-
1
-
-
84858726313
-
Regulation of cell death and autophagy by ikk and nf-kappab: Critical mechanisms in immune function and cancer
-
Baldwin AS (2012) Regulation of cell death and autophagy by IKK and NF-kappaB: critical mechanisms in immune function and cancer. Immunol Rev 246: 327-345
-
(2012)
Immunol Rev
, vol.246
, pp. 327-345
-
-
Baldwin, A.S.1
-
2
-
-
33750454819
-
Mutations in the nf-kappab signaling pathway: Implications for human disease
-
Courtois G, Gilmore TD (2006) Mutations in the NF-kappaB signaling pathway: implications for human disease. Oncogene 25: 6831-6843
-
(2006)
Oncogene
, vol.25
, pp. 6831-6843
-
-
Courtois, G.1
Gilmore, T.D.2
-
3
-
-
84856641109
-
Nf-kappab the first quarter-century: Remarkable progress and outstanding questions
-
Hayden MS, Ghosh S (2012) NF-kappaB, the first quarter-century: remarkable progress and outstanding questions. Genes Dev 26: 203-234
-
(2012)
Genes Dev
, vol.26
, pp. 203-234
-
-
Hayden, M.S.1
Ghosh, S.2
-
4
-
-
84858744393
-
It takes two to tango: Ikappabs, the multifunctional partners of nf-kappab
-
Hinz M, Arslan SC, Scheidereit C (2012) It takes two to tango: IkappaBs, the multifunctional partners of NF-kappaB. Immunol Rev 246: 59-76
-
(2012)
Immunol Rev
, vol.246
, pp. 59-76
-
-
Hinz, M.1
Arslan, S.C.2
Scheidereit, C.3
-
5
-
-
84858739354
-
Regulation of nf-kappab by ubiquitination and degradation of the ikappabs
-
Kanarek N, Ben-Neriah Y (2012) Regulation of NF-kappaB by ubiquitination and degradation of the IkappaBs. Immunol Rev 246: 77-94
-
(2012)
Immunol Rev
, vol.246
, pp. 77-94
-
-
Kanarek, N.1
Ben-Neriah, Y.2
-
6
-
-
0033199348
-
Nf-kappab p105 is a target of ikappab kinases and controls signal induction of bcl-3-p50 complexes
-
Heissmeyer V, Krappmann D, Wulczyn FG, Scheidereit C (1999) NF-kappaB p105 is a target of IkappaB kinases and controls signal induction of Bcl-3-p50 complexes. EMBO J 18: 4766-4778
-
(1999)
EMBO J
, vol.18
, pp. 4766-4778
-
-
Heissmeyer, V.1
Krappmann, D.2
Wulczyn, F.G.3
Scheidereit, C.4
-
7
-
-
0030004897
-
Site-specific phosphorylation of ikappabalpha by a novel ubiquitination-dependent protein kinase activity
-
Chen ZJ, Parent L, Maniatis T (1996) Site-specific phosphorylation of IkappaBalpha by a novel ubiquitination-dependent protein kinase activity. Cell 84: 853-862
-
(1996)
Cell
, vol.84
, pp. 853-862
-
-
Chen, Z.J.1
Parent, L.2
Maniatis, T.3
-
8
-
-
0030610362
-
A cytokine-responsive ikappab kinase that activates the transcription factor nf-kappab
-
DiDonato JA, Hayakawa M, Rothwarf DM, Zandi E, Karin M (1997) A cytokine-responsive IkappaB kinase that activates the transcription factor NF-kappaB. Nature 388: 548-554
-
(1997)
Nature
, vol.388
, pp. 548-554
-
-
DiDonato, J.A.1
Hayakawa, M.2
Rothwarf, D.M.3
Zandi, E.4
Karin, M.5
-
9
-
-
0030685825
-
Ikk-1 and ikk-2: Cytokine-activated ikappab kinases essential for nf-kappab activation
-
Mercurio F, Zhu H, Murray BW, Shevchenko A, Bennett BL, Li J, Young DB, Barbosa M, Mann M, Manning A, Rao A (1997) IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation. Science 278: 860-866
-
(1997)
Science
, vol.278
, pp. 860-866
-
-
Mercurio, F.1
Zhu, H.2
Murray, B.W.3
Shevchenko, A.4
Bennett, B.L.5
Li, J.6
Young, D.B.7
Barbosa, M.8
Mann, M.9
Manning, A.10
Rao, A.11
-
10
-
-
0031586174
-
Identification and characterization of an ikappab kinase
-
Regnier CH, Song HY, Gao X, Goeddel DV, Cao Z, Rothe M (1997) Identification and characterization of an IkappaB kinase. Cell 90: 373-383
-
(1997)
Cell
, vol.90
, pp. 373-383
-
-
Regnier, C.H.1
Song, H.Y.2
Gao, X.3
Goeddel, D.V.4
Cao, Z.5
Rothe, M.6
-
11
-
-
0030611595
-
Ikappab kinase-beta: Nf-kappab activation and complex formation with ikappab kinase-alpha and nik
-
Woronicz JD, Gao X, Cao Z, Rothe M, Goeddel DV (1997) IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK. Science 278: 866-869
-
(1997)
Science
, vol.278
, pp. 866-869
-
-
Woronicz, J.D.1
Gao, X.2
Cao, Z.3
Rothe, M.4
Goeddel, D.V.5
-
12
-
-
0030613551
-
The ikappab kinase complex (ikk) contains two kinase subunits, ikkalpha and ikkbeta, necessary for ikappab phosphorylation and nf-kappab activation
-
Zandi E, Rothwarf DM, Delhase M, Hayakawa M, Karin M (1997) The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation. Cell 91: 243-252
-
(1997)
Cell
, vol.91
, pp. 243-252
-
-
Zandi, E.1
Rothwarf, D.M.2
Delhase, M.3
Hayakawa, M.4
Karin, M.5
-
13
-
-
0032575379
-
Direct phosphorylation of ikappab by ikkalpha and ikkbeta: Discrimination between free and nf-kappabbound substrate
-
Zandi E, Chen Y, Karin M (1998) Direct phosphorylation of IkappaB by IKKalpha and IKKbeta: discrimination between free and NF-kappaBbound substrate. Science 281: 1360-1363
-
(1998)
Science
, vol.281
, pp. 1360-1363
-
-
Zandi, E.1
Chen, Y.2
Karin, M.3
-
14
-
-
0032541657
-
Ikk-gamma is an essential regulatory subunit of the ikappab kinase complex
-
Rothwarf DM, Zandi E, Natoli G, Karin M (1998) IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex. Nature 395: 297-300
-
(1998)
Nature
, vol.395
, pp. 297-300
-
-
Rothwarf, D.M.1
Zandi, E.2
Natoli, G.3
Karin, M.4
-
15
-
-
0032568792
-
Complementation cloning of nemo, a component of the ikappab kinase complex essential for nf-kappab activation
-
Yamaoka S, Courtois G, Bessia C, Whiteside ST, Weil R, Agou F, Kirk HE, Kay RJ, Israel A (1998) Complementation cloning of NEMO, a component of the IkappaB kinase complex essential for NF-kappaB activation. Cell 93: 1231-1240
-
(1998)
Cell
, vol.93
, pp. 1231-1240
-
-
Yamaoka, S.1
Courtois, G.2
Bessia, C.3
Whiteside, S.T.4
Weil, R.5
Agou, F.6
Kirk, H.E.7
Kay, R.J.8
Israel, A.9
-
17
-
-
84867339398
-
The crystal structure of the catalytic domain of the nf-kappab inducing kinase reveals a narrow but flexible active site
-
de Leon-Boenig G, Bowman KK, Feng JA, Crawford T, Everett C, Franke Y, Oh A, Stanley M, Staben ST, Starovasnik MA, Wallweber HJ, Wu J, Wu LC, Johnson AR, Hymowitz SG (2012) The crystal structure of the catalytic domain of the NF-kappaB inducing kinase reveals a narrow but flexible active site. Structure 20: 1704-1714
-
(2012)
Structure
, vol.20
, pp. 1704-1714
-
-
De Leon-Boenig, G.1
Bowman, K.K.2
Feng, J.A.3
Crawford, T.4
Everett, C.5
Franke, Y.6
Oh, A.7
Stanley, M.8
Staben, S.T.9
Starovasnik, M.A.10
Wallweber, H.J.11
Wu, J.12
Wu, L.C.13
Johnson, A.R.14
Hymowitz, S.G.15
-
18
-
-
56349164232
-
Nonredundant and complementary functions of traf2 and traf3 in a ubiquitination cascade that activates nik-dependent alternative nf-kappab signaling
-
Vallabhapurapu S, Matsuzawa A, Zhang W, Tseng PH, Keats JJ, Wang H, Vignali DA, Bergsagel PL, Karin M (2008) Nonredundant and complementary functions of TRAF2 and TRAF3 in a ubiquitination cascade that activates NIK-dependent alternative NF-kappaB signaling. Nat Immunol 9: 1364-1370
