메뉴 건너뛰기




Volumn 13, Issue 1, 2014, Pages 107-121

Plant derived inhibitors of NF-κB

Author keywords

Cancer; Inflammation; NF B; Phytochemicals

Indexed keywords

ANACARDIC ACID; ARTEMISININ; BUTEIN; CARNOSIC ACID; CARNOSOL; CATECHIN; CELASTROL; CURCUMIN; EMBELIN; EPIGALLOCATECHIN GALLATE; I KAPPA B; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; ISOLIQUIRITIGENIN; LUTEOLIN; MITOGEN ACTIVATED PROTEIN KINASE; NARINGENIN; PHOSPHATIDYLINOSITOL 3 KINASE; PICEATANNOL; PLANT MEDICINAL PRODUCT; PLUMBAGIN; PROTEIN KINASE B; PROTEIN P53; QUERCETIN; RESVERATROL; ROSMARINIC ACID; THYMOQUINONE; UNINDEXED DRUG; WEDELOLACTONE; XANTHOHUMOL;

EID: 84896718284     PISSN: 15687767     EISSN: 1572980X     Source Type: Journal    
DOI: 10.1007/s11101-013-9293-5     Document Type: Review
Times cited : (34)

References (76)
  • 1
    • 55349112154 scopus 로고    scopus 로고
    • Modification of cysteine residue in p65 subunit of nuclear factor-κB (NF-κB) by Picroliv suppresses NF-κB-regulated gene products and potentiates apoptosis
    • Anand P, Kunnumakkara AB, Harikumar KB, Ahn KS, Badmaev V, Aggarwal BB (2008) Modification of cysteine residue in p65 subunit of nuclear factor-κB (NF-κB) by Picroliv suppresses NF-κB-regulated gene products and potentiates apoptosis. Cancer Res 68:8861-8870
    • (2008) Cancer Res , vol.68 , pp. 8861-8870
    • Anand, P.1    Kunnumakkara, A.B.2    Harikumar, K.B.3    Ahn, K.S.4    Badmaev, V.5    Aggarwal, B.B.6
  • 2
    • 80051782157 scopus 로고    scopus 로고
    • Barrier protective effects of lycopene in human endothelial cells
    • Bae JW, Bae JS (2011) Barrier protective effects of lycopene in human endothelial cells. Inflamm Res 60:751-758
    • (2011) Inflamm Res , vol.60 , pp. 751-758
    • Bae, J.W.1    Bae, J.S.2
  • 3
    • 78650878363 scopus 로고    scopus 로고
    • NF-κB, inflammation, and metabolic disease
    • Baker RG, Hayden MS, Gosh S (2011) NF-κB, inflammation, and metabolic disease. Cell Metab 13:11-22
    • (2011) Cell Metab , vol.13 , pp. 11-22
    • Baker, R.G.1    Hayden, M.S.2    Gosh, S.3
  • 4
    • 84860146666 scopus 로고    scopus 로고
    • The AKT/NF-κB inhibitor xanthohumol is a potent anti-lymphocytic leukemia drug overcoming chemoresistance and cell infiltration
    • Benelli R, Vene R, Ciarlo M, Carlone S, Barbieri O, Ferrari N (2012) The AKT/NF-κB inhibitor xanthohumol is a potent anti-lymphocytic leukemia drug overcoming chemoresistance and cell infiltration. Biochem Pharmacol 83:1634-1642
    • (2012) Biochem Pharmacol , vol.83 , pp. 1634-1642
    • Benelli, R.1    Vene, R.2    Ciarlo, M.3    Carlone, S.4    Barbieri, O.5    Ferrari, N.6
  • 5
    • 79952752154 scopus 로고    scopus 로고
    • β-Caryophyllene inhibits dextran sulfate sodium-induced colitis in mice through CB2 receptor activation and PPARγ pathway
    • Bento AF, Marcon R, Dutra RC, Claudino RF, Cola M, Leite DFP, Calixto JB (2011) β-Caryophyllene inhibits dextran sulfate sodium-induced colitis in mice through CB2 receptor activation and PPARγ pathway. Am J Pathol 178(3):1153-1166
    • (2011) Am J Pathol , vol.178 , Issue.3 , pp. 1153-1166
    • Bento, A.F.1    Marcon, R.2    Dutra, R.C.3    Claudino, R.F.4    Cola, M.5    Leite, D.F.P.6    Calixto, J.B.7
  • 6
    • 79958043464 scopus 로고    scopus 로고
    • Catechin suppresses an array of signalling molecules and modulates alcohol-induced endotoxin mediated liver injury in a rat model
    • Bharrhan S, Koul A, Chopra K, Rishi P (2011) Catechin suppresses an array of signalling molecules and modulates alcohol-induced endotoxin mediated liver injury in a rat model. PLoS One 6(6):e20635
    • (2011) PLoS One , vol.6 , Issue.6
    • Bharrhan, S.1    Koul, A.2    Chopra, K.3    Rishi, P.4
  • 7
    • 79251598329 scopus 로고    scopus 로고
    • Quercetin regulates oxidized LDL induced inflammatory changes in human PBMCs by modulating the TLR-NF-κB signaling pathway
    • Bhaskar S, Shalini V, Helen A (2011) Quercetin regulates oxidized LDL induced inflammatory changes in human PBMCs by modulating the TLR-NF-κB signaling pathway. Immunobiol 216:367-373
    • (2011) Immunobiol , vol.216 , pp. 367-373
    • Bhaskar, S.1    Shalini, V.2    Helen, A.3
  • 8
    • 84866729793 scopus 로고    scopus 로고
    • Sulfated derivative of 20(S)-Ginsenoside Rh2 inhibits inflammatory cytokines through MAPKs and NF-kappa B pathways in LPS-induced RAW264.7 macrophages
