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Volumn 33, Issue 14, 2014, Pages 1755-1763

Multilayer control of the EMT master regulators

Author keywords

Cancer metastasis; E3 ubiquitin ligase; EMT; Snail; Twist; Zeb

Indexed keywords

OCTAMER TRANSCRIPTION FACTOR 4; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SLUG; TRANSCRIPTION FACTOR SNAIL; UVOMORULIN;

EID: 84897977206     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2013.128     Document Type: Review
Times cited : (277)

References (152)
  • 1
    • 0036674501 scopus 로고    scopus 로고
    • Dissemination and growth of cancer cells in metastatic sites
    • Chambers AF, Groom AC, MacDonald IC. Dissemination and growth of cancer cells in metastatic sites. Nat Rev 2002; 2: 563-572
    • (2002) Nat Rev , vol.2 , pp. 563-572
    • Chambers, A.F.1    Groom, A.C.2    MacDonald, I.C.3
  • 2
    • 63049090100 scopus 로고    scopus 로고
    • Metastasis: From dissemination to organspecific colonization
    • Nguyen DX, Bos PD, Massague J. Metastasis: From dissemination to organspecific colonization. Nat Rev 2009; 9: 274-284
    • (2009) Nat Rev , vol.9 , pp. 274-284
    • Nguyen, D.X.1    Bos, P.D.2    Massague, J.3
  • 3
    • 80054686286 scopus 로고    scopus 로고
    • Tumor metastasis: Molecular insights and evolving paradigms
    • Valastyan S, Weinberg RA. Tumor metastasis: Molecular insights and evolving paradigms. Cell 2011; 147: 275-292
    • (2011) Cell , vol.147 , pp. 275-292
    • Valastyan, S.1    Weinberg, R.A.2
  • 4
    • 0038481970 scopus 로고    scopus 로고
    • The pathogenesis of cancer metastasis: The -seed and soil- hypothesis revisited
    • Fidler IJ. The pathogenesis of cancer metastasis: The -seed and soil- hypothesis revisited. Nat Rev 2003; 3: 453-458
    • (2003) Nat Rev , vol.3 , pp. 453-458
    • Fidler, I.J.1
  • 5
    • 80053157914 scopus 로고    scopus 로고
    • Unravelling the complexity of metastasis-molecular understanding and targeted therapies
    • Sethi N, Kang Y. Unravelling the complexity of metastasis-molecular understanding and targeted therapies. Nat Rev 2011; 11: 735-748
    • (2011) Nat Rev , vol.11 , pp. 735-748
    • Sethi, N.1    Kang, Y.2
  • 6
    • 81855169565 scopus 로고    scopus 로고
    • Cancer invasion and the microenvironment: Plasticity and reciprocity
    • Friedl P, Alexander S. Cancer invasion and the microenvironment: Plasticity and reciprocity. Cell 2011; 147: 992-1009
    • (2011) Cell , vol.147 , pp. 992-1009
    • Friedl, P.1    Alexander, S.2
  • 7
    • 44449144396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition: At the crossroads of development and tumor metastasis
    • Yang J, Weinberg RA. Epithelial-mesenchymal transition: At the crossroads of development and tumor metastasis. Dev Cell 2008; 14: 818-829
    • (2008) Dev Cell , vol.14 , pp. 818-829
    • Yang, J.1    Weinberg, R.A.2
  • 8
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • Thiery JP, Acloque H, Huang RY, Nieto MA. Epithelial-mesenchymal transitions in development and disease. Cell 2009; 139: 871-890
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 9
    • 80052712201 scopus 로고    scopus 로고
    • The ins and outs of the epithelial to mesenchymal transition in health and disease
    • Nieto MA. The ins and outs of the epithelial to mesenchymal transition in health and disease. Annu Rev Cell Dev Biol 2011; 27: 347-376
    • (2011) Annu Rev Cell Dev Biol , vol.27 , pp. 347-376
    • Nieto, M.A.1
  • 10
    • 4043052971 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions: Twist in development and metastasis
    • Kang Y, Massague J. Epithelial-mesenchymal transitions: Twist in development and metastasis. Cell 2004; 118: 277-279
    • (2004) Cell , vol.118 , pp. 277-279
    • Kang, Y.1    Massague, J.2
  • 11
    • 80052730533 scopus 로고    scopus 로고
    • Reciprocal repression between Sox3 and snail transcription factors defines embryonic territories at gastrulation
    • Acloque H, Ocana OH, Matheu A, Rizzoti K, Wise C, Lovell-Badge R, et al. Reciprocal repression between Sox3 and snail transcription factors defines embryonic territories at gastrulation. Dev Cell 2011; 21: 546-558
    • (2011) Dev Cell , vol.21 , pp. 546-558
    • Acloque, H.1    Ocana, O.H.2    Matheu, A.3    Rizzoti, K.4    Wise, C.5    Lovell-Badge, R.6
  • 12
    • 47549106286 scopus 로고    scopus 로고
    • EMT and MET in carcinoma-clinical observations, regulatory pathways and new models
    • Thompson EW, Williams ED. EMT and MET in carcinoma-clinical observations, regulatory pathways and new models. Clin Exp Metastasis 2008; 25: 591-592
    • (2008) Clin Exp Metastasis , vol.25 , pp. 591-592
    • Thompson, E.W.1    Williams, E.D.2
  • 13
    • 2942707848 scopus 로고    scopus 로고
    • Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis
    • Yang J, Mani SA, Donaher JL, Ramaswamy S, Itzykson RA, Come C, et al. Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell 2004; 117: 927-939
    • (2004) Cell , vol.117 , pp. 927-939
    • Yang, J.1    Mani, S.A.2    Donaher, J.L.3    Ramaswamy, S.4    Itzykson, R.A.5    Come, C.6
  • 14
    • 22244473343 scopus 로고    scopus 로고
    • The fallacy of epithelial mesenchymal transition in neoplasia
    • discussion-1
    • Tarin D, Thompson EW, Newgreen DF. The fallacy of epithelial mesenchymal transition in neoplasia. Cancer Res 2005; 65: 5996-6000, discussion-1
    • (2005) Cancer Res , vol.65 , pp. 5996-6000
    • Tarin, D.1    Thompson, E.W.2    Newgreen, D.F.3
  • 15
    • 22244492306 scopus 로고    scopus 로고
    • Carcinoma invasion and metastasis: A role for epithelial-mesenchymal transition
    • discussion 5
    • Thompson EW, Newgreen DF, Tarin D. Carcinoma invasion and metastasis: A role for epithelial-mesenchymal transition? Cancer Res 2005; 65: 5991-5995 discussion 5
    • (2005) Cancer Res , vol.65 , pp. 5991-5995
    • Thompson, E.W.1    Newgreen, D.F.2    Tarin, D.3
  • 16
    • 0035964349 scopus 로고    scopus 로고
    • Variable beta-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment
    • Brabletz T, Jung A, Reu S, Porzner M, Hlubek F, Kunz-Schughart LA, et al. Variable beta-catenin expression in colorectal cancers indicates tumor progression driven by the tumor environment. Proc Natl Acad Sci USA 2001; 98: 10356-10361
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 10356-10361
    • Brabletz, T.1    Jung, A.2    Reu, S.3    Porzner, M.4    Hlubek, F.5    Kunz-Schughart, L.A.6
  • 18
    • 42149114501 scopus 로고    scopus 로고
    • Crosstalk between tumor cells and microenvironment via Wnt pathway in colorectal cancer dissemination
    • Huang D, Du X. Crosstalk between tumor cells and microenvironment via Wnt pathway in colorectal cancer dissemination. World J Gastroenterol 2008; 14: 1823-1827
    • (2008) World J Gastroenterol , vol.14 , pp. 1823-1827
    • Huang, D.1    Du, X.2
  • 19
    • 0036595629 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in tumour progression
    • Thiery JP. Epithelial-mesenchymal transitions in tumour progression. Nat Rev 2002; 2: 442-454
    • (2002) Nat Rev , vol.2 , pp. 442-454
    • Thiery, J.P.1
  • 20
    • 70349165716 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition in cancer metastasis: Mechanisms, markers and strategies to overcome drug resistance in the clinic
    • Voulgari A, Pintzas A. Epithelial-mesenchymal transition in cancer metastasis: Mechanisms, markers and strategies to overcome drug resistance in the clinic. Biochim Biophys Acta 2009; 1796: 75-90
    • (2009) Biochim Biophys Acta , vol.1796 , pp. 75-90
    • Voulgari, A.1    Pintzas, A.2
  • 21
    • 84861527239 scopus 로고    scopus 로고
    • To differentiate or not-routes towards metastasis