-
(2008)
Nat Immunol
, vol.9
, pp. 1364-1370
-
-
Vallabhapurapu, S.1
Matsuzawa, A.2
Zhang, W.3
Tseng, P.H.4
Keats, J.J.5
Wang, H.6
Vignali, D.A.7
Bergsagel, P.L.8
Karin, M.9
-
19
-
-
56349164239
-
Noncanonical nf-kappab activation requires coordinated assembly of a regulatory complex of the adaptors ciap1, ciap2, traf2 and traf3 and the kinase nik
-
Zarnegar BJ, Wang Y, Mahoney DJ, Dempsey PW, Cheung HH, He J, Shiba T, Yang X, Yeh WC, Mak TW, Korneluk RG, Cheng G (2008) Noncanonical NF-kappaB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK. Nat Immunol 9: 1371-1378
-
(2008)
Nat Immunol
, vol.9
, pp. 1371-1378
-
-
Zarnegar, B.J.1
Wang, Y.2
Mahoney, D.J.3
Dempsey, P.W.4
Cheung, H.H.5
He, J.6
Shiba, T.7
Yang, X.8
Yeh, W.C.9
Mak, T.W.10
Korneluk, R.G.11
Cheng, G.12
-
20
-
-
84858735072
-
The noncanonical nf-kappab pathway
-
Sun SC (2012) The noncanonical NF-kappaB pathway. Immunol Rev 246: 125-140
-
(2012)
Immunol Rev
, vol.246
, pp. 125-140
-
-
Sun, S.C.1
-
21
-
-
84874193578
-
Otud7b controls non-canonical nf-kappab activation through deubiquitination of traf3
-
Hu H, Brittain GC, Chang JH, Puebla-Osorio N, Jin J, Zal A, Xiao Y, Cheng X, Chang M, Fu YX, Zal T, Zhu C, Sun SC (2013) OTUD7B controls non-canonical NF-kappaB activation through deubiquitination of TRAF3. Nature 494: 371-374
-
(2013)
Nature
, vol.494
, pp. 371-374
-
-
Hu, H.1
Brittain, G.C.2
Chang, J.H.3
Puebla-Osorio, N.4
Jin, J.5
Zal, A.6
Xiao, Y.7
Cheng, X.8
Chang, M.9
Fu, Y.X.10
Zal, T.11
Zhu, C.12
Sun, S.C.13
-
22
-
-
77957252647
-
The ikk complex, a central regulator of nf-kappab activation
-
Israel A (2010) The IKK complex, a central regulator of NF-kappaB activation. Cold Spring Harb Perspect Biol 2: a000158
-
(2010)
Cold Spring Harb Perspect Biol
, vol.2
-
-
Israel, A.1
-
23
-
-
33750443289
-
Ikappab kinase complexes: Gateways to nf-kappab activation and transcription
-
Scheidereit C (2006) IkappaB kinase complexes: gateways to NF-kappaB activation and transcription. Oncogene 25: 6685-6705
-
(2006)
Oncogene
, vol.25
, pp. 6685-6705
-
-
Scheidereit, C.1
-
24
-
-
1942484963
-
Ikappab kinase-alpha acts in the epidermis to control skeletal and craniofacial morphogenesis
-
Sil AK, Maeda S, Sano Y, Roop DR, Karin M (2004) IkappaB kinase-alpha acts in the epidermis to control skeletal and craniofacial morphogenesis. Nature 428: 660-664
-
(2004)
Nature
, vol.428
, pp. 660-664
-
-
Sil, A.K.1
Maeda, S.2
Sano, Y.3
Roop, D.R.4
Karin, M.5
-
25
-
-
0032583947
-
Nf-kappab-inducing kinase activates ikk-alpha by phosphorylation of ser-176
-
Ling L, Cao Z, Goeddel DV (1998) NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176. Proc Natl Acad Sci U S A 95: 3792-3797
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 3792-3797
-
-
Ling, L.1
Cao, Z.2
Goeddel, D.V.3
-
26
-
-
8544230698
-
A novel ubiquitin-like domain in ikappab kinase beta is required for functional activity of the kinase
-
May MJ, Larsen SE, Shim JH, Madge LA, Ghosh S (2004) A novel ubiquitin-like domain in IkappaB kinase beta is required for functional activity of the kinase. J Biol Chem 279: 45528-45539
-
(2004)
J Biol Chem
, vol.279
, pp. 45528-45539
-
-
May, M.J.1
Larsen, S.E.2
Shim, J.H.3
Madge, L.A.4
Ghosh, S.5
-
27
-
-
84881225453
-
Crystal structure of a human ikappab kinase beta asymmetric dimer
-
Liu S., Misquitta Y. R., Olland A., Johnson M. A., Kelleher K. S., Kriz R., Lin L. L., Stahl M., Mosyak L. (2013) Crystal Structure of A Human IkappaB Kinase beta Asymmetric Dimer. J Biol Chem 288: 22758-22767
-
(2013)
J Biol Chem
, vol.288
, pp. 22758-22767
-
-
Liu, S.1
Misquitta, Y.R.2
Olland, A.3
Johnson, M.A.4
Kelleher, K.S.5
Kriz, R.6
Lin, L.L.7
Stahl, M.8
Mosyak, L.9
-
28
-
-
84879339450
-
A structural basis for ikappab kinase 2 activation via oligomerization-dependent trans auto-phosphorylation
-
Polley S, Huang DB, Hauenstein AV, Fusco AJ, Zhong X, Vu D, Schrofelbauer B, Kim Y, Hoffmann A, Verma IM, Ghosh G, Huxford T (2013) A structural basis for IkappaB kinase 2 activation via oligomerization-dependent trans auto-phosphorylation. PLoS Biol 11: e1001581
-
(2013)
PLoS Biol
, vol.11
-
-
Polley, S.1
Huang, D.B.2
Hauenstein, A.V.3
Fusco, A.J.4
Zhong, X.5
Vu, D.6
Schrofelbauer, B.7
Kim, Y.8
Hoffmann, A.9
Verma, I.M.10
Ghosh, G.11
Huxford, T.12
-
29
-
-
79955481873
-
Crystal structure of inhibitor of kappab kinase beta
-
Xu G, Lo YC, Li Q, Napolitano G, Wu X, Jiang X, Dreano M, Karin M, Wu H (2011) Crystal structure of inhibitor of kappaB kinase beta. Nature 472: 325-330
-
(2011)
Nature
, vol.472
, pp. 325-330
-
-
Xu, G.1
Lo, Y.C.2
Li, Q.3
Napolitano, G.4
Wu, X.5
Jiang, X.6
Dreano, M.7
Karin, M.8
Wu, H.9
-
30
-
-
51249095133
-
The ikk-related kinases: From innate immunity to oncogenesis
-
Clement JF, Meloche S, Servant MJ (2008) The IKK-related kinases: from innate immunity to oncogenesis. Cell Res 18: 889-899
-
(2008)
Cell Res
, vol.18
, pp. 889-899
-
-
Clement, J.F.1
Meloche, S.2
Servant, M.J.3
-
31
-
-
84875814149
-
Crystal structure and mechanism of activation of tank-binding kinase 1
-
Larabi A, Devos JM, Ng SL, Nanao MH, Round A, Maniatis T, Panne D (2013) Crystal structure and mechanism of activation of TANK-binding kinase 1. Cell Rep 3: 734-746
-
(2013)
Cell Rep
, vol.3
, pp. 734-746
-
-
Larabi, A.1
Devos, J.M.2
Ng, S.L.3
Nanao, M.H.4
Round, A.5
Maniatis, T.6
Panne, D.7
-
32
-
-
84875808591
-
Structure and ubiquitination-dependent activation of tankbinding kinase 1
-
Tu D, Zhu Z, Zhou AY, Yun CH, Lee KE, Toms AV, Li Y, Dunn GP, Chan E, Thai T, Yang S, Ficarro SB, Marto JA, Jeon H, Hahn WC, Barbie DA, Eck MJ (2013) Structure and ubiquitination-dependent activation of TANKbinding kinase 1. Cell Rep 3: 747-758
-
(2013)
Cell Rep
, vol.3
, pp. 747-758
-
-
Tu, D.1
Zhu, Z.2
Zhou, A.Y.3
Yun, C.H.4
Lee, K.E.5
Toms, A.V.6
Li, Y.7
Dunn, G.P.8
Chan, E.9
Thai, T.10
Yang, S.11
Ficarro, S.B.12
Marto, J.A.13
Jeon, H.14
Hahn, W.C.15
Barbie, D.A.16
Eck, M.J.17
-
33
-
-
84862233012
-
Molecular basis of tank-binding kinase 1 activation by transautophosphorylation
-
Ma X, Helgason E, Phung QT, Quan CL, Iyer RS, Lee MW, Bowman KK, Starovasnik MA, Dueber EC (2012) Molecular basis of Tank-binding kinase 1 activation by transautophosphorylation. Proc Natl Acad Sci U S A 109: 9378-9383
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, pp. 9378-9383
-
-
Ma, X.1
Helgason, E.2
Phung, Q.T.3
Quan, C.L.4
Iyer, R.S.5
Lee, M.W.6
Bowman, K.K.7
Starovasnik, M.A.8
Dueber, E.C.9
-
34
-
-
84863840549
-
Nemo ensures signaling specificity of the pleiotropic ikkbeta by directing its kinase activity toward ikappabalpha
