Exploiting adaptive laboratory evolution of streptomyces clavuligerus for antibiotic discovery and overproduction

PLoS ONE

Volumn 7, Issue 3, 2012, Pages

  Charusanti, Pep ^a   Fong, Nicole L ^a   Nagarajan, Harish ^a,b   Pereira, Alban R ^c   Li, Howard J ^a   Abate, Elisa A ^a   Su, Yongxuan ^b   Gerwick, William H ^c   Palsson, Bernhard O ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; HOLOMYCIN; LEUCINE; METICILLIN; UNCLASSIFIED DRUG; VALINE; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; LACTAM;

ADAPTATION; AMINO ACID SUBSTITUTION; ARTICLE; BACTERIAL GROWTH; BACTERIAL STRAIN; DRUG SYNTHESIS; EVOLUTION; GENE SEQUENCE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LABORATORY TEST; MASS SPECTROMETRY; METABOLITE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; NONHUMAN; PLASMID; POLYMERASE CHAIN REACTION; SINGLE NUCLEOTIDE POLYMORPHISM; SOLID PHASE EXTRACTION; STREPTOMYCES CLAVULIGERUS; WILD TYPE; ANTIBIOTIC RESISTANCE; BACTERIAL GENOME; BIOSYNTHESIS; CHEMISTRY; GENETICS; METABOLISM; STREPTOMYCES;

METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; STREPTOMYCES CLAVULIGERUS;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BIOLOGICAL EVOLUTION; DRUG RESISTANCE, BACTERIAL; GENOME, BACTERIAL; LACTAMS; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; PLASMIDS; POLYMORPHISM, SINGLE NUCLEOTIDE; STREPTOMYCES;

EID: 84863359225     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0033727     Document Type: Article

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