    • Brabletz T. To differentiate or not-routes towards metastasis. Nat Rev 2012; 12: 425-436
    • (2012) Nat Rev , vol.12 , pp. 425-436
    • Brabletz, T.1
  • 22
    • 43049165453 scopus 로고    scopus 로고
    • The epithelialmesenchymal transition generates cells with properties of stem cells
    • Mani SA, Guo W, Liao MJ, Eaton EN, Ayyanan A, Zhou AY, et al. The epithelialmesenchymal transition generates cells with properties of stem cells. Cell 2008; 133: 704-715
    • (2008) Cell , vol.133 , pp. 704-715
    • Mani, S.A.1    Guo, W.2    Liao, M.J.3    Eaton, E.N.4    Ayyanan, A.5    Zhou, A.Y.6
  • 23
    • 84870845421 scopus 로고    scopus 로고
    • Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis
    • Tsai JH, Donaher JL, Murphy DA, Chau S, Yang J. Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis. Cancer Cell 2012; 22: 725-736
    • (2012) Cancer Cell , vol.22 , pp. 725-736
    • Tsai, J.H.1    Donaher, J.L.2    Murphy, D.A.3    Chau, S.4    Yang, J.5
  • 24
    • 47549092230 scopus 로고    scopus 로고
    • Bypassing cellular EGF receptor dependence through epithelial-To- mesenchymal-like transitions
    • Barr S, Thomson S, Buck E, Russo S, Petti F, Sujka-Kwok I, et al. Bypassing cellular EGF receptor dependence through epithelial-To-mesenchymal- like transitions. Clin Exp Metastasis 2008; 25: 685-693
    • (2008) Clin Exp Metastasis , vol.25 , pp. 685-693
    • Barr, S.1    Thomson, S.2    Buck, E.3    Russo, S.4    Petti, F.5    Sujka-Kwok, I.6
  • 26
    • 35848963863 scopus 로고    scopus 로고
    • Direct repression of cyclin D1 by SIP1 attenuates cell cycle progression in cells undergoing an epithelial mesenchymal transition
    • Mejlvang J, Kriajevska M, Vandewalle C, Chernova T, Sayan AE, Berx G, et al. Direct repression of cyclin D1 by SIP1 attenuates cell cycle progression in cells undergoing an epithelial mesenchymal transition. Mol Biol Cell 2007; 18: 4615-4624
    • (2007) Mol Biol Cell , vol.18 , pp. 4615-4624
    • Mejlvang, J.1    Kriajevska, M.2    Vandewalle, C.3    Chernova, T.4    Sayan, A.E.5    Berx, G.6
  • 27
    • 0035149139 scopus 로고    scopus 로고
    • The invasion front of human colorectal adenocarcinomas shows co-localization of nuclear beta-catenin, cyclin D1, and p16INK4A and is a region of low proliferation
    • Jung A, Schrauder M, Oswald U, Knoll C, Sellberg P, Palmqvist R, et al. The invasion front of human colorectal adenocarcinomas shows co-localization of nuclear beta-catenin, cyclin D1, and p16INK4A and is a region of low proliferation. Am J Pathol 2001; 159: 1613-1617
    • (2001) Am J Pathol , vol.159 , pp. 1613-1617
    • Jung, A.1    Schrauder, M.2    Oswald, U.3    Knoll, C.4    Sellberg, P.5    Palmqvist, R.6
  • 28
    • 0034723255 scopus 로고    scopus 로고
    • Methylation patterns of the E-cadherin 5- CpG island are unstable and reflect the dynamic, heterogeneous loss of E-cadherin expression during metastatic progression
    • Graff JR, Gabrielson E, Fujii H, Baylin SB, Herman JG. Methylation patterns of the E-cadherin 5- CpG island are unstable and reflect the dynamic, heterogeneous loss of E-cadherin expression during metastatic progression. J Biol Chem 2000; 275: 2727-2732
    • (2000) J Biol Chem , vol.275 , pp. 2727-2732
    • Graff, J.R.1    Gabrielson, E.2    Fujii, H.3    Baylin, S.B.4    Herman, J.G.5
  • 29
    • 34250779831 scopus 로고    scopus 로고
    • Expression of E-cadherin in human ductal breast cancer carcinoma in situ, invasive carcinomas, their lymph node metastases, their distant metastases, carcinomas with recurrence and in recurrence
    • Jeschke U, Mylonas I, Kuhn C, Shabani N, Kunert-Keil C, Schindlbeck C, et al. Expression of E-cadherin in human ductal breast cancer carcinoma in situ, invasive carcinomas, their lymph node metastases, their distant metastases, carcinomas with recurrence and in recurrence. Anticancer Res 2007; 27: 1969-1974
    • (2007) Anticancer Res , vol.27 , pp. 1969-1974
    • Jeschke, U.1    Mylonas, I.2    Kuhn, C.3    Shabani, N.4    Kunert-Keil, C.5    Schindlbeck, C.6
  • 30
    • 33846092040 scopus 로고    scopus 로고
    • Expression pattern of adhesion molecules (E-cadherin, alpha-, beta-, gamma-catenin and claudin-7), their influence on survival in primary breast carcinoma, and their corresponding axillary lymph node metastasis
    • Park D, Karesen R, Axcrona U, Noren T, Sauer T. Expression pattern of adhesion molecules (E-cadherin, alpha-, beta-, gamma-catenin and claudin-7), their influence on survival in primary breast carcinoma, and their corresponding axillary lymph node metastasis. APMIS 2007; 115: 52-65
    • (2007) APMIS , vol.115 , pp. 52-65
    • Park, D.1    Karesen, R.2    Axcrona, U.3    Noren, T.4    Sauer, T.5
  • 31
    • 77954304397 scopus 로고    scopus 로고
    • Breast carcinoma cells re-express E-cadherin during mesenchymal to epithelial reverting transition
    • Chao YL, Shepard CR, Wells A. Breast carcinoma cells re-express E-cadherin during mesenchymal to epithelial reverting transition. Mol Cancer 2010; 9: 179
    • (2010) Mol Cancer , vol.9 , pp. 179
    • Chao, Y.L.1    Shepard, C.R.2    Wells, A.3
  • 32
    • 84870816403 scopus 로고    scopus 로고
    • Metastatic colonization requires the repression of the epithelial-mesenchymal transition inducer Prrx1
    • Ocana OH, Corcoles R, Fabra A, Moreno-Bueno G, Acloque H, Vega S, et al. Metastatic colonization requires the repression of the epithelial-mesenchymal transition inducer Prrx1. Cancer Cell 2012; 22: 709-724
    • (2012) Cancer Cell , vol.22 , pp. 709-724
    • Ocana, O.H.1    Corcoles, R.2    Fabra, A.3    Moreno-Bueno, G.4    Acloque, H.5    Vega, S.6
  • 33
    • 84860578009 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition can suppress major attributes of human epithelial tumor-initiating cells
    • Celia-Terrassa T, Meca-Cortes O, Mateo F, De Paz AM, Rubio N, Arnal-Estape A, et al. Epithelial-mesenchymal transition can suppress major attributes of human epithelial tumor-initiating cells. J Clin Investig 2012; 122: 1849-1868
    • (2012) J Clin Investig , vol.122 , pp. 1849-1868
    • Celia-Terrassa, T.1    Meca-Cortes, O.2    Mateo, F.3    De Paz, A.M.4    Rubio, N.5    Arnal-Estape, A.6
  • 34
    • 80052470207 scopus 로고    scopus 로고
    • Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization
    • Korpal M, Ell BJ, Buffa FM, Ibrahim T, Blanco MA, Celia-Terrassa T, et al. Direct targeting of Sec23a by miR-200s influences cancer cell secretome and promotes metastatic colonization. Nat Med 2011; 17: 1101-1108
    • (2011) Nat Med , vol.17 , pp. 1101-1108
    • Korpal, M.1    Ell, B.J.2    Buffa, F.M.3    Ibrahim, T.4    Blanco, M.A.5    Celia-Terrassa, T.6
  • 35
    • 33845809125 scopus 로고    scopus 로고
    • Mesenchymal-To-epithelial transition facilitates bladder cancer metastasis: Role of fibroblast growth factor receptor-2
    • Chaffer CL, Brennan JP, Slavin JL, Blick T, Thompson EW, Williams ED. Mesenchymal-To-epithelial transition facilitates bladder cancer metastasis: Role of fibroblast growth factor receptor-2. Cancer Res 2006; 66: 11271-11278
    • (2006) Cancer Res , vol.66 , pp. 11271-11278
    • Chaffer, C.L.1    Brennan, J.P.2    Slavin, J.L.3    Blick, T.4    Thompson, E.W.5    Williams, E.D.6
  • 37
  • 38
    • 34249289041 scopus 로고    scopus 로고
    • Zeb and bHLH factors in tumour progression: An alliance against the epithelial phenotype
    • Peinado H, Olmeda D, Cano AS. Zeb and bHLH factors in tumour progression: An alliance against the epithelial phenotype? Nat Rev Cancer 2007; 7: 415-428
    • (2007) Nat Rev Cancer , vol.7 , pp. 415-428
    • Peinado, H.1    Olmeda, D.2    Cano, A.S.3
  • 39
