-
1
-
-
33244463813
-
Complex networks orchestrate epithelial-mesenchymal transitions
-
Thiery, J. P. & Sleeman, J. P. Complex networks orchestrate epithelial-mesenchymal transitions. Nature Rev. Mol. Cell Biol. 7, 131-142 (2006).
-
(2006)
Nature Rev. Mol. Cell Biol
, vol.7
, pp. 131-142
-
-
Thiery, J.P.1
Sleeman, J.P.2
-
2
-
-
0036595629
-
-
Thiery, J. P. Epithelial-mesenchymal transitions in tumour progression. Nature Rev. Cancer 2, 442-454 (2002). The first comprehensive review to compile evidence for EMT in tumorigenesis.
-
Thiery, J. P. Epithelial-mesenchymal transitions in tumour progression. Nature Rev. Cancer 2, 442-454 (2002). The first comprehensive review to compile evidence for EMT in tumorigenesis.
-
-
-
-
3
-
-
33751252276
-
Cancer metastasis: Building a framework
-
Gupta, G. P. & Massague, J. Cancer metastasis: building a framework. Cell 127, 679-695 (2006).
-
(2006)
Cell
, vol.127
, pp. 679-695
-
-
Gupta, G.P.1
Massague, J.2
-
4
-
-
0028245813
-
Cadherin expression in carcinomas: Role in the formation of cell junctions and the prevention of invasiveness
-
Birchmeier, W. & Behrens, J. Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness. Biochim. Biophys. Acta. 1198, 11-26 (1994).
-
(1994)
Biochim. Biophys. Acta
, vol.1198
, pp. 11-26
-
-
Birchmeier, W.1
Behrens, J.2
-
5
-
-
34249276569
-
New potential therapeutic targets to combat epithelial tumor invasion
-
Peinado, H. & Cano, A. New potential therapeutic targets to combat epithelial tumor invasion. Clin. Transl. Oncol. 8, 851-857 (2006).
-
(2006)
Clin. Transl. Oncol
, vol.8
, pp. 851-857
-
-
Peinado, H.1
Cano, A.2
-
6
-
-
22244473343
-
The fallacy of epithelial mesenchymal transition in neoplasia
-
Tarin, D., Thompson, E. W. & Newgreen, D. F. The fallacy of epithelial mesenchymal transition in neoplasia. Cancer Res. 65, 5996-6000 (2005).
-
(2005)
Cancer Res
, vol.65
, pp. 5996-6000
-
-
Tarin, D.1
Thompson, E.W.2
Newgreen, D.F.3
-
7
-
-
33749024777
-
Reassessing epithelial to mesenchymal transition as a prerequisite for carcinoma invasion and metastasis
-
Christiansen, J. J. & Rajasekaran, A. K. Reassessing epithelial to mesenchymal transition as a prerequisite for carcinoma invasion and metastasis. Cancer Res. 66, 8319-8326 (2006).
-
(2006)
Cancer Res
, vol.66
, pp. 8319-8326
-
-
Christiansen, J.J.1
Rajasekaran, A.K.2
-
8
-
-
23844528776
-
-
Barrallo-Gimeno, A. & Nieto, M. A. The Snail genes as inducers of cell movement and survival: implications in development and cancer. Development 132, 3151-3161 (2005). An excellent review of the implication of Snail factors in processes other than EMT.
-
Barrallo-Gimeno, A. & Nieto, M. A. The Snail genes as inducers of cell movement and survival: implications in development and cancer. Development 132, 3151-3161 (2005). An excellent review of the implication of Snail factors in processes other than EMT.
-
-
-
-
9
-
-
0033789680
-
The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells
-
Batlle, E. et al. The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells. Nature Cell Biol. 2, 84-89 (2000).
-
(2000)
Nature Cell Biol
, vol.2
, pp. 84-89
-
-
Batlle, E.1
-
10
-
-
0033784843
-
-
Cano, A. et al. The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nature Cell Biol. 2, 76-83 (2000). Together with reference 9, characterizes SNAI1 as the first E-cadherin repressor and EMT inducer in carcinoma cells.
-
Cano, A. et al. The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nature Cell Biol. 2, 76-83 (2000). Together with reference 9, characterizes SNAI1 as the first E-cadherin repressor and EMT inducer in carcinoma cells.
-
-
-
-
11
-
-
0037326569
-
The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: A comparison with Snail and E47 repressors
-
Bolos, V. et al. The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressors. J. Cell Sci. 116, 499-511 (2003).
-
(2003)
J. Cell Sci
, vol.116
, pp. 499-511
-
-
Bolos, V.1
-
12
-
-
0037086277
-
The SLUG zinc-finger protein represses E-cadherin in breast cancer
-
Hajra, K. M., Chen, D. Y. & Fearon, E. R. The SLUG zinc-finger protein represses E-cadherin in breast cancer. Cancer Res. 62, 1613-1618 (2002).
-
(2002)
Cancer Res
, vol.62
, pp. 1613-1618
-
-
Hajra, K.M.1
Chen, D.Y.2
Fearon, E.R.3
-
13
-
-
0034964418
-
The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion
-
Comijn, J. et al. The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion. Mol. Cell 7, 1267-1278 (2001).
-
(2001)
Mol. Cell
, vol.7
, pp. 1267-1278
-
-
Comijn, J.1
-
14
-
-
20144388095
-
δEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells
-
Eger, A. et al. δEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells. Oncogene 24, 2375-2385 (2005).
-
(2005)
Oncogene
, vol.24
, pp. 2375-2385
-
-
Eger, A.1
-
15
-
-
0035920152
-
A new role for E12/E47 in the repression of E-cadherin expression and epithelial-mesenchymal transitions
-
Perez-Moreno, M. A. et al. A new role for E12/E47 in the repression of E-cadherin expression and epithelial-mesenchymal transitions. J. Biol. Chem. 276, 27424-27431 (2001).
-
(2001)
J. Biol. Chem
, vol.276
, pp. 27424-27431
-
-
Perez-Moreno, M.A.1
-
16
-
-
2942707848
-
-
Yang, J. et al. Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell 117, 927-939 (2004). The first demonstration of the capability of TWIST to induce EMT and metastasis.
-
Yang, J. et al. Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell 117, 927-939 (2004). The first demonstration of the capability of TWIST to induce EMT and metastasis.
-
-
-
-
17
-
-
0036513626
-
The snail superfamily of zinc-finger transcription factors
-
Nieto, M. A. The snail superfamily of zinc-finger transcription factors. Nature Rev. Mol. Cell Biol. 3, 155-166 (2002).
-
(2002)
Nature Rev. Mol. Cell Biol
, vol.3
, pp. 155-166
-
-
Nieto, M.A.1
-
18
-
-
15944363787
-
Unraveling signalling cascades for the Snail family of transcription factors
-
De Craene, B., van Roy, F. & Berx, G. Unraveling signalling cascades for the Snail family of transcription factors. Cell Signal. 17, 535-547 (2005).
-
(2005)
Cell Signal
, vol.17
, pp. 535-547
-
-
De Craene, B.1
van Roy, F.2
Berx, G.3
-
19
-
-
24644480749
-
Molecular requirements for epithelial-mesenchymal transition during tumor progression
-
Huber, M. A., Kraut, N. & Beug, H. Molecular requirements for epithelial-mesenchymal transition during tumor progression. Curr. Opin. Cell Biol. 17, 548-558 (2005).
-
(2005)
Curr. Opin. Cell Biol
, vol.17
, pp. 548-558
-
-
Huber, M.A.1
Kraut, N.2
Beug, H.3
-
20
-
-
0345736990
-
Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of β-catenin, and enhanced tumor cell invasion
-
Lu, Z., Ghosh, S., Wang, Z. & Hunter, T. Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of β-catenin, and enhanced tumor cell invasion. Cancer Cell 4, 499-515 (2003).
-
(2003)
Cancer Cell
, vol.4
, pp. 499-515
-
-
Lu, Z.1
Ghosh, S.2
Wang, Z.3
Hunter, T.4
-
21
-
-
6044231839
-
Regulation of Snail transcription during epithelial to mesenchymal transition of tumor cells
-
Barbera, M. J. et al. Regulation of Snail transcription during epithelial to mesenchymal transition of tumor cells. Oncogene 23, 7345-7354 (2004).
-
(2004)
Oncogene
, vol.23
, pp. 7345-7354
-
-
Barbera, M.J.1
-
22
-
-
0038756636
-
Transforming growth factor β-1 induces snail transcription factor in epithelial cell lines: Mechanisms for epithelial mesenchymal transitions
-
Peinado, H., Quintanilla, M. & Cano, A. Transforming growth factor β-1 induces snail transcription factor in epithelial cell lines: mechanisms for epithelial mesenchymal transitions. J. Biol. Chem. 278, 21113-21123 (2003).
-
(2003)
J. Biol. Chem
, vol.278
, pp. 21113-21123
-
-
Peinado, H.1
Quintanilla, M.2
Cano, A.3
-
23
-
-
9144246932
-
Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation
-
Timmerman, L. A. et al. Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation. Genes Dev. 18, 99-115 (2004).
-
(2004)
Genes Dev
, vol.18
, pp. 99-115
-
-
Timmerman, L.A.1
-
24
-
-
1842524153
-
Integration of TGF-β/Smad and Jagged1/Notch signalling in epithelial-to-mesenchymal transition
-
Zavadil, J., Cermak, L., Soto-Nieves, N. & Bottinger, E. P. Integration of TGF-β/Smad and Jagged1/Notch signalling in epithelial-to-mesenchymal transition. EMBO J. 23, 1155-1165 (2004).
-
(2004)
EMBO J
, vol.23
, pp. 1155-1165
-
-
Zavadil, J.1
Cermak, L.2
Soto-Nieves, N.3
Bottinger, E.P.4
-
25
-
-
33646596637
-
Cooperation between snail and LEF-1 transcription factors is essential for TGF-β1-induced epithelial-mesenchymal transition
-
Medici, D., Hay, E. D. & Goodenough, D. A. Cooperation between snail and LEF-1 transcription factors is essential for TGF-β1-induced epithelial-mesenchymal transition. Mol. Biol. Cell 17, 1871-1879 (2006).