-
Schrofelbauer B, Polley S, Behar M, Ghosh G, Hoffmann A (2012) NEMO ensures signaling specificity of the pleiotropic IKKbeta by directing its kinase activity toward IkappaBalpha. Mol Cell 47: 111-121
-
(2012)
Mol Cell
, vol.47
, pp. 111-121
-
-
Schrofelbauer, B.1
Polley, S.2
Behar, M.3
Ghosh, G.4
Hoffmann, A.5
-
35
-
-
3142546430
-
The trimerization domain of nemo is composed of the interacting c-terminal cc2 and lz coiled-coil subdomains
-
Agou F, Traincard F, Vinolo E, Courtois G, Yamaoka S, Israel A, Veron M (2004) The trimerization domain of NEMO is composed of the interacting C-terminal CC2 and LZ coiled-coil subdomains. J Biol Chem 279: 27861-27869
-
(2004)
J Biol Chem
, vol.279
, pp. 27861-27869
-
-
Agou, F.1
Traincard, F.2
Vinolo, E.3
Courtois, G.4
Yamaoka, S.5
Israel, A.6
Veron, M.7
-
36
-
-
0037332580
-
Tetrameric oligomerization of ikappab kinase gamma (ikkgamma) is obligatory for ikk complex activity and nf-kappab activation
-
Tegethoff S, Behlke J, Scheidereit C (2003) Tetrameric oligomerization of IkappaB kinase gamma (IKKgamma) is obligatory for IKK complex activity and NF-kappaB activation. Mol Cell Biol 23: 2029-2041
-
(2003)
Mol Cell Biol
, vol.23
, pp. 2029-2041
-
-
Tegethoff, S.1
Behlke, J.2
Scheidereit, C.3
-
37
-
-
42949159409
-
Structure of a nemo/ikk-associating domain reveals architecture of the interaction site
-
Rushe M, Silvian L, Bixler S, Chen LL, Cheung A, Bowes S, Cuervo H, Berkowitz S, Zheng T, Guckian K, Pellegrini M, Lugovskoy A (2008) Structure of a NEMO/IKK-associating domain reveals architecture of the interaction site. Structure 16: 798-808
-
(2008)
Structure
, vol.16
, pp. 798-808
-
-
Rushe, M.1
Silvian, L.2
Bixler, S.3
Chen, L.L.4
Cheung, A.5
Bowes, S.6
Cuervo, H.7
Berkowitz, S.8
Zheng, T.9
Guckian, K.10
Pellegrini, M.11
Lugovskoy, A.12
-
38
-
-
44449125603
-
Crystal structure of a vflip-ikkgamma complex: Insights into viral activation of the ikk signalosome
-
Bagneris C, Ageichik AV, Cronin N, Wallace B, Collins M, Boshoff C, Waksman G, Barrett T (2008) Crystal structure of a vFlip-IKKgamma complex: insights into viral activation of the IKK signalosome. Mol Cell 30: 620-631
-
(2008)
Mol Cell
, vol.30
, pp. 620-631
-
-
Bagneris, C.1
Ageichik, A.V.2
Cronin, N.3
Wallace, B.4
Collins, M.5
Boshoff, C.6
Waksman, G.7
Barrett, T.8
-
39
-
-
59149093017
-
The zinc finger of nemo is a functional ubiquitin-binding domain
-
Cordier F, Grubisha O, Traincard F, Veron M, Delepierre M, Agou F (2009) The zinc finger of NEMO is a functional ubiquitin-binding domain. J Biol Chem 284: 2902-2907
-
(2009)
J Biol Chem
, vol.284
, pp. 2902-2907
-
-
Cordier, F.1
Grubisha, O.2
Traincard, F.3
Veron, M.4
Delepierre, M.5
Agou, F.6
-
40
-
-
70450225039
-
Darpin-assisted crystallography of the cc2-lz domain of nemo reveals a coupling between dimerization and ubiquitin binding
-
Grubisha O, Kaminska M, Duquerroy S, Fontan E, Cordier F, Haouz A, Raynal B, Chiaravalli J, Delepierre M, Israel A, Veron M, Agou F (2010) DARPin-assisted crystallography of the CC2-LZ domain of NEMO reveals a coupling between dimerization and ubiquitin binding. J Mol Biol 395: 89-104
-
(2010)
J Mol Biol
, vol.395
, pp. 89-104
-
-
Grubisha, O.1
Kaminska, M.2
Duquerroy, S.3
Fontan, E.4
Cordier, F.5
Haouz, A.6
Raynal, B.7
Chiaravalli, J.8
Delepierre, M.9
Israel, A.10
Veron, M.11
Agou, F.12
-
41
-
-
62549155321
-
Specific recognition of linear ubiquitin chains by nemo is important for nf-kappab activation
-
Rahighi S, Ikeda F, Kawasaki M, Akutsu M, Suzuki N, Kato R, Kensche T, Uejima T, Bloor S, Komander D, Randow F, Wakatsuki S, Dikic I (2009) Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation. Cell 136: 1098-1109
-
(2009)
Cell
, vol.136
, pp. 1098-1109
-
-
Rahighi, S.1
Ikeda, F.2
Kawasaki, M.3
Akutsu, M.4
Suzuki, N.5
Kato, R.6
Kensche, T.7
Uejima, T.8
Bloor, S.9
Komander, D.10
Randow, F.11
Wakatsuki, S.12
Dikic, I.13
-
42
-
-
84863338304
-
Ubiquitination in signaling to and activation of ikk
-
Chen ZJ (2012) Ubiquitination in signaling to and activation of IKK. Immunol Rev 246: 95-106
-
(2012)
Immunol Rev
, vol.246
, pp. 95-106
-
-
Chen, Z.J.1
-
43
-
-
84858113865
-
No one can whistle a symphony alone-how different ubiquitin linkages cooperate to orchestrate nf-kappab activity
-
Schmukle AC, Walczak H (2012) No one can whistle a symphony alone-how different ubiquitin linkages cooperate to orchestrate NF-kappaB activity. J Cell Sci 125: 549-559
-
(2012)
J Cell Sci
, vol.125
, pp. 549-559
-
-
Schmukle, A.C.1
Walczak, H.2
-
44
-
-
79961003254
-
New mechanism of x-linked anhidrotic ectodermal dysplasia with immunodeficiency: Impairment of ubiquitin binding despite normal folding of nemo protein
-
Hubeau M, Ngadjeua F, Puel A, Israel L, Feinberg J, Chrabieh M, Belani K, Bodemer C, Fabre I, Plebani A, Boisson-Dupuis S, Picard C, Fischer A, Israel A, Abel L, Veron M, Casanova JL, Agou F, Bustamante J (2011) New mechanism of X-linked anhidrotic ectodermal dysplasia with immunodeficiency: impairment of ubiquitin binding despite normal folding of NEMO protein. Blood 118: 926-935
-
(2011)
Blood
, vol.118
, pp. 926-935
-
-
Hubeau, M.1
Ngadjeua, F.2
Puel, A.3
Israel, L.4
Feinberg, J.5
Chrabieh, M.6
Belani, K.7
Bodemer, C.8
Fabre, I.9
Plebani, A.10
Boisson-Dupuis, S.11
Picard, C.12
Fischer, A.13
Israel, A.14
Abel, L.15
Veron, M.16
Casanova, J.L.17
Agou, F.18
Bustamante, J.19
-
45
-
-
61649103747
-
Structural basis for recognition of diubiquitins by nemo
-
Lo YC, Lin SC, Rospigliosi CC, Conze DB, Wu CJ, Ashwell JD, Eliezer D, Wu H (2009) Structural basis for recognition of diubiquitins by NEMO. Mol Cell 33: 602-615
-
(2009)
Mol Cell
, vol.33
, pp. 602-615
-
-
Lo, Y.C.1
Lin, S.C.2
Rospigliosi, C.C.3
Conze, D.B.4
Wu, C.J.5
Ashwell, J.D.6
Eliezer, D.7
Wu, H.8
-
46
-
-
67349231313
-
Molecular discrimination of structurally equivalent lys 63-linked and linear polyubiquitin chains
-
Komander D, Reyes-Turcu F, Licchesi JD, Odenwaelder P, Wilkinson KD, Barford D (2009) Molecular discrimination of structurally equivalent Lys 63-linked and linear polyubiquitin chains. EMBO Rep 10: 466-473
-
(2009)
EMBO Rep
, vol.10
, pp. 466-473
-
-
Komander, D.1
Reyes-Turcu, F.2
Licchesi, J.D.3
Odenwaelder, P.4
Wilkinson, K.D.5
Barford, D.6
-
47
-
-
78650300883
-
C-iap1 and ubch5 promote k11-linked polyubiquitination of rip1 in tnf signalling
-
Dynek JN, Goncharov T, Dueber EC, Fedorova AV, Izrael-Tomasevic A, Phu L, Helgason E, Fairbrother WJ, Deshayes K, Kirkpatrick DS, Vucic D (2010) c-IAP1 and UbcH5 promote K11-linked polyubiquitination of RIP1 in TNF signalling. EMBO J 29: 4198-4209
-
(2010)
EMBO J
, vol.29
, pp. 4198-4209
-
-
Dynek, J.N.1