    • 0033789680 scopus 로고    scopus 로고
    • The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells
    • Batlle E, Sancho E, Franci C, Dominguez D, Monfar M, Baulida J, et al. The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells. Nat Cell Biol 2000; 2: 84-89
    • (2000) Nat Cell Biol , vol.2 , pp. 84-89
    • Batlle, E.1    Sancho, E.2    Franci, C.3    Dominguez, D.4    Monfar, M.5    Baulida, J.6
  • 40
    • 0033784843 scopus 로고    scopus 로고
    • The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression
    • Cano A, Perez-Moreno MA, Rodrigo I, Locascio A, Blanco MJ, del Barrio MG, et al. The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nat Cell Biol 2000; 2: 76-83
    • (2000) Nat Cell Biol , vol.2 , pp. 76-83
    • Cano, A.1    Perez-Moreno, M.A.2    Rodrigo, I.3    Locascio, A.4    Blanco, M.J.5    Del Barrio, M.G.6
  • 41
    • 0037086277 scopus 로고    scopus 로고
    • The slug zinc-finger protein represses e-cadherin in breast cancer
    • Hajra KM, Chen DY, Fearon ER. The SLUG zinc-finger protein represses E-cadherin in breast cancer. Cancer Res 2002; 62: 1613-1618
    • (2002) Cancer Res , vol.62 , pp. 1613-1618
    • Hajra, K.M.1    Chen, D.Y.2    Fearon, E.R.3
  • 42
    • 20144388095 scopus 로고    scopus 로고
    • Deltaef1 is a transcriptional repressor of e-cadherin and regulates epithelial plasticity in breast cancer cells
    • Eger A, Aigner K, Sonderegger S, Dampier B, Oehler S, Schreiber M, et al. DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells. Oncogene 2005; 24: 2375-2385
    • (2005) Oncogene , vol.24 , pp. 2375-2385
    • Eger, A.1    Aigner, K.2    Sonderegger, S.3    Dampier, B.4    Oehler, S.5    Schreiber, M.6
  • 43
    • 0034964418 scopus 로고    scopus 로고
    • The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion
    • Comijn J, Berx G, Vermassen P, Verschueren K, van Grunsven L, Bruyneel E, et al. The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion. Mol Cell 2001; 7: 1267-1278
    • (2001) Mol Cell , vol.7 , pp. 1267-1278
    • Comijn, J.1    Berx, G.2    Vermassen, P.3    Verschueren, K.4    Van Grunsven, L.5    Bruyneel, E.6
  • 46
    • 34547141894 scopus 로고    scopus 로고
    • Mesenchyme forkhead 1 (foxc2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers
    • Mani SA, Yang J, Brooks M, Schwaninger G, Zhou A, Miura N, et al. Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers. Proc Natl Acad Sci USA. 2007; 104: 10069-10074
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 10069-10074
    • Mani, S.A.1    Yang, J.2    Brooks, M.3    Schwaninger, G.4    Zhou, A.5    Miura, N.6
  • 47
    • 79951849322 scopus 로고    scopus 로고
    • Forkhead transcription factor foxq1 promotes epithelial-mesenchymal transition and breast cancer metastasis
    • Zhang H, Meng F, Liu G, Zhang B, Zhu J, Wu F, et al. Forkhead transcription factor foxq1 promotes epithelial-mesenchymal transition and breast cancer metastasis. Cancer Res 2011; 71: 1292-1301
    • (2011) Cancer Res , vol.71 , pp. 1292-1301
    • Zhang, H.1    Meng, F.2    Liu, G.3    Zhang, B.4    Zhu, J.5    Wu, F.6
  • 48
    • 34547620873 scopus 로고    scopus 로고
    • Kruppel-like factor 8 induces epithelial to mesenchymal transition and epithelial cell invasion
    • Wang X, Zheng M, Liu G, Xia W, McKeown-Longo PJ, Hung MC, et al. Kruppel-like factor 8 induces epithelial to mesenchymal transition and epithelial cell invasion. Cancer Res 2007; 67: 7184-7193
    • (2007) Cancer Res , vol.67 , pp. 7184-7193
    • Wang, X.1    Zheng, M.2    Liu, G.3    Xia, W.4    McKeown-Longo, P.J.5    Hung, M.C.6
  • 49
    • 0038756636 scopus 로고    scopus 로고
    • Transforming growth factor beta-1 induces snail transcription factor in epithelial cell lines: Mechanisms for epithelial mesenchymal transitions
    • Peinado H, Quintanilla M, Cano A. Transforming growth factor beta-1 induces snail transcription factor in epithelial cell lines: Mechanisms for epithelial mesenchymal transitions. J Biol Chem 2003; 278: 21113-21123
    • (2003) J Biol Chem , vol.278 , pp. 21113-21123
    • Peinado, H.1    Quintanilla, M.2    Cano, A.3
  • 50
    • 0034235433 scopus 로고    scopus 로고
    • Slug is an essential target of tgfbeta2 signaling in the developing chicken heart
    • Romano LA, Runyan RB. Slug is an essential target of TGFbeta2 signaling in the developing chicken heart. Dev Biol 2000; 223: 91-102
    • (2000) Dev Biol , vol.223 , pp. 91-102
    • Romano, L.A.1    Runyan, R.B.2
  • 51
    • 57749114754 scopus 로고    scopus 로고
    • Hmga2 and smads co-regulate snail1 expression during induction of epithelial-Tomesenchymal transition
    • Thuault S, Tan EJ, Peinado H, Cano A, Heldin CH, Moustakas A. HMGA2 and Smads co-regulate SNAIL1 expression during induction of epithelial-Tomesenchymal transition. J Biol Chem 2008; 283: 33437-33446
    • (2008) J Biol Chem , vol.283 , pp. 33437-33446
    • Thuault, S.1    Tan, E.J.2    Peinado, H.3    Cano, A.4    Heldin, C.H.5    Moustakas, A.6
  • 52
    • 9144246932 scopus 로고    scopus 로고
    • Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation
    • Timmerman LA, Grego-Bessa J, Raya A, Bertran E, Perez-Pomares JM, Diez J, et al. Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation. Genes Dev 2004; 18: 99-115
    • (2004) Genes Dev , vol.18 , pp. 99-115
    • Timmerman, L.A.1    Grego-Bessa, J.2    Raya, A.3    Bertran, E.4    Perez-Pomares, J.M.5    Diez, J.6
  • 54
    • 12144266241 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3 is an endogenous inhibitor of Snail transcription: Implications for the epithelial-mesenchymal transition
    • Bachelder RE, Yoon SO, Franci C, De Herreros AG, Mercurio AM. Glycogen synthase kinase-3 is an endogenous inhibitor of Snail transcription: Implications for the epithelial-mesenchymal transition. J Cell Biol 2005; 168: 29-33
    • (2005) J Cell Biol , vol.168 , pp. 29-33
    • Bachelder, R.E.1    Yoon, S.O.2    Franci, C.3    De Herreros, A.G.4    Mercurio, A.M.5
  • 55
    • 5444269904 scopus 로고    scopus 로고
    • Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition
    • Zhou BP, Deng J, Xia W, Xu J, Li YM, Gunduz M, et al. Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition. Nat Cell Biol 2004; 6: 931-940
    • (2004) Nat Cell Biol , vol.6 , pp. 931-940
    • Zhou, B.P.1    Deng, J.2    Xia, W.3    Xu, J.4    Li, Y.M.5    Gunduz, M.6
  • 56
    • 25144488085 scopus 로고    scopus 로고
    • Wnt, hedgehog and snail: Sister pathways that control by GSK-3beta and beta-Trcp in the regulation of metastasis
    • Zhou BP, Hung MC. Wnt, hedgehog and snail: Sister pathways that control by GSK-3beta and beta-Trcp in the regulation of metastasis. Cell Cycle 2005; 4: 772-776
    • (2005) Cell Cycle , vol.4 , pp. 772-776
    • Zhou, B.P.1    Hung, M.C.2
  • 57
    • 21844432918 scopus 로고    scopus 로고
    • Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability
    • Radisky DC, Levy DD, Littlepage LE, Liu H, Nelson CM, Fata JE, et al. Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability. Nature 2005; 436: 123-127
    • (2005) Nature , vol.436 , pp. 123-127
    • Radisky, D.C.1    Levy, D.D.2    Littlepage, L.E.3    Liu, H.4    Nelson, C.M.5    Fata, J.E.6
  • 58
    • 0141760411 scopus 로고    scopus 로고
    • Hypoxia attenuates the expression of E-cadherin via up-regulation of SNAIL in ovarian carcinoma cells
    • Imai T, Horiuchi A, Wang C, Oka K, Ohira S, Nikaido T, et al. Hypoxia attenuates the expression of E-cadherin via up-regulation of SNAIL in ovarian carcinoma cells. Am J Pathol 2003; 163: 1437-1447
    • (2003) Am J Pathol , vol.163 , pp. 1437-1447
    • Imai, T.1    Horiuchi, A.2    Wang, C.3    Oka, K.4    Ohira, S.5    Nikaido, T.6
