A chemostat study of Streptomyces peucetius var. caesius N47

Applied Microbiology and Biotechnology

Volumn 73, Issue 6, 2007, Pages 1267-1274

  Kiviharju, Kristiina ^a   Moilanen, Ulla ^a   Leisola, Matti ^a   Eerikäinen, Tero ^a  

^a AALTO UNIVERSITY   (Finland)

Author keywords

rhodomycinone; Chemostat; Metabolic flux analysis; Streptomyces peucetius var. caesius

Indexed keywords

BIOMASS; CELL CULTURE; CHEMOSTATS; GLUCOSE; METABOLISM; PH EFFECTS;

METABOLIC FLUX ANALYSIS; RHODOMYCINONE; SHIKIMATE PATHWAY; STREPTOMYCES PEUCETIUS;

BACTERIA;

EPSILON RHODOMYCINONE; PHOSPHATE; SHIKIMIC ACID;

BACTERIUM; BIOMASS; CHEMOSTAT; FLUX MEASUREMENT; METABOLISM; PH;

AIRFLOW; ANIMAL CELL; ARTICLE; BACTERIAL METABOLISM; CHEMOSTAT; CITRIC ACID CYCLE; CONTROLLED STUDY; CORRELATION ANALYSIS; ENVIRONMENTAL PARAMETERS; GLUCOSE INTAKE; MICROBIAL BIOMASS; NONHUMAN; PENTOSE PHOSPHATE CYCLE; PH; SPECIES CULTIVATION; STEADY STATE; STREPTOMYCES; TEMPERATURE;

ANTHRACYCLINES; BACTERIOLOGICAL TECHNIQUES; BIOREACTORS; GLUCOSE; HYDROGEN-ION CONCENTRATION; PHOSPHATES; STREPTOMYCES; TEMPERATURE;

STREPTOMYCES PEUCETIUS;

EID: 33846180736     PISSN: 01757598     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00253-006-0607-z     Document Type: Article

References (32)

