Enzyme-directed mutasynthesis: A combined experimental and theoretical approach to substrate recognition of a polyketide synthase

ACS Chemical Biology

Volumn 8, Issue 2, 2013, Pages 443-450

  Sundermann, Uschi ^a,b   Bravo Rodriguez, Kenny ^c   Klopries, Stephan ^a   Kushnir, Susanna ^a   Gomez, Hansel ^c,d   Sanchez Garcia, Elsa ^c   Schulz, Frank ^a,b  

^a TU DORTMUND UNIVERSITY   (Germany)

^b MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

^c MAX PLANCK INSTITUT FÜR KOHLENFORSCHUNG   (Germany)

^d UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROMYCIN; FUNCTIONAL GROUP; MALONIC ACID; POLYKETIDE SYNTHASE; THIOESTER; ACYLTRANSFERASE; BIOLOGICAL PRODUCT; MALONIC ACID DERIVATIVE;

ARTICLE; ENZYME DIRECTED MUTASYNTHESIS; ENZYME SUBSTRATE; ENZYME SYNTHESIS; MUTAGENESIS; POINT MUTATION; PRIORITY JOURNAL; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME SPECIFICITY; GENETICS; METABOLISM; MOLECULAR DYNAMICS; PROTEIN ENGINEERING; SACCHAROPOLYSPORA;

ACYLTRANSFERASES; BIOLOGICAL PRODUCTS; ERYTHROMYCIN; MALONATES; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MOLECULAR STRUCTURE; POINT MUTATION; POLYKETIDE SYNTHASES; PROTEIN ENGINEERING; SACCHAROPOLYSPORA; SUBSTRATE SPECIFICITY;

EID: 84874030515     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb300505w     Document Type: Article

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