456529
-
CCR2 modulates inflammatory and metabolic effects of high-fat feeding
-
Weisberg SP, Hunter D, Huber R, Lemieux J, Slaymaker S, et al. (2006) CCR2 modulates inflammatory and metabolic effects of high-fat feeding. J Clin Invest 116: 115-124.
-
(2006)
J Clin Invest
, vol.116
, pp. 115-124
-
-
Weisberg, S.P.1
Hunter, D.2
Huber, R.3
Lemieux, J.4
Slaymaker, S.5
-
44
-
-
58149102605
-
Role of CC chemokine receptor2 in bone marrow cells in the recruitment of macrophages into obese adipose tissue
-
Ito A, Suganami T, Yamauchi A, Degawa-Yamauchi M, Tanaka M, et al. (2008) Role of CC chemokine receptor2 in bone marrow cells in the recruitment of macrophages into obese adipose tissue. J Biol Chem 283: 35715-35723.
-
(2008)
J Biol Chem
, vol.283
, pp. 35715-35723
-
-
Ito, A.1
Suganami, T.2
Yamauchi, A.3
Degawa-Yamauchi, M.4
Tanaka, M.5
-
45
-
-
77149154977
-
An increase in the circulating concentration of monocyte chemoattractant protein-1 elicits systemic insulin resistance irrespective of adipose tissue inflammation in mice
-
Tateya S, Tamori Y, Kawaguchi T, Kanda H, Kasuga M (2010) An increase in the circulating concentration of monocyte chemoattractant protein-1 elicits systemic insulin resistance irrespective of adipose tissue inflammation in mice. Endocrinology 151: 971-979.
-
(2010)
Endocrinology
, vol.151
, pp. 971-979
-
-
Tateya, S.1
Tamori, Y.2
Kawaguchi, T.3
Kanda, H.4
Kasuga, M.5
-
46
-
-
17944365228
-
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
-
Yamauchi T, Kamon J, Waki H, Terauchi Y, Kubota N, et al. (2001) The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 7: 941-946.
-
(2001)
Nat Med
, vol.7
, pp. 941-946
-
-
Yamauchi, T.1
Kamon, J.2
Waki, H.3
Terauchi, Y.4
Kubota, N.5
-
47
-
-
0036063777
-
Diet-induced insulin resistance in mice lacking adiponectin/ACRP30
-
Maeda N, Shimomura I, Kishida K, Nishizawa H, Matsuda M, et al. (2002) Diet-induced insulin resistance in mice lacking adiponectin/ACRP30. Nat Med 8: 731-737.
-
(2002)
Nat Med
, vol.8
, pp. 731-737
-
-
Maeda, N.1
Shimomura, I.2
Kishida, K.3
Nishizawa, H.4
Matsuda, M.5
-
48
-
-
67949091182
-
Activating transcription factor 3 constitutes a negative feedback mechanism that attenuates saturated Fatty acid/toll-like receptor 4 signaling and macrophage activation in obese adipose tissue
-
Suganami T, Yuan X, Shimoda Y, Uchio-Yamada K, Nakagawa N, et al. (2009) Activating transcription factor 3 constitutes a negative feedback mechanism that attenuates saturated Fatty acid/toll-like receptor 4 signaling and macrophage activation in obese adipose tissue. Circ Res 105: 25-32.
-
(2009)
Circ Res
, vol.105
, pp. 25-32
-
-
Suganami, T.1
Yuan, X.2
Shimoda, Y.3
Uchio-Yamada, K.4
Nakagawa, N.5
-
49
-
-
73949117849
-
Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle
-
Ishikawa E, Ishikawa T, Morita YS, Toyonaga K, Yamada H, et al. (2009) Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle. J Exp Med 206: 2879-2888.
-
(2009)
J Exp Med
, vol.206
, pp. 2879-2888
-
-
Ishikawa, E.1
Ishikawa, T.2
Morita, Y.S.3
Toyonaga, K.4
Yamada, H.5
-
50
-
-
60549100678
-
C-type lectin Mincle is an activating receptor for pathogenic fungus, Malassezia
-
Yamasaki S, Matsumoto M, Takeuchi O, Matsuzawa T, Ishikawa E, et al. (2009) C-type lectin Mincle is an activating receptor for pathogenic fungus, Malassezia. Proc Natl Acad Sci U S A 106: 1897-1902.
