Critical role for lysyl oxidase in mesenchymal stem cell-driven breast cancer malignancy

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 43, 2012, Pages 17460-17465

  El Haibi, Christelle P ^a   Bell, George W ^b   Zhang, Jiangwen ^c   Collmann, Anthony Y ^a   Wood, David ^d   Scherber, Cally M ^e   Csizmadia, Eva ^f   Mariani, Odette ^g   Zhu, Cuihua ^a   Campagne, Antoine ^a,g   Toner, Mehmet ^e   Bhatia, Sangeeta N ^d   Irimia, Daniel ^e   Vincent Salomon, Anne ^g   Karnoub, Antoine E ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^c HARVARD UNIVERSITY   (United States)

^d MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^e SHRINERS HOSPITALS FOR CHILDREN   (United States)

^f BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^g INSTITUT CURIE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

HERMES ANTIGEN; HYALURONIC ACID; PROTEIN LYSINE 6 OXIDASE; TRANSCRIPTION FACTOR TWIST;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW CELL; BONE METASTASIS; BREAST CARCINOMA; CANCER INVASION; CANCER STEM CELL; CARCINOMA CELL; CELL NUCLEUS; CELL POPULATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME SYNTHESIS; EPITHELIAL MESENCHYMAL TRANSITION; GENE TRANSLOCATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; LUNG METASTASIS; MESENCHYMAL STEM CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN FUNCTION; PROTEIN PROCESSING; SIGNAL TRANSDUCTION;

BREAST NEOPLASMS; CELL LINE, TUMOR; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; HUMANS; MESENCHYMAL STROMAL CELLS; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; NEOPLASTIC STEM CELLS; PROTEIN-LYSINE 6-OXIDASE; RNA, MESSENGER;

EID: 84867902937     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1206653109     Document Type: Article

References (38)

