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Volumn 195, Issue 3, 2011, Pages 417-433

A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial-mesenchymal transition

Author keywords

[No Author keywords available]

Indexed keywords

AXIN; BETA CATENIN; LYMPHOID ENHANCER FACTOR 1; MICRORNA; MICRORNA 34; MICRORNA 34A; PROTEIN P53; SNAIL 1 PROTEIN; TRANSCRIPTION FACTOR SNAIL; UNCLASSIFIED DRUG; LEF1 PROTEIN, HUMAN; MIRN34 MICRORNA, HUMAN; SNAIL FAMILY TRANSCRIPTION FACTORS; TRANSCRIPTION FACTOR;

EID: 84855729906     PISSN: 00219525     EISSN: 15408140     Source Type: Journal    
DOI: 10.1083/jcb.201103097     Document Type: Article
Times cited : (378)

References (74)
  • 2
    • 23844528776 scopus 로고    scopus 로고
    • The Snail genes as inducers of cell movement and survival: implications in development and cancer
    • Barrallo-Gimeno, A., and M.A. Nieto. 2005. The Snail genes as inducers of cell movement and survival: implications in development and cancer. Development. 132:3151-3161. http://dx.doi.org/10.1242/dev.01907
    • (2005) Development , vol.132 , pp. 3151-3161
    • Barrallo-Gimeno, A.1    Nieto, M.A.2
  • 5
    • 70349443284 scopus 로고    scopus 로고
    • When mutants gain new powers: news from the mutant p53 field
    • Brosh, R., and V. Rotter. 2009. When mutants gain new powers: news from the mutant p53 field. Nat. Rev. Cancer. 9:701-713.
    • (2009) Nat. Rev. Cancer. , vol.9 , pp. 701-713
    • Brosh, R.1    Rotter, V.2
  • 7
    • 44649163918 scopus 로고    scopus 로고
    • A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells
    • Burk, U., J. Schubert, U. Wellner, O. Schmalhofer, E. Vincan, S. Spaderna, and T. Brabletz. 2008. A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells. EMBO Rep. 9:582-589. http://dx.doi.org/10.1038/embor.2008.74
    • (2008) EMBO Rep , vol.9 , pp. 582-589
    • Burk, U.1    Schubert, J.2    Wellner, U.3    Schmalhofer, O.4    Vincan, E.5    Spaderna, S.6    Brabletz, T.7
  • 11
    • 34548044683 scopus 로고    scopus 로고
    • Loss of p53 and Ink4a/Arf cooperate in a cell autonomous fashion to induce metastasis of hepatocellular carcinoma cells
    • Chen, Y.W., D.S. Klimstra, M.E. Mongeau, J.L. Tatem, V. Boyartchuk, and B.C. Lewis. 2007. Loss of p53 and Ink4a/Arf cooperate in a cell autonomous fashion to induce metastasis of hepatocellular carcinoma cells. Cancer Res. 67:7589-7596. http://dx.doi.org/10.1158/0008-5472.CAN-07-0381
    • (2007) Cancer Res , vol.67 , pp. 7589-7596
    • Chen, Y.W.1    Klimstra, D.S.2    Mongeau, M.E.3    Tatem, J.L.4    Boyartchuk, V.5    Lewis, B.C.6
  • 12
    • 49749150980 scopus 로고    scopus 로고
    • A functional screen identifies miR-34a as a candidate neuroblastoma tumor suppressor gene
    • Cole, K.A., E.F. Attiyeh, Y.P. Mosse, M.J. Laquaglia, S.J. Diskin, G.M. Brodeur, and J.M. Maris. 2008. A functional screen identifies miR-34a as a candidate neuroblastoma tumor suppressor gene. Mol. Cancer Res. 6:735-742. http://dx.doi.org/10.1158/1541-7786.MCR-07-2102
    • (2008) Mol. Cancer Res. , vol.6 , pp. 735-742
    • Cole, K.A.1    Attiyeh, E.F.2    Mosse, Y.P.3    Laquaglia, M.J.4    Diskin, S.J.5    Brodeur, G.M.6    Maris, J.M.7
  • 13
    • 34548803950 scopus 로고    scopus 로고
    • MicroRNA-34b and MicroRNA-34c are targets of p53 and cooperate in control of cell proliferation and adhesion-independent growth