-
(2006)
Mol. Biol. Cell
, vol.17
, pp. 1871-1879
-
-
Medici, D.1
Hay, E.D.2
Goodenough, D.A.3
-
26
-
-
0345599013
-
Autoregulation of E-cadherin expression by cadherin-cadherin interactions: The roles of β-catenin signaling, Slug, and MAPK
-
Conacci-Sorrell, M. et al. Autoregulation of E-cadherin expression by cadherin-cadherin interactions: the roles of β-catenin signaling, Slug, and MAPK. J. Cell Biol. 163, 847-857 (2003).
-
(2003)
J. Cell Biol
, vol.163
, pp. 847-857
-
-
Conacci-Sorrell, M.1
-
27
-
-
33646137784
-
Cooperative action of Sox9, Snail2 and PKA signaling in early neural crest development
-
Sakai, D., Suzuki, T., Osumi, N. & Wakamatsu, Y. Cooperative action of Sox9, Snail2 and PKA signaling in early neural crest development. Development 133, 1323-1333 (2006).
-
(2006)
Development
, vol.133
, pp. 1323-1333
-
-
Sakai, D.1
Suzuki, T.2
Osumi, N.3
Wakamatsu, Y.4
-
28
-
-
0035839534
-
Cloning and characterization of three Xenopus slug promoters reveal direct regulation by Lef/β-catenin signaling
-
Vallin, J. et al. Cloning and characterization of three Xenopus slug promoters reveal direct regulation by Lef/β-catenin signaling. J. Biol. Chem. 276, 30350-30358 (2001).
-
(2001)
J. Biol. Chem
, vol.276
, pp. 30350-30358
-
-
Vallin, J.1
-
29
-
-
33746034613
-
Transforming growth factor-beta employs HMGA2 to elicit epithelial-mesenchymal transition
-
Thuault, S. et al. Transforming growth factor-beta employs HMGA2 to elicit epithelial-mesenchymal transition. J. Cell Biol. 174, 175-183 (2006).
-
(2006)
J. Cell Biol
, vol.174
, pp. 175-183
-
-
Thuault, S.1
-
30
-
-
33746173092
-
Repression of prostaglandin dehydrogenase by epidermal growth factor and snail increases prostaglandin E2 and promotes cancer progression
-
Mann, J. R. et al. Repression of prostaglandin dehydrogenase by epidermal growth factor and snail increases prostaglandin E2 and promotes cancer progression. Cancer Res. 66, 6649-6656 (2006).
-
(2006)
Cancer Res
, vol.66
, pp. 6649-6656
-
-
Mann, J.R.1
-
31
-
-
33744925683
-
Cyclooxygenase-2-dependent regulation of E-cadherin: Prostaglandin E(2) induces transcriptional repressors ZEB1 and snail in non-small cell lung cancer
-
Dohadwala, M. et al. Cyclooxygenase-2-dependent regulation of E-cadherin: prostaglandin E(2) induces transcriptional repressors ZEB1 and snail in non-small cell lung cancer. Cancer Res. 66, 5338-5345 (2006).
-
(2006)
Cancer Res
, vol.66
, pp. 5338-5345
-
-
Dohadwala, M.1
-
32
-
-
29144495415
-
Endothelin-1 promotes epithelial-tomesenchymal transition in human ovarian cancer cells
-
Rosano, L. et al. Endothelin-1 promotes epithelial-tomesenchymal transition in human ovarian cancer cells. Cancer Res. 65, 11649-11657 (2005).
-
(2005)
Cancer Res
, vol.65
, pp. 11649-11657
-
-
Rosano, L.1
-
33
-
-
31544463515
-
Vascular endothelial growth factor receptor-1 activation mediates epithelial to mesenchymal transition in human pancreatic carcinoma cells
-
Yang, A. D. et al. Vascular endothelial growth factor receptor-1 activation mediates epithelial to mesenchymal transition in human pancreatic carcinoma cells. Cancer Res. 66, 46-51 (2006).
-
(2006)
Cancer Res
, vol.66
, pp. 46-51
-
-
Yang, A.D.1
-
34
-
-
9344260855
-
Autocrine motility factor signaling enhances pancreatic cancer metastasis
-
Tsutsumi, S., Yanagawa, T., Shimura, T., Kuwano, H. & Raz, A. Autocrine motility factor signaling enhances pancreatic cancer metastasis. Clin. Cancer Res. 10, 7775-7784 (2004).
-
(2004)
Clin. Cancer Res
, vol.10
, pp. 7775-7784
-
-
Tsutsumi, S.1
Yanagawa, T.2
Shimura, T.3
Kuwano, H.4
Raz, A.5
-
35
-
-
0037103359
-
Zinc-finger transcription factor Slug contributes to the function of the stem cell factor c-kit signaling pathway
-
Perez-Losada, J. et al. Zinc-finger transcription factor Slug contributes to the function of the stem cell factor c-kit signaling pathway. Blood 100, 1274-1286 (2002).
-
(2002)
Blood
, vol.100
, pp. 1274-1286
-
-
Perez-Losada, J.1
-
36
-
-
33847282998
-
Raf 1 represses expression of the tight junction protein occludin via activation of the zinc-finger transcription factor slug
-
Wang, Z. et al. Raf 1 represses expression of the tight junction protein occludin via activation of the zinc-finger transcription factor slug. Oncogene 26, 1222-1230 (2007).
-
(2007)
Oncogene
, vol.26
, pp. 1222-1230
-
-
Wang, Z.1
-
37
-
-
33845932039
-
Calreticulin represses E-cadherin gene expression in Madin-Darby canine kidney cells via Slug
-
Hayashida, Y. et al. Calreticulin represses E-cadherin gene expression in Madin-Darby canine kidney cells via Slug. J. Biol. Chem. 281, 32469-32484 (2006).
-
(2006)
J. Biol. Chem
, vol.281
, pp. 32469-32484
-
-
Hayashida, Y.1
-
38
-
-
33846569179
-
VHL Promotes E2 BOX-dependent E-cadherin Transcription by HIF-mediated Regulation of SIP1 and Snail
-
Evans, A. J. et al. VHL Promotes E2 BOX-dependent E-cadherin Transcription by HIF-mediated Regulation of SIP1 and Snail. Mol. Cell Biol. (2006).
-
(2006)
Mol. Cell Biol
-
-
Evans, A.J.1
-
39
-
-
21844432918
-
Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability
-
Radisky, D. C. et al. Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability. Nature 436, 123-127 (2005).
-
(2005)
Nature
, vol.436
, pp. 123-127
-
-
Radisky, D.C.1
-
40
-
-
27744527762
-
Laminin-5 with transforming growth factor-β1 induces epithelial to mesenchymal transition in hepatocellular carcinoma
-
Giannelli, G., Bergamini, C., Fransvea, E., Sgarra, C. & Antonaci, S. Laminin-5 with transforming growth factor-β1 induces epithelial to mesenchymal transition in hepatocellular carcinoma. Gastroenterology 129, 1375-1383 (2005).
-
(2005)
Gastroenterology
, vol.129
, pp. 1375-1383
-
-
Giannelli, G.1
Bergamini, C.2
Fransvea, E.3
Sgarra, C.4
Antonaci, S.5
-
41
-
-
33744938665
-
Androgen regulation of prostasin gene expression is mediated by sterol-regulatory element-binding proteins and SLUG
-
Chen, M., Chen, L. M. & Chai, K. X. Androgen regulation of prostasin gene expression is mediated by sterol-regulatory element-binding proteins and SLUG. Prostate 66, 911-920 (2006).
-
(2006)
Prostate
, vol.66
, pp. 911-920
-
-
Chen, M.1
Chen, L.M.2
Chai, K.X.3
-
42
-
-
0037453706
-
-
Fujita, N. et al. MTA3, a Mi-2/NuRD complex subunit, regulates an invasive growth pathway in breast cancer. Cell 113, 207-219 (2003). Demonstration of the link between MTA3 and ligated ER with the negative regulation of Snail expression in breast carcinoma cells.
-
Fujita, N. et al. MTA3, a Mi-2/NuRD complex subunit, regulates an invasive growth pathway in breast cancer. Cell 113, 207-219 (2003). Demonstration of the link between MTA3 and ligated ER with the negative regulation of Snail expression in breast carcinoma cells.
-
-
-
-
43
-
-
1642520846
-
Transcriptional activation by the zinc-finger homeodomain protein δ EF1 in estrogen signaling cascades
-
Dillner, N. B. & Sanders, M. M. Transcriptional activation by the zinc-finger homeodomain protein δ EF1 in estrogen signaling cascades. DNA Cell Biol. 23, 25-34 (2004).
-
(2004)
DNA Cell Biol
, vol.23
, pp. 25-34
-
-
Dillner, N.B.1
Sanders, M.M.2
-
44
-
-
33645909102
-
Snail1 transcriptional repressor binds to its own promoter and controls its expression
-
Peiro, S. et al. Snail1 transcriptional repressor binds to its own promoter and controls its expression. Nucleic Acids Res. 34, 2077-2084 (2006).
-
(2006)
Nucleic Acids Res
, vol.34
, pp. 2077-2084
-
-
Peiro, S.1
-
45
-
-
27744550696
-
Regulation of Slug transcription in embryonic ectoderm by β-catenin-Lef/Tcf and BMP-Smad signaling
-
Sakai, D. et al. Regulation of Slug transcription in embryonic ectoderm by β-catenin-Lef/Tcf and BMP-Smad signaling. Dev. Growth Differ. 47, 471-482 (2005).
-
(2005)
Dev. Growth Differ
, vol.47
, pp. 471-482
-
-
Sakai, D.1
-
46
-
-
12144266241
-
Glycogen synthase kinase-3 is an endogenous inhibitor of Snail transcription: Implications for the epithelial-mesenchymal transition
-
Bachelder, R. E., Yoon, S. O., Franci, C., de Herreros, A. G. & Mercurio, A. M. Glycogen synthase kinase-3 is an endogenous inhibitor of Snail transcription: implications for the epithelial-mesenchymal transition. J. Cell Biol. 168, 29-33 (2005).
