Bharangin, a diterpenoid quinonemethide, abolishes constitutive and inducible nuclear factor-κB (NF-κB) activation by modifying p65 on cysteine 38 residue and reducing inhibitor of nuclear factor-κB α kinase activation, leading to suppression of NF-κB-regulated gene expression and sensitization of tumor cells to chemotherapeutic agents

Molecular Pharmacology

Volumn 80, Issue 5, 2011, Pages 769-781

  Gupta, Subash C ^a   Kannappan, Ramaswamy ^a   Kim, Jihye ^a   Rahman, Ghazi M ^b   Francis, Sajin K ^c   Raveendran, Reshma ^c   Nair, Mangalam S ^c   Das, Joydip ^b   Aggarwal, Bharat B ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b UNIVERSITY OF HOUSTON   (United States)

^c REGIONAL RESEARCH LABORATORY CSIR   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BHARANGIN; CYSTEINE; DITERPENOID; DNA; I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PROTEIN KINASE B; SYNAPTOTAGMIN I; TRANSFORMING GROWTH FACTOR BETA ACTIVATED KINASE 1; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED DEATH DOMAIN PROTEIN; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 2; UNCLASSIFIED DRUG;

ANGIOGENESIS; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL INVASION; CELL PROLIFERATION; CELL SURVIVAL; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME DEGRADATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENE EXPRESSION; HUMAN; HUMAN CELL; MYELOMA CELL; PRIORITY JOURNAL; PROTEIN BINDING; TUMOR CELL; UPREGULATION;

APOPTOSIS; BLOTTING, WESTERN; CARCINOGENS; CELL LINE, TUMOR; CYSTEINE; ELECTROPHORETIC MOBILITY SHIFT ASSAY; FLAVONOIDS; GENE EXPRESSION; GENES, REPORTER; HUMANS; IMMUNOHISTOCHEMISTRY; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; NF-KAPPA B; PHOSPHORYLATION;

EID: 80054778012     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.111.073122     Document Type: Article

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