Goncharov, T.2
Dueber, E.C.3
Fedorova, A.V.4
Izrael-Tomasevic, A.5
Phu, L.6
Helgason, E.7
Fairbrother, W.J.8
Deshayes, K.9
Kirkpatrick, D.S.10
Vucic, D.11
-
48
-
-
70350020147
-
Nemo specifically recognizes k63-linked poly-ubiquitin chains through a new bipartite ubiquitin-binding domain
-
Laplantine E, Fontan E, Chiaravalli J, Lopez T, Lakisic G, Veron M, Agou F, Israel A (2009) NEMO specifically recognizes K63-linked poly-ubiquitin chains through a new bipartite ubiquitin-binding domain. EMBO J 28: 2885-2895
-
(2009)
EMBO J
, vol.28
, pp. 2885-2895
-
-
Laplantine, E.1
Fontan, E.2
Chiaravalli, J.3
Lopez, T.4
Lakisic, G.5
Veron, M.6
Agou, F.7
Israel, A.8
-
49
-
-
40849140675
-
Solution structure of nemo zinc finger and impact of an anhidrotic ectodermal dysplasia with immunodeficiency-related point mutation
-
Cordier F, Vinolo E, Veron M, Delepierre M, Agou F (2008) Solution structure of NEMO zinc finger and impact of an anhidrotic ectodermal dysplasia with immunodeficiency-related point mutation. J Mol Biol 377: 1419-1432
-
(2008)
J Mol Biol
, vol.377
, pp. 1419-1432
-
-
Cordier, F.1
Vinolo, E.2
Veron, M.3
Delepierre, M.4
Agou, F.5
-
50
-
-
79960419007
-
Nf-kappab essential modulator (nemo) interaction with linear and lys-63 ubiquitin chains contributes to nf-kappab activation
-
Hadian K, Griesbach RA, Dornauer S, Wanger TM, Nagel D, Metlitzky M, Beisker W, Schmidt-Supprian M, Krappmann D (2011) NF-kappaB essential modulator (NEMO) interaction with linear and lys-63 ubiquitin chains contributes to NF-kappaB activation. J Biol Chem 286: 26107-26117
-
(2011)
J Biol Chem
, vol.286
, pp. 26107-26117
-
-
Hadian, K.1
Griesbach, R.A.2
Dornauer, S.3
Wanger, T.M.4
Nagel, D.5
Metlitzky, M.6
Beisker, W.7
Schmidt-Supprian, M.8
Krappmann, D.9
-
51
-
-
84863621364
-
Analysis of nuclear factor-kappab (nf-kappab) essential modulator (nemo) binding to linear and lysine-linked ubiquitin chains and its role in the activation of nf-kappab
-
Kensche T, Tokunaga F, Ikeda F, Goto E, Iwai K, Dikic I (2012) Analysis of nuclear factor-kappaB (NF-kappaB) essential modulator (NEMO) binding to linear and lysine-linked ubiquitin chains and its role in the activation of NF-kappaB. J Biol Chem 287: 23626-23634
-
(2012)
J Biol Chem
, vol.287
, pp. 23626-23634
-
-
Kensche, T.1
Tokunaga, F.2
Ikeda, F.3
Goto, E.4
Iwai, K.5
Dikic, I.6
-
52
-
-
84884345970
-
Activation of the canonical ikk complex by k63/m1-linked hybrid ubiquitin chains
-
Emmerich C. H., Ordureau A., Strickson S., Arthur J. S., Pedrioli P. G., Komander D., Cohen P. (2013) Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains. Proc Natl Acad Sci U S A 110: 15247-15252
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. 15247-15252
-
-
Emmerich, C.H.1
Ordureau, A.2
Strickson, S.3
Arthur, J.S.4
Pedrioli, P.G.5
Komander, D.6
Cohen, P.7
-
53
-
-
36148967696
-
Signal responsiveness of ikappab kinases is determined by cdc37-assisted transient interaction with hsp90
-
Hinz M, Broemer M, Arslan SC, Otto A, Mueller EC, Dettmer R, Scheidereit C (2007) Signal responsiveness of IkappaB kinases is determined by Cdc37-assisted transient interaction with Hsp90. J Biol Chem 282: 32311-32319
-
(2007)
J Biol Chem
, vol.282
, pp. 32311-32319
-
-
Hinz, M.1
Broemer, M.2
Arslan, S.C.3
Otto, A.4
Mueller, E.C.5
Dettmer, R.6
Scheidereit, C.7
-
54
-
-
0034703023
-
The i kappa b kinase (ikk) complex is tripartite and contains ikk gamma but not ikap as a regular component
-
Krappmann D, Hatada EN, Tegethoff S, Li J, Klippel A, Giese K, Baeuerle PA, Scheidereit C (2000) The I kappa B kinase (IKK) complex is tripartite and contains IKK gamma but not IKAP as a regular component. J Biol Chem 275: 29779-29787
-
(2000)
J Biol Chem
, vol.275
, pp. 29779-29787
-
-
Krappmann, D.1
Hatada, E.N.2
Tegethoff, S.3
Li, J.4
Klippel, A.5
Giese, K.6
Baeuerle, P.A.7
Scheidereit, C.8
-
55
-
-
0035965199
-
Complete reconstitution of human ikappab kinase (ikk) complex in yeast. Assessment of its stoichiometry and the role of ikkgamma on the complex activity in the absence of stimulation
-
Miller BS, Zandi E (2001) Complete reconstitution of human IkappaB kinase (IKK) complex in yeast. Assessment of its stoichiometry and the role of IKKgamma on the complex activity in the absence of stimulation. J Biol Chem 276: 36320-36326
-
(2001)
J Biol Chem
, vol.276
, pp. 36320-36326
-
-
Miller, B.S.1
Zandi, E.2
-
56
-
-
35648976505
-
Inhibitor kappab kinase beta binding by inhibitor kappab kinase gamma
-
Drew D, Shimada E, Huynh K, Bergqvist S, Talwar R, Karin M, Ghosh G (2007) Inhibitor kappaB kinase beta binding by inhibitor kappaB kinase gamma. Biochemistry 46: 12482-12490
-
(2007)
Biochemistry
, vol.46
, pp. 12482-12490
-
-
Drew, D.1
Shimada, E.2
Huynh, K.3
Bergqvist, S.4
Talwar, R.5
Karin, M.6
Ghosh, G.7
-
57
-
-
17944378526
-
Activation by ikkalpha of a second, evolutionary conserved, nf-kappa b signaling pathway
-
Senftleben U, Cao Y, Xiao G, Greten FR, Krahn G, Bonizzi G, Chen Y, Hu Y, Fong A, Sun SC, Karin M (2001) Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway. Science 293: 1495-1499
-
(2001)
Science
, vol.293
, pp. 1495-1499
-
-
Senftleben, U.1
Cao, Y.2
Xiao, G.3
Greten, F.R.4
Krahn, G.5
Bonizzi, G.6
Chen, Y.7
Hu, Y.8
Fong, A.9
Sun, S.C.10
Karin, M.11
-
58
-
-
67650724069
-
Regulation and function of nf-kappab transcription factors in the immune system
-
Vallabhapurapu S, Karin M (2009) Regulation and function of NF-kappaB transcription factors in the immune system. Annu Rev Immunol 27: 693-733
-
(2009)
Annu Rev Immunol
, vol.27
, pp. 693-733
-
-
Vallabhapurapu, S.1
Karin, M.2
-
59
-
-
84857126437
-
Genome-wide sirna screen for mediators of nf-kappab activation
-
Gewurz BE, Towfic F, Mar JC, Shinners NP, Takasaki K, Zhao B, Cahir-McFarland ED, Quackenbush J, Xavier RJ, Kieff E (2012) Genome-wide siRNA screen for mediators of NF-kappaB activation. Proc Natl Acad Sci U S A 109: 2467-2472
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, pp. 2467-2472
-
-
Gewurz, B.E.1
Towfic, F.2
Mar, J.C.3
Shinners, N.P.4
Takasaki, K.5
Zhao, B.6
Cahir-McFarland, E.D.7
Quackenbush, J.8
Xavier, R.J.9
Kieff, E.10
-
60
-
-
84860672660
-
Kaposi's sarcoma associated herpesvirus encoded viral flice inhibitory protein k13 activates nf-kappab pathway independent of traf6, tak1 and lubac
-
Matta H, Gopalakrishnan R, Graham C, Tolani B, Khanna A, Yi H, Suo Y, Chaudhary PM (2012) Kaposi's sarcoma associated herpesvirus encoded viral FLICE inhibitory protein K13 activates NF-kappaB pathway independent of TRAF6, TAK1 and LUBAC. PLoS ONE 7: e36601
-
(2012)
PLoS ONE
, vol.7
-
-
Matta, H.1
Gopalakrishnan, R.2
Graham, C.3
Tolani, B.4
Khanna, A.5
Yi, H.6
Suo, Y.7