    • Bi WY, Fu BD, Shen HQ, Wei Q, Zhang C, Song Z, Qin QQ, Li HP, Lv S, Wu SC, Yi PF, Wei XB (2012) Sulfated derivative of 20(S)-Ginsenoside Rh2 inhibits inflammatory cytokines through MAPKs and NF-kappa B pathways in LPS-induced RAW264.7 macrophages. Inflammation 35(5): 1659-1668
    • (2012) Inflammation , vol.35 , Issue.5 , pp. 1659-1668
    • Bi, W.Y.1    Fu, B.D.2    Shen, H.Q.3    Wei, Q.4    Zhang, C.5    Song, Z.6    Qin, Q.Q.7    Li, H.P.8    Lv, S.9    Wu, S.C.10    Yi, P.F.11    Wei, X.B.12
  • 9
    • 80051484401 scopus 로고    scopus 로고
    • Curcumin modulates nuclear factor κB (NF-κB)-mediated Inflammation in human tenocytes in Vitro role of the phosphatidylinositol 3-kinase/akt pathway
    • Buhrmann C, Mobasheri A, Busch F, Aldinger C, Stahlmann R, Montaseri A, Shakibaei M (2011) Curcumin modulates nuclear factor κB (NF-κB)-mediated Inflammation in human tenocytes in Vitro role of the phosphatidylinositol 3-kinase/akt pathway. JBC 286(32):28556-28566
    • (2011) JBC , vol.286 , Issue.32 , pp. 28556-28566
    • Buhrmann, C.1    Mobasheri, A.2    Busch, F.3    Aldinger, C.4    Stahlmann, R.5    Montaseri, A.6    Shakibaei, M.7
  • 12
    • 79551646077 scopus 로고    scopus 로고
    • Natural products triggering biological targets - A review of the anti-inflammatory phytochemicals targeting the arachidonic acid pathway in allergy asthma and rheumatoid arthritis
    • Chen S (2011) Natural products triggering biological targets - a review of the anti-inflammatory phytochemicals targeting the arachidonic acid pathway in allergy asthma and rheumatoid arthritis. Curr Drug Targets 12:288-301
    • (2011) Curr Drug Targets , vol.12 , pp. 288-301
    • Chen, S.1
  • 13
    • 84861444178 scopus 로고    scopus 로고
    • Santamarin, a sesquiterpene lactone isolated from Saussurea lappa, represses LPS-induced inflammatory responses via expression of heme oxygenase-1 in murine macrophage cells
    • Choi HG, Lee DS, Li B, Choi YH, Lee SH, Kim YC (2012) Santamarin, a sesquiterpene lactone isolated from Saussurea lappa, represses LPS-induced inflammatory responses via expression of heme oxygenase-1 in murine macrophage cells. Int Immunopharmacol 13:271-279
    • (2012) Int Immunopharmacol , vol.13 , pp. 271-279
    • Choi, H.G.1    Lee, D.S.2    Li, B.3    Choi, Y.H.4    Lee, S.H.5    Kim, Y.C.6
  • 14
    • 84862811331 scopus 로고    scopus 로고
    • Cardamonin from Alpinia rafflesiana inhibits inflammatory responses in IFN-γ/LPS-stimulated BV2 microglia via NF-κB signalling pathway
    • Chow YL, Lee KH, Vidyadaran S, Lajis NH, Akhtar MN, Israf DA, Syahid A (2012) Cardamonin from Alpinia rafflesiana inhibits inflammatory responses in IFN-γ/LPS-stimulated BV2 microglia via NF-κB signalling pathway. Int Immunopharmacol 12:657-665
    • (2012) Int Immunopharmacol , vol.12 , pp. 657-665
    • Chow, Y.L.1    Lee, K.H.2    Vidyadaran, S.3    Lajis, N.H.4    Akhtar, M.N.5    Israf, D.A.6    Syahid, A.7
  • 15
    • 79953064635 scopus 로고    scopus 로고
    • Inhibition of NF-kappa B activity in mammary epithelium increases tumor latency and decreases tumor burden
    • Connelly L, Barham W, Onishko HM, Sherrill T, Chodosh LA, Blackwell TS, Yull FE (2011) Inhibition of NF-kappa B activity in mammary epithelium increases tumor latency and decreases tumor burden. Oncogene 30:1402-1412
    • (2011) Oncogene , vol.30 , pp. 1402-1412
    • Connelly, L.1    Barham, W.2    Onishko, H.M.3    Sherrill, T.4    Chodosh, L.A.5    Blackwell, T.S.6    Yull, F.E.7
  • 16
    • 84858718448 scopus 로고    scopus 로고
    • NF-κB and the link between inflammation and cancer
    • DiDonato JA, Mercurio F, Karin M (2012) NF-κB and the link between inflammation and cancer. Immunol Rev 246: 379-400
    • (2012) Immunol Rev , vol.246 , pp. 379-400
    • DiDonato, J.A.1    Mercurio, F.2    Karin, M.3
  • 17
    • 84856433514 scopus 로고    scopus 로고
    • Quince (Cydonia oblonga Miller) peel polyphenols modulate LPS-induced inflammation in human THP-1-derived macrophages through NF-κB, p38MAPK and Akt inhibition
    • Essafi-Benkhadir K, Refai A, Riahi I, Fattouch S, Karoui H, Essafi M (2012) Quince (Cydonia oblonga Miller) peel polyphenols modulate LPS-induced inflammation in human THP-1-derived macrophages through NF-κB, p38MAPK and Akt inhibition. Biochem Biophys Res Commun 418:180-185