    • Corney, D.C., A. Flesken-Nikitin, A.K. Godwin, W. Wang, and A.Y. Nikitin. 2007. MicroRNA-34b and MicroRNA-34c are targets of p53 and cooperate in control of cell proliferation and adhesion-independent growth. Cancer Res. 67:8433-8438. http://dx.doi.org/10.1158/0008-5472.CAN-07-1585
    • (2007) Cancer Res , vol.67 , pp. 8433-8438
    • Corney, D.C.1    Flesken-Nikitin, A.2    Godwin, A.K.3    Wang, W.4    Nikitin, A.Y.5
  • 16
    • 49649116469 scopus 로고    scopus 로고
    • Gain of oncogenic function of p53 mutants induces invasive phenotypes in human breast cancer cells by silencing CCN5/WISP-2
    • Dhar, G., S. Banerjee, K. Dhar, O. Tawfik, M.S. Mayo, P.J. Vanveldhuizen, and S.K. Banerjee. 2008. Gain of oncogenic function of p53 mutants induces invasive phenotypes in human breast cancer cells by silencing CCN5/WISP-2. Cancer Res. 68:4580-4587. http://dx.doi.org/10.1158/0008-5472.CAN-08-0316
    • (2008) Cancer Res , vol.68 , pp. 4580-4587
    • Dhar, G.1    Banerjee, S.2    Dhar, K.3    Tawfik, O.4    Mayo, M.S.5    Vanveldhuizen, P.J.6    Banerjee, S.K.7
  • 18
    • 34347382959 scopus 로고    scopus 로고
    • Loss of p53 promotes RhoA-ROCK-dependent cell migration and invasion in 3D matrices
    • Gadea, G., M. de Toledo, C. Anguille, and P. Roux. 2007. Loss of p53 promotes RhoA-ROCK-dependent cell migration and invasion in 3D matrices. J. Cell Biol. 178:23-30. http://dx.doi.org/10.1083/jcb.200701120
    • (2007) J. Cell Biol. , vol.178 , pp. 23-30
    • Gadea, G.1    de Toledo, M.2    Anguille, C.3    Roux, P.4
  • 20
    • 79955419817 scopus 로고    scopus 로고
    • Snail and the microRNA-200 family act in opposition to regulate epithelial-to-mesenchymal transition and germ layer fate restriction in differentiating ESCs
    • Gill, J.G., E.M. Langer, R.C. Lindsley, M. Cai, T.L. Murphy, M. Kyba, and K.M. Murphy. 2011. Snail and the microRNA-200 family act in opposition to regulate epithelial-to-mesenchymal transition and germ layer fate restriction in differentiating ESCs. Stem Cells.
    • (2011) Stem Cells
    • Gill, J.G.1    Langer, E.M.2    Lindsley, R.C.3    Cai, M.4    Murphy, T.L.5    Kyba, M.6    Murphy, K.M.7
  • 21
    • 46149089421 scopus 로고    scopus 로고
    • Growth-inhibitory and tumor-suppressive functions of p53 depend on its repression of CD44 expression
    • Godar, S., T.A. Ince, G.W. Bell, D. Feldser, J.L. Donaher, J. Bergh, A. Liu, K. Miu, R.S. Watnick, F. Reinhardt, et al. 2008. Growth-inhibitory and tumor-suppressive functions of p53 depend on its repression of CD44 expression. Cell. 134:62-73. http://dx.doi.org/10.1016/j.cell.2008.06.006
    • (2008) Cell , vol.134 , pp. 62-73
    • Godar, S.1    Ince, T.A.2    Bell, G.W.3    Feldser, D.4    Donaher, J.L.5    Bergh, J.6    Liu, A.7    Miu, K.8    Watnick, R.S.9    Reinhardt, F.10
  • 24
    • 35548957247 scopus 로고    scopus 로고
    • microRNAs join the p53 network-another piece in the tumour-suppression puzzle
    • He, L., X. He, S.W. Lowe, and G.J. Hannon. 2007b. microRNAs join the p53 network-another piece in the tumour-suppression puzzle. Nat. Rev. Cancer. 7:819-822. http://dx.doi.org/10.1038/nrc2232
    • (2007) Nat. Rev. Cancer. , vol.7 , pp. 819-822
    • He, L.1    He, X.2    Lowe, S.W.3    Hannon, G.J.4
  • 25
    • 74249123570 scopus 로고    scopus 로고
    • The miR-34 family in cancer and apoptosis
    • Hermeking, H. 2010. The miR-34 family in cancer and apoptosis. Cell Death Differ. 17:193-199. http://dx.doi.org/10.1038/cdd.2009.56
    • (2010) Cell Death Differ , vol.17 , pp. 193-199
    • Hermeking, H.1