Chaudhary, P.M.8
-
61
-
-
0034644474
-
Activation of the ikappab kinase complex by traf6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain
-
Deng L, Wang C, Spencer E, Yang L, Braun A, You J, Slaughter C, Pickart C, Chen ZJ (2000) Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. Cell 103: 351-361
-
(2000)
Cell
, vol.103
, pp. 351-361
-
-
Deng, L.1
Wang, C.2
Spencer, E.3
Yang, L.4
Braun, A.5
You, J.6
Slaughter, C.7
Pickart, C.8
Chen, Z.J.9
-
62
-
-
0035913278
-
Tak1 is a ubiquitin-dependent kinase of mkk and ikk
-
Wang C, Deng L, Hong M, Akkaraju GR, Inoue J, Chen ZJ (2001) TAK1 is a ubiquitin-dependent kinase of MKK and IKK. Nature 412: 346-351
-
(2001)
Nature
, vol.412
, pp. 346-351
-
-
Wang, C.1
Deng, L.2
Hong, M.3
Akkaraju, G.R.4
Inoue, J.5
Chen, Z.J.6
-
63
-
-
0346496017
-
Differential regulation of interleukin 1 receptor and toll-like receptor signaling by mekk3
-
Huang Q, Yang J, Lin Y, Walker C, Cheng J, Liu ZG, Su B (2004) Differential regulation of interleukin 1 receptor and Toll-like receptor signaling by MEKK3. Nat Immunol 5: 98-103
-
(2004)
Nat Immunol
, vol.5
, pp. 98-103
-
-
Huang, Q.1
Yang, J.2
Lin, Y.3
Walker, C.4
Cheng, J.5
Liu, Z.G.6
Su, B.7
-
64
-
-
0034922161
-
The essential role of mekk3 in tnf-induced nf-kappab activation
-
Yang J, Lin Y, Guo Z, Cheng J, Huang J, Deng L, Liao W, Chen Z, Liu Z, Su B (2001) The essential role of MEKK3 in TNF-induced NF-kappaB activation. Nat Immunol 2: 620-624
-
(2001)
Nat Immunol
, vol.2
, pp. 620-624
-
-
Yang, J.1
Lin, Y.2
Guo, Z.3
Cheng, J.4
Huang, J.5
Deng, L.6
Liao, W.7
Chen, Z.8
Liu, Z.9
Su, B.10
-
65
-
-
33746365872
-
Tlr8-mediated nf-kappab and jnk activation are tak1-independent and mekk3-dependent
-
Qin J, Yao J, Cui G, Xiao H, Kim TW, Fraczek J, Wightman P, Sato S, Akira S, Puel A, Casanova JL, Su B, Li X (2006) TLR8-mediated NF-kappaB and JNK activation are TAK1-independent and MEKK3-dependent. J Biol Chem 281: 21013-21021
-
(2006)
J Biol Chem
, vol.281
, pp. 21013-21021
-
-
Qin, J.1
Yao, J.2
Cui, G.3
Xiao, H.4
Kim, T.W.5
Fraczek, J.6
Wightman, P.7
Sato, S.8
Akira, S.9
Puel, A.10
Casanova, J.L.11
Su, B.12
Li, X.13
-
66
-
-
34249017742
-
Interleukin-1 (il-1)-induced tak1-dependent versus mekk3-dependent nfkappab activation pathways bifurcate at il-1 receptor-associated kinase modification
-
Yao J, Kim TW, Qin J, Jiang Z, Qian Y, Xiao H, Lu Y, Qian W, Gulen MF, Sizemore N, DiDonato J, Sato S, Akira S, Su B, Li X (2007) Interleukin-1 (IL-1)-induced TAK1-dependent Versus MEKK3-dependent NFkappaB activation pathways bifurcate at IL-1 receptor-associated kinase modification. J Biol Chem 282: 6075-6089
-
(2007)
J Biol Chem
, vol.282
, pp. 6075-6089
-
-
Yao, J.1
Kim, T.W.2
Qin, J.3
Jiang, Z.4
Qian, Y.5
Xiao, H.6
Lu, Y.7
Qian, W.8
Gulen, M.F.9
Sizemore, N.10
DiDonato, J.11
Sato, S.12
Akira, S.13
Su, B.14
Li, X.15
-
67
-
-
0033537719
-
Positive and negative regulation of ikappab kinase activity through ikkbeta subunit phosphorylation
-
Delhase M, Hayakawa M, Chen Y, Karin M (1999) Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation. Science 284: 309-313
-
(1999)
Science
, vol.284
, pp. 309-313
-
-
Delhase, M.1
Hayakawa, M.2
Chen, Y.3
Karin, M.4
-
68
-
-
58149178554
-
Traf6 autoubiquitination-independent activation of the nfkappab and mapk pathways in response to il-1 and rankl
-
Walsh MC, Kim GK, Maurizio PL, Molnar EE, Choi Y (2008) TRAF6 autoubiquitination-independent activation of the NFkappaB and MAPK pathways in response to IL-1 and RANKL. PLoS ONE 3: e4064
-
(2008)
PLoS ONE
, vol.3
-
-
Walsh, M.C.1
Kim, G.K.2
Maurizio, P.L.3
Molnar, E.E.4
Choi, Y.5
-
69
-
-
69949093459
-
Direct activation of protein kinases by unanchored polyubiquitin chains
-
Xia ZP, Sun LJ, Chen X, Pineda G, Jiang XM, Adhikari A, Zeng WW, Chen ZJ (2009) Direct activation of protein kinases by unanchored polyubiquitin chains. Nature 461: 114-U125
-
(2009)
Nature
, vol.461
-
-
Xia, Z.P.1
Sun, L.J.2
Chen, X.3
Pineda, G.4
Jiang, X.M.5
Adhikari, A.6
Zeng, W.W.7
Chen, Z.J.8
-
70
-
-
70350015537
-
A ubiquitin replacement strategy in human cells reveals distinct mechanisms of ikk activation by tnfalpha and il-1beta
-
Xu M, Skaug B, Zeng W, Chen ZJ (2009) A ubiquitin replacement strategy in human cells reveals distinct mechanisms of IKK activation by TNFalpha and IL-1beta. Mol Cell 36: 302-314
-
(2009)
Mol Cell
, vol.36
, pp. 302-314
-
-
Xu, M.1
Skaug, B.2
Zeng, W.3
Chen, Z.J.4
-
71
-
-
79953240109
-
Linear ubiquitination prevents inflammation and regulates immune signalling
-
Gerlach B, Cordier SM, Schmukle AC, Emmerich CH, Rieser E, Haas TL, Webb AI, Rickard JA, Anderton H, Wong WW, Nachbur U, Gangoda L, Warnken U, Purcell AW, Silke J, Walczak H (2011) Linear ubiquitination prevents inflammation and regulates immune signalling. Nature 471: 591-596
-
(2011)
Nature
, vol.471
, pp. 591-596
-
-
Gerlach, B.1
Cordier, S.M.2
Schmukle, A.C.3
Emmerich, C.H.4
Rieser, E.5
Haas, T.L.6
Webb, A.I.7
Rickard, J.A.8
Anderton, H.9
Wong, W.W.10
Nachbur, U.11
Gangoda, L.12
Warnken, U.13
Purcell, A.W.14
Silke, J.15
Walczak, H.16
-
72
-
-
59649103156
-
Involvement of linear polyubiquitylation of nemo in nf-kappab activation
-
Tokunaga F, Sakata S, Saeki Y, Satomi Y, Kirisako T, Kamei K, Nakagawa T, Kato M, Murata S, Yamaoka S, Yamamoto M, Akira S, Takao T, Tanaka K, Iwai K (2009) Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation. Nat Cell Biol 11: 123-132
-
(2009)
Nat Cell Biol
, vol.11
, pp. 123-132
-
-
Tokunaga, F.1
Sakata, S.2
Saeki, Y.3
Satomi, Y.4
Kirisako, T.5
Kamei, K.6
Nakagawa, T.7
Kato, M.8
Murata, S.9
Yamaoka, S.10
Yamamoto, M.11
Akira, S.12
Takao, T.13
Tanaka, K.14
Iwai, K.15
-
73
-
-
84862761186
-
Diverse ubiquitin signaling in nf-kappab activation
-
Iwai K (2012) Diverse ubiquitin signaling in NF-kappaB activation. Trends Cell Biol 22: 355-364
-
(2012)
Trends Cell Biol
, vol.22
, pp. 355-364
-
-
Iwai, K.1
-
74
-
-
84876886863
-
The e3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of nemo
-
Muller-Rischart AK, Pilsl A, Beaudette P, Patra M, Hadian K, Funke M, Peis R, Deinlein A, Schweimer C, Kuhn PH, Lichtenthaler SF, Motori E, Hrelia S, Wurst W, Trumbach D, Langer T, Krappmann D, Dittmar G, Tatzelt J, Winklhofer KF (2013) The E3 ligase parkin maintains mitochondrial integrity by increasing linear ubiquitination of NEMO. Mol Cell 49: 908-921
-
(2013)
Mol Cell
, vol.49
, pp. 908-921
-
-
Muller-Rischart, A.K.1
Pilsl, A.2
Beaudette, P.3
Patra, M.4
Hadian, K.5
Funke, M.6
Peis, R.7
Deinlein, A.8
Schweimer, C.9
Kuhn, P.H.10
Lichtenthaler, S.F.11
Motori, E.12
Hrelia, S.13
Wurst, W.14
Trumbach, D.15
Langer, T.16
Krappmann, D.17
Dittmar, G.18
Tatzelt, J.19
Winklhofer, K.F.20
more..
