Phenalinolactones A-D, terpenoglycoside antibiotics from Streptomyces sp. Tü 6071

Journal of Antibiotics

Volumn 64, Issue 3, 2011, Pages 229-232

  Gebhardt, Klaus ^a   Meyer, Sven W ^b   Schinko, Jochen ^a   Bringmann, Gerhard ^b   Zeeck, Axel ^b   Fiedler, Hans Peter ^a  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

screening; Streptomyces; structure determination; terpenoglycoside antibiotics

Indexed keywords

ANTIBIOTIC AGENT; GAMMA LACTONE DERIVATIVE; PHENALINOLACTONE A; PHENALINOLACTONE B; PHENALINOLACTONE C; PHENALINOLACTONE D; TERPENOGLYCOSIDE ANTIBIOTIC; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ARTICLE; BIOLOGICAL ACTIVITY; DRUG DETERMINATION; DRUG ISOLATION; DRUG STRUCTURE; MASS SPECTROMETRY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; STREPTOMYCES;

ANTI-BACTERIAL AGENTS; DITERPENES; GLYCOSIDES; GRAM-POSITIVE BACTERIA; LACTONES; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MICROBIAL SENSITIVITY TESTS; STREPTOMYCES;

POSIBACTERIA; STREPTOMYCES; STREPTOMYCES SP.;

EID: 79953180059     PISSN: 00218820     EISSN: 18811469     Source Type: Journal    
DOI: 10.1038/ja.2010.165     Document Type: Article

References (12)

1. Nachtigall, J. et al. Two new aurachins from Rhodococcus sp. Acta 2259. J. Antibiot. 63, 567-569 (2010).
2. Jakobi,M. et al. Maltophilin: a new antifungal compound produced by Stenotrophomonas maltophila R3089. J. Antibiot. 49, 1101-1104 (1996).
3. Graupner,P.R. et al. Dihydromaltophilin; a novel fungicidal tetramic acid containing metabolite from Streptomyces sp. J. Antibiot. 50, 1014-1019 (1997).
4. Shigemori, H., Bae, M.- A., Yazawa, K., Sasaki, T. & Kobayashi, J. Alteramide A, a new tetracyclic alkaloid from a bacterium Alteromonas sp. associated with the marine sponge Halichondria okadai. J. Org. Chem. 57, 4317-4320 (1992).
5. Fiedler, H.- P. Biosynthetic capacities of actinomycetes. 1. Screening for secondary metabolites by HPLC and UV-visible absorbance spectral libraries. Nat. Prod. Lett. 2, 119-128 (1993).
6. Gebhardt, K., Pukall, R. & Fiedler, H.- P. Streptocidins A-D, novel cyclic decapeptide antibiotics produced by Streptomyces sp. Tü 6071. I. Taxonomy, fermentation, isolation and biological activities. J. Antibiot. 54, 428-433 (2001).
7. Shigemori,H. et al. Brasilicardin A, a novel tricyclic metabolite with potent immunosuppressive activity from actinomycete Nocardia brasiliensis. J. Org. Chem. 63, 6900-6904 (1988).
8. Komaki,H.et al. Brasilicardin A, a new terpenoid antibiotic from pathogenic Nocardia brasiliensis: fermentation, isolation and biological activity. J. Antibiot. 52, 13-19 (1999).
9. Komaki,H.et al. Antitumor activity of brasilicardin A, a novel terpenoid antibiotic from Nocardia brasiliensis. J. Antibiot. 53, 75-77 (2000).
10. Dü rr, C. et al. Biosynthesis of the terpene phenalinolactone in Streptomyces sp. Tü 6071: analysis of the gene cluster and generation of derivatives. Chem. Biol. 13, 365-377 (2006).
11. Pouchert, C. J. & Behnke, J. J. The Aldrich Library of 13C and 1H FTNMR Spectra 1st edn (Aldrich Chemical Company Inc., Milwaukee, WI, USA, 1993).
12. Grever, M. R., Shepartz, S. A. & Chabner, B. A. The National Cancer Institute: cancer drug discovery and development program. Semin. Oncol. 19, 622-638 (1992).