  • 26
    • 35148852661 scopus 로고    scopus 로고
    • Snail-induced down-regulation of DeltaNp63alpha acquires invasive phenotype of human squamous cell carcinoma
    • Higashikawa, K., S. Yoneda, K. Tobiume, M. Taki, H. Shigeishi, and N. Kamata. 2007. Snail-induced down-regulation of DeltaNp63alpha acquires invasive phenotype of human squamous cell carcinoma. Cancer Res. 67:9207-9213. http://dx.doi.org/10.1158/0008-5472.CAN-07-0932
    • (2007) Cancer Res , vol.67 , pp. 9207-9213
    • Higashikawa, K.1    Yoneda, S.2    Tobiume, K.3    Taki, M.4    Shigeishi, H.5    Kamata, N.6
  • 27
    • 0029340307 scopus 로고
    • The effects of wild type p53 tumor suppressor gene expression on the normal human cervical epithelial cells or human epidermal keratinocytes transformed with human papillomavirus type 16 DNA
    • Kim, K.H., T.K. Park, D.J. Yoon, and Y.S. Kim. 1995. The effects of wild type p53 tumor suppressor gene expression on the normal human cervical epithelial cells or human epidermal keratinocytes transformed with human papillomavirus type 16 DNA. Yonsei Med. J. 36:287-298.
    • (1995) Yonsei Med. J. , vol.36 , pp. 287-298
    • Kim, K.H.1    Park, T.K.2    Yoon, D.J.3    Kim, Y.S.4
  • 30
    • 60649089997 scopus 로고    scopus 로고
    • Cancer metastasis is accelerated through immunosuppression during Snail-induced EMT of cancer cells
    • Kudo-Saito, C., H. Shirako, T. Takeuchi, and Y. Kawakami. 2009. Cancer metastasis is accelerated through immunosuppression during Snail-induced EMT of cancer cells. Cancer Cell. 15:195-206. http://dx.doi.org/10.1016/j.ccr.2009.01.023
    • (2009) Cancer Cell , vol.15 , pp. 195-206
    • Kudo-Saito, C.1    Shirako, H.2    Takeuchi, T.3    Kawakami, Y.4
  • 31
    • 44849091255 scopus 로고    scopus 로고
    • Nutlin-3a activates p53 to both down-regulate inhibitor of growth 2 and up-regulate mir-34a, mir-34b, and mir-34c expression, and induce senescence
    • Kumamoto, K., E.A. Spillare, K. Fujita, I. Horikawa, T. Yamashita, E. Appella, M. Nagashima, S. Takenoshita, J. Yokota, and C.C. Harris. 2008. Nutlin-3a activates p53 to both down-regulate inhibitor of growth 2 and up-regulate mir-34a, mir-34b, and mir-34c expression, and induce senescence. Cancer Res. 68:3193-3203. http://dx.doi.org/10.1158/0008-5472.CAN-07-2780
    • (2008) Cancer Res , vol.68 , pp. 3193-3203
    • Kumamoto, K.1    Spillare, E.A.2    Fujita, K.3    Horikawa, I.4    Yamashita, T.5    Appella, E.6    Nagashima, M.7    Takenoshita, S.8    Yokota, J.9    Harris, C.C.10
  • 32
    • 36348929959 scopus 로고    scopus 로고
    • Identification of candidate genes involved in neuroblastoma progression by combining genomic and expression microarrays with survival data
    • Łastowska, M., V. Viprey, M. Santibanez-Koref, I. Wappler, H. Peters, C. Cullinane, P. Roberts, A.G. Hall, D.A. Tweddle, A.D. Pearson, et al. 2007. Identification of candidate genes involved in neuroblastoma progression by combining genomic and expression microarrays with survival data. Oncogene. 26:7432-7444. http://dx.doi.org/10.1038/sj.onc.1210552
    • (2007) Oncogene , vol.26 , pp. 7432-7444
    • Lastowska, M.1    Viprey, V.2    Santibanez-Koref, M.3    Wappler, I.4    Peters, H.5    Cullinane, C.6    Roberts, P.7    Hall, A.G.8    Tweddle, D.A.9    Pearson, A.D.10
  • 34
    • 13444278808 scopus 로고    scopus 로고
    • The absence of p53 promotes metastasis in a novel somatic mouse model for hepatocellular carcinoma