-
75
-
-
84884283799
-
Defective immune responses in mice lacking lubac-mediated linear ubiquitination in b cells
-
Sasaki Y., Sano S., Nakahara M., Murata S., Kometani K., Aiba Y., Sakamoto S., Watanabe Y., Tanaka K., Kurosaki T., Iwai K. (2013) Defective immune responses in mice lacking LUBAC-mediated linear ubiquitination in B cells. EMBO J 32: 2463-2476
-
(2013)
EMBO J
, vol.32
, pp. 2463-2476
-
-
Sasaki, Y.1
Sano, S.2
Nakahara, M.3
Murata, S.4
Kometani, K.5
Aiba, Y.6
Sakamoto, S.7
Watanabe, Y.8
Tanaka, K.9
Kurosaki, T.10
Iwai, K.11
-
76
-
-
79953239980
-
Sharpin forms a linear ubiquitin ligase complex regulating nf-kappab activity and apoptosis
-
Ikeda F, Deribe YL, Skanland SS, Stieglitz B, Grabbe C, Franz-Wachtel M, van Wijk SJ, Goswami P, Nagy V, Terzic J, Tokunaga F, Androulidaki A, Nakagawa T, Pasparakis M, Iwai K, Sundberg JP, Schaefer L, Rittinger K, Macek B, Dikic I (2011) SHARPIN forms a linear ubiquitin ligase complex regulating NF-kappaB activity and apoptosis. Nature 471: 637-641
-
(2011)
Nature
, vol.471
, pp. 637-641
-
-
Ikeda, F.1
Deribe, Y.L.2
Skanland, S.S.3
Stieglitz, B.4
Grabbe, C.5
Franz-Wachtel, M.6
Van Wijk, S.J.7
Goswami, P.8
Nagy, V.9
Terzic, J.10
Tokunaga, F.11
Androulidaki, A.12
Nakagawa, T.13
Pasparakis, M.14
Iwai, K.15
Sundberg, J.P.16
Schaefer, L.17
Rittinger, K.18
Macek, B.19
Dikic, I.20
more..
-
77
-
-
79953237668
-
Sharpin is a component of the nf-kappab-activating linear ubiquitin chain assembly complex
-
Tokunaga F, Nakagawa T, Nakahara M, Saeki Y, Taniguchi M, Sakata S, Tanaka K, Nakano H, Iwai K (2011) SHARPIN is a component of the NF-kappaB-activating linear ubiquitin chain assembly complex. Nature 471: 633-636
-
(2011)
Nature
, vol.471
, pp. 633-636
-
-
Tokunaga, F.1
Nakagawa, T.2
Nakahara, M.3
Saeki, Y.4
Taniguchi, M.5
Sakata, S.6
Tanaka, K.7
Nakano, H.8
Iwai, K.9
-
78
-
-
84869429707
-
Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited hoil-1 and lubac deficiency
-
Boisson B, Laplantine E, Prando C, Giliani S, Israelsson E, Xu Z, Abhyankar A, Israel L, Trevejo-Nunez G, Bogunovic D, Cepika AM, MacDuff D, Chrabieh M, Hubeau M, Bajolle F, Debre M, Mazzolari E, Vairo D, Agou F, Virgin HW, et al (2012) Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency. Nat Immunol 13: 1178-1186
-
(2012)
Nat Immunol
, vol.13
, pp. 1178-1186
-
-
Boisson, B.1
Laplantine, E.2
Prando, C.3
Giliani, S.4
Israelsson, E.5
Xu, Z.6
Abhyankar, A.7
Israel, L.8
Trevejo-Nunez, G.9
Bogunovic, D.10
Cepika, A.M.11
MacDuff, D.12
Chrabieh, M.13
Hubeau, M.14
Bajolle, F.15
Debre, M.16
Mazzolari, E.17
Vairo, D.18
Agou, F.19
Virgin, H.W.20
more..
-
79
-
-
77957677615
-
Polyubiquitin conjugation to nemo by triparite motif protein 23 (trim23) is critical in antiviral defense
-
Arimoto K, Funami K, Saeki Y, Tanaka K, Okawa K, Takeuchi O, Akira S, Murakami Y, Shimotohno K (2010) Polyubiquitin conjugation to NEMO by triparite motif protein 23 (TRIM23) is critical in antiviral defense. Proc Natl Acad Sci U S A 107: 15856-15861
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 15856-15861
-
-
Arimoto, K.1
Funami, K.2
Saeki, Y.3
Tanaka, K.4
Okawa, K.5
Takeuchi, O.6
Akira, S.7
Murakami, Y.8
Shimotohno, K.9
-
80
-
-
0141621240
-
A role for nf-kappab essential modifier/ikappab kinase-gamma (nemo/ikkgamma) ubiquitination in the activation of the ikappab kinase complex by tumor necrosis factor-alpha
-
Tang ED, Wang CY, Xiong Y, Guan KL (2003) A role for NF-kappaB essential modifier/IkappaB kinase-gamma (NEMO/IKKgamma) ubiquitination in the activation of the IkappaB kinase complex by tumor necrosis factor-alpha. J Biol Chem 278: 37297-37305
-
(2003)
J Biol Chem
, vol.278
, pp. 37297-37305
-
-
Tang, E.D.1
Wang, C.Y.2
Xiong, Y.3
Guan, K.L.4
-
81
-
-
33646034316
-
Activation of ikk by tnfalpha requires site-specific ubiquitination of rip1 and polyubiquitin binding by nemo
-
Ea CK, Deng L, Xia ZP, Pineda G, Chen ZJ (2006) Activation of IKK by TNFalpha requires site-specific ubiquitination of RIP1 and polyubiquitin binding by NEMO. Mol Cell 22: 245-257
-
(2006)
Mol Cell
, vol.22
, pp. 245-257
-
-
Ea, C.K.1
Deng, L.2
Xia, Z.P.3
Pineda, G.4
Chen, Z.J.5
-
82
-
-
49549117842
-
Ubiquitin chain editing revealed by polyubiquitin linkage-specific antibodies
-
Newton K, Matsumoto ML, Wertz IE, Kirkpatrick DS, Lill JR, Tan J, Dugger D, Gordon N, Sidhu SS, Fellouse FA, Komuves L, French DM, Ferrando RE, Lam C, Compaan D, Yu C, Bosanac I, Hymowitz SG, Kelley RF, Dixit VM (2008) Ubiquitin chain editing revealed by polyubiquitin linkage-specific antibodies. Cell 134: 668-678
-
(2008)
Cell
, vol.134
, pp. 668-678
-
-
Newton, K.1
Matsumoto, M.L.2
Wertz, I.E.3
Kirkpatrick, D.S.4
Lill, J.R.5
Tan, J.6
Dugger, D.7
Gordon, N.8
Sidhu, S.S.9
Fellouse, F.A.10
Komuves, L.11
French, D.M.12
Ferrando, R.E.13
Lam, C.14
Compaan, D.15
Yu, C.16
Bosanac, I.17
Hymowitz, S.G.18
Kelley, R.F.19
Dixit, V.M.20
more..
