Enhancement and selective production of phoslactomycin B, a protein phosphatase IIa inhibitor, through identification and engineering of the corresponding biosynthetic gene cluster

Journal of Biological Chemistry

Volumn 278, Issue 37, 2003, Pages 35552-35557

  Palaniappan, Nadaraj ^a   Kim, Beom Seok ^a   Sekiyama, Yasuyo ^b   Osada, Hiroyuki ^b   Reynolds, Kevin A ^a,c  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b RIKEN   (Japan)

^c Inst Struct Biol/Drug Discovery   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOSYNTHESIS; ESTERIFICATION; GENES; TUMORS;

ANTITUMOR ACTIVITY;

PROTEINS;

CYCLOHEXANECARBOXYLIC ACID DERIVATIVE; PHOSLACTOMYCIN B; PHOSPHOPROTEIN PHOSPHATASE 2A; POLYKETIDE; PROTEIN SERINE THREONINE KINASE;

ALLELE; ANTINEOPLASTIC ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; BIOSYNTHESIS; CHEMICAL BOND; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; ESTERIFICATION; FERMENTATION; GENE CLUSTER; GENE SEQUENCE; GENETIC ANALYSIS; HYDROXYLATION; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN ENGINEERING; STREPTOMYCES;

ANTINEOPLASTIC AGENTS; ESCHERICHIA COLI; GENES, SYNTHETIC; LACTONES; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; ORGANOPHOSPHORUS COMPOUNDS; PHOSPHOPROTEIN PHOSPHATASE; STREPTOMYCES;

STREPTOMYCES; STREPTOMYCES SP.; STREPTOMYCES SP. HK803;

EID: 0041816073     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M305082200     Document Type: Article

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