    • Lewis, B.C., D.S. Klimstra, N.D. Socci, S. Xu, J.A. Koutcher, and H.E. Varmus. 2005. The absence of p53 promotes metastasis in a novel somatic mouse model for hepatocellular carcinoma. Mol. Cell. Biol. 25:1228-1237. http://dx.doi.org/10.1128/MCB.25.4.1228-1237.2005
    • (2005) Mol. Cell. Biol. , vol.25 , pp. 1228-1237
    • Lewis, B.C.1    Klimstra, D.S.2    Socci, N.D.3    Xu, S.4    Koutcher, J.A.5    Varmus, H.E.6
  • 36
    • 77952956786 scopus 로고    scopus 로고
    • p53 inhibits tumor cell invasion via the degradation of snail protein in hepatocellular carcinoma
    • Lim, S.O., H. Kim, and G. Jung. 2010. p53 inhibits tumor cell invasion via the degradation of snail protein in hepatocellular carcinoma. FEBS Lett. 584:2231-2236. http://dx.doi.org/10.1016/j.febslet.2010.04.006
    • (2010) FEBS Lett , vol.584 , pp. 2231-2236
    • Lim, S.O.1    Kim, H.2    Jung, G.3
  • 38
    • 75649122615 scopus 로고    scopus 로고
    • Phosphorylation of serine 11 and serine 92 as new positive regulators of human Snail1 function: potential involvement of casein kinase-2 and the cAMP-activated kinase protein kinase A
    • MacPherson, M.R., P. Molina, S. Souchelnytskyi, C. Wernstedt, J. Martin-Pérez, F. Portillo, and A. Cano. 2010. Phosphorylation of serine 11 and serine 92 as new positive regulators of human Snail1 function: potential involvement of casein kinase-2 and the cAMP-activated kinase protein kinase A. Mol. Biol. Cell. 21:244-253. http://dx.doi.org/10.1091/mbc.E09-06-0504
    • (2010) Mol. Biol. Cell. , vol.21 , pp. 244-253
    • MacPherson, M.R.1    Molina, P.2    Souchelnytskyi, S.3    Wernstedt, C.4    Martin-Pérez, J.5    Portillo, F.6    Cano, A.7
  • 39
    • 77950476293 scopus 로고    scopus 로고
    • ERbeta impedes prostate cancer EMT by destabilizing HIF-1alpha and inhibiting VEGF-mediated snail nuclear localization: implications for Gleason grading
    • Mak, P., I. Leav, B. Pursell, D. Bae, X. Yang, C.A. Taglienti, L.M. Gouvin, V.M. Sharma, and A.M. Mercurio. 2010. ERbeta impedes prostate cancer EMT by destabilizing HIF-1alpha and inhibiting VEGF-mediated snail nuclear localization: implications for Gleason grading. Cancer Cell. 17:319-332. http://dx.doi.org/10.1016/j.ccr.2010.02.030
    • (2010) Cancer Cell , vol.17 , pp. 319-332
    • Mak, P.1    Leav, I.2    Pursell, B.3    Bae, D.4    Yang, X.5    Taglienti, C.A.6    Gouvin, L.M.7    Sharma, V.M.8    Mercurio, A.M.9
  • 43
    • 0030949463 scopus 로고    scopus 로고
    • Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC
    • Morin, P.J., A.B. Sparks, V. Korinek, N. Barker, H. Clevers, B. Vogelstein, and K.W. Kinzler. 1997. Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science. 275:1787-1790. http://dx.doi.org/10.1126/science.275.5307.1787
    • (1997) Science , vol.275 , pp. 1787-1790
    • Morin, P.J.1    Sparks, A.B.2    Korinek, V.3    Barker, N.4    Clevers, H.5    Vogelstein, B.6    Kinzler, K.W.7
  • 44
    • 42049110952 scopus 로고    scopus 로고
    • Trp53 deletion stimulates the formation of metastatic pancreatic tumors
    • Morton, J.P., D.S. Klimstra, M.E. Mongeau, and B.C. Lewis. 2008. Trp53 deletion stimulates the formation of metastatic pancreatic tumors. Am. J. Pathol. 172:1081-1087. http://dx.doi.org/10.2353/ajpath.2008.070778
    • (2008) Am. J. Pathol. , vol.172 , pp. 1081-1087
    • Morton, J.P.1    Klimstra, D.S.2    Mongeau, M.E.3    Lewis, B.C.4
  • 45
    • 66349124406 scopus 로고    scopus 로고