  • 59
    • 34547610957 scopus 로고    scopus 로고
    • UPAR induces epithelialmesenchymal transition in hypoxic breast cancer cells
    • Lester RD, Jo M, Montel V, Takimoto S, Gonias SL. uPAR induces epithelialmesenchymal transition in hypoxic breast cancer cells. J Cell Biol 2007; 178: 425-436
    • (2007) J Cell Biol , vol.178 , pp. 425-436
    • Lester, R.D.1    Jo, M.2    Montel, V.3    Takimoto, S.4    Gonias, S.L.5
  • 60
    • 70450142560 scopus 로고    scopus 로고
    • Inflammation and EMT: An alliance towards organ fibrosis and cancer progression
    • Lopez-Novoa JM, Nieto MA. Inflammation and EMT: An alliance towards organ fibrosis and cancer progression. EMBO Mol Med 2009; 1: 303-314
    • (2009) EMBO Mol Med , vol.1 , pp. 303-314
    • Lopez-Novoa, J.M.1    Nieto, M.A.2
  • 61
    • 77954372059 scopus 로고    scopus 로고
    • Hypoxia stimulates hepatocyte epithelial to mesenchymal transition by hypoxia-inducible factor and transforming growth factor-beta-dependent mechanisms
    • Copple BL. Hypoxia stimulates hepatocyte epithelial to mesenchymal transition by hypoxia-inducible factor and transforming growth factor-beta-dependent mechanisms. Liver Int 2010; 30: 669-682
    • (2010) Liver Int , vol.30 , pp. 669-682
    • Copple, B.L.1
  • 62
    • 84863160718 scopus 로고    scopus 로고
    • Critical and reciprocal regulation of KLF4 and SLUG in transforming growth factor beta-initiated prostate cancer epithelial-mesenchymal transition
    • Liu YN, Abou-Kheir W, Yin JJ, Fang L, Hynes P, Casey O, et al. Critical and reciprocal regulation of KLF4 and SLUG in transforming growth factor beta-initiated prostate cancer epithelial-mesenchymal transition. Mol Cell Biol 2012; 32: 941-953
    • (2012) Mol Cell Biol , vol.32 , pp. 941-953
    • Liu, Y.N.1    Abou-Kheir, W.2    Yin, J.J.3    Fang, L.4    Hynes, P.5    Casey, O.6
  • 63
    • 84872608167 scopus 로고    scopus 로고
    • MiR-1 and miR-200 inhibit EMT via Slug-dependent and tumorigenesis via Slug-independent mechanisms
    • Liu YN, Yin JJ, Abou-Kheir W, Hynes PG, Casey OM, Fang L, et al. MiR-1 and miR-200 inhibit EMT via Slug-dependent and tumorigenesis via Slug-independent mechanisms. Oncogene 2012; 32: 296-306
    • (2012) Oncogene , vol.32 , pp. 296-306
    • Liu, Y.N.1    Yin, J.J.2    Abou-Kheir, W.3    Hynes, P.G.4    Casey, O.M.5    Fang, L.6
  • 64
    • 40349091380 scopus 로고    scopus 로고
    • Loss of singleminded-2s in the mouse mammary gland induces an epithelial-mesenchymal transition associated with up-regulation of slug and matrix metalloprotease 2
    • Laffin B, Wellberg E, Kwak HI, Burghardt RC, Metz RP, Gustafson T, et al. Loss of singleminded-2s in the mouse mammary gland induces an epithelial-mesenchymal transition associated with up-regulation of slug and matrix metalloprotease 2. Mol Cell Biol 2008; 28: 1936-1946
    • (2008) Mol Cell Biol , vol.28 , pp. 1936-1946
    • Laffin, B.1    Wellberg, E.2    Kwak, H.I.3    Burghardt, R.C.4    Metz, R.P.5    Gustafson, T.6
  • 65
    • 84869045299 scopus 로고    scopus 로고
    • Elf5 inhibits the epithelial-mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2
    • Chakrabarti R, Hwang J, Andres Blanco M, Wei Y, Lukacisin M, Romano RA, et al. Elf5 inhibits the epithelial-mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2 Nat Cell Biol 2012; 14: 1212-1222
    • (2012) Nat Cell Biol , vol.14 , pp. 1212-1222
    • Chakrabarti, R.1    Hwang, J.2    Andres Blanco, M.3    Wei, Y.4    Lukacisin, M.5    Romano, R.A.6
  • 67
    • 84866874659 scopus 로고    scopus 로고
    • MiR-145 regulates epithelial to mesenchymal transition of breast cancer cells by targeting Oct4
    • Hu J, Guo H, Li H, Liu Y, Liu J, Chen L, et al. MiR-145 regulates epithelial to mesenchymal transition of breast cancer cells by targeting Oct4. PLoS One 2012; 7: E45965
    • (2012) PLoS One , vol.7
    • Hu, J.1    Guo, H.2    Li, H.3    Liu, Y.4    Liu, J.5    Chen, L.6
  • 68
    • 84855729906 scopus 로고    scopus 로고
    • A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial-mesenchymal transition
    • Kim NH, Kim HS, Li XY, Lee I, Choi HS, Kang SE, et al. A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial-mesenchymal transition. J Cell Biol 2011; 195: 417-433
    • (2011) J Cell Biol , vol.195 , pp. 417-433
    • Kim, N.H.1    Kim, H.S.2    Li, X.Y.3    Lee, I.4    Choi, H.S.5    Kang, S.E.6
  • 69
    • 80052316514 scopus 로고    scopus 로고
    • Targeting epigenetic regulation of miR-34a for treatment of pancreatic cancer by inhibition of pancreatic cancer stem cells
    • Nalls D, Tang SN, Rodova M, Srivastava RK, Shankar S. Targeting epigenetic regulation of miR-34a for treatment of pancreatic cancer by inhibition of pancreatic cancer stem cells. PLoS One 2011; 6: E24099
    • (2011) PLoS One , vol.6
    • Nalls, D.1    Tang, S.N.2    Rodova, M.3    Srivastava, R.K.4    Shankar, S.5
  • 70
    • 84055184850 scopus 로고    scopus 로고
    • MiR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions
    • Siemens H, Jackstadt R, Hunten S, Kaller M, Menssen A, Gotz U, et al. miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions. Cell Cycle 2011; 10: 4256-4271
    • (2011) Cell Cycle , vol.10 , pp. 4256-4271
    • Siemens, H.1    Jackstadt, R.2    Hunten, S.3    Kaller, M.4    Menssen, A.5    Gotz, U.6
  • 71
    • 84857507248 scopus 로고    scopus 로고
    • MicroRNA-30a inhibits epithelial-To-mesenchymal transition by targeting Snai1 and is downregulated in non-small cell lung cancer
    • Kumarswamy R, Mudduluru G, Ceppi P, Muppala S, Kozlowski M, Niklinski J, et al. MicroRNA-30a inhibits epithelial-To-mesenchymal transition by targeting Snai1 and is downregulated in non-small cell lung cancer. Int J Cancer 2012; 130: 2044-2053
    • (2012) Int J Cancer , vol.130 , pp. 2044-2053
    • Kumarswamy, R.1    Mudduluru, G.2    Ceppi, P.3    Muppala, S.4    Kozlowski, M.5    Niklinski, J.6
  • 73
    • 82755182755 scopus 로고    scopus 로고
    • MicroRNA-9 up-regulates E-cadherin through inhibition of NF-kappaB1-Snail1 pathway in melanoma
    • Liu S, Kumar SM, Lu H, Liu A, Yang R, Pushparajan A, et al. MicroRNA-9 up-regulates E-cadherin through inhibition of NF-kappaB1-Snail1 pathway in melanoma. J Pathol 2012; 226: 61-72
    • (2012) J Pathol , vol.226 , pp. 61-72
    • Liu, S.1    Kumar, S.M.2    Lu, H.3    Liu, A.4    Yang, R.5    Pushparajan, A.6
  • 74
    • 79960799901 scopus 로고    scopus 로고
    • Let-7d functions as novel regulator of epithelial-mesenchymal transition and chemoresistant property in oral cancer
    • Chang CJ, Hsu CC, Chang CH, Tsai LL, Chang YC, Lu SW, et al. Let-7d functions as novel regulator of epithelial-mesenchymal transition and chemoresistant property in oral cancer. Oncol Rep 2011; 26: 1003-1010
    • (2011) Oncol Rep , vol.26 , pp. 1003-1010
    • Chang, C.J.1    Hsu, C.C.2    Chang, C.H.3    Tsai, L.L.4    Chang, Y.C.5    Lu, S.W.6
  • 75
    • 77958117982 scopus 로고    scopus 로고
    • MiR-124a is important for migratory cell fate transition during gastrulation of human embryonic stem cells
    • Lee MR, Kim JS, Kim KS. miR-124a is important for migratory cell fate transition during gastrulation of human embryonic stem cells. Stem Cells 2010; 28: 1550-1559
    • (2010) Stem Cells , vol.28 , pp. 1550-1559
    • Lee, M.R.1    Kim, J.S.2    Kim, K.S.3
  • 76
    • 84858992906 scopus 로고    scopus 로고
    • Loss of brain-enriched miR-124 microRNA enhances stem-like traits and invasiveness of glioma cells
    • Xia H, Cheung WK, Ng SS, Jiang X, Jiang S, Sze J, et al. Loss of brain-enriched miR-124 microRNA enhances stem-like traits and invasiveness of glioma cells. J Biol Chem 2012; 287: 9962-9971