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 1897-1902
-
-
Yamasaki, S.1
Matsumoto, M.2
Takeuchi, O.3
Matsuzawa, T.4
Ishikawa, E.5
-
51
-
-
79952392892
-
Increased expression of macrophage-inducible C-type lectin in adipose tissue of obese mice and humans
-
Ichioka M, Suganami T, Tsuda N, Shirakawa I, Hirata Y, et al. (2011) Increased expression of macrophage-inducible C-type lectin in adipose tissue of obese mice and humans. Diabetes 60: 819-826.
-
(2011)
Diabetes
, vol.60
, pp. 819-826
-
-
Ichioka, M.1
Suganami, T.2
Tsuda, N.3
Shirakawa, I.4
Hirata, Y.5
-
52
-
-
52549125928
-
Mincle is an ITAM-coupled activating receptor that senses damaged cells
-
Yamasaki S, Ishikawa E, Sakuma M, Hara H, Ogata K, et al. (2008) Mincle is an ITAM-coupled activating receptor that senses damaged cells. Nat Immunol 9: 1179-1188.
-
(2008)
Nat Immunol
, vol.9
, pp. 1179-1188
-
-
Yamasaki, S.1
Ishikawa, E.2
Sakuma, M.3
Hara, H.4
Ogata, K.5
-
53
-
-
79955693448
-
The inflammasome in atherosclerosis and type 2 diabetes
-
Masters SL, Latz E, O'Neill LA (2011) The inflammasome in atherosclerosis and type 2 diabetes. Sci Transl Med 3: 81ps17.
-
(2011)
Sci Transl Med
, vol.3
-
-
Masters, S.L.1
Latz, E.2
O'Neill, L.A.3
-
54
-
-
77950362382
-
The inflammasomes
-
Schroder K, Tschopp J (2010) The inflammasomes. Cell 140: 821-832.
-
(2010)
Cell
, vol.140
, pp. 821-832
-
-
Schroder, K.1
Tschopp, J.2
-
55
-
-
78649498271
-
The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity
-
Stienstra R, Joosten LA, Koenen T, van Tits B, van Diepen JA, et al. (2010) The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity. Cell Metab 12: 593-605.
-
(2010)
Cell Metab
, vol.12
, pp. 593-605
-
-
Stienstra, R.1
Joosten, L.A.2
Koenen, T.3
van Tits, B.4
van Diepen, J.A.5
-
56
-
-
79751512463
-
The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
-
Vandanmagsar B, Youm YH, Ravussin A, Galgani JE, Stadler K, et al. (2011) The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance. Nat Med 17: 179-188.
-
(2011)
Nat Med
, vol.17
, pp. 179-188
-
-
Vandanmagsar, B.1
Youm, Y.H.2
Ravussin, A.3
Galgani, J.E.4
Stadler, K.5
-
57
-
-
77951800951
-
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
-
Duewell P, Kono H, Rayner KJ, Sirois CM, Vladimer G, et al. (2010) NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals. Nature 464: 1357-1361.
-
(2010)
Nature
, vol.464
, pp. 1357-1361
-
-
Duewell, P.1
Kono, H.2
Rayner, K.J.3
Sirois, C.M.4
Vladimer, G.5
-
58
-
-
80355133234
-
Macrophagemediated inflammation in metabolic disease
-
Chawla A, Nguyen KD, Goh YP (2011) Macrophagemediated inflammation in metabolic disease. Nat Rev Immunol 11: 738-749.
-
(2011)
Nat Rev Immunol
, vol.11
, pp. 738-749
-
-
Chawla, A.1
Nguyen, K.D.2
Goh, Y.P.3
-
59
-
-
79957920754
-
Inflammatory links between obesity and metabolic disease
-
Lumeng CN, Saltiel AR (2011) Inflammatory links between obesity and metabolic disease. J Clin Invest 121: 2111-2117.
-
(2011)
J Clin Invest
, vol.121
, pp. 2111-2117
-
-
Lumeng, C.N.1
Saltiel, A.R.2
-
60
-
-
53149119231
-
Neutrophils transiently infiltrate intra-abdominal fat early in the course of high-fat feeding
-
Elgazar-Carmon V, Rudich A, Hadad N, Levy R (2008) Neutrophils transiently infiltrate intra-abdominal fat early in the course of high-fat feeding. J Lipid Res 49: 1894-1903.
-
(2008)
J Lipid Res
, vol.49
, pp. 1894-1903
-
-
Elgazar-Carmon, V.1
Rudich, A.2
Hadad, N.3
Levy, R.4
-
61
-
-
68349150756
-
CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity
-
Nishimura S, Manabe I, Nagasaki M, Eto K, Yamashita H, et al. (2009) CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat Med 15: 914-920.
