Curcumin modulates nuclear factor κB (nf-κB)-mediated inflammation in human tenocytes in vitro: Role of the phosphatidylinositol 3-kinase/Akt pathway

Journal of Biological Chemistry

Volumn 286, Issue 32, 2011, Pages 28556-28566

  Buhrmann, Constanze ^a   Mobasheri, Ali ^b   Busch, Franziska ^a   Aldinger, Constance ^a   Stahlmann, Ralf ^c   Montaseri, Azadeh ^d   Shakibaei, Mehdi ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^d TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-INFLAMMATORY EFFECTS; CASPASE-3; CATABOLIC PROCESS; CELL MODEL; CELL SURVIVAL; CURCUMIN; CYCLOOXYGENASE 2; CYTOKINES; DOWN-REGULATION; GENE PRODUCTS; IN-VITRO; INFLAMMATORY PROCESS; INFLAMMATORY SIGNALING; INTERLEUKIN-1; MATRIX; MATRIX METALLOPROTEINASE-1; NON-STEROIDAL ANTI-INFLAMMATORY DRUGS; NUCLEAR FACTORS; NUCLEAR TRANSLOCATIONS; PHARMACOLOGICAL TREATMENT; PHOSPHATIDYLINOSITOL; PHOSPHATIDYLINOSITOL 3-KINASE; SIGNALING PATHWAYS; TENDINOPATHY; TUMOR NECROSIS FACTORS; WORTMANNIN;

CELL CULTURE; CELL DEATH; DEGRADATION; ENZYME INHIBITION; GENES; PHOSPHORYLATION; SIGNALING; TENDONS; TRANSCRIPTION; TRANSCRIPTION FACTORS;

PATHOLOGY;

CASPASE 3; COLLAGENASE 3; CURCUMIN; CYCLOOXYGENASE 2; GELATINASE B; GENE PRODUCT; I KAPPA B ALPHA; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; INTERSTITIAL COLLAGENASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN P85; WORTMANNIN;

ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; CELL NUCLEUS; CELL SURVIVAL; CONCENTRATION RESPONSE; CONNECTIVE TISSUE CELL; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; ENZYME DEGRADATION; ENZYME SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; INHIBITION KINETICS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; TENDINITIS; TENOCYTE;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BCL-2-ASSOCIATED X PROTEIN; CELL SURVIVAL; CELLS, CULTURED; COLLAGENASES; CURCUMIN; CYCLOOXYGENASE 2; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; INFLAMMATION; INTERLEUKIN-1BETA; MALE; MIDDLE AGED; NF-KAPPA B; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TENDONS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 80051484401     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.256180     Document Type: Article

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