Induction of ZEB proteins by inactivation of RB protein is key determinant of mesenchymal phenotype of breast cancer

Journal of Biological Chemistry

Volumn 287, Issue 11, 2012, Pages 7896-7906

  Arima, Yoshimi ^a,b   Hayashi, Hidemi ^c   Sasaki, Mikako ^a,b   Hosonaga, Mari ^a,d   Goto, Takaaki M ^a,b   Chiyoda, Tatsuyuki ^a,b   Kuninaka, Shinji ^a,b   Shibata, Tatsuhiro ^e   Ohata, Hirokazu ^e   Nakagama, Hitoshi ^e   Taya, Yoichi ^f   Saya, Hideyuki ^a,b  

^a KEIO UNIVERSITY   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c Link Genomics Inc   (Japan)

^d TOKYO MEDICAL UNIVERSITY   (Japan)

^e NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^f NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

ADHESION MOLECULES; BREAST CANCER; CANCER CELLS; CELL CYCLE CONTROL; CYCLIN-DEPENDENT KINASE INHIBITORS; DOWN-REGULATION; E-CADHERINS; EPITHELIAL-MESENCHYMAL TRANSITION; HUMAN BREAST CANCER CELLS; INVASIVENESS; KEY DETERMINANTS; MICRORNAS; RETINOBLASTOMA PROTEIN; SCREENING PROGRAMS; TRANSCRIPTIONAL REPRESSORS; TUMOR PROGRESSIONS; UP-REGULATION;

ADHESION; CELL CULTURE; DIAGNOSIS; GENES; GLYCOPROTEINS; PHOSPHORYLATION; PROTEINS;

CELLS;

BIOLOGICAL MARKER; CYCLIN DEPENDENT KINASE INHIBITOR; MICRORNA; MICRORNA 200; RETINOBLASTOMA PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; ZEB PROTEIN; ZEB1 PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BREAST CANCER; CANCER CELL; CANCER INVASION; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; E CADHERIN GENE; EPITHELIAL MESENCHYMAL TRANSITION; EPITHELIUM CELL; FEMALE; GENE; GENE INACTIVATION; HUMAN; HUMAN CELL; HUMAN TISSUE; MESENCHYME; MOUSE; MULTIGENE FAMILY; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; TRANSCRIPTION REGULATION; UPREGULATION;

BREAST NEOPLASMS; CADHERINS; CELL CYCLE; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; EPITHELIAL CELLS; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HOMEODOMAIN PROTEINS; HUMANS; MICRORNAS; NEOPLASM INVASIVENESS; PROTEIN KINASE INHIBITORS; RETINOBLASTOMA PROTEIN; RNA, NEOPLASM; TRANSCRIPTION FACTORS; TUMOR MARKERS, BIOLOGICAL; UP-REGULATION;

EID: 84858016877     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.313759     Document Type: Article

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