Cryptopleurine targets NF-κB pathway, leading to inhibition of gene products associated with cell survival, proliferation, invasion, and angiogenesis

PLoS ONE

Volumn 7, Issue 6, 2012, Pages

  Jin, Hong Ri ^b   Jin, Song Zhu ^a   Cai, Xing Fu ^b   Li, Donghao ^a   Wu, Xue ^a   Nan, Ji Xing ^a   Lee, Jung Joon ^a,b   Jin, Xuejun ^a  

^a YANBIAN UNIVERSITY   (China)

^b Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALOID; CRYPTOPLEURINE; I KAPPA B ALPHA; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANGIOGENESIS; APOPTOSIS; ARTICLE; CELL INVASION; CELL PROLIFERATION; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG TARGETING; EMBRYO; ENZYME INHIBITION; GENE EXPRESSION; GENE PRODUCT; HUMAN; HUMAN CELL; IN VITRO STUDY; INFLAMMATION; PROMOTER REGION; PROTEIN DEGRADATION; PROTEIN DNA BINDING; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT; REPORTER GENE;

ALKALOIDS; ANIMALS; APOPTOSIS; CELL LINE; CELL NUCLEUS; CELL PROLIFERATION; CELL SURVIVAL; CYTOKINES; GENE EXPRESSION; GENES, REPORTER; HUMANS; I-KAPPA B KINASE; I-KAPPA B PROTEINS; INFLAMMATION; MICE; NEOPLASM INVASIVENESS; NEOVASCULARIZATION, PATHOLOGIC; NF-KAPPA B; PHOSPHORYLATION; PROTEIN TRANSPORT; PROTEOLYSIS; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84863111654     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0040355     Document Type: Article

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