-
83
-
-
33645703930
-
Sensing of lys 63-linked polyubiquitination by nemo is a key event in nf-kappab activation [corrected]
-
Wu CJ, Conze DB, Li T, Srinivasula SM, Ashwell JD (2006) Sensing of Lys 63-linked polyubiquitination by NEMO is a key event in NF-kappaB activation [corrected]. Nat Cell Biol 8: 398-406
-
(2006)
Nat Cell Biol
, vol.8
, pp. 398-406
-
-
Wu, C.J.1
Conze, D.B.2
Li, T.3
Srinivasula, S.M.4
Ashwell, J.D.5
-
84
-
-
33645148675
-
Regulation of ubiquitin-binding proteins by monoubiquitination
-
Hoeller D, Crosetto N, Blagoev B, Raiborg C, Tikkanen R, Wagner S, Kowanetz K, Breitling R, Mann M, Stenmark H, Dikic I (2006) Regulation of ubiquitin-binding proteins by monoubiquitination. Nat Cell Biol 8: 163-169
-
(2006)
Nat Cell Biol
, vol.8
, pp. 163-169
-
-
Hoeller, D.1
Crosetto, N.2
Blagoev, B.3
Raiborg, C.4
Tikkanen, R.5
Wagner, S.6
Kowanetz, K.7
Breitling, R.8
Mann, M.9
Stenmark, H.10
Dikic, I.11
-
85
-
-
77957333810
-
A cytoplasmic atm-traf6-ciap1 module links nuclear dna damage signaling to ubiquitin-mediated nf-kappab activation
-
Hinz M, Stilmann M, Arslan SC, Khanna KK, Dittmar G, Scheidereit C (2010) A cytoplasmic ATM-TRAF6-cIAP1 module links nuclear DNA damage signaling to ubiquitin-mediated NF-kappaB activation. Mol Cell 40: 63-74
-
(2010)
Mol Cell
, vol.40
, pp. 63-74
-
-
Hinz, M.1
Stilmann, M.2
Arslan, S.C.3
Khanna, K.K.4
Dittmar, G.5
Scheidereit, C.6
-
86
-
-
0344305376
-
Sequential modification of nemo/ikkgamma by sumo-1 and ubiquitin mediates nf-kappab activation by genotoxic stress
-
Huang TT, Wuerzberger-Davis SM, Wu ZH, Miyamoto S (2003) Sequential modification of NEMO/IKKgamma by SUMO-1 and ubiquitin mediates NF-kappaB activation by genotoxic stress. Cell 115: 565-576
-
(2003)
Cell
, vol.115
, pp. 565-576
-
-
Huang, T.T.1
Wuerzberger-Davis, S.M.2
Wu, Z.H.3
Miyamoto, S.4
-
87
-
-
84880794284
-
Innate immune-directed nf-kappab signaling requires site-specific nemo ubiquitination
-
Jun J. C., Kertesy S., Jones M. B., Marinis J. M., Cobb B. A., Tigno-Aranjuez J. T., Abbott D. W. (2013) Innate Immune-Directed NF-kappaB Signaling Requires Site-Specific NEMO Ubiquitination. Cell Rep 4: 352-361
-
(2013)
Cell Rep
, vol.4
, pp. 352-361
-
-
Jun, J.C.1
Kertesy, S.2
Jones, M.B.3
Marinis, J.M.4
Cobb, B.A.5
Tigno-Aranjuez, J.T.6
Abbott, D.W.7
-
88
-
-
84877757564
-
Molecular basis of nf-kappab signaling
-
Napetschnig J, Wu H (2013) Molecular basis of NF-kappaB signaling. Annu Rev Biophys 42: 443-468
-
(2013)
Annu Rev Biophys
, vol.42
, pp. 443-468
-
-
Napetschnig, J.1
Wu, H.2
-
89
-
-
77953714711
-
Helical assembly in the myd88-irak4-irak2 complex in tlr/il-1r signalling
-
Lin SC, Lo YC, Wu H (2010) Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling. Nature 465: 885-890
-
(2010)
Nature
, vol.465
, pp. 885-890
-
-
Lin, S.C.1
Lo, Y.C.2
Wu, H.3
-
90
-
-
79961133270
-
Mavs forms functional prion-like aggregates to activate and propagate antiviral innate immune response
-
Hou F, Sun L, Zheng H, Skaug B, Jiang QX, Chen ZJ (2011) MAVS forms functional prion-like aggregates to activate and propagate antiviral innate immune response. Cell 146: 448-461
-
(2011)
Cell
, vol.146
, pp. 448-461
-
-
Hou, F.1
Sun, L.2
Zheng, H.3
Skaug, B.4
Jiang, Q.X.5
Chen, Z.J.6
-
91
-
-
67349242723
-
E2 interaction and dimerization in the crystal structure of traf6
-
Yin Q, Lin SC, Lamothe B, Lu M, Lo YC, Hura G, Zheng L, Rich RL, Campos AD, Myszka DG, Lenardo MJ, Darnay BG, Wu H (2009) E2 interaction and dimerization in the crystal structure of TRAF6. Nat Struct Mol Biol 16: 658-666
-
(2009)
Nat Struct Mol Biol
, vol.16
, pp. 658-666
-
-
Yin, Q.1
Lin, S.C.2
Lamothe, B.3
Lu, M.4
Lo, Y.C.5
Hura, G.6
Zheng, L.7
Rich, R.L.8
Campos, A.D.9
Myszka, D.G.10
Lenardo, M.J.11
Darnay, B.G.12
Wu, H.13
-
92
-
-
84876221513
-
Higher-order assemblies in a new paradigm of signal transduction
-
WuH(2013) Higher-order assemblies in a new paradigm of signal transduction. Cell 153: 287-292
-
(2013)
Cell
, vol.153
, pp. 287-292
-
-
Wu, H.1
-
93
-
-
38049028109
-
Phosphorylation of serine 68 in the ikappab kinase (ikk)-binding domain of nemo interferes with the structure of the ikk complex and tumor necrosis factor-alpha-induced nf-kappab activity
-
Palkowitsch L, Leidner J, Ghosh S, Marienfeld RB (2008) Phosphorylation of serine 68 in the IkappaB kinase (IKK)-binding domain of NEMO interferes with the structure of the IKK complex and tumor necrosis factor-alpha-induced NF-kappaB activity. J Biol Chem 283: 76-86
-
(2008)
J Biol Chem
, vol.283
, pp. 76-86
-
-
Palkowitsch, L.1
Leidner, J.2
Ghosh, S.3
Marienfeld, R.B.4
-
94
-
-
33744948611
-
Regulation of ikappab kinase (ikk) complex by ikkgamma-dependent phosphorylation of the t-loop and c terminus of ikkbeta
-
Schomer-Miller B, Higashimoto T, Lee YK, Zandi E (2006) Regulation of IkappaB kinase (IKK) complex by IKKgamma-dependent phosphorylation of the T-loop and C terminus of IKKbeta. J Biol Chem 281: 15268-15276
-
(2006)
J Biol Chem
, vol.281
, pp. 15268-15276
-
-
Schomer-Miller, B.1
Higashimoto, T.2
Lee, Y.K.3
Zandi, E.4
-
95
-
-
33846528701
-
Negative feedback loop in t cell activation through ikappab kinase-induced phosphorylation and degradation of bcl10
-
Lobry C, Lopez T, Israel A, Weil R (2007) Negative feedback loop in T cell activation through IkappaB kinase-induced phosphorylation and degradation of Bcl10. Proc Natl Acad Sci U S A 104: 908-913
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 908-913
-
-
Lobry, C.1
Lopez, T.2
Israel, A.3
Weil, R.4
-
96
-
-
33745494351
-
Essential role for ikappab kinase beta in remodeling carma1-bcl10-malt1 complexes upon t cell activation
-
Wegener E, Oeckinghaus A, Papadopoulou N, Lavitas L, Schmidt-Supprian M, Ferch U, Mak TW, Ruland J, Heissmeyer V, Krappmann D (2006) Essential role for IkappaB kinase beta in remodeling Carma1-Bcl10-Malt1 complexes upon T cell activation. Mol Cell 23: 13-23
-
(2006)
Mol Cell
, vol.23
, pp. 13-23
-
-
Wegener, E.1
Oeckinghaus, A.2
Papadopoulou, N.3
Lavitas, L.4
Schmidt-Supprian, M.5
Ferch, U.6
Mak, T.W.7
Ruland, J.8
Heissmeyer, V.9
Krappmann, D.10
-
97
-
-
34547924464
-
Optineurin negatively regulates tnfalpha-induced nf-kappab activation by competing with nemo for ubiquitinated rip
-
Zhu G, Wu CJ, Zhao Y, Ashwell JD (2007) Optineurin negatively regulates TNFalpha-induced NF-kappaB activation by competing with NEMO for ubiquitinated RIP. Curr Biol 17: 1438-1443
-
(2007)
Curr Biol
, vol.17
, pp. 1438-1443
-
-
Zhu, G.1
Wu, C.J.2
Zhao, Y.3
Ashwell, J.D.4
-
98
-
-
77952419246
-
Mutations of optineurin in amyotrophic lateral sclerosis
-
Maruyama H, Morino H, Ito H, Izumi Y, Kato H, Watanabe Y, Kinoshita Y, Kamada M, Nodera H, Suzuki H, Komure O, Matsuura S, Kobatake K, Morimoto N, Abe K, Suzuki N, Aoki M, Kawata A, Hirai T, Kato T, et al (2010) Mutations of optineurin in amyotrophic lateral sclerosis. Nature 465: 223-226
-
(2010)
Nature
, vol.465
, pp. 223-226
-
-
Maruyama, H.1
Morino, H.2
Ito, H.3
Izumi, Y.4
Kato, H.5
Watanabe, Y.6
Kinoshita, Y.7
Kamada, M.8
Nodera, H.9
Suzuki, H.10
Komure, O.11
Matsuura, S.12
Kobatake, K.13
Morimoto, N.14
Abe, K.15
Suzuki, N.16
Aoki, M.17
Kawata, A.18
Hirai, T.19
Kato, T.20
more..