    • (2012) Biochem Biophys Res Commun , vol.418 , pp. 180-185
    • Essafi-Benkhadir, K.1    Refai, A.2    Riahi, I.3    Fattouch, S.4    Karoui, H.5    Essafi, M.6
  • 18
    • 79955123540 scopus 로고    scopus 로고
    • Lipopolysaccharide-stimulated activation of murine DC2.4 cells is attenuated by n-butylidenephthalide through suppression of the NF-κB pathway
    • Fu RH, Hran HJ, Chu CL, Huang CM, Liu SP, Wang YC, Lin YH, Shyu WC, Lin SZ (2011) Lipopolysaccharide-stimulated activation of murine DC2.4 cells is attenuated by n-butylidenephthalide through suppression of the NF-κB pathway. Biotechnol Lett 33:903-910
    • (2011) Biotechnol Lett , vol.33 , pp. 903-910
    • Fu, R.H.1    Hran, H.J.2    Chu, C.L.3    Huang, C.M.4    Liu, S.P.5    Wang, Y.C.6    Lin, Y.H.7    Shyu, W.C.8    Lin, S.Z.9
  • 19
    • 84858720357 scopus 로고    scopus 로고
    • Celebrating 25 years of NF-kB research
    • Ghosh S, Hayden MS (2012) Celebrating 25 years of NF-kB research. Immunol Rev 246:5-13
    • (2012) Immunol Rev , vol.246 , pp. 5-13
    • Ghosh, S.1    Hayden, M.S.2
  • 20
  • 21
    • 33750446341 scopus 로고    scopus 로고
    • Inhibitors of NF-kappaB signaling: 785 and counting
    • DOI 10.1038/sj.onc.1209982, PII 1209982
    • Gilmore TD, Herscovitch M (2006) Inhibitors of NF-kappa B signaling 785 and counting. Oncogene 25:6887-6899 (Pubitemid 44657858)
    • (2006) Oncogene , vol.25 , Issue.51 , pp. 6887-6899
    • Gilmore, T.D.1    Herscovitch, M.2
  • 22
    • 84859005485 scopus 로고    scopus 로고
    • Antitumor effect of berberine against primary effusion lymphoma via inhibition of NF-κB pathway
    • Goto H, Kariya R, Shimamoto M, Kudo E, Taura M, Katano H, Okada S (2012) Antitumor effect of berberine against primary effusion lymphoma via inhibition of NF-κB pathway. Cancer Sci 103(4):775-781
    • (2012) Cancer Sci , vol.103 , Issue.4 , pp. 775-781
    • Goto, H.1    Kariya, R.2    Shimamoto, M.3    Kudo, E.4    Taura, M.5    Katano, H.6    Okada, S.7
  • 23
    • 33746835021 scopus 로고    scopus 로고
    • Computational identification of transcriptional regulatory elements in DNA sequence
    • GuhaThakurta D (2006) Computational identification of transcriptional regulatory elements in DNA sequence. Nucleic Acid Res 34:3585-3598
    • (2006) Nucleic Acid Res , vol.34 , pp. 3585-3598
    • GuhaThakurta, D.1
  • 24
    • 77957592789 scopus 로고    scopus 로고
    • Regulation of survival proliferation invasion angiogenesis and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals
    • Gupta SC, Kim JH, Prasad S, Aggarwal BB (2010a) Regulation of survival proliferation invasion angiogenesis and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals. Cancer Metastasis Rev 29:405-434
    • (2010) Cancer Metastasis Rev , vol.29 , pp. 405-434
    • Gupta, S.C.1    Kim, J.H.2    Prasad, S.3    Aggarwal, B.B.4
  • 25
    • 77957570183 scopus 로고    scopus 로고
    • Inhibiting NF-κB activation by small molecules as therapeutic strategy
    • Gupta SC, Sundaram C, Reuter S, Aggarwal BB (2010b) Inhibiting NF-κB activation by small molecules as therapeutic strategy. Biochim Biophys Acta 1799:775-787
    • (2010) Biochim Biophys Acta , vol.1799 , pp. 775-787
    • Gupta, S.C.1    Sundaram, C.2    Reuter, S.3    Aggarwal, B.B.4
  • 26
    • 80054778012 scopus 로고    scopus 로고
    • Bharangin, a diterpenoid quinonemethide, abolishes constitutive and inducible nuclear factor-κB (NF-κB) activation by modifying p65 on Cysteine 38 residue and reducing inhibitor of nuclear factor-κB α Kinase activation, leading to suppression of NF-κB-regulated gene expression and sensitization of tumor cells to chemotherapeutic agents
    • Gupta SC, Kannappan R, Ghazi JK, Rahman M, Francis SK, Raveendran R, Nair MS, Das J, Aggarwal BB (2011a) Bharangin, a diterpenoid quinonemethide, abolishes constitutive and inducible nuclear factor-κB (NF-κB) activation by modifying p65 on Cysteine 38 residue and reducing inhibitor of nuclear factor-κB α Kinase activation, leading to suppression of NF-κB-regulated gene expression and sensitization of tumor cells to chemotherapeutic agents. Mol Pharmacol 80:769-781
    • (2011) Mol Pharmacol , vol.80 , pp. 769-781
    • Gupta, S.C.1    Kannappan, R.2    Ghazi, J.K.3    Rahman, M.4    Francis, S.K.5    Raveendran, R.6    Nair, M.S.7    Das, J.8    Aggarwal, B.B.9
  • 27
    • 79958848355 scopus 로고    scopus 로고