    • (2012) J Biol Chem , vol.287 , pp. 9962-9971
    • Xia, H.1    Cheung, W.K.2    Ng, S.S.3    Jiang, X.4    Jiang, S.5    Sze, J.6
  • 77
    • 84859121913 scopus 로고    scopus 로고
    • Epigenetic Silencing of miR-203 upregulates SNAI2 and contributes to the invasiveness of malignant breast cancer cells
    • Zhang Z, Zhang B, Li W, Fu L, Zhu Z, Dong JT. Epigenetic Silencing of miR-203 upregulates SNAI2 and contributes to the invasiveness of malignant breast cancer cells. Genes Cancer 2011; 2: 782-791
    • (2011) Genes Cancer , vol.2 , pp. 782-791
    • Zhang, Z.1    Zhang, B.2    Li, W.3    Fu, L.4    Zhu, Z.5    Dong, J.T.6
  • 78
    • 79960283982 scopus 로고    scopus 로고
    • The f-box protein ppa is a common regulator of core emt factors twist, snail, slug, and sip1
    • Lander R, Nordin K, LaBonne C. The F-box protein Ppa is a common regulator of core EMT factors Twist, Snail, Slug, and Sip1. J Cell Biol 2011; 194: 17-25
    • (2011) J Cell Biol , vol.194 , pp. 17-25
    • Lander, R.1    Nordin, K.2    LaBonne, C.3
  • 79
    • 33749391866 scopus 로고    scopus 로고
    • Slug stability is dynamically regulated during neural crest development by the f-box protein ppa
    • Vernon AE, LaBonne C. Slug stability is dynamically regulated during neural crest development by the F-box protein Ppa. Development 2006; 133: 3359-3370
    • (2006) Development , vol.133 , pp. 3359-3370
    • Vernon, A.E.1    LaBonne, C.2
  • 80
    • 0030659821 scopus 로고    scopus 로고
    • Sel-10, a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the CDC4 family of proteins
    • Hubbard EJ, Wu G, Kitajewski J, Greenwald I. sel-10, a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the CDC4 family of proteins. Genes Dev 1997; 11: 3182-3193
    • (1997) Genes Dev , vol.11 , pp. 3182-3193
    • Hubbard, E.J.1    Wu, G.2    Kitajewski, J.3    Greenwald, I.4
  • 81
    • 2942614705 scopus 로고    scopus 로고
    • Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7
    • Yada M, Hatakeyama S, Kamura T, Nishiyama M, Tsunematsu R, Imaki H, et al. Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7. EMBO J 2004; 23: 2116-2125
    • (2004) EMBO J , vol.23 , pp. 2116-2125
    • Yada, M.1    Hatakeyama, S.2    Kamura, T.3    Nishiyama, M.4    Tsunematsu, R.5    Imaki, H.6
  • 82
    • 2942650133 scopus 로고    scopus 로고
    • The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation
    • Welcker M, Orian A, Jin J, Grim JE, Harper JW, Eisenman RN, et al. The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation- dependent c-Myc protein degradation. Proc Natl Acad Sci USA 2004; 101: 9085-9090
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 9085-9090
    • Welcker, M.1    Orian, A.2    Jin, J.3    Grim, J.E.4    Harper, J.W.5    Eisenman, R.N.6
  • 83
    • 6944227551 scopus 로고    scopus 로고
    • A nucleolar isoform of the Fbw7 ubiquitin ligase regulates c-Myc and cell size
    • Welcker M, Orian A, Grim JE, Eisenman RN, Clurman BE. A nucleolar isoform of the Fbw7 ubiquitin ligase regulates c-Myc and cell size. Curr Biol 2004; 14: 1852-1857
    • (2004) Curr Biol , vol.14 , pp. 1852-1857
    • Welcker, M.1    Orian, A.2    Grim, J.E.3    Eisenman, R.N.4    Clurman, B.E.5
  • 84
    • 0035812709 scopus 로고    scopus 로고
    • Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase
    • Koepp DM, Schaefer LK, Ye X, Keyomarsi K, Chu C, Harper JW, et al. Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase. Science 2001; 294: 173-177
    • (2001) Science , vol.294 , pp. 173-177
    • Koepp, D.M.1    Schaefer, L.K.2    Ye, X.3    Keyomarsi, K.4    Chu, C.5    Harper, J.W.6
  • 85
    • 22244476115 scopus 로고    scopus 로고
    • The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase
    • Wei W, Jin J, Schlisio S, Harper JW, Kaelin Jr. WG. The v-Jun point mutation allows c-Jun to escape GSK3-dependent recognition and destruction by the Fbw7 ubiquitin ligase. Cancer Cell 2005; 8: 25-33
    • (2005) Cancer Cell , vol.8 , pp. 25-33
    • Wei, W.1    Jin, J.2    Schlisio, S.3    Harper, J.W.4    Kaelin Jr., W.G.5
  • 86
    • 77953158826 scopus 로고    scopus 로고
    • The Fbw7 tumor suppressor targets KLF5 for ubiquitin-mediated degradation and suppresses breast cell proliferation
    • Zhao D, Zheng HQ, Zhou Z, Chen C. The Fbw7 tumor suppressor targets KLF5 for ubiquitin-mediated degradation and suppresses breast cell proliferation. Cancer Res 2010; 70: 4728-4738
    • (2010) Cancer Res , vol.70 , pp. 4728-4738
    • Zhao, D.1    Zheng, H.Q.2    Zhou, Z.3    Chen, C.4
  • 87
    • 77953310667 scopus 로고    scopus 로고
    • The Fbw7/human CDC4 tumor suppressor targets proproliferative factor KLF5 for ubiquitination and degradation through multiple phosphodegron motifs
    • Liu N, Li H, Li S, Shen M, Xiao N, Chen Y, et al. The Fbw7/human CDC4 tumor suppressor targets proproliferative factor KLF5 for ubiquitination and degradation through multiple phosphodegron motifs. J Biol Chem 2010; 285: 18858-18867
    • (2010) J Biol Chem , vol.285 , pp. 18858-18867
    • Liu, N.1    Li, H.2    Li, S.3    Shen, M.4    Xiao, N.5    Chen, Y.6
  • 88
    • 0035860804 scopus 로고    scopus 로고
    • Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor
    • Gupta-Rossi N, Le Bail O, Gonen H, Brou C, Logeat F, Six E, et al. Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor. J Biol Chem 2001; 276: 34371-34378
    • (2001) J Biol Chem , vol.276 , pp. 34371-34378
    • Gupta-Rossi, N.1    Le Bail, O.2    Gonen, H.3    Brou, C.4    Logeat, F.5    Six, E.6
  • 90
    • 33751514601 scopus 로고    scopus 로고
    • A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells
    • Yook JI, Li XY, Ota I, Hu C, Kim HS, Kim NH, et al. A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells. Nat Cell Biol 2006; 8: 1398-1406
    • (2006) Nat Cell Biol , vol.8 , pp. 1398-1406
    • Yook, J.I.1    Li, X.Y.2    Ota, I.3    Hu, C.4    Kim, H.S.5    Kim, N.H.6
  • 91
    • 84855358964 scopus 로고    scopus 로고
    • Lats2 kinase potentiates Snail1 activity by promoting nuclear retention upon phosphorylation
    • Zhang K, Rodriguez-Aznar E, Yabuta N, Owen RJ, Mingot JM, Nojima H, et al. Lats2 kinase potentiates Snail1 activity by promoting nuclear retention upon phosphorylation. EMBO J 2012; 31: 29-43
    • (2012) EMBO J , vol.31 , pp. 29-43
    • Zhang, K.1    Rodriguez-Aznar, E.2    Yabuta, N.3    Owen, R.J.4    Mingot, J.M.5    Nojima, H.6
  • 92
    • 16844377441 scopus 로고    scopus 로고
    • Pak1 phosphorylation of snail, a master regulator of epithelial-To- mesenchyme transition, modulates snail-s subcellular localization and functions
    • Yang Z, Rayala S, Nguyen D, Vadlamudi RK, Chen S, Kumar R. Pak1 phosphorylation of snail, a master regulator of epithelial-To-mesenchyme transition, modulates snail-s subcellular localization and functions. Cancer Res 2005; 65: 3179-3184
    • (2005) Cancer Res , vol.65 , pp. 3179-3184
    • Yang, Z.1    Rayala, S.2    Nguyen, D.3    Vadlamudi, R.K.4    Chen, S.5    Kumar, R.6
  • 93
    • 53049108469 scopus 로고    scopus 로고
    • P70 S6 kinase promotes epithelial to mesenchymal transition through snail induction in ovarian cancer cells
    • Pon YL, Zhou HY, Cheung AN, Ngan HY, Wong AS. p70 S6 kinase promotes epithelial to mesenchymal transition through snail induction in ovarian cancer cells. Cancer Res 2008; 68: 6524-6532
    • (2008) Cancer Res , vol.68 , pp. 6524-6532
    • Pon, Y.L.1    Zhou, H.Y.2    Cheung, A.N.3    Ngan, H.Y.4    Wong, A.S.5
  • 94
    • 78049284317 scopus 로고    scopus 로고
    • Protein kinase D1 suppresses epithelial-To-mesenchymal transition through phosphorylation of snail