-
(2009)
Nat Med
, vol.15
, pp. 914-920
-
-
Nishimura, S.1
Manabe, I.2
Nagasaki, M.3
Eto, K.4
Yamashita, H.5
-
62
-
-
68349137821
-
Normalization of obesity-associated insulin resistance through immunotherapy
-
Winer S, Chan Y, Paltser G, Truong D, Tsui H, et al. (2009) Normalization of obesity-associated insulin resistance through immunotherapy. Nat Med 15: 921-929
-
(2009)
Nat Med
, vol.15
, pp. 921-929
-
-
Winer, S.1
Chan, Y.2
Paltser, G.3
Truong, D.4
Tsui, H.5
-
63
-
-
68349148211
-
Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters
-
Feuerer M, Herrero L, Cipolletta D, Naaz A, Wong J, et al. (2009) Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters. Nat Med 15: 930-939.
-
(2009)
Nat Med
, vol.15
, pp. 930-939
-
-
Feuerer, M.1
Herrero, L.2
Cipolletta, D.3
Naaz, A.4
Wong, J.5
-
64
-
-
46249117032
-
T-lymphocyte infiltration in visceral adipose tissue: A primary event in adipose tissue inflammation and the development of obesity-mediated insulin resistance
-
Kintscher U, Hartge M, Hess K, Foryst-Ludwig A, Clemenz M, et al. (2008) T-lymphocyte infiltration in visceral adipose tissue: a primary event in adipose tissue inflammation and the development of obesity-mediated insulin resistance. Arterioscler Thromb Vasc Biol 28: 1304-1310.
-
(2008)
Arterioscler Thromb Vasc Biol
, vol.28
, pp. 1304-1310
-
-
Kintscher, U.1
Hartge, M.2
Hess, K.3
Foryst-Ludwig, A.4
Clemenz, M.5
-
65
-
-
75749122181
-
Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells
-
Moro K, Yamada T, Tanabe M, Takeuchi T, Ikawa T, et al. (2010) Innate production of T(H)2 cytokines by adipose tissue-associated c-Kit(+)Sca-1(+) lymphoid cells. Nature 463: 540-544.
-
(2010)
Nature
, vol.463
, pp. 540-544
-
-
Moro, K.1
Yamada, T.2
Tanabe, M.3
Takeuchi, T.4
Ikawa, T.5
-
66
-
-
85027938385
-
B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies
-
Winer DA, Winer S, Shen L, Wadia PP, Yantha J, et al. (2011) B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies. Nat Med 17: 610-617.
-
(2011)
Nat Med
, vol.17
, pp. 610-617
-
-
Winer, D.A.1
Winer, S.2
Shen, L.3
Wadia, P.P.4
Yantha, J.5
-
67
-
-
62849107819
-
Metabolic dysregulation and adipose tissue fibrosis: Role of collagen VI
-
Khan T, Muise ES, Iyengar P, Wang ZV, Chandalia M, et al. (2009) Metabolic dysregulation and adipose tissue fibrosis: role of collagen VI. Mol Cell Biol 29: 1575-1591
-
(2009)
Mol Cell Biol
, vol.29
, pp. 1575-1591
-
-
Khan, T.1
Muise, E.S.2
Iyengar, P.3
Wang, Z.V.4
Chandalia, M.5
-
68
-
-
68349160704
-
Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice
-
Liu J, Divoux A, Sun J, Zhang J, Clement K, et al. (2009) Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice. Nat Med 15: 940-945.
-
(2009)
Nat Med
, vol.15
, pp. 940-945
-
-
Liu, J.1
Divoux, A.2
Sun, J.3
Zhang, J.4
Clement, K.5
-
69
-
-
58149379408
-
Needle and surgical biopsy techniques differentially affect adipose tissue gene expression profiles
-
Mutch DM, Tordjman J, Pelloux V, Hanczar B, Henegar C, et al. (2009) Needle and surgical biopsy techniques differentially affect adipose tissue gene expression profiles. Am J Clin Nutr 89: 51-57.
-
(2009)
Am J Clin Nutr
, vol.89
, pp. 51-57
-
-
Mutch, D.M.1
Tordjman, J.2
Pelloux, V.3
Hanczar, B.4
Henegar, C.5
-
70
-
-
78049295202
-
Fibrosis in human adipose tissue: Composition, distribution, and link with lipid metabolism and fat mass loss
-
Divoux A, Tordjman J, Lacasa D, Veyrie N, Hugol D, et al. (2010) Fibrosis in human adipose tissue: composition, distribution, and link with lipid metabolism and fat mass loss. Diabetes 59: 2817-2825.