    • p53 suppresses Src-induced podosome and rosette formation and cellular invasiveness through the upregulation of caldesmon
    • Mukhopadhyay, U.K., R. Eves, L. Jia, P. Mooney, and A.S. Mak. 2009. p53 suppresses Src-induced podosome and rosette formation and cellular invasiveness through the upregulation of caldesmon. Mol. Cell. Biol. 29:3088-3098. http://dx.doi.org/10.1128/MCB.01816-08
    • (2009) Mol. Cell. Biol. , vol.29 , pp. 3088-3098
    • Mukhopadhyay, U.K.1    Eves, R.2    Jia, L.3    Mooney, P.4    Mak, A.S.5
  • 47
    • 37549006304 scopus 로고    scopus 로고
    • SNAI1 is required for tumor growth and lymph node metastasis of human breast carcinoma MDA-MB-231 cells
    • Olmeda, D., G. Moreno-Bueno, J.M. Flores, A. Fabra, F. Portillo, and A. Cano. 2007. SNAI1 is required for tumor growth and lymph node metastasis of human breast carcinoma MDA-MB-231 cells. Cancer Res. 67:11721-11731. http://dx.doi.org/10.1158/0008-5472.CAN-07-2318
    • (2007) Cancer Res , vol.67 , pp. 11721-11731
    • Olmeda, D.1    Moreno-Bueno, G.2    Flores, J.M.3    Fabra, A.4    Portillo, F.5    Cano, A.6
  • 48
    • 49149107174 scopus 로고    scopus 로고
    • Snai1 and Snai2 collaborate on tumor growth and metastasis properties of mouse skin carcinoma cell lines
    • Olmeda, D., A. Montes, G. Moreno-Bueno, J.M. Flores, F. Portillo, and A. Cano. 2008. Snai1 and Snai2 collaborate on tumor growth and metastasis properties of mouse skin carcinoma cell lines. Oncogene. 27:4690-4701. http://dx.doi.org/10.1038/onc.2008.118
    • (2008) Oncogene , vol.27 , pp. 4690-4701
    • Olmeda, D.1    Montes, A.2    Moreno-Bueno, G.3    Flores, J.M.4    Portillo, F.5    Cano, A.6
  • 49
    • 73949087260 scopus 로고    scopus 로고
    • Induction of a MT1-MMP and MT2-MMP-dependent basement membrane transmigration program in cancer cells by Snail1
    • Ota, I., X.Y. Li, Y. Hu, and S.J. Weiss. 2009. Induction of a MT1-MMP and MT2-MMP-dependent basement membrane transmigration program in cancer cells by Snail1. Proc. Natl. Acad. Sci. USA. 106:20318-20323. http://dx.doi.org/10.1073/pnas.0910962106
    • (2009) Proc. Natl. Acad. Sci. USA. , vol.106 , pp. 20318-20323
    • Ota, I.1    Li, X.Y.2    Hu, Y.3    Weiss, S.J.4
  • 50
    • 34249289041 scopus 로고    scopus 로고
    • Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?
    • Peinado, H., D. Olmeda, and A. Cano. 2007. Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nat. Rev. Cancer. 7:415-428. http://dx.doi.org/10.1038/nrc2131
    • (2007) Nat. Rev. Cancer. , vol.7 , pp. 415-428
    • Peinado, H.1    Olmeda, D.2    Cano, A.3
  • 51
    • 63049123066 scopus 로고    scopus 로고
    • Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits
    • Polyak, K., and R.A. Weinberg. 2009. Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat. Rev. Cancer. 9:265-273. http://dx.doi.org/10.1038/nrc2620
    • (2009) Nat. Rev. Cancer. , vol.9 , pp. 265-273
    • Polyak, K.1    Weinberg, R.A.2
  • 53
    • 42449114966 scopus 로고    scopus 로고
    • Transcriptional control of human p53-regulated genes
    • Riley, T., E. Sontag, P. Chen, and A. Levine. 2008. Transcriptional control of human p53-regulated genes. Nat. Rev. Mol. Cell Biol. 9:402-412. http://dx.doi.org/10.1038/nrm2395
    • (2008) Nat. Rev. Mol. Cell Biol. , vol.9 , pp. 402-412
    • Riley, T.1    Sontag, E.2    Chen, P.3    Levine, A.4
  • 54
    • 54049137191 scopus 로고    scopus 로고
    • Breaching the basement membrane: who, when and how?
