The hypoxia-controlled FBXL14 ubiquitin ligase targets SNAIL1 for proteasome degradation

Journal of Biological Chemistry

Volumn 285, Issue 6, 2010, Pages 3794-3805

  Viñas Castells, Rosa ^a   Beltran, Manuel ^a   Valls, Gabriela ^a,d   Gómez, Irene ^b   García, José Miguel ^b   Montserrat Sentís, Bàrbara ^a,e   Baulida, Josep ^a   Bonilla, Félix ^b   De Herreros, Antonio García ^a,c   Díaz, Víctor M ^a,c  

^a HOSPITAL DEL MAR   (Spain)

^b HOSPITAL UNIVERSITARIO PUERTA DE HIERRO   (Spain)

^c UNIVERSITAT POMPEU FABRA   (Spain)

^d UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^e UNIVERSITY OF BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

DOWN-REGULATION; EPITHELIAL TO MESENCHYMAL TRANSITIONS; IN-VIVO; LIGASES; MASTER REGULATORS; POLYUBIQUITYLATION; PROTEASOMES; PROTEIN LEVEL; PROTEIN STABILITY; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; UBIQUITIN LIGASES; UBIQUITYLATION;

CARBONIC ANHYDRASE; DEGRADATION; RNA; TRANSCRIPTION FACTORS;

PHOSPHORYLATION;

CARBONATE DEHYDRATASE IX; CELL PROTEIN; F BOX PROTEIN; GLYCOGEN SYNTHASE KINASE 3BETA; MESSENGER RNA; PROTEASOME; PROTEIN FBXL14; PROTEIN SNAIL1; PROTEIN TWIST1; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR SNAIL; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; FBXL14 PROTEIN, HUMAN; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; NUCLEAR PROTEIN; SNAIL FAMILY TRANSCRIPTION FACTORS; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR TWIST; TWIST1 PROTEIN, HUMAN; TWIST1 PROTEIN, MOUSE; UBIQUITIN PROTEIN LIGASE;

ANIMAL CELL; ARTICLE; CELL HYPOXIA; CONTROLLED STUDY; DOWN REGULATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VIVO STUDY; MOLECULAR MECHANICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN TARGETING; UBIQUITINATION; UPREGULATION; ANIMAL; BINDING SITE; CELL LINE; CELL STRAIN 3T3; GENETIC TRANSFECTION; GENETICS; IMMUNOPRECIPITATION; METABOLISM; MUTATION; PHOSPHORYLATION; PROTEIN BINDING; RNA INTERFERENCE; TUMOR CELL LINE; WESTERN BLOTTING;

ANIMALS; BINDING SITES; BLOTTING, WESTERN; CELL HYPOXIA; CELL LINE; CELL LINE, TUMOR; DOWN-REGULATION; F-BOX PROTEINS; GLYCOGEN SYNTHASE KINASE 3; IMMUNOPRECIPITATION; MICE; MUTATION; NIH 3T3 CELLS; NUCLEAR PROTEINS; PHOSPHORYLATION; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BINDING; RNA INTERFERENCE; TRANSCRIPTION FACTORS; TRANSFECTION; TWIST TRANSCRIPTION FACTOR; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 77950505906     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.065995     Document Type: Article

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