    • Du C, Zhang C, Hassan S, Biswas MH, Balaji KC. Protein kinase D1 suppresses epithelial-To-mesenchymal transition through phosphorylation of snail. Cancer Res 2010; 70: 7810-7819
    • (2010) Cancer Res , vol.70 , pp. 7810-7819
    • Du, C.1    Zhang, C.2    Hassan, S.3    Biswas, M.H.4    Balaji, K.C.5
  • 95
    • 84856032510 scopus 로고    scopus 로고
    • Protein kinase D1 maintains the epithelial phenotype by inducing a DNA-bound, inactive SNAI1 transcriptional repressor complex
    • Bastea LI, Doppler H, Balogun B, Storz P. Protein kinase D1 maintains the epithelial phenotype by inducing a DNA-bound, inactive SNAI1 transcriptional repressor complex. PLoS One 2012; 7: E30459
    • (2012) PLoS One , vol.7
    • Bastea, L.I.1    Doppler, H.2    Balogun, B.3    Storz, P.4
  • 96
    • 84866542850 scopus 로고    scopus 로고
    • Protein kinase D1 mediates anchorage-dependent and -independent growth of tumor cells via the zinc finger transcription factor Snail1
    • Eiseler T, Kohler C, Nimmagadda SC, Jamali A, Funk N, Joodi G, et al. Protein kinase D1 mediates anchorage-dependent and -independent growth of tumor cells via the zinc finger transcription factor Snail1. J Biol Chem 2012; 287: 32367-32380
    • (2012) J Biol Chem , vol.287 , pp. 32367-32380
    • Eiseler, T.1    Kohler, C.2    Nimmagadda, S.C.3    Jamali, A.4    Funk, N.5    Joodi, G.6
  • 97
    • 84867371728 scopus 로고    scopus 로고
    • Canonical wnt signaling regulates slug activity and links epithelial-mesenchymal transition with epigenetic breast cancer 1 early onset (brca1) repression
    • Wu ZQ, Li XY, Hu CY, Ford M, Kleer CG, Weiss SJ. Canonical Wnt signaling regulates Slug activity and links epithelial-mesenchymal transition with epigenetic Breast Cancer 1, Early Onset (BRCA1) repression. Proc Natl Acad Sci USA 2012; 109: 16654-16659.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 16654-16659
    • Wu, Z.Q.1    Li, X.Y.2    Hu, C.Y.3    Ford, M.4    Kleer, C.G.5    Weiss, S.J.6
  • 98
    • 68749099671 scopus 로고    scopus 로고
    • Identification of selective inhibitors of cancer stem cells by high-Throughput screening
    • Gupta PB, Onder TT, Jiang G, Tao K, Kuperwasser C, Weinberg RA, et al. Identification of selective inhibitors of cancer stem cells by high-Throughput screening. Cell 2009; 138: 645-659
    • (2009) Cell , vol.138 , pp. 645-659
    • Gupta, P.B.1    Onder, T.T.2    Jiang, G.3    Tao, K.4    Kuperwasser, C.5    Weinberg, R.A.6
  • 99
    • 60649089997 scopus 로고    scopus 로고
    • Cancer metastasis is accelerated through immunosuppression during snail-induced emt of cancer cells
    • Kudo-Saito C, Shirako H, Takeuchi T, Kawakami Y. Cancer metastasis is accelerated through immunosuppression during Snail-induced EMT of cancer cells. Cancer Cell 2009; 15: 195-206
    • (2009) Cancer Cell , vol.15 , pp. 195-206
    • Kudo-Saito, C.1    Shirako, H.2    Takeuchi, T.3    Kawakami, Y.4
  • 101
    • 0027987346 scopus 로고
    • M-Twist is an inhibitor of muscle differentiation
    • Hebrok M, Wertz K, Fuchtbauer EM. M-Twist is an inhibitor of muscle differentiation. Dev Biol 1994; 165: 537-544
    • (1994) Dev Biol , vol.165 , pp. 537-544
    • Hebrok, M.1    Wertz, K.2    Fuchtbauer, E.M.3
  • 102
    • 0028933142 scopus 로고
    • Twist is required in head mesenchyme for cranial neural tube morphogenesis
    • Chen ZF, Behringer RR. Twist is required in head mesenchyme for cranial neural tube morphogenesis. Genes Dev 1995; 9: 686-699
    • (1995) Genes Dev , vol.9 , pp. 686-699
    • Chen, Z.F.1    Behringer, R.R.2
  • 103
    • 12144288066 scopus 로고    scopus 로고
    • A twist code determines the onset of osteoblast differentiation
    • Bialek P, Kern B, Yang X, Schrock M, Sosic D, Hong N, et al. A twist code determines the onset of osteoblast differentiation. Dev Cell 2004; 6: 423-435
    • (2004) Dev Cell , vol.6 , pp. 423-435
    • Bialek, P.1    Kern, B.2    Yang, X.3    Schrock, M.4    Sosic, D.5    Hong, N.6
  • 104
    • 78651401992 scopus 로고    scopus 로고
    • Snail2 is an essential mediator of Twist1-induced epithelial mesenchymal transition and metastasis
    • Casas E, Kim J, Bendesky A, Ohno-Machado L, Wolfe CJ, Yang J. Snail2 is an essential mediator of Twist1-induced epithelial mesenchymal transition and metastasis. Cancer Res 2011; 71: 245-254
    • (2011) Cancer Res , vol.71 , pp. 245-254
    • Casas, E.1    Kim, J.2    Bendesky, A.3    Ohno-Machado, L.4    Wolfe, C.J.5    Yang, J.6
  • 106
    • 45849087087 scopus 로고    scopus 로고
    • Induction of EMT by twist proteins as a collateral effect of tumor-promoting inactivation of premature senescence
    • Ansieau S, Bastid J, Doreau A, Morel AP, Bouchet BP, Thomas C, et al. Induction of EMT by twist proteins as a collateral effect of tumor-promoting inactivation of premature senescence. Cancer Cell 2008; 14: 79-89
    • (2008) Cancer Cell , vol.14 , pp. 79-89
    • Ansieau, S.1    Bastid, J.2    Doreau, A.3    Morel, A.P.4    Bouchet, B.P.5    Thomas, C.6
  • 107
    • 57749092869 scopus 로고    scopus 로고
    • Epithelialmesenchymal transition induced by growth suppressor p12CDK2-AP1 promotes tumor cell local invasion but suppresses distant colony growth
    • Tsuji T, Ibaragi S, Shima K, Hu MG, Katsurano M, Sasaki A, et al. Epithelialmesenchymal transition induced by growth suppressor p12CDK2-AP1 promotes tumor cell local invasion but suppresses distant colony growth. Cancer Res 2008; 68: 10377-10386
    • (2008) Cancer Res , vol.68 , pp. 10377-10386
    • Tsuji, T.1    Ibaragi, S.2    Shima, K.3    Hu, M.G.4    Katsurano, M.5    Sasaki, A.6
  • 109
    • 35148886434 scopus 로고    scopus 로고
    • Tumour invasion and metastasis initiated by microRNA-10b in breast cancer
    • Ma L, Teruya-Feldstein J, Weinberg RA. Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature 2007; 449: 682-688
    • (2007) Nature , vol.449 , pp. 682-688
    • Ma, L.1    Teruya-Feldstein, J.2    Weinberg, R.A.3
  • 111
    • 0034601487 scopus 로고    scopus 로고
    • Genomic analysis of metastasis reveals an essential role for RhoC
    • Clark EA, Golub TR, Lander ES, Hynes RO. Genomic analysis of metastasis reveals an essential role for RhoC. Nature 2000; 406: 532-535
    • (2000) Nature , vol.406 , pp. 532-535
    • Clark, E.A.1    Golub, T.R.2    Lander, E.S.3    Hynes, R.O.4
  • 112
    • 0033587146 scopus 로고    scopus 로고
    • The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
    • Maxwell PH, Wiesener MS, Chang GW, Clifford SC, Vaux EC, Cockman ME, et al. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 1999; 399: 271-275
    • (1999) Nature , vol.399 , pp. 271-275
    • Maxwell, P.H.1    Wiesener, M.S.2    Chang, G.W.3    Clifford, S.C.4    Vaux, E.C.5    Cockman, M.E.6
  • 114
    • 0032100732 scopus 로고    scopus 로고
    • HIF-1 alpha is required for solid tumor formation and embryonic vascularization
    • Ryan HE, Lo J, Johnson RS. HIF-1 alpha is required for solid tumor formation and embryonic vascularization. EMBO J 1998; 17: 3005-3156
    • (1998) EMBO J , vol.17 , pp. 3005-3156
    • Ryan, H.E.1    Lo, J.2    Johnson, R.S.3
  • 115
    • 15444342958 scopus 로고    scopus 로고
    • Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha
    • Iyer NV, Kotch LE, Agani F, Leung SW, Laughner E, Wenger RH, et al. Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 alpha. Genes Dev 1998; 12: 149-162
    • (1998) Genes Dev , vol.12 , pp. 149-162
    • Iyer, N.V.1    Kotch, L.E.2    Agani, F.3    Leung, S.W.4    Laughner, E.5    Wenger, R.H.6
  • 119
    • 84862513160 scopus 로고    scopus 로고
    • Down-regulation of mir-214 contributes to intrahepatic cholangiocarcinoma metastasis by targeting twist