    • Rowe, R.G., and S.J. Weiss. 2008. Breaching the basement membrane: who, when and how? Trends Cell Biol. 18:560-574. http://dx.doi.org/10.1016/j.tcb.2008.08.007
    • (2008) Trends Cell Biol , vol.18 , pp. 560-574
    • Rowe, R.G.1    Weiss, S.J.2
  • 55
    • 70350233406 scopus 로고    scopus 로고
    • Navigating ECM barriers at the invasive front: the cancer cell-stroma interface
    • Rowe, R.G., and S.J. Weiss. 2009. Navigating ECM barriers at the invasive front: the cancer cell-stroma interface. Annu. Rev. Cell Dev. Biol. 25:567-595. http://dx.doi.org/10.1146/annurev.cellbio.24.110707.175315
    • (2009) Annu. Rev. Cell Dev. Biol. , vol.25 , pp. 567-595
    • Rowe, R.G.1    Weiss, S.J.2
  • 58
    • 44049090235 scopus 로고    scopus 로고
    • Notch signaling mediates hypoxia-induced tumor cell migration and invasion
    • Sahlgren, C., M.V. Gustafsson, S. Jin, L. Poellinger, and U. Lendahl. 2008. Notch signaling mediates hypoxia-induced tumor cell migration and invasion. Proc. Natl. Acad. Sci. USA. 105:6392-6397. http://dx.doi.org/10.1073/pnas.0802047105
    • (2008) Proc. Natl. Acad. Sci. USA. , vol.105 , pp. 6392-6397
    • Sahlgren, C.1    Gustafsson, M.V.2    Jin, S.3    Poellinger, L.4    Lendahl, U.5
  • 59
    • 0025639158 scopus 로고
    • The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53
    • Scheffner, M., B.A. Werness, J.M. Huibregtse, A.J. Levine, and P.M. Howley. 1990. The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell. 63:1129-1136. http://dx.doi.org/10.1016/0092-8674(90)90409-8
    • (1990) Cell , vol.63 , pp. 1129-1136
    • Scheffner, M.1    Werness, B.A.2    Huibregtse, J.M.3    Levine, A.J.4    Howley, P.M.5
  • 60
    • 34250868124 scopus 로고    scopus 로고
    • Differential regulation of microRNAs by p53 revealed by massively parallel sequencing: miR-34a is a p53 target that induces apoptosis and G1-arrest
    • Tarasov, V., P. Jung, B. Verdoodt, D. Lodygin, A. Epanchintsev, A. Menssen, G. Meister, and H. Hermeking. 2007. Differential regulation of microRNAs by p53 revealed by massively parallel sequencing: miR-34a is a p53 target that induces apoptosis and G1-arrest. Cell Cycle. 6:1586-1593. http://dx.doi.org/10.4161/cc.6.13.4436
    • (2007) Cell Cycle , vol.6 , pp. 1586-1593
    • Tarasov, V.1    Jung, P.2    Verdoodt, B.3    Lodygin, D.4    Epanchintsev, A.5    Menssen, A.6    Meister, G.7    Hermeking, H.8
  • 61
    • 70450198396 scopus 로고    scopus 로고
    • Epithelialmesenchymal transitions in development and disease
    • Thiery, J.P., H. Acloque, R.Y. Huang, and M.A. Nieto. 2009. Epithelialmesenchymal transitions in development and disease. Cell. 139:871-890. http://dx.doi.org/10.1016/j.cell.2009.11.007
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 64
    • 0034676455 scopus 로고    scopus 로고
    • Surfing the p53 network
    • Vogelstein, B., D. Lane, and A.J. Levine. 2000. Surfing the p53 network. Nature. 408:307-310. http://dx.doi.org/10.1038/35042675
    • (2000) Nature , vol.408 , pp. 307-310
    • Vogelstein, B.1    Lane, D.2    Levine, A.J.3
  • 66
    • 34249812122 scopus 로고    scopus 로고
    • MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells
