The Fbw7/human CDC4 tumor suppressor targets proproliferative factor KLF5 for ubiquitination and degradation through multiple phosphodegron motifs

Journal of Biological Chemistry

Volumn 285, Issue 24, 2010, Pages 18858-18867

  Liu, Ning ^a   Li, Hui ^a   Li, Shuangxi ^a   Shen, Mingyue ^a   Xiao, Ning ^a   Chen, Yunfei ^a   Wang, Yan ^a   Wang, Weichao ^a   Wang, Rui ^a   Wang, Qian ^a   Sun, Jianhua ^a   Wang, Ping ^a  

^a EAST CHINA NORMAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL ACTIVITIES; CANCER CELLS; GENE REGULATIONS; GLYCOGEN SYNTHASE KINASE-3; NEGATIVE REGULATORS; PROTEASOMES; PROTEIN STABILITY; TUMOR SUPPRESSORS; TUMORIGENESIS; UBIQUITIN; UBIQUITIN LIGASES; UBIQUITINATION;

CELL PROLIFERATION; TRANSCRIPTION; TRANSCRIPTION FACTORS; TUMORS;

DEGRADATION;

GLYCOGEN SYNTHASE KINASE 3BETA; KRUPPEL LIKE FACTOR 4; KRUPPEL LIKE FACTOR 5; PROTEIN FBW7; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CARCINOGENESIS; CELL PROLIFERATION; CONTROLLED STUDY; EMBRYO; GENE CONTROL; GENE MUTATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN METABOLISM; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; UBIQUITINATION;

AMINO ACID MOTIFS; CELL CYCLE PROTEINS; CELL LINE; CELL LINE, TUMOR; CELL PROLIFERATION; CYTOPLASM; F-BOX PROTEINS; FLOW CYTOMETRY; GLYCOGEN SYNTHASE KINASE 3; HELA CELLS; HUMANS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MUTATION; PHOSPHORYLATION; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES;

EID: 77953310667     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.099440     Document Type: Article

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