1. Bissell MJ, Radisky D (2001) Putting tumours in context. Nat Rev Cancer 1:46-54. (Pubitemid 33741880)
2. Polyak K, Kalluri R (2010) The role of the microenvironment in mammary gland development and cancer. Cold Spring Harb Perspect Biol 2:a003244.
3. Bianco P, Robey PG, Simmons PJ (2008) Mesenchymal stem cells: Revisiting history, concepts, and assays. Cell Stem Cell 2:313-319. (Pubitemid 351467394)
4. Karp JM, Leng Teo GS (2009) Mesenchymal stem cell homing: The devil is in the details. Cell Stem Cell 4:206-216.
5. Dvorak HF (1986) Tumors: Wounds that do not heal. Similarities between tumor stroma generation and wound healing. N Engl J Med 315:1650-1659.
6. El-Haibi CP, Karnoub AE (2010) Mesenchymal stem cells in the pathogenesis and therapy of breast cancer. J Mammary Gland Biol Neoplasia 15:399-409.
7. Karnoub AE, et al. (2007) Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature 449:557-563. (Pubitemid 47525152)
8. Kidd S, et al. (2009) Direct evidence of mesenchymal stem cell tropism for tumor and wounding microenvironments using in vivo bioluminescent imaging. Stem Cells 27:2614-2623.
9. Goldstein RH, Reagan MR, Anderson K, Kaplan DL, Rosenblatt M (2010) Human bone marrow-derived MSCs can home to orthotopic breast cancer tumors and promote bone metastasis. Cancer Res 70:10044-10050.
10. Roodhart JM, et al. (2011) Mesenchymal stem cells induce resistance to chemotherapy through the release of platinum-induced fatty acids. Cancer Cell 20:370-383.
11. Liu S, et al. (2011) Breast cancer stem cells are regulated by mesenchymal stem cells through cytokine networks. Cancer Res 71:614-624.
12. Kagan HM, LiW(2003) Lysyl oxidase: Properties, specificity, and biological roles inside and outside of the cell. J Cell Biochem 88:660-672. (Pubitemid 36258816)
13. Csiszar K (2001) Lysyl oxidases: A novel multifunctional amine oxidase family. Prog Nucleic Acid Res Mol Biol 70:1-32.
14. Lucero HA, Kagan HM (2006) Lysyl oxidase: An oxidative enzyme and effector of cell function. Cell Mol Life Sci 63:2304- 2316.
15. Mäki JM (2009) Lysyl oxidases in mammalian development and certain pathological conditions. Histol Histopathol 24:651-660.
16. Kirschmann DA, et al. (2002) A molecular role for lysyl oxidase in breast cancer invasion. Cancer Res 62:4478-4483. (Pubitemid 34827311)
17. Payne SL, et al. (2005) Lysyl oxidase regulates breast cancer cell migration and adhesion through a hydrogen peroxide-mediated mechanism. Cancer Res 65:11429-11436. (Pubitemid 41821700)
18. Erler JT, et al. (2006) Lysyl oxidase is essential for hypoxia-induced metastasis. Nature 440:1222-1226.
19. Erler JT, et al. (2009) Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche. Cancer Cell 15:35-44.
20. Wilmarth KR, Froines JR (1992) In vitro and in vivo inhibition of lysyl oxidase by aminopropionitriles. J Toxicol Environ Health 37:411-423.
21. Yang J, Weinberg RA (2008) Epithelial-mesenchymal transition: At the crossroads of development and tumor metastasis. Dev Cell 14:818-829. (Pubitemid 351757205)
22. Chaffer CL, Weinberg RA (2011) A perspective on cancer cell metastasis. Science 331:1559-1564.
23. Mani SA, et al. (2008) The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell 133:704-715. (Pubitemid 351636299)
24. Morel AP, et al. (2008) Generation of breast cancer stem cells through epithelialmesenchymal transition. PLoS One 3:e2888.
25. Creighton CJ, Chang JC, Rosen JM (2010) Epithelial-mesenchymal transition (EMT) in tumor-initiating cells and its clinical implications in breast cancer. J Mammary Gland Biol Neoplasia 15:253-260.
26. Ginestier C, et al. (2007) ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome. Cell Stem Cell 1:555- 567.
27. Levental KR, et al. (2009) Matrix crosslinking forces tumor progression by enhancing integrin signaling. Cell 139:891 -906.
28. Park HW, Shin JS, Kim CW (2007) Proteome of mesenchymal stem cells. Proteomics 7:2881-2894.
29. Astachov L, Vago R, Aviv M, Nevo Z (2011) Hyaluronan and mesenchymal stem cells: From germ layer to cartilage and bone. Front Biosci 16:261-276.
30. Toole BP (2009) Hyaluronan-CD44 Interactions in Cancer: Paradoxes and Possibilities. Clin Cancer Res 15:7462-7468.
31. Tammi R, et al. (2001) Hyaluronan enters keratinocytes by a novel endocytic route for catabolism. J Biol Chem 276:35111-35122.
32. Janiszewska M, De Vito C, Le Bitoux MA, Fusco C, Stamenkovic I (2010) Transportin regulates nuclear import of CD44. J Biol Chem 285:30548-30557.
33. Su YJ, Lai HM, Chang YW, Chen GY, Lee JL (2011) Direct reprogramming of stem cell properties in colon cancer cells by CD44. EMBO J 30:3186-3199.
34. Lien HC, et al. (2007) Molecular signatures of metaplastic carcinoma of the breast by large-scale transcriptional profiling: Identification of genes potentially related to epithelial-mesenchymal transition. Oncogene 26:7859- 7871.
35. Hennessy BT, et al. (2009) Characterization of a naturally occurring breast cancer subset enriched in epithelial-to-mesenchymal transition and stem cell characteristics. Cancer Res 69:4116-4124.
36. Pez F, et al. (2011) The HIF-1-inducible lysyl oxidase activates HIF-1 via the Akt pathway in a positive regulation loop and synergizes with HIF-1 in promoting tumor cell growth. Cancer Res 71:1647-1657.
37. Blick T, et al. (2010) Epithelial mesenchymal transition traits in human breast cancer cell lines parallel the CD44(hi/)CD24 (lo/-) stem cell phenotype in human breast cancer. J Mammary Gland Biol Neoplasia 15:235-252.
38. McLean K, et al. (2011) Human ovarian carcinoma-associated mesenchymal stem cells regulate cancer stem cells and tumorigenesis via altered BMP production. J Clin Invest 121:3206-3219.