-
(2005)
J. Cell Biol
, vol.168
, pp. 29-33
-
-
Bachelder, R.E.1
Yoon, S.O.2
Franci, C.3
de Herreros, A.G.4
Mercurio, A.M.5
-
47
-
-
33747625686
-
Hepatocyte growth factor induces cell scattering through MAPK/Egr-1-mediated upregulation of Snail
-
Grotegut, S., von Schweinitz, D., Christofori, G. & Lehembre, F. Hepatocyte growth factor induces cell scattering through MAPK/Egr-1-mediated upregulation of Snail. EMBO J. 25, 3534-3545 (2006).
-
(2006)
EMBO J
, vol.25
, pp. 3534-3545
-
-
Grotegut, S.1
von Schweinitz, D.2
Christofori, G.3
Lehembre, F.4
-
48
-
-
0034680368
-
Snail/slug family of repressors: Slowly going into the fast lane of development and cancer
-
Hemavathy, K., Ashraf, S. I. & Ip, Y. T. Snail/slug family of repressors: slowly going into the fast lane of development and cancer. Gene 257, 1-12 (2000).
-
(2000)
Gene
, vol.257
, pp. 1-12
-
-
Hemavathy, K.1
Ashraf, S.I.2
Ip, Y.T.3
-
49
-
-
23144464750
-
-
Perk, J., Iavarone, A. & Benezra, R. Id family of helixloop-helix proteins in cancer. Nature Rev. Cancer 5, 603-614 (2005). An excellent review of the implication of Id proteins in cancer.
-
Perk, J., Iavarone, A. & Benezra, R. Id family of helixloop-helix proteins in cancer. Nature Rev. Cancer 5, 603-614 (2005). An excellent review of the implication of Id proteins in cancer.
-
-
-
-
50
-
-
0042347689
-
Id proteins in development, cell cycle and cancer
-
Ruzinova, M. B. & Benezra, R. Id proteins in development, cell cycle and cancer. Trends Cell Biol. 13, 410-418 (2003).
-
(2003)
Trends Cell Biol
, vol.13
, pp. 410-418
-
-
Ruzinova, M.B.1
Benezra, R.2
-
51
-
-
0038324071
-
Opposing functions of ZEB proteins in the regulation of the TGFβ/BMP signaling pathway
-
Postigo, A. A. Opposing functions of ZEB proteins in the regulation of the TGFβ/BMP signaling pathway. EMBO J. 22, 2443-2452 (2003).
-
(2003)
EMBO J
, vol.22
, pp. 2443-2452
-
-
Postigo, A.A.1
-
52
-
-
33750328156
-
-
ed. Esteller, M, Springer
-
Peinado, H. & Cano, A. Regulation of the E-cadherin Cell-Cell Adhesion Gene in DNA methylation, epigenetics and metastasis, 157-190 (ed. Esteller, M.) (Springer, 2005).
-
(2005)
Regulation of the E-cadherin Cell-Cell Adhesion Gene in DNA methylation, epigenetics and metastasis
, pp. 157-190
-
-
Peinado, H.1
Cano, A.2
-
53
-
-
5444230567
-
Transcriptional regulation of cadherins during development and carcinogenesis
-
Peinado, H., Portillo, F. & Cano, A. Transcriptional regulation of cadherins during development and carcinogenesis. Int. J. Dev. Biol. 48, 365-375 (2004).
-
(2004)
Int. J. Dev. Biol
, vol.48
, pp. 365-375
-
-
Peinado, H.1
Portillo, F.2
Cano, A.3
-
54
-
-
0033916759
-
Human Slug is a repressor that localizes to sites of active transcription
-
Hemavathy, K., Guru, S. C., Harris, J., Chen, J. D. & Ip, Y. T. Human Slug is a repressor that localizes to sites of active transcription. Mol. Cell Biol. 20, 5087-5095 (2000).
-
(2000)
Mol. Cell Biol
, vol.20
, pp. 5087-5095
-
-
Hemavathy, K.1
Guru, S.C.2
Harris, J.3
Chen, J.D.4
Ip, Y.T.5
-
55
-
-
0346363757
-
Snail mediates E-cadherin repression by the recruitment of the Sin3A/histone deacetylase 1 (HDAC1)/HDAC2 complex
-
Peinado, H., Ballestar, E., Esteller, M. & Cano, A. Snail mediates E-cadherin repression by the recruitment of the Sin3A/histone deacetylase 1 (HDAC1)/HDAC2 complex. Mol. Cell Biol. 24, 306-319 (2004).
-
(2004)
Mol. Cell Biol
, vol.24
, pp. 306-319
-
-
Peinado, H.1
Ballestar, E.2
Esteller, M.3
Cano, A.4
-
56
-
-
20444469625
-
Regulation of BRCA2 gene expression by the SLUG repressor protein in human breast cells
-
Tripathi, M. K. et al. Regulation of BRCA2 gene expression by the SLUG repressor protein in human breast cells. J. Biol. Chem. 280, 17163-17171 (2005).
-
(2005)
J. Biol. Chem
, vol.280
, pp. 17163-17171
-
-
Tripathi, M.K.1
-
57
-
-
33846003783
-
Human SLUG does not directly bind to CtBP1
-
Bailey, C. K., Misra, S., Mittal, M. K. & Chaudhuri, G. Human SLUG does not directly bind to CtBP1. Biochem. Biophys. Res. Commun. 353, 661-664 (2006).
-
(2006)
Biochem. Biophys. Res. Commun
, vol.353
, pp. 661-664
-
-
Bailey, C.K.1
Misra, S.2
Mittal, M.K.3
Chaudhuri, G.4
-
58
-
-
0242669199
-
Coordinated histone modifications mediated by a CtBP co-repressor complex
-
Shi, Y. et al. Coordinated histone modifications mediated by a CtBP co-repressor complex. Nature 422, 735-738 (2003).
-
(2003)
Nature
, vol.422
, pp. 735-738
-
-
Shi, Y.1
-
59
-
-
0037492820
-
Interaction between Smad-interacting protein-1 and the corepressor C-terminal binding protein is dispensable for transcriptional repression of E-cadherin
-
van Grunsven, L. A. et al. Interaction between Smad-interacting protein-1 and the corepressor C-terminal binding protein is dispensable for transcriptional repression of E-cadherin. J. Biol. Chem. 278, 26135-26145 (2003).
-
(2003)
J. Biol. Chem
, vol.278
, pp. 26135-26145
-
-
van Grunsven, L.A.1
-
60
-
-
33748868126
-
The expression levels of the transcriptional regulators p300 and CtBP modulate the correlations between SNAIL, ZEB1, E-cadherin and vitamin D receptor in human colon carcinomas
-
Pena, C. et al. The expression levels of the transcriptional regulators p300 and CtBP modulate the correlations between SNAIL, ZEB1, E-cadherin and vitamin D receptor in human colon carcinomas. Int. J. Cancer 119, 2098-2104 (2006).
-
(2006)
Int. J. Cancer
, vol.119
, pp. 2098-2104
-
-
Pena, C.1
-
61
-
-
0038324070
-
Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins
-
Postigo, A. A., Depp, J. L., Taylor, J. J. & Kroll, K. L. Regulation of Smad signaling through a differential recruitment of coactivators and corepressors by ZEB proteins. EMBO J. 22, 2453-2462 (2003).
-
(2003)
EMBO J
, vol.22
, pp. 2453-2462
-
-
Postigo, A.A.1
Depp, J.L.2
Taylor, J.J.3
Kroll, K.L.4
-
62
-
-
8644237368
-
Nuclear speckle-associated protein Pnn/DRS binds to the transcriptional corepressor CtBP and relieves CtBP-mediated repression of the E-cadherin gene
-
Alpatov, R. et al. Nuclear speckle-associated protein Pnn/DRS binds to the transcriptional corepressor CtBP and relieves CtBP-mediated repression of the E-cadherin gene. Mol. Cell Biol. 24, 10223-10235 (2004).
-
(2004)
Mol. Cell Biol
, vol.24
, pp. 10223-10235
-
-
Alpatov, R.1
-
63
-
-
27444442397
-
Pc2-mediated sumoylation of Smad-interacting protein 1 attenuates transcriptional repression of E-cadherin
-
Long, J., Zuo, D. & Park, M. Pc2-mediated sumoylation of Smad-interacting protein 1 attenuates transcriptional repression of E-cadherin. J. Biol. Chem. 280, 35477-35489 (2005).
-
(2005)
J. Biol. Chem
, vol.280
, pp. 35477-35489
-
-
Long, J.1
Zuo, D.2
Park, M.3
-
64
-
-
33645224806
-
Acetylation by p300 regulates nuclear localization and function of the transcriptional corepressor CtBP2
-
Zhao, L. J., Subramanian, T., Zhou, Y. & Chinnadurai, G. Acetylation by p300 regulates nuclear localization and function of the transcriptional corepressor CtBP2. J. Biol. Chem. 281, 4183-4189 (2006).
-
(2006)
J. Biol. Chem
, vol.281
, pp. 4183-4189
-
-
Zhao, L.J.1
Subramanian, T.2
Zhou, Y.3
Chinnadurai, G.4
-
65
-
-
0037040581
-
Regulation of corepressor function by nuclear NADH
-
Zhang, Q., Piston, D. W. & Goodman, R. H. Regulation of corepressor function by nuclear NADH. Science 295, 1895-1897 (2002).
-
(2002)
Science
, vol.295
, pp. 1895-1897
-
-
Zhang, Q.1
Piston, D.W.2
Goodman, R.H.3
-
66
-
-
5044248294
-
A role for Id in the regulation of TGFβ-induced epithelial-mesenchymal transdifferentiation
-
Kondo, M. et al. A role for Id in the regulation of TGFβ-induced epithelial-mesenchymal transdifferentiation. Cell Death Differ. 11, 1092-1101 (2004).
-
(2004)
Cell Death Differ
, vol.11
, pp. 1092-1101
-
-
Kondo, M.1
-
67
-
-
0038450250
-
Phosphorylation regulates the subcellular location and activity of the snail transcriptional repressor
-
Dominguez, D. et al. Phosphorylation regulates the subcellular location and activity of the snail transcriptional repressor. Mol. Cell Biol. 23, 5078-5089 (2003).
