Santamarin, a sesquiterpene lactone isolated from Saussurea lappa, represses LPS-induced inflammatory responses via expression of heme oxygenase-1 in murine macrophage cells

International Immunopharmacology

Volumn 13, Issue 3, 2012, Pages 271-279

  Choi, Hyun Gyu ^a   Lee, Dong Sung ^a   Li, Bin ^a   Choi, Yeon Ho ^b   Lee, Seung Ho ^b   Kim, Youn Chul ^a  

^a Wonkwang University   (South Korea)

^b Yeungnam University   (South Korea)

Author keywords

Anti inflammatory effect; Heme oxygenase (HO) 1; Murine peritoneal macrophage; RAW264.7 cells; Santamarin; Saussurea lappa

Indexed keywords

ANTIINFLAMMATORY AGENT; CYCLOOXYGENASE 2; HEME OXYGENASE 1; I KAPPA B KINASE ALPHA; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; MESSENGER RNA; NITRIC OXIDE; PROSTAGLANDIN E2; PROTOPORPHYRIN TIN; SANTAMARIN; SESQUITERPENE DERIVATIVE; SYNAPTOTAGMIN I; TRANSCRIPTION FACTOR NRF2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; CELL PROTECTION; CELL VIABILITY; CHEMICAL STRUCTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXICITY; DNA BINDING; DRUG EFFECT; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME INHIBITION; ENZYME SYNTHESIS; INFLAMMATION; MEDICINAL PLANT; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SAUSSUREA LAPPA;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BASE SEQUENCE; CELL LINE; CYCLOOXYGENASE 2; CYTOKINES; DINOPROSTONE; GENE EXPRESSION; HEME OXYGENASE-1; I-KAPPA B PROTEINS; LIPOPOLYSACCHARIDES; MACROPHAGES; MEDICINE, TRADITIONAL; MICE; NF-E2-RELATED FACTOR 2; NF-KAPPA B; NITRIC OXIDE SYNTHASE TYPE II; PLANTS, MEDICINAL; RNA, MESSENGER; SAUSSUREA; SESQUITERPENES;

EID: 84861444178     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2012.04.016     Document Type: Article

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