    • Role of nuclear factor κB-mediated inflammatory pathways in cancer-related symptoms and their regulation by nutritional agents
    • Gupta SC, Kim JH, Kannappan R, Reuter S, Dougherty PM, Aggarwal BB (2011b) Role of nuclear factor κB-mediated inflammatory pathways in cancer-related symptoms and their regulation by nutritional agents. Exp Biol Med 236:658-671
    • (2011) Exp Biol Med , vol.236 , pp. 658-671
    • Gupta, S.C.1    Kim, J.H.2    Kannappan, R.3    Reuter, S.4    Dougherty, P.M.5    Aggarwal, B.B.6
  • 28
    • 84865549508 scopus 로고    scopus 로고
    • Plumbagin, a plant derived natural agent inhibits the growth of pancreatic cancer cells in in vitro and in vivo via targeting EGFR, Stat3 and NF-κB signaling pathways
    • Hafeez BB, Jamal MS, Fischer JW, Mustafa A, Verma AK (2012) Plumbagin, a plant derived natural agent inhibits the growth of pancreatic cancer cells in in vitro and in vivo via targeting EGFR, Stat3 and NF-κB signaling pathways. Int J Cancer 131:2175-2186
    • (2012) Int J Cancer , vol.131 , pp. 2175-2186
    • Hafeez, B.B.1    Jamal, M.S.2    Fischer, J.W.3    Mustafa, A.4    Verma, A.K.5
  • 29
    • 77951035820 scopus 로고    scopus 로고
    • Escin, a pentacyclic triterpene, chemosensitizes human tumor cells through inhibition of nuclear factor-κB signaling pathway
    • Harikumar KB, Sung B, Pandey MK, Guha S, Krishnan S, Aggarwal BB (2010a) Escin, a pentacyclic triterpene, chemosensitizes human tumor cells through inhibition of nuclear factor-κB signaling pathway. Mol Pharmacol 77:818-827
    • (2010) Mol Pharmacol , vol.77 , pp. 818-827
    • Harikumar, K.B.1    Sung, B.2    Pandey, M.K.3    Guha, S.4    Krishnan, S.5    Aggarwal, B.B.6
  • 30
    • 77952941515 scopus 로고    scopus 로고
    • Sesamin manifests chemopreventive effects through the suppression of NF-κB-regulated cell survival, proliferation, invasion, and angiogenic gene products
    • Harikumar KB, Sung B, Tharakan ST, Pandey MK, Joy B, Guha S, Krishnan S, Aggarwal BB (2010b) Sesamin manifests chemopreventive effects through the suppression of NF-κB-regulated cell survival, proliferation, invasion, and angiogenic gene products. Mol Cancer Res 8:751-761
    • (2010) Mol Cancer Res , vol.8 , pp. 751-761
    • Harikumar, K.B.1    Sung, B.2    Tharakan, S.T.3    Pandey, M.K.4    Joy, B.5    Guha, S.6    Krishnan, S.7    Aggarwal, B.B.8
  • 32
    • 78049440454 scopus 로고    scopus 로고
    • Cell proliferation inhibitory and apoptosis-inducing properties of anacardic acid and lunasin in human breast cancer MDA-MB-231 cells
    • Hsieh CC, Hernández-Ledesma B, de Lumen BO (2011) Cell proliferation inhibitory and apoptosis-inducing properties of anacardic acid and lunasin in human breast cancer MDA-MB-231 cells. Food Chem 125:630-636
    • (2011) Food Chem , vol.125 , pp. 630-636
    • Hsieh, C.C.1    Hernández-Ledesma, B.2    De Lumen, B.O.3
  • 33
    • 79955838953 scopus 로고    scopus 로고
    • Anti-tumor effect of luteolin is accompanied by AMP-activated protein kinase and nuclear factor-κB modulation in HepG2 hepatocarcinoma cells
    • Hwang JT, Park OJ, Lee YK, Sung MJ, Hur HJ, Kim MS, Ha JH, Kwon DY (2011) Anti-tumor effect of luteolin is accompanied by AMP-activated protein kinase and nuclear factor-κB modulation in HepG2 hepatocarcinoma cells. Int J Mol Med 28:25-31
    • (2011) Int J Mol Med , vol.28 , pp. 25-31
    • Hwang, J.T.1    Park, O.J.2    Lee, Y.K.3    Sung, M.J.4    Hur, H.J.5    Kim, M.S.6    Ha, J.H.7    Kwon, D.Y.8
  • 34
    • 84863111654 scopus 로고    scopus 로고
    • Cryptopleurine targets NF-κB pathway, leading to inhibition of gene products associated with cell survival, proliferation, invasion, and angiogenesis
    • Jin HR, Jin SZ, Cai XF, Li D, Wu X, Nan JX, Lee JJ, Jin X (2012) Cryptopleurine targets NF-κB pathway, leading to inhibition of gene products associated with cell survival, proliferation, invasion, and angiogenesis. PLoS One 7(6)
    • (2012) PLoS One , vol.7 , Issue.6
    • Jin, H.R.1    Jin, S.Z.2    Cai, X.F.3    Li, D.4    Wu, X.5    Nan, J.X.6    Lee, J.J.7    Jin, X.8
  • 35
    • 77955919158 scopus 로고    scopus 로고
    • Diosgenin inhibits macrophage-derived inflammatory mediators through downregulation of CK2, JNK, NF-κB and AP-1 activation