-
(2003)
Mol. Cell Biol
, vol.23
, pp. 5078-5089
-
-
Dominguez, D.1
-
68
-
-
16844377441
-
Pak1 phosphorylation of snail, a master regulator of epithelial-to-mesenchyme transition, modulates snail's subcellular localization and functions
-
Yang, Z. et al. Pak1 phosphorylation of snail, a master regulator of epithelial-to-mesenchyme transition, modulates snail's subcellular localization and functions. Cancer Res. 65, 3179-3184 (2005).
-
(2005)
Cancer Res
, vol.65
, pp. 3179-3184
-
-
Yang, Z.1
-
69
-
-
2442674220
-
Zinc transporter LIVI controls epithelial-mesenchymal transition in zebrafish gastrula organizer
-
Yamashita, S. et al. Zinc transporter LIVI controls epithelial-mesenchymal transition in zebrafish gastrula organizer. Nature 429, 298-302 (2004).
-
(2004)
Nature
, vol.429
, pp. 298-302
-
-
Yamashita, S.1
-
70
-
-
5444269904
-
-
Zhou, B. P. et al. Dual regulation of Snail by GSK-3β-mediated phosphorylation in control of epithelialmesenchymal transition. Nature Cell Biol. 6, 931-940 (2004). Pioneering study that showed the posttranscriptional regulation of SNAI1 subcellular localization and stability by GSK3β kinase.
-
Zhou, B. P. et al. Dual regulation of Snail by GSK-3β-mediated phosphorylation in control of epithelialmesenchymal transition. Nature Cell Biol. 6, 931-940 (2004). Pioneering study that showed the posttranscriptional regulation of SNAI1 subcellular localization and stability by GSK3β kinase.
-
-
-
-
71
-
-
33751514601
-
A Wnt-Axin2-GSK3β cascade regulates Snail1 activity in breast cancer cells
-
Yook, J. I. et al. A Wnt-Axin2-GSK3β cascade regulates Snail1 activity in breast cancer cells. Nature Cell Biol. 8, 1398-1406 (2006).
-
(2006)
Nature Cell Biol
, vol.8
, pp. 1398-1406
-
-
Yook, J.I.1
-
72
-
-
27144518237
-
-
Peinado, H. et al. A molecular role for lysyl oxidase-like 2 enzyme in snail regulation and tumor progression. EMBO J. 24, 3446-3458 (2005). Showed for the first time that LOXL2 and/or LOXL3 regulate SNAI1 protein stability and functional activity.
-
Peinado, H. et al. A molecular role for lysyl oxidase-like 2 enzyme in snail regulation and tumor progression. EMBO J. 24, 3446-3458 (2005). Showed for the first time that LOXL2 and/or LOXL3 regulate SNAI1 protein stability and functional activity.
-
-
-
-
73
-
-
29244463349
-
Switching on-off Snail: LOXL2 versus GSK3β
-
Peinado, H., Portillo, F. & Cano, A. Switching on-off Snail: LOXL2 versus GSK3β. Cell Cycle 4, 1749-1752 (2005).
-
(2005)
Cell Cycle
, vol.4
, pp. 1749-1752
-
-
Peinado, H.1
Portillo, F.2
Cano, A.3
-
74
-
-
33749391866
-
Slug stability is dynamically regulated during neural crest development by the F-box protein Ppa
-
Vernon, A. E. & Labonne, C. Slug stability is dynamically regulated during neural crest development by the F-box protein Ppa. Development 133, 3359-3370 (2006).
-
(2006)
Development
, vol.133
, pp. 3359-3370
-
-
Vernon, A.E.1
Labonne, C.2
-
75
-
-
16344385453
-
-
Lluis, F., Ballestar, E., Suelves, M., Esteller, M. & Munoz-Canoves, P. E47 phosphorylation by p38 MAPK promotes MyoD/E47 association and muscle-specific gene transcription. EMBO J. 24, 974-984 (2005).
-
Lluis, F., Ballestar, E., Suelves, M., Esteller, M. & Munoz-Canoves, P. E47 phosphorylation by p38 MAPK promotes MyoD/E47 association and muscle-specific gene transcription. EMBO J. 24, 974-984 (2005).
-
-
-
-
76
-
-
0034617278
-
Serine/Threonine kinases 3pK and MAPK-activated protein kinase 2 interact with the basic helix-loop-helix transcription factor E47 and repress its transcriptional activity
-
Neufeld, B. et al. Serine/Threonine kinases 3pK and MAPK-activated protein kinase 2 interact with the basic helix-loop-helix transcription factor E47 and repress its transcriptional activity. J. Biol. Chem. 275, 20239-20242 (2000).
-
(2000)
J. Biol. Chem
, vol.275
, pp. 20239-20242
-
-
Neufeld, B.1
-
77
-
-
0035896595
-
Identification of the E2A gene products as regulatory targets of the G1 cyclin-dependent kinases
-
Chu, C. & Kohtz, D. S. Identification of the E2A gene products as regulatory targets of the G1 cyclin-dependent kinases. J. Biol. Chem. 276, 8524-8534 (2001).
-
(2001)
J. Biol. Chem
, vol.276
, pp. 8524-8534
-
-
Chu, C.1
Kohtz, D.S.2
-
78
-
-
0242556813
-
Notch-induced E2A ubiquitination and degradation are controlled by MAP kinase activities
-
Nie, L., Xu, M., Vladimirova, A. & Sun, X. H. Notch-induced E2A ubiquitination and degradation are controlled by MAP kinase activities. EMBO J. 22, 5780-5792 (2003).
-
(2003)
EMBO J
, vol.22
, pp. 5780-5792
-
-
Nie, L.1
Xu, M.2
Vladimirova, A.3
Sun, X.H.4
-
79
-
-
33750358078
-
Genetic profiling of epithelial cells expressing e-cadherin repressors reveals a distinct role for snail, slug, and e47 factors in epithelial-mesenchymal transition
-
Moreno-Bueno, G. et al. Genetic profiling of epithelial cells expressing e-cadherin repressors reveals a distinct role for snail, slug, and e47 factors in epithelial-mesenchymal transition. Cancer Res. 66, 9543-9556 (2006).
-
(2006)
Cancer Res
, vol.66
, pp. 9543-9556
-
-
Moreno-Bueno, G.1
-
80
-
-
29344474933
-
Mouse cDNA microarray analysis uncovers Slug targets in mouse embryonic fibroblasts
-
Bermejo-Rodriguez, C. et al. Mouse cDNA microarray analysis uncovers Slug targets in mouse embryonic fibroblasts. Genomics 87, 113-118 (2006).
-
(2006)
Genomics
, vol.87
, pp. 113-118
-
-
Bermejo-Rodriguez, C.1
-
81
-
-
29144485712
-
SIP1/ZEB2 induces EMT by repressing genes of different epithelial cell-cell junctions
-
Vandewalle, C. et al. SIP1/ZEB2 induces EMT by repressing genes of different epithelial cell-cell junctions. Nucleic Acids Res. 33, 6566-6578 (2005).
-
(2005)
Nucleic Acids Res
, vol.33
, pp. 6566-6578
-
-
Vandewalle, C.1
-
82
-
-
33751582928
-
Snail activation disrupts tissue homeostasis and induces fibrosis in the adult kidney
-
Boutet, A. et al. Snail activation disrupts tissue homeostasis and induces fibrosis in the adult kidney. EMBO J. 25, 5603-5613 (2006).
-
(2006)
EMBO J
, vol.25
, pp. 5603-5613
-
-
Boutet, A.1
-
83
-
-
33748279836
-
Snail controls differentiation of hepatocytes by repressing HNF4α expression
-
Cicchini, C. et al. Snail controls differentiation of hepatocytes by repressing HNF4α expression. J. Cell Physiol. 209, 230-238 (2006).
-
(2006)
J. Cell Physiol
, vol.209
, pp. 230-238
-
-
Cicchini, C.1
-
84
-
-
22244432840
-
The transcription factor snail induces tumor cell invasion through modulation of the epithelial cell differentiation program
-
De Craene, B. et al. The transcription factor snail induces tumor cell invasion through modulation of the epithelial cell differentiation program. Cancer Res. 65, 6237-6244 (2005).
-
(2005)
Cancer Res
, vol.65
, pp. 6237-6244
-
-
De Craene, B.1
-
85
-
-
4644229397
-
The transcription factor SNAIL represses vitamin D receptor expression and responsiveness in human colon cancer
-
Palmer, H. G. et al. The transcription factor SNAIL represses vitamin D receptor expression and responsiveness in human colon cancer. Nature Med. 10, 917-919 (2004).
-
(2004)
Nature Med
, vol.10
, pp. 917-919
-
-
Palmer, H.G.1
-
86
-
-
4344662447
-
Aberrant expression of the transcription factors snail and slug alters the response to genotoxic stress
-
Kajita, M., McClinic, K. N. & Wade, P. A. Aberrant expression of the transcription factors snail and slug alters the response to genotoxic stress. Mol. Cell Biol. 24, 7559-7566 (2004).
-
(2004)
Mol. Cell Biol
, vol.24
, pp. 7559-7566
-
-
Kajita, M.1
McClinic, K.N.2
Wade, P.A.3
-
87
-
-
27744547091
-
Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma
-
Wu, W. S. et al. Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma. Cell 123, 641-653 (2005).
-
(2005)
Cell
, vol.123
, pp. 641-653
-
-
Wu, W.S.1
-
88
-
-
1542373736
-
Repression of Na, K-ATPase β1-subunit by the transcription factor snail in carcinoma
-
Espineda, C. E., Chang, J. H., Twiss, J., Rajasekaran, S. A. & Rajasekaran, A. K. Repression of Na, K-ATPase β1-subunit by the transcription factor snail in carcinoma. Mol. Biol. Cell. 15, 1364-1373 (2004).
-
(2004)
Mol. Biol. Cell
, vol.15
, pp. 1364-1373
-
-
Espineda, C.E.1
Chang, J.H.2
Twiss, J.3
Rajasekaran, S.A.4
Rajasekaran, A.K.5
-
89
-
-
22344441001
-
The zinc-finger transcription factor Snail downregulates proliferating cell nuclear antigen expression in colorectal carcinoma cells
-
Park, J. H. et al. The zinc-finger transcription factor Snail downregulates proliferating cell nuclear antigen expression in colorectal carcinoma cells. Int. J. Oncol. 26, 1541-1547 (2005).
