메뉴 건너뛰기




Volumn 68, Issue 2, 2008, Pages 537-544

The transcriptional repressor ZEB1 promotes metastasis and loss of cell polarity in cancer

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; PROTEIN LG12; PROTEIN ZEB1; REPRESSOR PROTEIN; UNCLASSIFIED DRUG; HOMEODOMAIN PROTEIN; KARYOPHERIN BETA; LATE GESTATION LUNG 2 KARYOPHERIN; TRANSCRIPTION FACTOR; ZEB1 PROTEIN, HUMAN;

EID: 39049160267     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-07-5682     Document Type: Article
Times cited : (460)

References (30)
  • 1
    • 34249289041 scopus 로고    scopus 로고
    • Snail, Zeb and bHLH factors in tumour progression: An alliance against the epithelial phenotype?
    • Peinado H, Olmeda D, Cano A. Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nat Rev Cancer 2007;7:415-28.
    • (2007) Nat Rev Cancer , vol.7 , pp. 415-428
    • Peinado, H.1    Olmeda, D.2    Cano, A.3
  • 2
    • 34447272058 scopus 로고    scopus 로고
    • Mechanisms of metastasis: Epithelial-to-mesenchymal transition and contribution of tumor microenvironment
    • Tse JC, Kalluri R. Mechanisms of metastasis: epithelial-to-mesenchymal transition and contribution of tumor microenvironment. J Cell Biochem 2007;101:816-29.
    • (2007) J Cell Biochem , vol.101 , pp. 816-829
    • Tse, J.C.1    Kalluri, R.2
  • 3
    • 0033789680 scopus 로고    scopus 로고
    • The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells
    • Batlle E, Sancho E, Franci C, et al. The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells. Nat Cell Biol 2000;2:84-9.
    • (2000) Nat Cell Biol , vol.2 , pp. 84-89
    • Batlle, E.1    Sancho, E.2    Franci, C.3
  • 4
    • 0033784843 scopus 로고    scopus 로고
    • The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression
    • Cano A, Perez-Moreno MA, Rodrigo I, et al. The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nat Cell Biol 2000;2:76-83.
    • (2000) Nat Cell Biol , vol.2 , pp. 76-83
    • Cano, A.1    Perez-Moreno, M.A.2    Rodrigo, I.3
  • 5
    • 0037326569 scopus 로고    scopus 로고
    • The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: A comparison with Snail and E47 repressors
    • Bolos V, Peinado H, Perez-Moreno MA, Fraga MF, Esteller M, Cano A. The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressors. J Cell Sci 2003;116:499-511.
    • (2003) J Cell Sci , vol.116 , pp. 499-511
    • Bolos, V.1    Peinado, H.2    Perez-Moreno, M.A.3    Fraga, M.F.4    Esteller, M.5    Cano, A.6
  • 6
    • 2942707848 scopus 로고    scopus 로고
    • Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis
    • Yang J, Mani SA, Donaher JL, et al. Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell 2004;117:927-39.
    • (2004) Cell , vol.117 , pp. 927-939
    • Yang, J.1    Mani, S.A.2    Donaher, J.L.3
  • 7
    • 0035920152 scopus 로고    scopus 로고
    • A new role for E12/E47 in the repression of E-cadherin expression and epithelial-mesenchymal transitions
    • Perez-Moreno MA, Locascio A, Rodrigo I, et al. A new role for E12/E47 in the repression of E-cadherin expression and epithelial-mesenchymal transitions. J Biol Chem 2001;276:27424-31.
    • (2001) J Biol Chem , vol.276 , pp. 27424-27431
    • Perez-Moreno, M.A.1    Locascio, A.2    Rodrigo, I.3
  • 9
    • 0030960196 scopus 로고    scopus 로고
    • Postigo AA, Dean DC. ZEB, a vertebrate homolog of Drosophila Zfh-1, is a negative regulator of muscle differentiation. EMBO J 1997;16:3935-43.
    • Postigo AA, Dean DC. ZEB, a vertebrate homolog of Drosophila Zfh-1, is a negative regulator of muscle differentiation. EMBO J 1997;16:3935-43.
  • 10
    • 0034964418 scopus 로고    scopus 로고
    • The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion
    • Comijn J, Berx G, Vermassen P, et al. The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion. Mol Cell 2001;7:1267-78.
    • (2001) Mol Cell , vol.7 , pp. 1267-1278
    • Comijn, J.1    Berx, G.2    Vermassen, P.3
  • 11
    • 0035964349 scopus 로고    scopus 로고
    • Variable β-catenin expression in colorectal cancer indicates a tumor progression driven by the tumor environment
    • Brabletz T, Jung A, Reu S, et al. Variable β-catenin expression in colorectal cancer indicates a tumor progression driven by the tumor environment. Proc Natl Acad Sci U S A 2001;98:10356-61.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 10356-10361