    • Li B, Han Q, Zhu Y, Yu Y, Wang J, Jiang X. Down-regulation of miR-214 contributes to intrahepatic cholangiocarcinoma metastasis by targeting Twist. FEBS J 2012; 279: 2393-2398
    • (2012) FEBS J , vol.279 , pp. 2393-2398
    • Li, B.1    Han, Q.2    Zhu, Y.3    Yu, Y.4    Wang, J.5    Jiang, X.6
  • 120
    • 84870065750 scopus 로고    scopus 로고
    • Translational control of twist1 expression in mcf-10a cell lines recapitulating breast cancer progression
    • Nairismagi ML, Vislovukh A, Meng Q, Kratassiouk G, Beldiman C, Petretich M, et al. Translational control of TWIST1 expression in MCF-10A cell lines recapitulating breast cancer progression. Oncogene 2012; 31: 4960-4966
    • (2012) Oncogene , vol.31 , pp. 4960-4966
    • Nairismagi, M.L.1    Vislovukh, A.2    Meng, Q.3    Kratassiouk, G.4    Beldiman, C.5    Petretich, M.6
  • 121
    • 84871952125 scopus 로고    scopus 로고
    • Constitutive proteasomal degradation of TWIST-1 in epithelial-ovarian cancer stem cells impacts differentiation and metastatic potential
    • Yin G, Alvero AB, Craveiro V, Holmberg JC, Fu HH, Montagna MK, et al. Constitutive proteasomal degradation of TWIST-1 in epithelial-ovarian cancer stem cells impacts differentiation and metastatic potential. Oncogene 2013; 32: 39-49
    • (2013) Oncogene , vol.32 , pp. 39-49
    • Yin, G.1    Alvero, A.B.2    Craveiro, V.3    Holmberg, J.C.4    Fu, H.H.5    Montagna, M.K.6
  • 122
    • 79957883313 scopus 로고    scopus 로고
    • Phosphorylation of serine 68 of Twist1 by MAPKs stabilizes Twist1 protein and promotes breast cancer cell invasiveness
    • Hong J, Zhou J, Fu J, He T, Qin J, Wang L, et al. Phosphorylation of serine 68 of Twist1 by MAPKs stabilizes Twist1 protein and promotes breast cancer cell invasiveness. Cancer Res 2011; 71: 3980-3990
    • (2011) Cancer Res , vol.71 , pp. 3980-3990
    • Hong, J.1    Zhou, J.2    Fu, J.3    He, T.4    Qin, J.5    Wang, L.6
  • 123
    • 0035065576 scopus 로고    scopus 로고
    • Mutations in sip1, encoding smad interacting protein-1, cause a form of hirschsprung disease
    • Wakamatsu N, Yamada Y, Yamada K, Ono T, Nomura N, Taniguchi H, et al. Mutations in SIP1, encoding Smad interacting protein-1, cause a form of Hirschsprung disease. Nat Genet 2001; 27: 369-370
    • (2001) Nat Genet , vol.27 , pp. 369-370
    • Wakamatsu, N.1    Yamada, Y.2    Yamada, K.3    Ono, T.4    Nomura, N.5    Taniguchi, H.6
  • 124
    • 34249748851 scopus 로고    scopus 로고
    • Novel mutations in the ZEB1 gene identified in Czech and British patients with posterior polymorphous corneal dystrophy
    • Liskova P, Tuft SJ, Gwilliam R, Ebenezer ND, Jirsova K, Prescott Q, et al. Novel mutations in the ZEB1 gene identified in Czech and British patients with posterior polymorphous corneal dystrophy. Hum Mutat 2007; 28: 638
    • (2007) Hum Mutat , vol.28 , pp. 638
    • Liskova, P.1    Tuft, S.J.2    Gwilliam, R.3    Ebenezer, N.D.4    Jirsova, K.5    Prescott, Q.6
  • 125
    • 0037322308 scopus 로고    scopus 로고
    • Mice lacking ZFHX1B, the gene that codes for Smad-interacting protein-1, reveal a role for multiple neural crest cell defects in the etiology of Hirschsprung disease-mental retardation syndrome
    • Van De Putte T, Maruhashi M, Francis A, Nelles L, Kondoh H, Huylebroeck D, et al. Mice lacking ZFHX1B, the gene that codes for Smad-interacting protein-1, reveal a role for multiple neural crest cell defects in the etiology of Hirschsprung disease-mental retardation syndrome. Am J Hum Genet 2003; 72: 465-470
    • (2003) Am J Hum Genet , vol.72 , pp. 465-470
    • Van De Putte, T.1    Maruhashi, M.2    Francis, A.3    Nelles, L.4    Kondoh, H.5    Huylebroeck, D.6
  • 126
    • 34147147030 scopus 로고    scopus 로고
    • Collagen type I-induced Smad-interacting protein 1 expression downregulates E-cadherin in pancreatic cancer
    • Imamichi Y, Konig A, Gress T, Menke A. Collagen type I-induced Smad-interacting protein 1 expression downregulates E-cadherin in pancreatic cancer. Oncogene 2007; 26: 2381-2385
    • (2007) Oncogene , vol.26 , pp. 2381-2385
    • Imamichi, Y.1    Konig, A.2    Gress, T.3    Menke, A.4
  • 127
    • 33644821962 scopus 로고    scopus 로고
    • Expression of SIP1 in oral squamous cell carcinomas: Implications for E-cadherin expression and tumor progression
    • Maeda G, Chiba T, Okazaki M, Satoh T, Taya Y, Aoba T, et al. Expression of SIP1 in oral squamous cell carcinomas: Implications for E-cadherin expression and tumor progression. Int J Oncol 2005; 27: 1535-1541
    • (2005) Int J Oncol , vol.27 , pp. 1535-1541
    • Maeda, G.1    Chiba, T.2    Okazaki, M.3    Satoh, T.4    Taya, Y.5    Aoba, T.6
  • 128
    • 33748116186 scopus 로고    scopus 로고
    • A transient emt-linked loss of basement membranes indicates metastasis and poor survival in colorectal cancer
    • Spaderna S, Schmalhofer O, Hlubek F, Berx G, Eger A, Merkel S, et al. A transient, EMT-linked loss of basement membranes indicates metastasis and poor survival in colorectal cancer. Gastroenterology 2006; 131: 830-840
    • (2006) Gastroenterology , vol.131 , pp. 830-840
    • Spaderna, S.1    Schmalhofer, O.2    Hlubek, F.3    Berx, G.4    Eger, A.5    Merkel, S.6
  • 129
    • 39049160267 scopus 로고    scopus 로고
    • The transcriptional repressor ZEB1 promotes metastasis and loss of cell polarity in cancer
    • Spaderna S, Schmalhofer O, Wahlbuhl M, Dimmler A, Bauer K, Sultan A, et al. The transcriptional repressor ZEB1 promotes metastasis and loss of cell polarity in cancer. Cancer Res 2008; 68: 537-544
    • (2008) Cancer Res , vol.68 , pp. 537-544
    • Spaderna, S.1    Schmalhofer, O.2    Wahlbuhl, M.3    Dimmler, A.4    Bauer, K.5    Sultan, A.6
  • 130
  • 131
    • 73049110243 scopus 로고    scopus 로고
    • The emt-Activator zeb1 promotes tumorigenicity by repressing stemness-inhibiting micrornas
    • Wellner U, Schubert J, Burk UC, Schmalhofer O, Zhu F, Sonntag A, et al. The EMT-Activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs. Nat Cell Biol 2009; 11: 1487-1495
    • (2009) Nat Cell Biol , vol.11 , pp. 1487-1495
    • Wellner, U.1    Schubert, J.2    Burk, U.C.3    Schmalhofer, O.4    Zhu, F.5    Sonntag, A.6
  • 132
    • 0033568198 scopus 로고    scopus 로고
    • New mode of dna binding of multi-zinc finger transcription factors: Deltaef1 family members bind with two hands to two target sites
    • Remacle JE, Kraft H, Lerchner W, Wuytens G, Collart C, Verschueren K, et al. New mode of DNA binding of multi-zinc finger transcription factors: DeltaEF1 family members bind with two hands to two target sites. EMBO J 1999; 18: 5073-5084
    • (1999) EMBO J , vol.18 , pp. 5073-5084
    • Remacle, J.E.1    Kraft, H.2    Lerchner, W.3    Wuytens, G.4    Collart, C.5    Verschueren, K.6
  • 133
    • 1942469421 scopus 로고    scopus 로고
    • Snail and sip1 increase cancer invasion by upregulating mmp family in hepatocellular carcinoma cells
    • Miyoshi A, Kitajima Y, Sumi K, Sato K, Hagiwara A, Koga Y, et al. Snail and SIP1 increase cancer invasion by upregulating MMP family in hepatocellular carcinoma cells. Br J Cancer 2004; 90: 1265-1273
    • (2004) Br J Cancer , vol.90 , pp. 1265-1273
    • Miyoshi, A.1    Kitajima, Y.2    Sumi, K.3    Sato, K.4    Hagiwara, A.5    Koga, Y.6
  • 134
    • 33747005330 scopus 로고    scopus 로고
    • Involvement of Ets-1 transcription factor in inducing matrix metalloproteinase-2 expression by epithelial-mesenchymal transition in human squamous carcinoma cells
    • Taki M, Verschueren K, Yokoyama K, Nagayama M, Kamata N. Involvement of Ets-1 transcription factor in inducing matrix metalloproteinase-2 expression by epithelial-mesenchymal transition in human squamous carcinoma cells. Int J Oncol 2006; 28: 487-496.