-
(2005)
Int. J. Oncol
, vol.26
, pp. 1541-1547
-
-
Park, J.H.1
-
90
-
-
33750869288
-
A ubiquitin ligase, skeletrophin, is a negative regulator of melanoma invasion
-
Takeuchi, T., Adachi, Y., Sonobe, H., Furihata, M. & Ohtsuki, Y. A ubiquitin ligase, skeletrophin, is a negative regulator of melanoma invasion. Oncogene 25, 7059-7069 (2006).
-
(2006)
Oncogene
, vol.25
, pp. 7059-7069
-
-
Takeuchi, T.1
Adachi, Y.2
Sonobe, H.3
Furihata, M.4
Ohtsuki, Y.5
-
91
-
-
2442705493
-
Snail blocks the cell cycle and confers resistance to cell death
-
Vega, S. et al. Snail blocks the cell cycle and confers resistance to cell death. Genes Dev. 18, 1131-1143 (2004).
-
(2004)
Genes Dev
, vol.18
, pp. 1131-1143
-
-
Vega, S.1
-
92
-
-
0142211292
-
Mouse Snail family transcription repressors regulate chondrocyte, extracellular matrix, type II collagen, and aggrecan
-
Seki, K. et al. Mouse Snail family transcription repressors regulate chondrocyte, extracellular matrix, type II collagen, and aggrecan. J. Biol. Chem. 278, 41862-41870 (2003).
-
(2003)
J. Biol. Chem
, vol.278
, pp. 41862-41870
-
-
Seki, K.1
-
93
-
-
33746365139
-
Slug regulates integrin expression and cell proliferation in human epidermal keratinocytes
-
Turner, F. E. et al. Slug regulates integrin expression and cell proliferation in human epidermal keratinocytes. J. Biol. Chem. 281, 21321-21331 (2006).
-
(2006)
J. Biol. Chem
, vol.281
, pp. 21321-21331
-
-
Turner, F.E.1
-
94
-
-
8844274852
-
Snail regulates p21(WAF/CIP1) expression in cooperation with E2A and Twist
-
Takahashi, E. et al. Snail regulates p21(WAF/CIP1) expression in cooperation with E2A and Twist. Biochem. Biophys. Res. Commun. 325, 1136-1144 (2004).
-
(2004)
Biochem. Biophys. Res. Commun
, vol.325
, pp. 1136-1144
-
-
Takahashi, E.1
-
95
-
-
0037131409
-
Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression
-
Guaita, S. et al. Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression. J. Biol. Chem. 277, 39209-39216 (2002).
-
(2002)
J. Biol. Chem
, vol.277
, pp. 39209-39216
-
-
Guaita, S.1
-
96
-
-
27744542002
-
Regulation of ocular lens development by Smad-interacting protein 1 involving Foxe3 activation
-
Yoshimoto, A., Saigou, Y., Higashi, Y. & Kondoh, H. Regulation of ocular lens development by Smad-interacting protein 1 involving Foxe3 activation. Development 132, 4437-4448 (2005).
-
(2005)
Development
, vol.132
, pp. 4437-4448
-
-
Yoshimoto, A.1
Saigou, Y.2
Higashi, Y.3
Kondoh, H.4
-
97
-
-
33645733588
-
N-cadherin gene expression in prostate carcinoma is modulated by integrin-dependent nuclear translocation of Twist1
-
Alexander, N. R. et al. N-cadherin gene expression in prostate carcinoma is modulated by integrin-dependent nuclear translocation of Twist1. Cancer Res. 66, 3365-3369 (2006).
-
(2006)
Cancer Res
, vol.66
, pp. 3365-3369
-
-
Alexander, N.R.1
-
98
-
-
3843115623
-
Regulation of cellular senescence and p16(INK4a) expression by Id1 and E47 proteins in human diploid fibroblast
-
Zheng, W., Wang, H., Xue, L., Zhang, Z. & Tong, T. Regulation of cellular senescence and p16(INK4a) expression by Id1 and E47 proteins in human diploid fibroblast. J. Biol. Chem. 279, 31524-31532 (2004).
-
(2004)
J. Biol. Chem
, vol.279
, pp. 31524-31532
-
-
Zheng, W.1
Wang, H.2
Xue, L.3
Zhang, Z.4
Tong, T.5
-
99
-
-
0038370027
-
Smooth muscle α-actin gene requires two E-boxes for proper expression in vivo and is a target of class I basic helix-loop-helix proteins
-
Kumar, M. S., Hendrix, J. A., Johnson, A. D. & Owens, G. K. Smooth muscle α-actin gene requires two E-boxes for proper expression in vivo and is a target of class I basic helix-loop-helix proteins. Circ. Res. 92, 840-847 (2003).
-
(2003)
Circ. Res
, vol.92
, pp. 840-847
-
-
Kumar, M.S.1
Hendrix, J.A.2
Johnson, A.D.3
Owens, G.K.4
-
100
-
-
33747005330
-
Involvement of Ets-1 transcription factor in inducing matrix metalloproteinase-2 expression by epithelial-mesenchymal transition in human squamous carcinoma cells
-
Taki, M., Verschueren, K., Yokoyama, K., Nagayama, M. & Kamata, N. Involvement of Ets-1 transcription factor in inducing matrix metalloproteinase-2 expression by epithelial-mesenchymal transition in human squamous carcinoma cells. Int. J. Oncol. 28, 487-496 (2006).
-
(2006)
Int. J. Oncol
, vol.28
, pp. 487-496
-
-
Taki, M.1
Verschueren, K.2
Yokoyama, K.3
Nagayama, M.4
Kamata, N.5
-
101
-
-
24344483881
-
Upregulation of MMP-9 in MDCK epithelial cell line in response to expression of the Snail transcription factor
-
Jorda, M. et al. Upregulation of MMP-9 in MDCK epithelial cell line in response to expression of the Snail transcription factor. J. Cell Sci. 118, 3371-3385 (2005).
-
(2005)
J. Cell Sci
, vol.118
, pp. 3371-3385
-
-
Jorda, M.1
-
102
-
-
0033568198
-
New mode of DNA binding of multi-zinc finger transcription factors: δEF1 family members bind with two hands to two target sites
-
Remacle, J. E. et al. New mode of DNA binding of multi-zinc finger transcription factors: δEF1 family members bind with two hands to two target sites. EMBO J. 18, 5073-5084 (1999).
-
(1999)
EMBO J
, vol.18
, pp. 5073-5084
-
-
Remacle, J.E.1
-
103
-
-
85047698213
-
Correlation of Snail expression with histological grade and lymph node status in breast carcinomas
-
Blanco, M. J. et al. Correlation of Snail expression with histological grade and lymph node status in breast carcinomas. Oncogene 21, 3241-3246 (2002).
-
(2002)
Oncogene
, vol.21
, pp. 3241-3246
-
-
Blanco, M.J.1
-
104
-
-
0035963314
-
-
Cheng, C. W. et al. Mechanisms of inactivation of E-cadherin in breast carcinoma: modification of the two-hit hypothesis of tumor suppressor gene. Oncogene 20, 3814-3823 (2001). First indication that transcriptional repression mechanisms have a dynamic role in E-cadherin downregulation.
-
Cheng, C. W. et al. Mechanisms of inactivation of E-cadherin in breast carcinoma: modification of the two-hit hypothesis of tumor suppressor gene. Oncogene 20, 3814-3823 (2001). First indication that transcriptional repression mechanisms have a dynamic role in E-cadherin downregulation.
-
-
-
-
105
-
-
33749371302
-
Snail and slug play distinct roles during breast carcinoma progression
-
Come, C. et al. Snail and slug play distinct roles during breast carcinoma progression. Clin. Cancer Res. 12, 5395-5402 (2006).
-
(2006)
Clin. Cancer Res
, vol.12
, pp. 5395-5402
-
-
Come, C.1
-
106
-
-
16844368863
-
Snail, Slug, and Smad-interacting protein 1 as novel parameters of disease aggressiveness in metastatic ovarian and breast carcinoma
-
Elloul, S. et al. Snail, Slug, and Smad-interacting protein 1 as novel parameters of disease aggressiveness in metastatic ovarian and breast carcinoma. Cancer 103, 1631-1643 (2005).
-
(2005)
Cancer
, vol.103
, pp. 1631-1643
-
-
Elloul, S.1
-
107
-
-
24944450362
-
-
Moody, S. E. et al. The transcriptional repressor Snail promotes mammary tumor recurrence. Cancer Cell 8, 197-209 (2005). First implication of SNAI1 in breast cancer recurrence.
-
Moody, S. E. et al. The transcriptional repressor Snail promotes mammary tumor recurrence. Cancer Cell 8, 197-209 (2005). First implication of SNAI1 in breast cancer recurrence.
-
-
-
-
108
-
-
21244437500
-
Expression of the transcription factors snail, slug, and twist and their clinical significance in human breast cancer
-
Martin, T. A., Goyal, A., Watkins, G. & Jiang, W. G. Expression of the transcription factors snail, slug, and twist and their clinical significance in human breast cancer. Ann. Surg. Oncol. 12, 488-496 (2005).
-
(2005)
Ann. Surg. Oncol
, vol.12
, pp. 488-496
-
-
Martin, T.A.1
Goyal, A.2
Watkins, G.3
Jiang, W.G.4
-
109
-
-
33750866948
-
Expression of E-cadherin transcriptional regulators in ovarian carcinoma
-
Elloul, S. et al. Expression of E-cadherin transcriptional regulators in ovarian carcinoma. Virchows Arch. 449, 520-528 (2006).
-
(2006)
Virchows Arch
, vol.449
, pp. 520-528
-
-
Elloul, S.1
-
110
-
-
27944447368
-
E-cadherin and vitamin D receptor regulation by SNAIL and ZEB1 in colon cancer: Clinicopathological correlations
-
Pena, C. et al. E-cadherin and vitamin D receptor regulation by SNAIL and ZEB1 in colon cancer: clinicopathological correlations. Hum. Mol. Genet. 14, 3361-3370 (2005).