    • Brabletz, T.1    Jung, A.2    Reu, S.3
  • 12
    • 22144497081 scopus 로고    scopus 로고
    • Invasion and metastasis in colorectal cancer: Epithelial-mesenchymal transition, mesenchymal-epithelial transition, stem cells and β-catenin
    • Brabletz T, Hlubek F, Spaderna S, et al. Invasion and metastasis in colorectal cancer: epithelial-mesenchymal transition, mesenchymal-epithelial transition, stem cells and β-catenin. Cells Tissues Organs 2005;179:56-65.
    • (2005) Cells Tissues Organs , vol.179 , pp. 56-65
    • Brabletz, T.1    Hlubek, F.2    Spaderna, S.3
  • 13
    • 33748116186 scopus 로고    scopus 로고
    • A transient, EMT-linked loss of basement membranes indicates metastasis and poor survival in colorectal cancer
    • Spaderna S, Schmalhofer O, Hlubek F, et al. A transient, EMT-linked loss of basement membranes indicates metastasis and poor survival in colorectal cancer. Gastroenterology 2006;131:830-40.
    • (2006) Gastroenterology , vol.131 , pp. 830-840
    • Spaderna, S.1    Schmalhofer, O.2    Hlubek, F.3
  • 14
    • 34547141894 scopus 로고    scopus 로고
    • Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers
    • Mani SA, Yang J, Brooks M, et al. Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers. Proc Natl Acad Sci U S A 2007;104:10069-74.
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 10069-10074
    • Mani, S.A.1    Yang, J.2    Brooks, M.3
  • 15
    • 4944240215 scopus 로고    scopus 로고
    • Down-regulation of the homeodomain factor Cdx2 in colorectal cancer by collagen type I: An active role for the tumor environment in malignant tumor progression
    • Brabletz T, Spaderna S, Kolb J, et al. Down-regulation of the homeodomain factor Cdx2 in colorectal cancer by collagen type I: an active role for the tumor environment in malignant tumor progression. Cancer Res 2004;64:6973-7.
    • (2004) Cancer Res , vol.64 , pp. 6973-6977
    • Brabletz, T.1    Spaderna, S.2    Kolb, J.3
  • 16
    • 0036726313 scopus 로고    scopus 로고
    • Stable suppression of tumorigenicity by virus-mediated RNA interference
    • Brummelkamp TR, Bernards R, Agami R. Stable suppression of tumorigenicity by virus-mediated RNA interference. Cancer Cell 2002;2:243-7.
    • (2002) Cancer Cell , vol.2 , pp. 243-247
    • Brummelkamp, T.R.1    Bernards, R.2    Agami, R.3
  • 17
    • 0035890760 scopus 로고    scopus 로고
    • Expression of the invasion factor laminin γ2 in colorectal carcinomas is regulated by β-catenin
    • Hlubek F, Jung A, Kotzor N, Kirchner T, Brabletz T. Expression of the invasion factor laminin γ2 in colorectal carcinomas is regulated by β-catenin. Cancer Res 2001;61:8089-93.
    • (2001) Cancer Res , vol.61 , pp. 8089-8093
    • Hlubek, F.1    Jung, A.2    Kotzor, N.3    Kirchner, T.4    Brabletz, T.5
  • 18
    • 20144388095 scopus 로고    scopus 로고
    • ΔEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells
    • Eger A, Aigner K, Sonderegger S, et al. ΔEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells. Oncogene 2005;24:2375-85.
    • (2005) Oncogene , vol.24 , pp. 2375-2385
    • Eger, A.1    Aigner, K.2    Sonderegger, S.3
  • 19
    • 0037452071 scopus 로고    scopus 로고
    • Adaptation of core mechanisms to generate cell polarity
    • Nelson WJ. Adaptation of core mechanisms to generate cell polarity. Nature 2003;422:766-74.
    • (2003) Nature , vol.422 , pp. 766-774
    • Nelson, W.J.1
  • 20
    • 0036045770 scopus 로고    scopus 로고
    • The epithelial-specific adaptor AP1B mediates post-endocytic recycling to the basolateral membrane
    • Gan Y, McGraw TE, Rodriguez-Boulan E. The epithelial-specific adaptor AP1B mediates post-endocytic recycling to the basolateral membrane. Nat Cell Biol 2002;4:605-9.
    • (2002) Nat Cell Biol , vol.4 , pp. 605-609
    • Gan, Y.1    McGraw, T.E.2    Rodriguez-Boulan, E.3
  • 21
    • 0037078324 scopus 로고    scopus 로고
    • MAL2, a novel raft protein of the MAL family, is an essential component of the machinery for transcytosis in hepatoma HepG2 cells
    • de Marco MC, Martin-Belmonte F, Kremer L, et al. MAL2, a novel raft protein of the MAL family, is an essential component of the machinery for transcytosis in hepatoma HepG2 cells. J Cell Biol 2002;159:37-44.
