Transcriptome analysis of an antibiotic downregulator mutant and synergistic actinorhodin stimulation via disruption of a precursor flux regulator in Streptomyces coelicolor

Applied and Environmental Microbiology

Volumn 77, Issue 5, 2011, Pages 1872-1877

  Kim, Seon Hye ^a   Lee, Han Na ^a   Kim, Hye Jin ^a   Kim, Eung Soo ^a  

^a Inha University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

A-CARBON; ANTIBIOTIC PRODUCTION; MICROARRAY ANALYSIS; PHOSPHOFRUCTOKINASE; PRECURSOR FLUX; S. COELICOLOR; STREPTOMYCES COELICOLOR; TRANSCRIPTOME ANALYSIS;

GENES;

ANTIBIOTICS;

ACTINORHODINE; ANTHRAQUINONE DERIVATIVE; ANTIINFECTIVE AGENT; CARBON;

ANTIBIOTICS; BACTERIUM; ENZYME ACTIVITY; MICROBIAL ACTIVITY; MUTATION;

ARTICLE; GENE DELETION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MICROARRAY ANALYSIS; STREPTOMYCES COELICOLOR; TRANSCRIPTION INITIATION;

ANTHRAQUINONES; ANTI-BACTERIAL AGENTS; CARBON; GENE DELETION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, BACTERIAL; METABOLIC NETWORKS AND PATHWAYS; MICROARRAY ANALYSIS; STREPTOMYCES COELICOLOR; TRANSCRIPTIONAL ACTIVATION;

STREPTOMYCES COELICOLOR;

EID: 79953172246     PISSN: 00992240     EISSN: 10985336     Source Type: Journal    
DOI: 10.1128/AEM.02346-10     Document Type: Article

References (24)

1. Arias, P., M. A. Fernandez-Moreno, and F. Malpartida. 1999. Characterization of the pathway-specific positive transcriptional regulator for actinorhodin biosynthesis in Streptomyces coelicolor A3(2) as a DNA-binding protein. J. Bacteriol. 181:6958-6968.
2. Bibb, M. J. 1996. The regulation of antibiotic production in Streptomyces coelicolor A3(2). Microbiology 142:1335-1344.
3. Bibb, M. J. 2005. Regulation of secondary metabolism in streptomycetes. Curr. Opin. Microbiol. 8:208-215.
4. Bibb, M. J., G. R. Janssen, and J. M. Ward. 1985. Cloning and analysis of the promoter region of the erythromycin-resistance gene (ermE) of Streptomyces erythraeus. Gene 38:215-216.
5. Borodina, I., et al. 2008. Antibiotic overproduction in Streptomyces coelicolor A3(2) mediated by phosphofructokinase deletion. J. Biol. Chem. 283:25186-25199.
6. Challis, G. L., and D. A. Hopwood. 2003. Synergy and contingency as driving forces for the evolution of multiple secondary metabolite production by Streptomyces species. Proc. Natl. Acad. Sci. U. S. A. 100:14555-14561.
7. Chater, K. F., et al. 2002. Streptomyces coelicolor A3(2): from genome sequence to function. Methods Microbiol. 33:321-336.
8. Choi, S. U., C. K. Lee, Y. I. Hwang, H. Kinoshita, and T. Nihira. 2004. Intergeneric conjugal transfer of plasmid DNA from Escherichia coli to Kitasatospora setae, a bafilomycin B1 producer. Arch. Microbiol. 181:294-298.
9. Floriano, B., and M. Bibb. 1996. afsR is a pleiotropic but conditionally required regulatory gene for antibiotic production in Streptomyces coelicolor A3(2). Mol. Microbiol. 21:385-396.
10. Gust, B., G. L. Challis, K. Fowler, T. Kieser, and K. F. Chater. 2003. PCR-targeted Streptomyces gene replacement identifies a protein domain needed for biosynthesis of the sesquiterpene soil odor geosmin. Proc. Natl. Acad. Sci. U. S. A. 100:1541-1546.
11. Hopwood, D. A. 1999. Forty years of genetics with Streptomyces: from in vivo through in vitro to in silico. Microbiology 145:2183-2202.
12. Hopwood, D. A., K. F. Chater, and M. J. Bibb. 1995. Genetics of antibiotic production in Streptomyces coelicolor A3(2), a model streptomycete. Biotechnology 28:65-102.
13. Horinouchi, S., O. Hara, and T. Beppu. 1983. Cloning of a pleiotropic gene that positively controls biosynthesis of A-factor, actinorhodin, and prodigiosin in Streptomyces coelicolor A3(2) and Streptomyces lividans. J. Bacteriol. 155:1238-1248.
14. Kang, S. H., et al. 2007. Interspecies DNA microarray analysis identifies WblA as a pleiotropic down-regulator of antibiotic biosynthesis in Streptomyces. J. Bacteriol. 189:4315-4319.
15. Kieser, T., M. J. Bibb, K. F. Chater, M. J. Butler, and D. A. Hopwood. 2000. Practical Streptomyces genetics: a laboratory manual. John Innes Foundation, Norwich, United Kingdom
16. Lee, H. N., et al. 2010. Putative TetR family transcriptional regulator SCO1712 encodes an antibiotic downregulator in Streptomyces coelicolor. Appl. Environ. Microbiol. 76:3039-3043.
17. Lum, A. M., J. Huang, C. R. Hutchinson, and C. M. Kao. 2004. Reverse engineering of industrial pharmaceutical-producing actinomycete strains using DNA microarrays. Metab. Eng. 6:186-196.
18. Niraula, N. P., S. H. Kim, J. K. Sohng, and E. S. Kim. 2010. Biotechnological doxorubicin production: pathway and regulation engineering of strains for enhanced production. Appl. Microbiol. Biotechnol. 87:1187-1194.
19. Noh, J. H., S. H. Kim, H. N. Lee, S. Y. Lee, and E. S. Kim. 2010. Isolation and genetic manipulation of the antibiotic down-regulatory gene, wblA ortholog for doxorubicin-producing Streptomyces strain improvement. Appl. Microbiol. Biotechnol. 86:1145-1153.
20. Park, H. S., et al. 2003. Development of doxorubicin overproducing Streptomyces strain using protoplast regeneration. Sanop Misaengmul Hakhoe Chi 18:289-293.
21. Rodriguez, E., et al. 2003. Rapid engineering of polyketide overproduction by gene transfer to industrially optimized strains. J. Ind. Microbiol. Biotechnol. 30:480-488.
22. Ryu, Y. G., M. J. Butler, K. F. Chater, and K. J. Lee. 2006. Engineering of primary carbohydrate metabolism for increased production of actinorhodin in Streptomyces coelicolor. Appl. Environ. Microbiol. 72:7132-7139.
23. Vetrivel, K. S., and K. Dharmalingam. 2001. Isolation and characterization of stable mutants of Streptomyces peucetius defective in daunorubicin biosynthesis. J. Genet. 80:31-38.
24. White, J., and M. Bibb. 1997. bldA dependence of undecylprodigiosin production in Streptomyces coelicolor A3(2) involves a pathway-specific regulatory cascade. J. Bacteriol. 179:627-633.