    • Jung DH, Park HJ, Byun HE, Park YM, Kim TW, Kim BO, Um SH, Pyo S (2010) Diosgenin inhibits macrophage-derived inflammatory mediators through downregulation of CK2, JNK, NF-κB and AP-1 activation. Int Immunopharmacol 10:1047-1054
    • (2010) Int Immunopharmacol , vol.10 , pp. 1047-1054
    • Jung, D.H.1    Park, H.J.2    Byun, H.E.3    Park, Y.M.4    Kim, T.W.5    Kim, B.O.6    Um, S.H.7    Pyo, S.8
  • 38
    • 33845193845 scopus 로고    scopus 로고
    • The coffee diterpene kahweol inhibits tumor necrosis factor-alpha-induced expression of cell adhesion molecules in human endothelial cells
    • DOI 10.1016/j.taap.2006.09.013, PII S0041008X06003462
    • Kim HG, Kim JY, Hwang YP, Lee KJ, Lee KY, Kim DH, Kim DH, Jeong HG (2006) The coffee diterpene kahweol inhibits tumor necrosis factor-α-induced expression of cell adhesion molecules in human endothelial cells. Toxicol Appl Pharmacol 217:332-341 (Pubitemid 44855824)
    • (2006) Toxicology and Applied Pharmacology , vol.217 , Issue.3 , pp. 332-341
    • Kim, H.G.1    Kim, J.Y.2    Hwang, Y.P.3    Lee, K.J.4    Lee, K.Y.5    Kim, D.H.6    Kim, D.H.7    Jeong, H.G.8
  • 39
  • 40
    • 80855141780 scopus 로고    scopus 로고
    • Effects of impressic acid from Acanthopanax koreanum on NF-κB and PPARγ activities
    • Kim JA, Yang SY, Song SB, Kim YH (2011) Effects of impressic acid from Acanthopanax koreanum on NF-κB and PPARγ activities. Arch Pharm Res 34(8):1347-1351
    • (2011) Arch Pharm Res , vol.34 , Issue.8 , pp. 1347-1351
    • Kim, J.A.1    Yang, S.Y.2    Song, S.B.3    Kim, Y.H.4
  • 41
    • 80054696067 scopus 로고    scopus 로고
    • Cepharanthine exerts anti-inflammatory effects via NF-κB inhibition in a LPS-induced rat model of systemic inflammation
    • Kudo K, Hagiwara S, Hasegawa A, Kusaka J, Koga H, Noguchi T (2011) Cepharanthine exerts anti-inflammatory effects via NF-κB inhibition in a LPS-induced rat model of systemic inflammation. J Surg Res 171:199-204
    • (2011) J Surg Res , vol.171 , pp. 199-204
    • Kudo, K.1    Hagiwara, S.2    Hasegawa, A.3    Kusaka, J.4    Koga, H.5    Noguchi, T.6
  • 42
    • 77950189559 scopus 로고    scopus 로고
    • NF-κB inhibitory action of resveratrol: A probable mechanism of neuroprotection in experimental diabetic neuropathy
    • Kumar A, Sharma SS (2010) NF-κB inhibitory action of resveratrol: a probable mechanism of neuroprotection in experimental diabetic neuropathy. Biochem Biophys Res Commun 394:360-365
    • (2010) Biochem Biophys Res Commun , vol.394 , pp. 360-365
    • Kumar, A.1    Sharma, S.S.2
  • 43
    • 3843052483 scopus 로고    scopus 로고
    • Nuclear factor-kappaB: Its role in health and disease
    • Berl
    • Kumar A, Takada Y, Boriek AM, Aggarwal BB (2004) Nuclear factor-kappaB: its role in health and disease. J Mol Med (Berl) 82:432-448
    • (2004) J Mol Med , vol.82 , pp. 432-448
    • Kumar, A.1    Takada, Y.2    Boriek, A.M.3    Aggarwal, B.B.4
  • 45
    • 79953047271 scopus 로고    scopus 로고
    • Anti-inflammatory activity of Angelica dahurica ethanolic extract on RAW264.7 cells via upregulation of heme oxygenase-1
    • Lee MY, Lee JA, Seo CS, Ha H, Lee H, Son JK, Shin HK (2011) Anti-inflammatory activity of Angelica dahurica ethanolic extract on RAW264.7 cells via upregulation of heme oxygenase-1. Food Chem Toxicol 49:1047-1055
    • (2011) Food Chem Toxicol , vol.49 , pp. 1047-1055
    • Lee, M.Y.1    Lee, J.A.2    Seo, C.S.3    Ha, H.4    Lee, H.5    Son, J.K.6    Shin, H.K.7
  • 46
    • 77950540096 scopus 로고    scopus 로고
    • Maslinic acid potentiates the antitumor activity of tumor necrosis factor a by inhibiting NF-κB signaling pathway
    • Li C, Yang Z, Zhai C, Qiu W, Li D, Yi Z, Wang L, Tang J, Qian M, Luo J, Liu M (2010) Maslinic acid potentiates the antitumor activity of tumor necrosis factor a by inhibiting NF-κB signaling pathway. Mol Cancer 9:73
    • (2010) Mol Cancer , vol.9 , pp. 73
    • Li, C.1    Yang, Z.2    Zhai, C.3    Qiu, W.4    Li, D.5    Yi, Z.6    Wang, L.7    Tang, J.8    Qian, M.9    Luo, J.10    Liu, M.11
  • 48
    • 74949124948 scopus 로고    scopus 로고
    • Berbamine, a novel nuclear factor κB inhibitor, inhibits growth and induces apoptosis in human myeloma cells
    • Liang Y, Xu RZ, Zhang L, Zhao XY (2009) Berbamine, a novel nuclear factor κB inhibitor, inhibits growth and induces apoptosis in human myeloma cells. Acta Pharmacol Sinica 30:1659-1665
    • (2009) Acta Pharmacol Sinica , vol.30 , pp. 1659-1665