    • (2002) J Cell Biol , vol.159 , pp. 37-44
    • de Marco, M.C.1    Martin-Belmonte, F.2    Kremer, L.3
  • 22
    • 33646540110 scopus 로고    scopus 로고
    • Lethal giant larvae take on a life of their own
    • Wirtz-Peitz F, Knoblich JA. Lethal giant larvae take on a life of their own. Trends Cell Biol 2006;16:234-41.
    • (2006) Trends Cell Biol , vol.16 , pp. 234-241
    • Wirtz-Peitz, F.1    Knoblich, J.A.2
  • 23
    • 0031893101 scopus 로고    scopus 로고
    • Growth, metastasis, and invasiveness of Drosophila tumors caused by mutations in specific tumor suppressor genes
    • Woodhouse E, Hersperger E, Shearn A. Growth, metastasis, and invasiveness of Drosophila tumors caused by mutations in specific tumor suppressor genes. Dev Genes Evol 1998;207:542-50.
    • (1998) Dev Genes Evol , vol.207 , pp. 542-550
    • Woodhouse, E.1    Hersperger, E.2    Shearn, A.3
  • 24
    • 0031727409 scopus 로고    scopus 로고
    • Nuclear overexpression of the oncoprotein β-catenin in colorectal cancer is localized predominantly at the invasion front
    • Brabletz T, Jung A, Hermann K, Gunther K, Hohenberger W, Kirchner T. Nuclear overexpression of the oncoprotein β-catenin in colorectal cancer is localized predominantly at the invasion front. Pathol Res Pract 1998;194:701-4.
    • (1998) Pathol Res Pract , vol.194 , pp. 701-704
    • Brabletz, T.1    Jung, A.2    Hermann, K.3    Gunther, K.4    Hohenberger, W.5    Kirchner, T.6
  • 25
    • 35548974844 scopus 로고    scopus 로고
    • The transcription factor ZEB1 (δEF1) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarity
    • Aigner K, Dampier B, Descovich L, et al. The transcription factor ZEB1 (δEF1) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarity. Oncogene 2007;26:6979-88.
    • (2007) Oncogene , vol.26 , pp. 6979-6988
    • Aigner, K.1    Dampier, B.2    Descovich, L.3
  • 26
    • 33750505436 scopus 로고    scopus 로고
    • Par6-aPKC uncouples ErbB2 induced disruption of polarized epithelial organization from proliferation control
    • Aranda V, Haire T, Nolan ME, et al. Par6-aPKC uncouples ErbB2 induced disruption of polarized epithelial organization from proliferation control. Nat Cell Biol 2006;8:1235-45.
    • (2006) Nat Cell Biol , vol.8 , pp. 1235-1245
    • Aranda, V.1    Haire, T.2    Nolan, M.E.3
  • 27
    • 21044453012 scopus 로고    scopus 로고
    • Reduced expression of Hugl-1, the human homologue of Drosophila tumour suppressor gene lgl, contributes to progression of colorectal cancer
    • Schimanski CC, Schmitz G, Kashyap A, et al. Reduced expression of Hugl-1, the human homologue of Drosophila tumour suppressor gene lgl, contributes to progression of colorectal cancer. Oncogene 2005;24:3100-9.
    • (2005) Oncogene , vol.24 , pp. 3100-3109
    • Schimanski, C.C.1    Schmitz, G.2    Kashyap, A.3
  • 28
    • 9644265474 scopus 로고    scopus 로고
    • The human protein Hugl-1 substitutes for Drosophila lethal giant larvae tumour suppressor function in vivo
    • Grifoni D, Garoia F, Schimanski CC, et al. The human protein Hugl-1 substitutes for Drosophila lethal giant larvae tumour suppressor function in vivo. Oncogene 2004;23:8688-94.
    • (2004) Oncogene , vol.23 , pp. 8688-8694
    • Grifoni, D.1    Garoia, F.2    Schimanski, C.C.3
  • 29
    • 31844432828 scopus 로고    scopus 로고
    • Lgl, Pins and aPKC regulate neuroblast self-renewal versus differentiation
    • Lee CY, Robinson KJ, Doe CQ. Lgl, Pins and aPKC regulate neuroblast self-renewal versus differentiation. Nature 2006;439:594-8.
    • (2006) Nature , vol.439 , pp. 594-598
    • Lee, C.Y.1    Robinson, K.J.2    Doe, C.Q.3
  • 30
    • 25444495269 scopus 로고    scopus 로고
    • Opinion: Migrating cancer stem cells - an integrated concept of malignant tumour progression
    • Brabletz T, Jung A, Spaderna S, Hlubek F, Kirchner T. Opinion: migrating cancer stem cells - an integrated concept of malignant tumour progression. Nat Rev Cancer 2005;5:744-9.
    • (2005) Nat Rev Cancer , vol.5 , pp. 744-749
    • Brabletz, T.1    Jung, A.2    Spaderna, S.3    Hlubek, F.4    Kirchner, T.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.