Nimbolide, a neem limonoid abrogates canonical NF-κB and Wnt signaling to induce caspase-dependent apoptosis in human hepatocarcinoma (HepG2) cells

European Journal of Pharmacology

Volumn 681, Issue 1-3, 2012, Pages 6-14

  Kavitha, Krishnamurthy ^a   Vidya Priyadarsini, Ramamurthi ^a   Anitha, Prabukumar ^a   Ramalingam, Krishnan ^b   Sakthivel, Ramasamy ^b   Purushothaman, Gempuraj ^b   Singh, Abhishek Kumar ^a   Karunagaran, Devarajan ^b   Nagini, Siddavaram ^a  

^a ANNAMALAI UNIVERSITY   (India)

^b INDIAN INSTITUTE OF TECHNOLOGY MADRAS   (India)

Author keywords

HepG2; Intrinsic apoptosis; NF B; Nimbolide; Wnt catenin

Indexed keywords

BETA CATENIN; CASPASE; CASPASE 3; CASPASE 9; CYTOCHROME C; GLYCOGEN SYNTHASE KINASE 3BETA; I KAPPA B ALPHA; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NIMBOLIDE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P50; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; SYNAPTOTAGMIN I; WNT PROTEIN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL DESTRUCTION; CELL GROWTH; CELL STRAIN HEPG2; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; LIVER CELL CARCINOMA; PHYTOCHEMISTRY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; TUMOR ESCAPE; WNT SIGNALING PATHWAY;

APOPTOSIS; CASPASE 3; CASPASE 9; CELL LINE, TUMOR; HEP G2 CELLS; HUMANS; LIMONINS; NF-KAPPA B; SIGNAL TRANSDUCTION; WNT SIGNALING PATHWAY;

EID: 84863398751     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2012.01.024     Document Type: Article

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