Citreorosein, a naturally occurring anthraquinone derivative isolated from Polygoni cuspidati radix, attenuates cyclooxygenase-2-dependent prostaglandin D 2 generation by blocking Akt and JNK pathways in mouse bone marrow-derived mast cells

Food and Chemical Toxicology

Volumn 50, Issue 3-4, 2012, Pages 913-919

  Lu, Yue ^a   Suh, Seok Jong ^a   Li, Xian ^a   Hwang, Seung Lark ^a   Li, Ying ^a   Hwangbo, Kyoung ^a   Park, Soon Jin ^a   Murakami, Makoto ^b   Lee, Seung Ho ^a   Jahng, Yurndong ^a   Son, Jong Keun ^a   Kim, Cheorl Ho ^c   Chang, Hyeun Wook ^a  

^a Yeungnam University   (South Korea)

^b TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^c Sungkyunkwan University   (South Korea)

Author keywords

Akt; Citreorosein; Cyclooxygenase 2; JNK; Mast cells; NF B

Indexed keywords

ANTHRAQUINONE DERIVATIVE; ANTIINFLAMMATORY AGENT; CITREOROSEIN; CYCLOOXYGENASE 2; CYTOSOLIC PHOSPHOLIPASE A2; CYTOSOLIC PHOSPHOLIPASE A2 ALPHA; I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROSTAGLANDIN D2; PROTEIN C JUN; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR AP 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; BONE MARROW CELL; CONTROLLED STUDY; CYTOTOXICITY; DNA BINDING; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INDUCTION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; MAST CELL; MOUSE; NONHUMAN; POLYGONUM CUSPIDATUM; PROSTAGLANDIN SYNTHESIS INHIBITION; PROTEIN EXPRESSION;

ANIMALS; ANTHRAQUINONES; BASE SEQUENCE; BLOTTING, WESTERN; BONE MARROW CELLS; CELLS, CULTURED; CYCLOOXYGENASE 2; ELECTROPHORETIC MOBILITY SHIFT ASSAY; ENZYME INDUCTION; MALE; MAP KINASE KINASE 4; MAST CELLS; MICE; MICE, INBRED BALB C; NF-KAPPA B; OLIGONUCLEOTIDES; PHOSPHORYLATION; POLYGONUM; PROSTAGLANDIN D2; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION;

POLYGONACEAE;

EID: 84862777626     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2011.11.046     Document Type: Article

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