    • (2006) Int J Oncol , vol.28 , pp. 487-496
    • Taki, M.1    Verschueren, K.2    Yokoyama, K.3    Nagayama, M.4    Kamata, N.5
  • 135
    • 80054681545 scopus 로고    scopus 로고
    • In vivo identification of tumor- suppressive pten cernas in an oncogenic braf-induced mouse model of melanoma
    • Karreth FA, Tay Y, Perna D, Ala U, Tan SM, Rust AG, et al. In vivo identification of tumor- suppressive PTEN ceRNAs in an oncogenic BRAF-induced mouse model of melanoma. Cell 2011; 147: 382-395
    • (2011) Cell , vol.147 , pp. 382-395
    • Karreth, F.A.1    Tay, Y.2    Perna, D.3    Ala, U.4    Tan, S.M.5    Rust, A.G.6
  • 136
    • 33645090169 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1-dependent repression of e-cadherin in von hippel-lindau tumor suppressor-null renal cell carcinoma mediated by tcf3 zfhx1a, and zfhx1b
    • Krishnamachary B, Zagzag D, Nagasawa H, Rainey K, Okuyama H, Baek JH, et al. Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B. Cancer Res 2006; 66: 2725-2731
    • (2006) Cancer Res , vol.66 , pp. 2725-2731
    • Krishnamachary, B.1    Zagzag, D.2    Nagasawa, H.3    Rainey, K.4    Okuyama, H.5    Baek, J.H.6
  • 137
    • 84858016877 scopus 로고    scopus 로고
    • Induction of ZEB proteins by inactivation of RB protein is key determinant of mesenchymal phenotype of breast cancer
    • Arima Y, Hayashi H, Sasaki M, Hosonaga M, Goto TM, Chiyoda T, et al. Induction of ZEB proteins by inactivation of RB protein is key determinant of mesenchymal phenotype of breast cancer. J Biol Chem 2012; 287: 7896-7906
    • (2012) J Biol Chem , vol.287 , pp. 7896-7906
    • Arima, Y.1    Hayashi, H.2    Sasaki, M.3    Hosonaga, M.4    Goto, T.M.5    Chiyoda, T.6
  • 139
    • 27444442397 scopus 로고    scopus 로고
    • Pc2-mediated sumoylation of Smad-interacting protein 1 attenuates transcriptional repression of E-cadherin
    • Long J, Zuo D, Park M. Pc2-mediated sumoylation of Smad-interacting protein 1 attenuates transcriptional repression of E-cadherin. J Biol Chem 2005; 280: 35477-35489
    • (2005) J Biol Chem , vol.280 , pp. 35477-35489
    • Long, J.1    Zuo, D.2    Park, M.3
  • 140
    • 44649163918 scopus 로고    scopus 로고
    • A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells
    • Burk U, Schubert J, Wellner U, Schmalhofer O, Vincan E, Spaderna S, et al. A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells. EMBO Rep 2008; 9: 582-589
    • (2008) EMBO Rep , vol.9 , pp. 582-589
    • Burk, U.1    Schubert, J.2    Wellner, U.3    Schmalhofer, O.4    Vincan, E.5    Spaderna, S.6
  • 141
    • 43049103824 scopus 로고    scopus 로고
    • The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1
    • Gregory PA, Bert AG, Paterson EL, Barry SC, Tsykin A, Farshid G, et al. The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. Nat Cell Biol 2008; 10: 593-601
    • (2008) Nat Cell Biol , vol.10 , pp. 593-601
    • Gregory, P.A.1    Bert, A.G.2    Paterson, E.L.3    Barry, S.C.4    Tsykin, A.5    Farshid, G.6
  • 142
    • 47249091921 scopus 로고    scopus 로고
    • The miR-200 family inhibits epithelialmesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2
    • Korpal M, Lee ES, Hu G, Kang Y. The miR-200 family inhibits epithelialmesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2. J Biol Chem 2008; 283: 14910-14914
    • (2008) J Biol Chem , vol.283 , pp. 14910-14914
    • Korpal, M.1    Lee, E.S.2    Hu, G.3    Kang, Y.4
  • 143
    • 41649091906 scopus 로고    scopus 로고
    • The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2
    • Park SM, Gaur AB, Lengyel E, Peter ME. The miR-200 family determines the epithelial phenotype of cancer cells by targeting the E-cadherin repressors ZEB1 and ZEB2. Genes Dev 2008; 22: 894-907
    • (2008) Genes Dev , vol.22 , pp. 894-907
    • Park, S.M.1    Gaur, A.B.2    Lengyel, E.3    Peter, M.E.4
  • 144
    • 54049084380 scopus 로고    scopus 로고
    • A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition
    • Bracken CP, Gregory PA, Kolesnikoff N, Bert AG, Wang J, Shannon MF, et al. A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition. Cancer Res 2008; 68: 7846-7854
    • (2008) Cancer Res , vol.68 , pp. 7846-7854
    • Bracken, C.P.1    Gregory, P.A.2    Kolesnikoff, N.3    Bert, A.G.4    Wang, J.5    Shannon, M.F.6
  • 145
    • 80054884390 scopus 로고    scopus 로고
    • MicroRNA-138 suppresses epithelial-mesenchymal transition in squamous cell carcinoma cell lines
    • Liu X, Wang C, Chen Z, Jin Y, Wang Y, Kolokythas A, et al. MicroRNA-138 suppresses epithelial-mesenchymal transition in squamous cell carcinoma cell lines. Biochem J 2011; 440: 23-31
    • (2011) Biochem J , vol.440 , pp. 23-31
    • Liu, X.1    Wang, C.2    Chen, Z.3    Jin, Y.4    Wang, Y.5    Kolokythas, A.6
  • 147
    • 81955164748 scopus 로고    scopus 로고
    • MiRNA profiling in metastatic renal cell carcinoma reveals a tumour-suppressor effect for miR-215
    • White NM, Khella HW, Grigull J, Adzovic S, Youssef YM, Honey RJ, et al. miRNA profiling in metastatic renal cell carcinoma reveals a tumour-suppressor effect for miR-215. Br J Cancer 2011; 105: 1741-1749
    • (2011) Br J Cancer , vol.105 , pp. 1741-1749
    • White, N.M.1    Khella, H.W.2    Grigull, J.3    Adzovic, S.4    Youssef, Y.M.5    Honey, R.J.6
  • 148
    • 80053377344 scopus 로고    scopus 로고
    • MicroRNA-708 induces apoptosis and suppresses tumorigenicity in renal cancer cells
    • Saini S, Yamamura S, Majid S, Shahryari V, Hirata H, Tanaka Y, et al. MicroRNA-708 induces apoptosis and suppresses tumorigenicity in renal cancer cells. Cancer Res 2011; 71: 6208-6219
    • (2011) Cancer Res , vol.71 , pp. 6208-6219
    • Saini, S.1    Yamamura, S.2    Majid, S.3    Shahryari, V.4    Hirata, H.5    Tanaka, Y.6
  • 149
    • 80052428699 scopus 로고    scopus 로고
    • The social aspects of emt-met plasticity
    • Thompson EW, Haviv I. The social aspects of EMT-MET plasticity. Nat Med 2011; 17: 1048-1049
    • (2011) Nat Med , vol.17 , pp. 1048-1049
    • Thompson, E.W.1    Haviv, I.2
  • 150
    • 84870806564 scopus 로고    scopus 로고
    • EMT and MET in metastasis: Where are the cancer stem cells
    • Brabletz T. EMT and MET in metastasis: Where are the cancer stem cells? Cancer Cell 2012; 22: 699-701
    • (2012) Cancer Cell , vol.22 , pp. 699-701
    • Brabletz, T.1


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