-
(2005)
Hum. Mol. Genet
, vol.14
, pp. 3361-3370
-
-
Pena, C.1
-
111
-
-
33746658173
-
Effects of 1α, 25-dihydroxyvitamin D3 in human colon cancer cells
-
Gonzalez-Sancho, J. M., Larriba, M. J., Ordonez-Moran, P., Palmer, H. G. & Muñoz, A. Effects of 1α, 25-dihydroxyvitamin D3 in human colon cancer cells. Anticancer Res. 26, 2669-2681 (2006).
-
(2006)
Anticancer Res
, vol.26
, pp. 2669-2681
-
-
Gonzalez-Sancho, J.M.1
Larriba, M.J.2
Ordonez-Moran, P.3
Palmer, H.G.4
Muñoz, A.5
-
112
-
-
14544297919
-
The transcriptional repressor SNAIL is overexpressed in human colon cancer
-
Roy, H. K., Smyrk, T. C., Koetsier, J., Victor, T. A. & Wali, R. K. The transcriptional repressor SNAIL is overexpressed in human colon cancer. Dig. Dis. Sci. 50, 42-46 (2005).
-
(2005)
Dig. Dis. Sci
, vol.50
, pp. 42-46
-
-
Roy, H.K.1
Smyrk, T.C.2
Koetsier, J.3
Victor, T.A.4
Wali, R.K.5
-
113
-
-
33745086313
-
Slug expression is an independent prognostic parameter for poor survival in colorectal carcinoma patients
-
Shioiri, M. et al. Slug expression is an independent prognostic parameter for poor survival in colorectal carcinoma patients. Br. J. Cancer 94, 1816-1822 (2006).
-
(2006)
Br. J. Cancer
, vol.94
, pp. 1816-1822
-
-
Shioiri, M.1
-
114
-
-
0036840363
-
Differential expression of the epithelial-mesenchymal transition regulators snail, SIP1, and twist in gastric cancer
-
Rosivatz, E. et al. Differential expression of the epithelial-mesenchymal transition regulators snail, SIP1, and twist in gastric cancer. Am. J. Pathol. 161, 1881-1891 (2002).
-
(2002)
Am. J. Pathol
, vol.161
, pp. 1881-1891
-
-
Rosivatz, E.1
-
115
-
-
33644821841
-
Expression and nuclear localization of Snail, an E-cadherin repressor, in adenocarcinomas of the upper gastrointestinal tract
-
Rosivatz, E. et al. Expression and nuclear localization of Snail, an E-cadherin repressor, in adenocarcinomas of the upper gastrointestinal tract. Virchows Arch. 448, 277-287 (2006).
-
(2006)
Virchows Arch
, vol.448
, pp. 277-287
-
-
Rosivatz, E.1
-
116
-
-
3042766369
-
E-cadherin expression in patients with esophageal squamous cell carcinoma: Promoter hypermethylation, Snail overexpression, and clinicopathologic implications
-
Takeno, S. et al. E-cadherin expression in patients with esophageal squamous cell carcinoma: promoter hypermethylation, Snail overexpression, and clinicopathologic implications. Am. J. Clin. Pathol. 122, 78-84 (2004).
-
(2004)
Am. J. Clin. Pathol
, vol.122
, pp. 78-84
-
-
Takeno, S.1
-
117
-
-
31544465282
-
Overexpression of NBS1 induces epithelial-mesenchymal transition and co-expression of NBS1 and Snail predicts metastasis of head and neck cancer
-
Yang, M. H. et al. Overexpression of NBS1 induces epithelial-mesenchymal transition and co-expression of NBS1 and Snail predicts metastasis of head and neck cancer. Clin. Cancer Res.12, 507-515 (2006).
-
(2006)
Clin. Cancer Res
, vol.12
, pp. 507-515
-
-
Yang, M.H.1
-
118
-
-
0038744921
-
Increased invasion and matrix metalloproteinase-2 expression by Snail-induced mesenchymal transition in squamous cell carcinomas
-
Yokoyama, K. et al. Increased invasion and matrix metalloproteinase-2 expression by Snail-induced mesenchymal transition in squamous cell carcinomas. Int. J. Oncol. 22, 891-898 (2003).
-
(2003)
Int. J. Oncol
, vol.22
, pp. 891-898
-
-
Yokoyama, K.1
-
119
-
-
14844297318
-
Snail accelerates cancer invasion by upregulating MMP expression and is associated with poor prognosis of hepatocellular carcinoma
-
Miyoshi, A. et al. Snail accelerates cancer invasion by upregulating MMP expression and is associated with poor prognosis of hepatocellular carcinoma. Br. J. Cancer 92, 252-258 (2005).
-
(2005)
Br. J. Cancer
, vol.92
, pp. 252-258
-
-
Miyoshi, A.1
-
120
-
-
0038155087
-
Transcriptional repressor snail and progression of human hepatocellular carcinoma
-
Sugimachi, K. et al. Transcriptional repressor snail and progression of human hepatocellular carcinoma. Clin. Cancer Res. 9, 2657-2664 (2003).
-
(2003)
Clin. Cancer Res
, vol.9
, pp. 2657-2664
-
-
Sugimachi, K.1
-
121
-
-
12944277027
-
Slug expression in the E-cadherin preserved tumors is related to prognosis in patients with esophageal squamous cell carcinoma
-
Uchikado, Y. et al. Slug expression in the E-cadherin preserved tumors is related to prognosis in patients with esophageal squamous cell carcinoma. Clin. Cancer Res. 11, 1174-1180 (2005).
-
(2005)
Clin. Cancer Res
, vol.11
, pp. 1174-1180
-
-
Uchikado, Y.1
-
122
-
-
28144456743
-
Transcription repressor slug promotes carcinoma invasion and predicts outcome of patients with lung adenocarcinoma
-
Shih, J. Y. et al. Transcription repressor slug promotes carcinoma invasion and predicts outcome of patients with lung adenocarcinoma. Clin. Cancer Res. 11, 8070-8078 (2005).
-
(2005)
Clin. Cancer Res
, vol.11
, pp. 8070-8078
-
-
Shih, J.Y.1
-
123
-
-
33750987299
-
Expression of Snail, Slug and SIP1 in malignant mesothelioma effusions is associated with matrix metalloproteinase, but not with cadherin expression
-
Sivertsen, S. et al. Expression of Snail, Slug and SIP1 in malignant mesothelioma effusions is associated with matrix metalloproteinase, but not with cadherin expression. Lung Cancer 54, 309-317 (2006).
-
(2006)
Lung Cancer
, vol.54
, pp. 309-317
-
-
Sivertsen, S.1
-
124
-
-
9644275579
-
E-cadherin mutation and Snail overexpression as alternative mechanisms of E-cadherin inactivation in synovial sarcoma
-
Saito, T. et al. E-cadherin mutation and Snail overexpression as alternative mechanisms of E-cadherin inactivation in synovial sarcoma. Oncogene 23, 8629-8638 (2004).
-
(2004)
Oncogene
, vol.23
, pp. 8629-8638
-
-
Saito, T.1
-
125
-
-
25844508786
-
The melanocyte differentiation program predisposes to metastasis after neoplastic transformation
-
Gupta, P. B. et al. The melanocyte differentiation program predisposes to metastasis after neoplastic transformation. Nature Genet. 37, 1047-1054 (2005).
-
(2005)
Nature Genet
, vol.37
, pp. 1047-1054
-
-
Gupta, P.B.1
-
126
-
-
0037064125
-
Biological potential of a functional human SNAIL retrogene
-
Locascio, A., Vega, S., de Frutos, C. A., Manzanares, M. & Nieto, M. A. Biological potential of a functional human SNAIL retrogene. J. Biol. Chem. 277, 38803-38809 (2002).
-
(2002)
J. Biol. Chem
, vol.277
, pp. 38803-38809
-
-
Locascio, A.1
Vega, S.2
de Frutos, C.A.3
Manzanares, M.4
Nieto, M.A.5
-
127
-
-
33747835524
-
-
Franci, C. et al. Expression of Snail protein in tumor-stroma interface. Oncogene 25, 5134-5144 (2006). The first studty to show a reliable expression of SNAI1 by immunohistochemistry in human tumours.
-
Franci, C. et al. Expression of Snail protein in tumor-stroma interface. Oncogene 25, 5134-5144 (2006). The first studty to show a reliable expression of SNAI1 by immunohistochemistry in human tumours.
-
-
-
-
128
-
-
33644821962
-
Expression of SIP1 in oral squamous cell carcinomas: Implications for E-cadherin expression and tumor progression
-
Maeda, G. et al. Expression of SIP1 in oral squamous cell carcinomas: implications for E-cadherin expression and tumor progression. Int. J. Oncol. 27, 1535-1541 (2005).
-
(2005)
Int. J. Oncol
, vol.27
, pp. 1535-1541
-
-
Maeda, G.1
-
129
-
-
34147147030
-
Collagen type I-induced Smad-interacting protein 1 expression downregulates E-cadherin in pancreatic cancer
-
Imamichi, Y., Konig, A., Gress, T. & Menke, A. Collagen type I-induced Smad-interacting protein 1 expression downregulates E-cadherin in pancreatic cancer. Oncogene 26, 2381-2385 (2007).
-
(2007)
Oncogene
, vol.26
, pp. 2381-2385
-
-
Imamichi, Y.1
Konig, A.2
Gress, T.3
Menke, A.4
-
130
-
-
33645732687
-
The transcription factor ZEB1 is aberrantly expressed in aggressive uterine cancers
-
Spoelstra, N. S. et al. The transcription factor ZEB1 is aberrantly expressed in aggressive uterine cancers. Cancer Res. 66, 3893-3902 (2006).
-
(2006)
Cancer Res
, vol.66
, pp. 3893-3902
-
-
Spoelstra, N.S.1
-
131
-
-
28344444026
-
Twist overexpression induces in vivo angiogenesis and correlates with chromosomal instability in breast cancer
-
Mironchik, Y. et al. Twist overexpression induces in vivo angiogenesis and correlates with chromosomal instability in breast cancer. Cancer Res. 65, 10801-10809 (2005).