1. Arcamone F, Cassinelli G, Fantini G, Grein A, Orezzi P, Pol C, Spalla C (1969) Adriamycin, 14-hydroxydaunomycin, a new antitumor antibiotic from S. peucetius var. caesius. Biotechnol Bioeng 11:1101-1110
2. Avignone Rossa C, White J, Kuiper A, Postma PW, Bibb M, Teixeira de Mattos MJ (2002) Carbon flux distribution in antibiotic-producing chemostat cultures of Streptomyces lividans. Metab Eng 4:138-150
3. Bencini D, Wild J, O'Donovan G (1983) Linear one-step assay for the determination of orthophosphate. Anal Biochem 132:254-258
4. Bergter F, Riesenberg D (1982) Morphological and biochemical properties of Streptomyces hygroscopicus grown in chemostat. Folia Microbiol 27:303-307
5. Borodina I, Schöller C, Eliasson A, Nielsen J (2005a) Metabolic network analysis of Streptomyces tenebrarius, a Streptomyces species with an active Entner-Doudoroff pathway. Appl Environ Microbiol 71:2294-2302
6. Borodina I, Krabben P, Nielsen J (2005b) Genome-scale analysis of Streptomyces coelicolor A3(2) metabolism. Genome Res 15:820-829
7. Doran P (1995) Bioprocess engineering principles. Academic, London, UK
8. Hilliger M, Knorre A, Bergter F (1978) Erhaltungsstoffwechsel in glucoselimitierten chemostatenkulturen von Streptomyces hygroscopicus. Z Allg Mikrobiol 18:39-45
9. Hoskisson PA, Hobbs G (2005) Continuous culture - making a comeback? Microbiology 151:3153-3159
10. Hutchinson CR, Colombo AL (1999) Genetic engineering of doxorubicin production in Streptomyces peucetius: a review. J Ind Microbiol Biotechnol 23:647-652
11. Inoue S, Nishizawa Y, Nagai S (1982) Stimulation of streptomycin formation by Streptomyces griseus grown in a phosphate deficient culture. J Ferment Technol 60: 417-422
12. James P, Edwards C, Dawson M (1991) The effects of temperature, pH and growth rate on secondary metabolism in Streptomyces thermoviolaceus grown in a chemostat. J Gen Microbiol 137:1715-1720
13. Jonsbu E, Christensen B, Nielsen J (2001) Changes of in vivo fluxes through central metabolic pathways during the production of nystatin by Streptomyces noursei in batch culture. Appl Microbiol Biotechnol 56:93-100
14. Kang SG, Lee KJ (1997) Kinetic analysis of morphological differentiation and protease production in Streptomyces albidoflavus SMF301. Microbiology 143:2709-2714
15. Kantola J, Kunnari T, Mäntsälä P, Ylihonko K (2003) Expanding the scope of aromatic polyketides by combinatorial biosynthesis. Comb Chem High Throughput Screen 6:501-512
16. Kim H, Smith C, Micklefield J, Mavituna F (2004) Metabolic flux analysis for calcium dependent antibiotic (CDA) production in Streptomyces coelicolor. Metab Eng 6:313-325
17. Kirk S, Avignone Rossa C, Bushell M (2000) Growth limiting substrate affects antibiotic production and associated metabolic fluxes in Streptomyces clavuligerus. Biotechnol Lett 22:1803-1809
18. Kiviharju K, Leisola M, Eerikäinen T (2004) Optimization of Streptomyces peucetius var. caesius N47 cultivation and ε-rhodomycinone production using experimental designs and response surface methods. J Ind Microbiol Biotechnol 31:475-481
19. Kretschmer S (1985) Morphogenetic behaviour of two Streptomyces strains analyzed by the use of chemostats. J Basic Microbiol 25:569-574
20. Kretschmer S (1992) Location of branches within the apical hyphal region of Streptomyces granaticolor mycelia. J Basic Microbiol 32:35-42
21. Lee SH, Lee KJ (1994) Kinetics of the repression of tylosin biosynthesis by ammonium ion in Streptomyces fradiae. J Biotechnol 32:149-156
22. Martin JF (2004) Phosphate control of the biosynthesis of antibiotics and other secondary metabolites is mediated by the PhoR-PhoP system: an unfinished story. J Bacteriol 186:5197-5201
23. Melzoch K, Teixeira de Mattos M, Jeijssel O (1997) Production of actinorhodin by Streptomyces coelicolor A3(2) grown in chemostat culture. Biotechnol Bioeng 54:577-582
24. Noack D (1986) Directed selection of differentiation mutants of Streptomyces noursei using chemostat cultivation. J Basic Microbiol 26:231-239
25. Rhodes PM (1984) The production of oxytetracycline in chemostat culture. Biotechnol Bioeng 26:382-385
26. Riesenberg D, Erdmann A, Bergter F (1979) Distribution functions of variables characterizing the mycelial morphology of Streptomyces hygroscopicus grown in glucose-limited chemostat cultures. Z Allg Mikrobiol 19:481-487
27. Roth M, Neigenfind M, Bormann EJ, Noack D (1986) Use of chemostat for selection of Streptomyces hygroscopicus mutants altered in regulation of maltose utilization. Biotechnol Lett 8:479-484
28. Roth M, Neigenfind M, Hänel F, Bormann EJ (1987) Use of chemostat for selection of Streptomyces chrysomallus mutants altered in the induction of D-glucose isomerase. Biotechnol Lett 9:855-860
29. Segura D, Santana C, Gosh R, Escalante L, Sanchez S (1997) Anthracyclines: isolation of overproducing strains by the selection and genetic recombination of putative regulatory mutants of Streptomyces peucetius var. caesius. Appl Microbiol Biotechnol 48:615-620
30. Undisz K, Noack D (1993) Autonomous selection of differentiation mutants of Streptomyces lividans TK24 in continuous culture. Biotechnol Lett 15:13-18
31. Watve M, Tickoo R, Jog M, Bhole B (2001) How many antibiotics are produced by the genus Streptomyces? Arch Microbiol 176:386-390
32. Weber T, Welzel K, Pelzer S, Vente A, Wohlleben W (2003) Exploiting the genetic potential of polyketide producing streptomycetes. J Biotechnol 106:221-232