    • Welch, C., Y. Chen, and R.L. Stallings. 2007. MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells. Oncogene. 26:5017-5022. http://dx.doi.org/10.1038/sj.onc.1210293
    • (2007) Oncogene , vol.26 , pp. 5017-5022
    • Welch, C.1    Chen, Y.2    Stallings, R.L.3
  • 67
    • 65349092794 scopus 로고    scopus 로고
    • Stabilization of snail by NF-kappaB is required for inflammation-induced cell migration and invasion
    • Wu, Y., J. Deng, P.G. Rychahou, S. Qiu, B.M. Evers, and B.P. Zhou. 2009. Stabilization of snail by NF-kappaB is required for inflammation-induced cell migration and invasion. Cancer Cell. 15:416-428. http://dx.doi.org/10.1016/j.ccr.2009.03.016
    • (2009) Cancer Cell , vol.15 , pp. 416-428
    • Wu, Y.1    Deng, J.2    Rychahou, P.G.3    Qiu, S.4    Evers, B.M.5    Zhou, B.P.6
  • 68
    • 33847627873 scopus 로고    scopus 로고
    • Tumor suppressor p53 restricts Ras stimulation of RhoA and cancer cell motility
    • Xia, M., and H. Land. 2007. Tumor suppressor p53 restricts Ras stimulation of RhoA and cancer cell motility. Nat. Struct. Mol. Biol. 14:215-223. http://dx.doi.org/10.1038/nsmb1208
    • (2007) Nat. Struct. Mol. Biol. , vol.14 , pp. 215-223
    • Xia, M.1    Land, H.2
  • 69
    • 51649115553 scopus 로고    scopus 로고
    • miR-34a repression of SIRT1 regulates apoptosis
    • Yamakuchi, M., M. Ferlito, and C.J. Lowenstein. 2008. miR-34a repression of SIRT1 regulates apoptosis. Proc. Natl. Acad. Sci. USA. 105:13421-13426. http://dx.doi.org/10.1073/pnas.0801613105
    • (2008) Proc. Natl. Acad. Sci. USA. , vol.105 , pp. 13421-13426
    • Yamakuchi, M.1    Ferlito, M.2    Lowenstein, C.J.3
  • 70
    • 53049095294 scopus 로고    scopus 로고
    • Suppression of inhibitor of differentiation 2, a target of mutant p53, is required for gain-of-function mutations
    • Yan, W., G. Liu, A. Scoumanne, and X. Chen. 2008. Suppression of inhibitor of differentiation 2, a target of mutant p53, is required for gain-of-function mutations. Cancer Res. 68:6789-6796. http://dx.doi.org/10.1158/0008-5472.CAN-08-0810
    • (2008) Cancer Res , vol.68 , pp. 6789-6796
    • Yan, W.1    Liu, G.2    Scoumanne, A.3    Chen, X.4
  • 72
    • 15744374449 scopus 로고    scopus 로고
    • Wnt-dependent regulation of the E-cadherin repressor snail
    • Yook, J.I., X.Y. Li, I. Ota, E.R. Fearon, and S.J. Weiss. 2005. Wnt-dependent regulation of the E-cadherin repressor snail. J. Biol. Chem. 280:11740-11748. http://dx.doi.org/10.1074/jbc.M413878200
    • (2005) J. Biol. Chem. , vol.280 , pp. 11740-11748
    • Yook, J.I.1    Li, X.Y.2    Ota, I.3    Fearon, E.R.4    Weiss, S.J.5
  • 74
    • 5444269904 scopus 로고    scopus 로고
    • Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition
    • Zhou, B.P., J. Deng, W. Xia, J. Xu, Y.M. Li, M. Gunduz, and M.C. Hung. 2004. Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition. Nat. Cell Biol. 6:931-940. http://dx.doi.org/10.1038/ncb1173
    • (2004) Nat. Cell Biol. , vol.6 , pp. 931-940
    • Zhou, B.P.1    Deng, J.2    Xia, W.3    Xu, J.4    Li, Y.M.5    Gunduz, M.6    Hung, M.C.7


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