-
(2005)
Cancer Res
, vol.65
, pp. 10801-10809
-
-
Mironchik, Y.1
-
132
-
-
0037479867
-
Epigenetic and genetic alterations of APC and CDH1 genes in lobular breast cancer: Relationships with abnormal E-cadherin and catenin expression and microsatellite instability
-
Sarrio, D. et al. Epigenetic and genetic alterations of APC and CDH1 genes in lobular breast cancer: relationships with abnormal E-cadherin and catenin expression and microsatellite instability. Int. J. Cancer 106, 208-215 (2003).
-
(2003)
Int. J. Cancer
, vol.106
, pp. 208-215
-
-
Sarrio, D.1
-
133
-
-
20444453337
-
Up-regulation of TWIST in prostate cancer and its implication as a therapeutic target
-
Kwok, W. K. et al. Up-regulation of TWIST in prostate cancer and its implication as a therapeutic target. Cancer Res. 65, 5153-5162 (2005).
-
(2005)
Cancer Res
, vol.65
, pp. 5153-5162
-
-
Kwok, W.K.1
-
134
-
-
34249866557
-
Up-regulation of TWIST in oesophageal squamous cell carcinoma is associated with neoplastic transformation and distant metastasis
-
August, doi: 10.1036/jcp2006.039099
-
Yuen, H. F. et al. Up-regulation of TWIST in oesophageal squamous cell carcinoma is associated with neoplastic transformation and distant metastasis. J. Clin. Pathol. August 2006 (doi: 10.1036/jcp2006.039099).
-
(2006)
J. Clin. Pathol
-
-
Yuen, H.F.1
-
135
-
-
33749344520
-
Twist overexpression correlates with hepatocellular carcinoma metastasis through induction of epithelial-mesenchymal transition
-
Lee, T. K. et al. Twist overexpression correlates with hepatocellular carcinoma metastasis through induction of epithelial-mesenchymal transition. Clin. Cancer Res. 12, 5369-5376 (2006).
-
(2006)
Clin. Cancer Res
, vol.12
, pp. 5369-5376
-
-
Lee, T.K.1
-
136
-
-
33645127568
-
High Twist expression is involved in infiltrative endometrial cancer and affects patient survival
-
Kyo, S. et al. High Twist expression is involved in infiltrative endometrial cancer and affects patient survival. Hum. Pathol. 37, 431-438 (2006).
-
(2006)
Hum. Pathol
, vol.37
, pp. 431-438
-
-
Kyo, S.1
-
137
-
-
3442894137
-
Expression profiling reveals novel pathways in the transformation of melanocytes to melanomas
-
Hoek, K. et al. Expression profiling reveals novel pathways in the transformation of melanocytes to melanomas. Cancer Res. 64, 5270-5282 (2004).
-
(2004)
Cancer Res
, vol.64
, pp. 5270-5282
-
-
Hoek, K.1
-
138
-
-
33845325353
-
Reassessment of id1 protein expression in human mammary, prostate, and bladder cancers using a monospecific rabbit monoclonal anti-id1 antibody
-
Perk, J. et al. Reassessment of id1 protein expression in human mammary, prostate, and bladder cancers using a monospecific rabbit monoclonal anti-id1 antibody. Cancer Res. 66, 10870-10877 (2006).
-
(2006)
Cancer Res
, vol.66
, pp. 10870-10877
-
-
Perk, J.1
-
139
-
-
33947528384
-
Snail silencing effectively suppresses tumour growth and invasiveness
-
Olmeda, D., Jorda, M., Peinado, H., Fabra, A. & Cano, A. Snail silencing effectively suppresses tumour growth and invasiveness. Oncogene 26, 1862-1874 (2007).
-
(2007)
Oncogene
, vol.26
, pp. 1862-1874
-
-
Olmeda, D.1
Jorda, M.2
Peinado, H.3
Fabra, A.4
Cano, A.5
-
140
-
-
14644405666
-
A signaling pathway involving TGFβ2 and Snail in hair follicle morphogenesis
-
Jamora, C. et al. A signaling pathway involving TGFβ2 and Snail in hair follicle morphogenesis. PLoS Biol. 3, e11 (2005).
-
(2005)
PLoS Biol
, vol.3
-
-
Jamora, C.1
-
141
-
-
0033197540
-
-
Metzstein, M. M. & Horvitz, H. R. The C. elegans cell death specification gene ces-1 encodes a snail family zinc finger protein. Mol. Cell 4, 309-319 (1999).
-
Metzstein, M. M. & Horvitz, H. R. The C. elegans cell death specification gene ces-1 encodes a snail family zinc finger protein. Mol. Cell 4, 309-319 (1999).
-
-
-
-
142
-
-
0033197879
-
SLUG, a ces-1-related zinc finger transcription factor gene with antiapoptotic activity, is a downstream target of the E2A-HLF oncoprotein
-
Inukai, T. et al. SLUG, a ces-1-related zinc finger transcription factor gene with antiapoptotic activity, is a downstream target of the E2A-HLF oncoprotein. Mol. Cell 4, 343-352 (1999).
-
(1999)
Mol. Cell
, vol.4
, pp. 343-352
-
-
Inukai, T.1
-
143
-
-
19044372843
-
-
Inoue, A. et al. Slug, a highly conserved zinc finger transcriptional repressor, protects hematopoietic progenitor cells from radiation-induced apoptosis in vivo. Cancer Cell 2, 279-288 (2002). Functional characterization of the role of SNAI2 in the survival of haematological precursor cells.
-
Inoue, A. et al. Slug, a highly conserved zinc finger transcriptional repressor, protects hematopoietic progenitor cells from radiation-induced apoptosis in vivo. Cancer Cell 2, 279-288 (2002). Functional characterization of the role of SNAI2 in the survival of haematological precursor cells.
-
-
-
-
144
-
-
0038713805
-
The radioresistance biological function of the SCF/kit signaling pathway is mediated by the zinc-finger transcription factor Slug
-
Perez-Losada, J., Sanchez-Martin, M., Perez-Caro, M., Perez-Mancera, P. A. & Sanchez-Garcia, I. The radioresistance biological function of the SCF/kit signaling pathway is mediated by the zinc-finger transcription factor Slug. Oncogene 22, 4205-4211 (2003).
-
(2003)
Oncogene
, vol.22
, pp. 4205-4211
-
-
Perez-Losada, J.1
Sanchez-Martin, M.2
Perez-Caro, M.3
Perez-Mancera, P.A.4
Sanchez-Garcia, I.5
-
145
-
-
8744305031
-
Induction of stem cell factor/c-Kit/slug signal transduction in multidrug-resistant malignant mesothelioma cells
-
Catalano, A., Rodilossi, S., Rippo, M. R., Caprari, P. & Procopio, A. Induction of stem cell factor/c-Kit/slug signal transduction in multidrug-resistant malignant mesothelioma cells. J. Biol. Chem. 279, 46706-46714 (2004).
-
(2004)
J. Biol. Chem
, vol.279
, pp. 46706-46714
-
-
Catalano, A.1
Rodilossi, S.2
Rippo, M.R.3
Caprari, P.4
Procopio, A.5
-
146
-
-
30644468635
-
A twist for survival and cancer progression
-
Puisieux, A., Valsesia-Wittmann, S. & Ansieau, S. A twist for survival and cancer progression. Br. J. Cancer. 94, 13-17 (2006).
-
(2006)
Br. J. Cancer
, vol.94
, pp. 13-17
-
-
Puisieux, A.1
Valsesia-Wittmann, S.2
Ansieau, S.3
-
147
-
-
0842286741
-
Identification of a novel function of Twist, a bHLH protein, in the development of acquired taxol resistance in human cancer cells
-
Wang, X. et al. Identification of a novel function of Twist, a bHLH protein, in the development of acquired taxol resistance in human cancer cells. Oncogene 23, 474-482 (2004).
-
(2004)
Oncogene
, vol.23
, pp. 474-482
-
-
Wang, X.1
-
148
-
-
33746715020
-
Comparative promoter analysis of doxorubicin resistance-associated genes suggests E47 as a key regulatory element
-
Gyorffy, A. et al. Comparative promoter analysis of doxorubicin resistance-associated genes suggests E47 as a key regulatory element. Anticancer Res. 26, 2971-2976 (2006).
-
(2006)
Anticancer Res
, vol.26
, pp. 2971-2976
-
-
Gyorffy, A.1
-
149
-
-
33846901599
-
Snail in the frame of malignant tumor recurrence
-
De Craene, B. & Berx, G. Snail in the frame of malignant tumor recurrence. Breast Cancer Res. 8, 105 (2006).
-
(2006)
Breast Cancer Res
, vol.8
, pp. 105
-
-
De Craene, B.1
Berx, G.2
-
150
-
-
25444495269
-
Opinion: Migrating cancer stem cells- an integrated concept of malignant tumour progression
-
Brabletz, T., Jung, A., Spaderna, S., Hlubek, F. & Kirchner, T. Opinion: migrating cancer stem cells- an integrated concept of malignant tumour progression. Nature Rev. Cancer 5, 744-749 (2005).
-
(2005)
Nature Rev. Cancer
, vol.5
, pp. 744-749
-
-
Brabletz, T.1
Jung, A.2
Spaderna, S.3
Hlubek, F.4
Kirchner, T.5
-
151
-
-
33748967069
-
Of extracellular matrix, scaffolds, and signaling: Tissue architecture regulates development, homeostasis, and cancer
-
Nelson, C. M. & Bissell, M. J. Of extracellular matrix, scaffolds, and signaling: tissue architecture regulates development, homeostasis, and cancer. Annu. Rev. Cell. Dev. Biol. 22, 287-309 (2006).
-
(2006)
Annu. Rev. Cell. Dev. Biol
, vol.22
, pp. 287-309
-
-
Nelson, C.M.1
Bissell, M.J.2
-
152
-
-
27544496133
-
Expression of Frzb/secreted Frizzled-related protein 3, a secreted Wnt antagonist, in human androgen-independent prostate cancer PC-3 cells suppresses tumor growth and cellular invasiveness
-
Zi, X. et al. Expression of Frzb/secreted Frizzled-related protein 3, a secreted Wnt antagonist, in human androgen-independent prostate cancer PC-3 cells suppresses tumor growth and cellular invasiveness. Cancer Res. 65, 9762-9770 (2005).