-
(2010)
Diabetes
, vol.59
, pp. 2817-2825
-
-
Divoux, A.1
Tordjman, J.2
Lacasa, D.3
Veyrie, N.4
Hugol, D.5
-
71
-
-
78650039966
-
Adipose tissue dysfunction signals progression of hepatic steatosis towards nonalcoholic steatohepatitis in C57BL/6 mice
-
Duval C, Thissen U, Keshtkar S, Accart B, Stienstra R, et al. (2010) Adipose tissue dysfunction signals progression of hepatic steatosis towards nonalcoholic steatohepatitis in C57BL/6 mice. Diabetes 59: 3181-3191.
-
(2010)
Diabetes
, vol.59
, pp. 3181-3191
-
-
Duval, C.1
Thissen, U.2
Keshtkar, S.3
Accart, B.4
Stienstra, R.5
-
72
-
-
43149112800
-
Adipogenic capacity and the susceptibility to type 2 diabetes and metabolic syndrome
-
Wang MY, Grayburn P, Chen S, Ravazzola M, Orci L, et al. (2008) Adipogenic capacity and the susceptibility to type 2 diabetes and metabolic syndrome. Proc Natl Acad Sci U S A 105: 6139-6144.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 6139-6144
-
-
Wang, M.Y.1
Grayburn, P.2
Chen, S.3
Ravazzola, M.4
Orci, L.5
-
73
-
-
36849012057
-
Adipocyte death, adipose tissue remodeling, and obesity complications
-
Strissel KJ, Stancheva Z, Miyoshi H, Perfield JW, 2nd, DeFuria J, et al. (2007) Adipocyte death, adipose tissue remodeling, and obesity complications. Diabetes 56: 2910-2918.
-
(2007)
Diabetes
, vol.56
, pp. 2910-2918
-
-
Strissel, K.J.1
Stancheva, Z.2
Miyoshi, H.3
Perfield II, J.W.4
DeFuria, J.5
-
74
-
-
84861047531
-
A PPARgamma-FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis
-
Jonker JW, Suh JM, Atkins AR, Ahmadian M, Li P, et al. (2012) A PPARgamma-FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis. Nature 485: 391-394.
-
(2012)
Nature
, vol.485
, pp. 391-394
-
-
Jonker, J.W.1
Suh, J.M.2
Atkins, A.R.3
Ahmadian, M.4
Li, P.5
-
75
-
-
0031947715
-
Steatohepatitis: A tale of two "hits"?
-
Day CP, James OF (1998) Steatohepatitis: a tale of two "hits"? Gastroenterology 114: 842-845.
-
(1998)
Gastroenterology
, vol.114
, pp. 842-845
-
-
Day, C.P.1
James, O.F.2
-
76
-
-
4043077961
-
Molecular mediators of hepatic steatosis and liver injury
-
Browning JD, Horton JD (2004) Molecular mediators of hepatic steatosis and liver injury. J Clin Invest 114: 147-152.
-
(2004)
J Clin Invest
, vol.114
, pp. 147-152
-
-
Browning, J.D.1
Horton, J.D.2
-
77
-
-
27544450765
-
Divergence of melanocortin pathways in the control of food intake and energy expenditure
-
Balthasar N, Dalgaard LT, Lee CE, Yu J, Funahashi H, et al. (2005) Divergence of melanocortin pathways in the control of food intake and energy expenditure. Cell 123: 493-505.
-
(2005)
Cell
, vol.123
, pp. 493-505
-
-
Balthasar, N.1
Dalgaard, L.T.2
Lee, C.E.3
Yu, J.4
Funahashi, H.5
-
78
-
-
80055004124
-
Melanocortin 4 receptor-deficient mice as a novel mouse model of nonalcoholic steatohepatitis
-
Itoh M, Suganami T, Nakagawa N, Tanaka M, Yamamoto Y, et al. (2011) Melanocortin 4 receptor-deficient mice as a novel mouse model of nonalcoholic steatohepatitis. Am J Pathol 179: 2454-2463.
-
(2011)
Am J Pathol
, vol.179
, pp. 2454-2463
-
-
Itoh, M.1
Suganami, T.2
Nakagawa, N.3
Tanaka, M.4
Yamamoto, Y.5
|