    • Liang, Y.1    Xu, R.Z.2    Zhang, L.3    Zhao, X.Y.4
  • 49
    • 84864418149 scopus 로고    scopus 로고
    • Suppression of Akt/Foxp3-mediated miR-183 expression blocks Sp1-mediated ADAM17 expression and TNFα-mediated NF-κB activation in piceatannol-treated human leukemia U937 cells
    • Liu WS, Chang LS (2012) Suppression of Akt/Foxp3-mediated miR-183 expression blocks Sp1-mediated ADAM17 expression and TNFα-mediated NF-κB activation in piceatannol-treated human leukemia U937 cells. Biochem Pharmacol 84:670-680
    • (2012) Biochem Pharmacol , vol.84 , pp. 670-680
    • Liu, W.S.1    Chang, L.S.2
  • 50
    • 84855339789 scopus 로고    scopus 로고
    • DEDC, a new flavonoid induces apoptosis via a ROS-dependent mechanism in human neuroblastoma SH-SY5Y cells
    • Liu H, Jiang C, Xiong C, Ruan J (2012) DEDC, a new flavonoid induces apoptosis via a ROS-dependent mechanism in human neuroblastoma SH-SY5Y cells. Toxicol In Vitro 26:16-23
    • (2012) Toxicol in Vitro , vol.26 , pp. 16-23
    • Liu, H.1    Jiang, C.2    Xiong, C.3    Ruan, J.4
  • 51
    • 84862777626 scopus 로고    scopus 로고
    • Citreorosein, a naturally occurring anthraquinone derivative isolated from Polygoni cuspidati radix, attenuates cyclooxygenase-2-dependent prostaglandin D2 generation by blocking Akt and JNK pathways in mouse bone marrow-derived mast cells
    • Lu Y, Suh SJ, Li X, Hwang SL, Li Y, Hwangbo K, Park SJ, Murakami M, Lee SH, Jahng Y, Son JK, Kim CH, Chang HW (2012) Citreorosein, a naturally occurring anthraquinone derivative isolated from Polygoni cuspidati radix, attenuates cyclooxygenase-2-dependent prostaglandin D2 generation by blocking Akt and JNK pathways in mouse bone marrow-derived mast cells. Food Chem Toxicol 50:913-919
    • (2012) Food Chem Toxicol , vol.50 , pp. 913-919
    • Lu, Y.1    Suh, S.J.2    Li, X.3    Hwang, S.L.4    Li, Y.5    Hwangbo, K.6    Park, S.J.7    Murakami, M.8    Lee, S.H.9    Jahng, Y.10    Son, J.K.11    Kim, C.H.12    Chang, H.W.13
  • 52
    • 84863619176 scopus 로고    scopus 로고
    • Parthenolide, a sesquiterpene lactone, expresses multiple anti-cancer and anti-inflammatory activities
    • Mathema VB, Koh YS, Thakuri BC, Sillanpää M (2011) Parthenolide, a sesquiterpene lactone, expresses multiple anti-cancer and anti-inflammatory activities. Inflammation 35(2):560-565
    • (2011) Inflammation , vol.35 , Issue.2 , pp. 560-565
    • Mathema, V.B.1    Koh, Y.S.2    Thakuri, B.C.3    Sillanpää, M.4
  • 53
    • 77957020140 scopus 로고    scopus 로고
    • Butein suppresses the expression of nuclear factor-kappa B-mediated matrix metalloproteinase-9 and vascular endothelial growth factor in prostate cancer cells
    • Moon DO, Choi YH, Moon SK, Kim WJ, Kim GY (2010a) Butein suppresses the expression of nuclear factor-kappa B-mediated matrix metalloproteinase-9 and vascular endothelial growth factor in prostate cancer cells. Toxicol In Vitro 24:1927-1934
    • (2010) Toxicol in Vitro , vol.24 , pp. 1927-1934
    • Moon, D.O.1    Choi, Y.H.2    Moon, S.K.3    Kim, W.J.4    Kim, G.Y.5
  • 54
    • 74849083369 scopus 로고    scopus 로고
    • Rosmarinic acid sensitizes cell death through suppression of TNF-α-induced NF-κB activation and ROS generation in human leukemia U937 cells
    • Moon DO, Kim MO, Lee JD, Choi YH, Kim GY (2010b) Rosmarinic acid sensitizes cell death through suppression of TNF-α-induced NF-κB activation and ROS generation in human leukemia U937 cells. Cancer Lett 288:183-191
    • (2010) Cancer Lett , vol.288 , pp. 183-191
    • Moon, D.O.1    Kim, M.O.2    Lee, J.D.3    Choi, Y.H.4    Kim, G.Y.5
  • 55
    • 16844366650 scopus 로고    scopus 로고
    • Nuclear factor-kappaB inhibitors as sensitizers to anticancer drugs
    • DOI 10.1038/nrc1588
    • Nakanishi C, Toi M (2005) Nuclear factor-kappaB inhibitors as sensitizers to anticancer drugs. Nat Rev Cancer 5:297-309 (Pubitemid 40488635)
    • (2005) Nature Reviews Cancer , vol.5 , Issue.4 , pp. 297-309
    • Nakanishi, C.1    Toi, M.2
  • 57
  • 58
    • 80052451081 scopus 로고    scopus 로고
    • Leishmania major: Anti-leishmanial activity of Nuphar lutea extract mediated by the activation of transcription factor NF-κB
    • Ozer L, El-On J, Golan-Goldhirsh A, Gopas J (2010) Leishmania major: anti-leishmanial activity of Nuphar lutea extract mediated by the activation of transcription factor NF-κB. Exp Parasitol 126:510-516