-
(2005)
Cancer Res
, vol.65
, pp. 9762-9770
-
-
Zi, X.1
-
153
-
-
33846828787
-
NF-κB represses E-cadherin expression and enhances epithelial to mesenchymal transition of mammary epithelial cells: Potential involvement of ZEB-1 and ZEB-2
-
Chua, H. L. et al. NF-κB represses E-cadherin expression and enhances epithelial to mesenchymal transition of mammary epithelial cells: potential involvement of ZEB-1 and ZEB-2. Oncogene 26, 711-724 (2007).
-
(2007)
Oncogene
, vol.26
, pp. 711-724
-
-
Chua, H.L.1
-
154
-
-
3242885067
-
Snail and E47 repressors of E-cadherin induce distinct invasive and angiogenic properties in vivo
-
Peinado, H. et al. Snail and E47 repressors of E-cadherin induce distinct invasive and angiogenic properties in vivo. J. Cell Sci. 117, 2827-2839 (2004).
-
(2004)
J. Cell Sci
, vol.117
, pp. 2827-2839
-
-
Peinado, H.1
-
155
-
-
33750318206
-
Snail-dependent and- independent epithelial-mesenchymal transition in oral squamous carcinoma cells
-
Takkunen, M. et al. Snail-dependent and- independent epithelial-mesenchymal transition in oral squamous carcinoma cells. J. Histochem Cytochem. 54, 1263-1275 (2006).
-
(2006)
J. Histochem Cytochem
, vol.54
, pp. 1263-1275
-
-
Takkunen, M.1
-
156
-
-
33644766983
-
The transcription factors Slug and Snail act as repressors of Claudin-1 expression in epithelial cells
-
Martinez-Estrada, O. M. et al. The transcription factors Slug and Snail act as repressors of Claudin-1 expression in epithelial cells. Biochem. J. 394, 449-457 (2006).
-
(2006)
Biochem. J
, vol.394
, pp. 449-457
-
-
Martinez-Estrada, O.M.1
-
157
-
-
0038049137
-
Tumour-cell invasion and migration: Diversity and escape mechanisms
-
Friedl, P. & Wolf, K. Tumour-cell invasion and migration: diversity and escape mechanisms. Nature Rev. Cancer 3, 362-374 (2003).
-
(2003)
Nature Rev. Cancer
, vol.3
, pp. 362-374
-
-
Friedl, P.1
Wolf, K.2
-
158
-
-
12944260524
-
Developmental transcription factor slug is required for effective re-epithelialization by adult keratinocytes
-
Savagner, P. et al. Developmental transcription factor slug is required for effective re-epithelialization by adult keratinocytes. J. Cell Physiol. 202, 858-866 (2005).
-
(2005)
J. Cell Physiol
, vol.202
, pp. 858-866
-
-
Savagner, P.1
-
159
-
-
24644487312
-
TGF-β and epithelial- tomesenchymal transitions
-
Zavadil, J. & Bottinger, E. P. TGF-β and epithelial- tomesenchymal transitions. Oncogene 24, 5764-5774 (2005).
-
(2005)
Oncogene
, vol.24
, pp. 5764-5774
-
-
Zavadil, J.1
Bottinger, E.P.2
-
160
-
-
33645748171
-
Regulation of E-cadherin expression by VHL and hypoxia-inducible factor
-
Esteban, M. A. et al. Regulation of E-cadherin expression by VHL and hypoxia-inducible factor. Cancer Res. 66, 3567-3575 (2006).
-
(2006)
Cancer Res
, vol.66
, pp. 3567-3575
-
-
Esteban, M.A.1
-
161
-
-
33645090169
-
Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B
-
Krishnamachary, B. et al. Hypoxia-inducible factor-1-dependent repression of E-cadherin in von Hippel-Lindau tumor suppressor-null renal cell carcinoma mediated by TCF3, ZFHX1A, and ZFHX1B. Cancer Res. 66, 2725-2731 (2006).
-
(2006)
Cancer Res
, vol.66
, pp. 2725-2731
-
-
Krishnamachary, B.1
-
162
-
-
15544362735
-
Snail and Slug are major determinants of ovarian cancer invasiveness at the transcription level
-
Kurrey, N. K., K, A. & Bapat, S. A. Snail and Slug are major determinants of ovarian cancer invasiveness at the transcription level. Gynecol. Oncol. 97, 155-165 (2005).
-
(2005)
Gynecol. Oncol
, vol.97
, pp. 155-165
-
-
Kurrey, N.K.K.A.1
Bapat, S.A.2
-
163
-
-
0141760411
-
Hypoxia attenuates the expression of E-cadherin via up-regulation of SNAIL in ovarian carcinoma cells
-
Imai, T. et al. Hypoxia attenuates the expression of E-cadherin via up-regulation of SNAIL in ovarian carcinoma cells. Am. J. Pathol. 163, 1437-1447 (2003).
-
(2003)
Am. J. Pathol
, vol.163
, pp. 1437-1447
-
-
Imai, T.1
-
164
-
-
33646365644
-
Lysyl oxidase is essential for hypoxia-induced metastasis
-
Erler, J. T. et al. Lysyl oxidase is essential for hypoxia-induced metastasis. Nature 440, 1222-1226 (2006).
-
(2006)
Nature
, vol.440
, pp. 1222-1226
-
-
Erler, J.T.1
-
165
-
-
33745303045
-
-
Pouyssegur, J., Dayan, F. & Mazure, N. M. Hypoxia signalling in cancer and approaches to enforce tumour regression. Nature 441, 437-443 (2006). This study, together with reference 164, reflects the influence of the tumour microenvironment on the regulation of LOX proteins to promote tumour metastasis.
-
Pouyssegur, J., Dayan, F. & Mazure, N. M. Hypoxia signalling in cancer and approaches to enforce tumour regression. Nature 441, 437-443 (2006). This study, together with reference 164, reflects the influence of the tumour microenvironment on the regulation of LOX proteins to promote tumour metastasis.
-
-
-
-
166
-
-
0035167812
-
The mouse snail gene encodes a key regulator of the epithelial-mesenchymal transition
-
Carver, E. A., Jiang, R., Lan, Y., Oram, K. F. & Gridley, T. The mouse snail gene encodes a key regulator of the epithelial-mesenchymal transition. Mol. Cell Biol. 21, 8184-8188 (2001).
-
(2001)
Mol. Cell Biol
, vol.21
, pp. 8184-8188
-
-
Carver, E.A.1
Jiang, R.2
Lan, Y.3
Oram, K.F.4
Gridley, T.5
-
167
-
-
33745888092
-
Snail family genes are required for left-right asymmetry determination, but not neural crest formation, in mice
-
Murray, S. A. & Gridley, T. Snail family genes are required for left-right asymmetry determination, but not neural crest formation, in mice. Proc. Natl Acad. Sci. USA 103, 10300-10304 (2006).
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 10300-10304
-
-
Murray, S.A.1
Gridley, T.2
-
168
-
-
0034612270
-
Differential expression and function of members of the zfh-1 family of zinc finger/homeodomain repressors
-
Postigo, A. A. & Dean, D. C. Differential expression and function of members of the zfh-1 family of zinc finger/homeodomain repressors. Proc. Natl Acad. Sci. USA 97, 6391-6396 (2000).
-
(2000)
Proc. Natl Acad. Sci. USA
, vol.97
, pp. 6391-6396
-
-
Postigo, A.A.1
Dean, D.C.2
-
169
-
-
0037322308
-
Mice lacking ZFHX1B, the gene that codes for Smad-interacting protein-1, reveal a role for multiple neural crest cell defects in the etiology of Hirschsprung disease-mental retardation syndrome
-
Van de Putte, T. et al. Mice lacking ZFHX1B, the gene that codes for Smad-interacting protein-1, reveal a role for multiple neural crest cell defects in the etiology of Hirschsprung disease-mental retardation syndrome. Am. J. Hum. Genet. 72, 465-470 (2003).
-
(2003)
Am. J. Hum. Genet
, vol.72
, pp. 465-470
-
-
Van de Putte, T.1
-
170
-
-
0033980393
-
-
Massari, M. E. & Murre, C. Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms. Mol. Cell Biol. 20, 429-440 (2000). A comprehensive review of the bHLH family of proteins.
-
Massari, M. E. & Murre, C. Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms. Mol. Cell Biol. 20, 429-440 (2000). A comprehensive review of the bHLH family of proteins.
-
-
-
-
171
-
-
0028329080
-
Crystal structure of transcription factor E47: E-box recognition by a basic region helix-loop-helix dimer
-
Ellenberger, T., Fass, D., Arnaud, M. & Harrison, S. C. Crystal structure of transcription factor E47: E-box recognition by a basic region helix-loop-helix dimer. Genes Dev. 8, 970-980 (1994).
-
(1994)
Genes Dev
, vol.8
, pp. 970-980
-
-
Ellenberger, T.1
Fass, D.2
Arnaud, M.3
Harrison, S.C.4
-
172
-
-
0027472051
-
A new transcriptional-activation motif restricted to a class of helix-loop-helix proteins is functionally conserved in both yeast and mammalian cells
-
Quong, M. W., Massari, M. E., Zwart, R. & Murre, C. A new transcriptional-activation motif restricted to a class of helix-loop-helix proteins is functionally conserved in both yeast and mammalian cells. Mol. Cell Biol. 13, 792-800 (1993).
-
(1993)
Mol. Cell Biol
, vol.13
, pp. 792-800
-
-
Quong, M.W.1
Massari, M.E.2
Zwart, R.3
Murre, C.4
-
173
-
-
33644538251
-
FOXO transcription factors cooperate with delta EF1 to activate growth suppressive genes in B lymphocytes
-
Chen, J., Yusuf, I., Andersen, H. M. & Fruman, D. A. FOXO transcription factors cooperate with delta EF1 to activate growth suppressive genes in B lymphocytes. J. Immunol. 176, 2711-2721 (2006).
-
(2006)
J. Immunol
, vol.176
, pp. 2711-2721
-
-
Chen, J.1
Yusuf, I.2
Andersen, H.M.3
Fruman, D.A.4
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