Obesity development in caspase-1-deficient mice

International Journal of Obesity

Volumn 38, Issue 1, 2014, Pages 152-155

  Wang, H ^a   Capell, W ^a   Yoon, J H ^a   Faubel, S ^a   Eckel, R H ^a  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

caspase 1; energy balance; high fat diet; inflammation; interleukin 18; sex difference

Indexed keywords

ADIPONECTIN; FATTY ACID; GLUCOSE; INSULIN; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; LEPTIN; TRIACYLGLYCEROL;

AGE DISTRIBUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; DISEASE COURSE; FAT MASS; FEMALE; GLUCOSE BLOOD LEVEL; INSULIN SENSITIVITY; KNOCKOUT MOUSE; LIMIT OF DETECTION; LIPID DIET; LOW FAT DIET; MALE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; SEX DIFFERENCE; WILD TYPE;

MUS;

ANIMALS; BODY WEIGHT; CASPASE 1; DIET, HIGH-FAT; FEMALE; INFLAMMATION; INSULIN RESISTANCE; INTERLEUKIN-18; INTERLEUKIN-1BETA; MALE; MICE; MICE, KNOCKOUT; OBESITY; SEX FACTORS; TIME FACTORS;

EID: 84891836087     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/ijo.2013.59     Document Type: Article

References (21)

1. Pop C, Salvesen GS. Human caspases: activation, specificity, and regulation. J Biol Chem 2009; 284: 21777-21781.
2. Fantuzzi G, Dinarello CA. Interleukin-18 and interleukin-1 beta: two cytokine substrates for ICE (caspase-1). J Clin Immunol 1999; 19: 1-11.
3. Franchi L, Eigenbrod T, Munoz-Planillo R, Nunez G. The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis. Nat Immunol 2009; 10: 241-247.
4. Connat JL. [Inflammasome and cardiovascular diseases]. Ann Cardiol Angeiol (Paris) 2011; 60: 48-54.
5. Anders HJ, Muruve DA. The inflammasomes in kidney disease. J Am Soc Nephrol 2011; 22: 1007-1018.
6. Troseid M, Seljeflot I, Arnesen H. The role of interleukin-18 in the metabolic syndrome. Cardiovasc Diabetol 2010; 9: 11.
7. Netea MG, Joosten LA, Lewis E, Jensen DR, Voshol PJ, Kullberg BJ et al. Deficiency of interleukin-18 in mice leads to hyperphagia, obesity and insulin resistance. Nat Med 2006; 12: 650-656.
8. Membrez M, Ammon-Zufferey C, Philippe D, Aprikian O, Monnard I, Mace K et al. Interleukin-18 protein level is upregulated in adipose tissue of obese mice. Obesity (Silver Spring) 2009; 17: 393-395.
9. Bruun JM, Stallknecht B, Helge JW, Richelsen B. Interleukin-18 in plasma and adipose tissue: effects of obesity, insulin resistance, and weight loss. Eur J Endocrinol 2007; 157: 465-471.
10. Bosch M, Lopez-Bermejo A, Vendrell J, Musri M, Ricart W, Fernandez-Real JM. Circulating IL-18 concentration is associated with insulin sensitivity and glucose tolerance through increased fat-free mass. Diabetologia 2005; 48: 1841-1843.
11. Kuida K, Lippke JA, Ku G, Harding MW, Livingston DJ, Su MS et al. Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme. Science 1995; 267: 2000-2003.
12. Zilverschoon GR, Tack CJ, Joosten LA, Kullberg BJ, van der Meer JW, Netea MG. Interleukin-18 resistance in patients with obesity and type 2 diabetes mellitus. Int J Obes (Lond) 2008; 32: 1407-1414.
13. Louet JF, LeMay C, Mauvais-Jarvis F. Antidiabetic actions of estrogen: insight from human and genetic mouse models. Curr Atheroscler Rep 2004; 6: 180-185.
14. Brown LM, Clegg DJ. Central effects of estradiol in the regulation of food intake, body weight, and adiposity. J Steroid Biochem Mol Biol 2010; 122: 65-73.
15. Xu Y, Nedungadi TP, Zhu L, Sobhani N, Irani BG, Davis KE et al. Distinct hypothalamic neurons mediate estrogenic effects on energy homeostasis and reproduction. Cell Metab 2011; 14: 453-465.
16. Clegg DJ. Minireview: the year in review of estrogen regulation of metabolism. Mol Endocrinol 2012; 26: 1957-1960.
17. Larsen CM, Faulenbach M, Vaag A, Ehses JA, Donath MY, Mandrup-Poulsen T. Sustained effects of interleukin-1 receptor antagonist treatment in type 2 diabetes. Diab Care 2009; 32: 1663-1668.
18. Osborn O, Brownell SE, Sanchez-Alavez M, Salomon D, Gram H, Bartfai T. Treatment with an Interleukin 1 beta antibody improves glycemic control in dietinduced obesity. Cytokine 2008; 44: 141-148.
19. Osborn O, Gram H, Zorrilla EP, Conti B, Bartfai T. Insights into the roles of the inflammatory mediators IL-1, IL-18 and PGE2 in obesity and insulin resistance. Swiss Med Wkly 2008; 138: 665-673.
20. Stienstra R, Joosten LA, Koenen T, van TB, van Diepen JA, van den Berg SA et al. The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity. Cell Metab 2010; 12: 593-605.
21. Stienstra R, van Diepen JA, Tack CJ, Zaki MH, van de Veerdonk FL, Perera D et al. Inflammasome is a central player in the induction of obesity and insulin resistance. Proc Natl Acad Sci USA 2011; 108: 15324-15329.