    • (2010) Exp Parasitol , vol.126 , pp. 510-516
    • Ozer, L.1    El-On, J.2    Golan-Goldhirsh, A.3    Gopas, J.4
  • 59
    • 77956345011 scopus 로고    scopus 로고
    • Suppression of homodimerization of toll-like receptor 4 by isoliquiritigenin
    • Park SJ, Youn HS (2010) Suppression of homodimerization of toll-like receptor 4 by isoliquiritigenin. Phytochem 71: 1736-1740
    • (2010) Phytochem , vol.71 , pp. 1736-1740
    • Park, S.J.1    Youn, H.S.2
  • 60
    • 80053938368 scopus 로고    scopus 로고
    • Triptolide, histone acetyltransferase inhibitor, suppresses growth and chemosensitizes leukemic cells through inhibition of gene expression regulated by TNF-TNFR1-TRADD-TRAF2-NIK-TAK1-IKK pathway
    • Park B, Sung B, Yadav VR, Chaturvedi MM, Aggarwal BB (2011) Triptolide, histone acetyltransferase inhibitor, suppresses growth and chemosensitizes leukemic cells through inhibition of gene expression regulated by TNF-TNFR1-TRADD-TRAF2-NIK-TAK1-IKK pathway. Biochem Pharmacol 82:1134-1144
    • (2011) Biochem Pharmacol , vol.82 , pp. 1134-1144
    • Park, B.1    Sung, B.2    Yadav, V.R.3    Chaturvedi, M.M.4    Aggarwal, B.B.5
  • 61
    • 84856213846 scopus 로고    scopus 로고
    • The diverse and complex roles of NF-κB subunits in cancer
    • Perkins ND (2012) The diverse and complex roles of NF-κB subunits in cancer. Nar Rev Cancer 12:121-132
    • (2012) Nar Rev Cancer , vol.12 , pp. 121-132
    • Perkins, N.D.1
  • 62
    • 70350317603 scopus 로고    scopus 로고
    • Induction of apoptosis by lupeol in human epidermoid carcinoma A431 cells through regulation of mitochondrial, Akt/PKB and NFkB signaling pathways
    • Prasad S, Madan E, Nigam N, Roy P, George J, Shukla Y (2009) Induction of apoptosis by lupeol in human epidermoid carcinoma A431 cells through regulation of mitochondrial, Akt/PKB and NFkB signaling pathways. Cancer Biol Ther 8(17):1632-1639
    • (2009) Cancer Biol Ther , vol.8 , Issue.17 , pp. 1632-1639
    • Prasad, S.1    Madan, E.2    Nigam, N.3    Roy, P.4    George, J.5    Shukla, Y.6
  • 63
    • 77956246885 scopus 로고    scopus 로고
    • Crotepoxide chemosensitizes tumor cells through inhibition of expression of proliferation, invasion, and angiogenic proteins linked to proinflammatory pathway
    • Prasad S, Yadav VR, Sundaram C, Reuter S, Hema PS, Nair MS, Chaturvedi MM, Aggarwal BB (2010) Crotepoxide chemosensitizes tumor cells through inhibition of expression of proliferation, invasion, and angiogenic proteins linked to proinflammatory pathway. JBC 285(35):26987-26997
    • (2010) JBC , vol.285 , Issue.35 , pp. 26987-26997
    • Prasad, S.1    Yadav, V.R.2    Sundaram, C.3    Reuter, S.4    Hema, P.S.5    Nair, M.S.6    Chaturvedi, M.M.7    Aggarwal, B.B.8
  • 64
    • 78649673612 scopus 로고    scopus 로고
    • Embelin suppresses osteoclastogenesis induced by receptor activator of NF-κB ligand and tumor cells in vitro through inhibition of the NF-κB cell signaling pathway
    • Reuter S, Prasad S, Phromnoi K, Kannappan R, Yadav VR, Aggarwal BB (2010a) Embelin suppresses osteoclastogenesis induced by receptor activator of NF-κB ligand and tumor cells in vitro through inhibition of the NF-κB cell signaling pathway. Mol Cancer Res 8:1425-1436
    • (2010) Mol Cancer Res , vol.8 , pp. 1425-1436
    • Reuter, S.1    Prasad, S.2    Phromnoi, K.3    Kannappan, R.4    Yadav, V.R.5    Aggarwal, B.B.6
  • 65
    • 78649305848 scopus 로고    scopus 로고
    • Thiocolchicoside exhibits anticancer effects through downregulation of NF-κB pathway and its regulated gene products linked to inflammation and cancer
    • Reuter S, Prasad S, Phromnoi K, Ravindran J, Sung B, Yadav VR, Kannappan R, Chaturvedi MM, Aggarwal BB (2010b) Thiocolchicoside exhibits anticancer effects through downregulation of NF-κB pathway and its regulated gene products linked to inflammation and cancer. Cancer Prev Res 3:1462-1472
    • (2010) Cancer Prev Res , vol.3 , pp. 1462-1472
    • Reuter, S.1    Prasad, S.2    Phromnoi, K.3    Ravindran, J.4    Sung, B.5    Yadav, V.R.6    Kannappan, R.7    Chaturvedi, M.M.8    Aggarwal, B.B.9
  • 66
    • 84857035526 scopus 로고    scopus 로고
    • Phytochemicals suppress nuclear factor-κB signaling: Impact on health span and aging process
    • Salminen A, Kauppinen A, Kaamiranta K (2012) Phytochemicals suppress nuclear factor-κB signaling: impact on health span and aging process. Curr Opin Clin Nutr Metab Care 15:23-28
    • (2012) Curr Opin Clin Nutr Metab Care , vol.15 , pp. 23-28
    • Salminen, A.1    Kauppinen, A.2    Kaamiranta, K.3
  • 67
    • 0022930702 scopus 로고
    • Inducibility of K immunoglobulin enhancer-binding protein NF-kB by a posttranslational mechanism
    • Sen R, Baltimore D (1986) Inducibility of kappa immunoglobulin enhancer-binding protein NF-kappa B by a post-transcriptional mechanism. Cell 47:921-928 (Pubitemid 17005065)
    • (1986) Cell , vol.47 , Issue.6 , pp. 921-928
    • Sen, R.1    Baltimore, D.2
  • 69
    • 60249085139 scopus 로고    scopus 로고
    • Suppression of inducible nitric oxide synthase by (-)-isoeleutherin from the bulbs of Eleutherine americana through the regulation of NF-κB activity
    • Song SH, Min HY, Han AR, Nam JW, Seo EK, Park SW, Lee SH, Lee SK (2009) Suppression of inducible nitric oxide synthase by (-)-isoeleutherin from the bulbs of Eleutherine americana through the regulation of NF-κB activity. Int Immunopharmacol 9:298-302
    • (2009) Int Immunopharmacol , vol.9 , pp. 298-302
    • Song, S.H.1    Min, H.Y.2    Han, A.R.3    Nam, J.W.4    Seo, E.K.5    Park, S.W.6    Lee, S.H.7    Lee, S.K.8
  • 71
    • 77951049854 scopus 로고    scopus 로고
    • Noscapine, a benzylisoquinoline alkaloid, sensitizes leukemic cells to chemotherapeutic agents and cytokines by modulating the NF-κB signaling pathway
    • Sung B, Ahn KS, Aggarwal BB (2010) Noscapine, a benzylisoquinoline alkaloid, sensitizes leukemic cells to chemotherapeutic agents and cytokines by modulating the NF-κB signaling pathway. Cancer Res 70:3259-3268
    • (2010) Cancer Res , vol.70 , pp. 3259-3268
    • Sung, B.1    Ahn, K.S.2    Aggarwal, B.B.3
  • 72
    • 78650656795 scopus 로고    scopus 로고
    • The anti-malarial artemisinin inhibits pro-inflammatory cytokines via the NF-κB canonical signaling pathway in PMA-induced THP-1 monocytes
    • Wang Y, Huang Z, Wang L, Meng S, Fan Y, Chen T, Cao J, Jiang R, Wang C (2011) The anti-malarial artemisinin inhibits pro-inflammatory cytokines via the NF-κB canonical signaling pathway in PMA-induced THP-1 monocytes. Int J Mol Med 27:233-241
    • (2011) Int J Mol Med , vol.27 , pp. 233-241
    • Wang, Y.1    Huang, Z.2    Wang, L.3    Meng, S.4    Fan, Y.5    Chen, T.6    Cao, J.7    Jiang, R.8    Wang, C.9
  • 74
    • 79953706863 scopus 로고    scopus 로고
    • Naringenin attenuates mucous hypersecretion by modulating reactive oxygen species production and inhibiting NF-κB activity via EGFR-PI3K-Akt/ERK MAPKinase signaling in human airway epithelial cells
    • Yang J, Li Q, Zhou XD, Kolosov VP, Perelman JM (2011) Naringenin attenuates mucous hypersecretion by modulating reactive oxygen species production and inhibiting NF-κB activity via EGFR-PI3K-Akt/ERK MAPKinase signaling in human airway epithelial cells. Mol Cell Biochem 351:29-40
    • (2011) Mol Cell Biochem , vol.351 , pp. 29-40
    • Yang, J.1    Li, Q.2    Zhou, X.D.3    Kolosov, V.P.4    Perelman, J.M.5
  • 75
    • 84862960597 scopus 로고    scopus 로고
    • Antioxidant and anti-inflammatory potential of hesperetin metabolites obtained from hesperetin-administered rat serum: An ex vivo approach
    • Yang HL, Chen SC, Kumar KJS, Yu KN, Chao PDL, Tsai SY, Hou YC, Hseu YC (2012) Antioxidant and anti-inflammatory potential of hesperetin metabolites obtained from hesperetin-administered rat serum: an ex vivo approach. J Agric Food Chem 60:522-532
    • (2012) J Agric Food Chem , vol.60 , pp. 522-532
    • Yang, H.L.1    Chen, S.C.2    Kumar, K.J.S.3    Yu, K.N.4    Chao, P.D.L.5    Tsai, S.Y.6    Hou, Y.C.7    Hseu, Y.C.8
  • 76
    • 84862799831 scopus 로고    scopus 로고
    • Activation of nuclear factor-κB pathway is responsible for tumor necrosis factor-α-induced up-regulation of endothelin B2 receptor expression in vascular smooth muscle cells in vitro
    • Zhang W, Li XJ, Zeng X, Shen DY, Liu CQ, Zhang HJ, Xu CB, Li XY (2012) Activation of nuclear factor-κB pathway is responsible for tumor necrosis factor-α-induced up-regulation of endothelin B2 receptor expression in vascular smooth muscle cells in vitro. Toxicol Lett 209:107-112
    • (2012) Toxicol Lett , vol.209 , pp. 107-112
    • Zhang, W.1    Li, X.J.2    Zeng, X.3    Shen, D.Y.4    Liu, C.Q.5    Zhang, H.J.6    Xu, C.B.7    Li, X.Y.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.