-
99
-
-
84867032420
-
P47 negatively regulates ikk activation by inducing the lysosomal degradation of polyubiquitinated nemo
-
Shibata Y, Oyama M, Kozuka-Hata H, Han X, Tanaka Y, Gohda J, Inoue J (2012) p47 negatively regulates IKK activation by inducing the lysosomal degradation of polyubiquitinated NEMO. Nat Commun 3: 1061
-
(2012)
Nat Commun
, vol.3
, pp. 1061
-
-
Shibata, Y.1
Oyama, M.2
Kozuka-Hata, H.3
Han, X.4
Tanaka, Y.5
Gohda, J.6
Inoue, J.7
-
100
-
-
84858725584
-
Regulation of nf-kappab by deubiquitinases
-
Harhaj EW, Dixit VM (2012) Regulation of NF-kappaB by deubiquitinases. Immunol Rev 246: 107-124
-
(2012)
Immunol Rev
, vol.246
, pp. 107-124
-
-
Harhaj, E.W.1
Dixit, V.M.2
-
101
-
-
77955417276
-
Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase cezanne
-
Bremm A, Freund SM, Komander D (2010) Lys11-linked ubiquitin chains adopt compact conformations and are preferentially hydrolyzed by the deubiquitinase Cezanne. Nat Struct Mol Biol 17: 939-947
-
(2010)
Nat Struct Mol Biol
, vol.17
, pp. 939-947
-
-
Bremm, A.1
Freund, S.M.2
Komander, D.3
-
102
-
-
43749122598
-
Nf-kappab suppression by the deubiquitinating enzyme cezanne: A novel negative feedback loop in pro-inflammatory signaling
-
Enesa K, Zakkar M, Chaudhury H, le Luong A, Rawlinson L, Mason JC, Haskard DO, Dean JL, Evans PC (2008) NF-kappaB suppression by the deubiquitinating enzyme Cezanne: a novel negative feedback loop in pro-inflammatory signaling. J Biol Chem 283: 7036-7045
-
(2008)
J Biol Chem
, vol.283
, pp. 7036-7045
-
-
Enesa, K.1
Zakkar, M.2
Chaudhury, H.3
Le Luong, A.4
Rawlinson, L.5
Mason, J.C.6
Haskard, D.O.7
Dean, J.L.8
Evans, P.C.9
-
103
-
-
74049114641
-
Ubiquitin-specific peptidase 21 inhibits tumor necrosis factor alpha-induced nuclear factor kappab activation via binding to and deubiquitinating receptor-interacting protein 1
-
Xu G, Tan X, Wang H, Sun W, Shi Y, Burlingame S, Gu X, Cao G, Zhang T, Qin J, Yang J (2010) Ubiquitin-specific peptidase 21 inhibits tumor necrosis factor alpha-induced nuclear factor kappaB activation via binding to and deubiquitinating receptor-interacting protein 1. J Biol Chem 285: 969-978
-
(2010)
J Biol Chem
, vol.285
, pp. 969-978
-
-
Xu, G.1
Tan, X.2
Wang, H.3
Sun, W.4
Shi, Y.5
Burlingame, S.6
Gu, X.7
Cao, G.8
Zhang, T.9
Qin, J.10
Yang, J.11
-
104
-
-
84880851215
-
Otulin restricts met1-linked ubiquitination to control innate immune signaling
-
Fiil BK, Damgaard RB, Wagner SA, Keusekotten K, Fritsch M, Bekker-Jensen S, Mailand N, Choudhary C, Komander D, Gyrd-Hansen M (2013) OTULIN restricts Met1-linked ubiquitination to control innate immune signaling. Mol Cell 50: 818-830
-
(2013)
Mol Cell
, vol.50
, pp. 818-830
-
-
Fiil, B.K.1
Damgaard, R.B.2
Wagner, S.A.3
Keusekotten, K.4
Fritsch, M.5
Bekker-Jensen, S.6
Mailand, N.7
Choudhary, C.8
Komander, D.9
Gyrd-Hansen, M.10
-
105
-
-
84878862687
-
Otulin antagonizes lubac signaling by specifically hydrolyzing met1-linked polyubiquitin
-
Keusekotten K, Elliott PR, Glockner L, Fiil BK, Damgaard RB, Kulathu Y, Wauer T, Hospenthal MK, Gyrd-Hansen M, Krappmann D, Hofmann K, Komander D (2013) OTULIN antagonizes LUBAC signaling by specifically hydrolyzing Met1-linked polyubiquitin. Cell 153: 1312-1326
-
(2013)
Cell
, vol.153
, pp. 1312-1326
-
-
Keusekotten, K.1
Elliott, P.R.2
Glockner, L.3
Fiil, B.K.4
Damgaard, R.B.5
Kulathu, Y.6
Wauer, T.7
Hospenthal, M.K.8
Gyrd-Hansen, M.9
Krappmann, D.10
Hofmann, K.11
Komander, D.12
-
106
-
-
84879390723
-
The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis
-
Rivkin E, Almeida SM, Ceccarelli DF, Juang YC, MacLean TA, Srikumar T, Huang H, Dunham WH, Fukumura R, Xie G, Gondo Y, Raught B, Gingras AC, Sicheri F, Cordes SP (2013) The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis. Nature 498: 318-324
-
(2013)
Nature
, vol.498
, pp. 318-324
-
-
Rivkin, E.1
Almeida, S.M.2
Ceccarelli, D.F.3
Juang, Y.C.4
MacLean, T.A.5
Srikumar, T.6
Huang, H.7
Dunham, W.H.8
Fukumura, R.9
Xie, G.10
Gondo, Y.11
Raught, B.12
Gingras, A.C.13
Sicheri, F.14
Cordes, S.P.15
-
107
-
-
79960468868
-
Nf-kappab induction of the sumo protease senp2: A negative feedback loop to attenuate cell survival response to genotoxic stress
-
Lee MH, Mabb AM, Gill GB, Yeh ET, Miyamoto S (2011) NF-kappaB induction of the SUMO protease SENP2: a negative feedback loop to attenuate cell survival response to genotoxic stress. Mol Cell 43: 180-191
-
(2011)
Mol Cell
, vol.43
, pp. 180-191
-
-
Lee, M.H.1
Mabb, A.M.2
Gill, G.B.3
Yeh, E.T.4
Miyamoto, S.5
-
108
-
-
0033537739
-
Severe liver degeneration in mice lacking the ikappab kinase 2 gene
-
Li Q, Van Antwerp D, Mercurio F, Lee KF, Verma IM (1999) Severe liver degeneration in mice lacking the IkappaB kinase 2 gene. Science 284: 321-325
-
(1999)
Science
, vol.284
, pp. 321-325
-
-
Li, Q.1
Van Antwerp, D.2
Mercurio, F.3
Lee, K.F.4
Verma, I.M.5
-
109
-
-
0033532386
-
The ikkbeta subunit of ikappab kinase (ikk) is essential for nuclear factor kappab activation and prevention of apoptosis
-
Li ZW, Chu W, Hu Y, Delhase M, Deerinck T, Ellisman M, Johnson R, Karin M (1999) The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis. J Exp Med 189: 1839-1845
-
(1999)
J Exp Med
, vol.189
, pp. 1839-1845
-
-
Li, Z.W.1
Chu, W.2
Hu, Y.3
Delhase, M.4
Deerinck, T.5
Ellisman, M.6
Johnson, R.7
Karin, M.8
-
110
-
-
34247874508
-
Interleukin-1-induced nfkappab activation is nemo-dependent but does not require ikkbeta
-
Solt LA, Madge LA, Orange JS, May MJ (2007) Interleukin-1-induced NFkappaB activation is NEMO-dependent but does not require IKKbeta. J Biol Chem 282: 8724-8733
-
(2007)
J Biol Chem
, vol.282
, pp. 8724-8733
-
-
Solt, L.A.1
Madge, L.A.2
Orange, J.S.3
May, M.J.4
-
111
-
-
0033563227
-
Ikk1-deficient mice exhibit abnormal development of skin and skeleton
-
Li Q, Lu Q, Hwang JY, Buscher D, Lee KF, Izpisua-Belmonte JC, Verma IM (1999) IKK1-deficient mice exhibit abnormal development of skin and skeleton. Genes Dev 13: 1322-1328
-
(1999)
Genes Dev
, vol.13
, pp. 1322-1328
-
-
Li, Q.1
Lu, Q.2
Hwang, J.Y.3
Buscher, D.4
Lee, K.F.5
Izpisua-Belmonte, J.C.6
Verma, I.M.7
-
112
-
-
54349102235
-
Ikkalpha, a critical regulator of epidermal differentiation and a suppressor of skin cancer
-
Descargues P, Sil AK, Karin M (2008) IKKalpha, a critical regulator of epidermal differentiation and a suppressor of skin cancer. EMBO J 27: 2639-2647
-
(2008)
EMBO J
, vol.27
, pp. 2639-2647
-
-
Descargues, P.1
Sil, A.K.2
Karin, M.3
-
113
-
-
33751217161
-
A critical role for i kappab kinase alpha in the development of human and mouse squamous cell carcinomas
-
Liu B, Park E, Zhu F, Bustos T, Liu J, Shen J, Fischer SM, Hu Y (2006) A critical role for I kappaB kinase alpha in the development of human and mouse squamous cell carcinomas. Proc Natl Acad Sci U S A 103: 17202-17207
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 17202-17207
-
-
Liu, B.1
Park, E.2
Zhu, F.3
Bustos, T.4
Liu, J.5
Shen, J.6
Fischer, S.M.7
Hu, Y.8
-
114
-
-
50349089030
-
Ikkalpha is required to maintain skin homeostasis and prevent skin cancer
-
Liu B, Xia X, Zhu F, Park E, Carbajal S, Kiguchi K, DiGiovanni J, Fischer SM, Hu Y (2008) IKKalpha is required to maintain skin homeostasis and prevent skin cancer. Cancer Cell 14: 212-225
-
(2008)
Cancer Cell
, vol.14
, pp. 212-225
-
-
Liu, B.1
Xia, X.2
Zhu, F.3
Park, E.4
Carbajal, S.5
Kiguchi, K.6
DiGiovanni, J.7
Fischer, S.M.8
Hu, Y.9
-
115
-
-
84876789628
-
Loss of acinar cell ikkalpha triggers spontaneous pancreatitis in mice
-
Li N, Wu X, Holzer RG, Lee JH, Todoric J, Park EJ, Ogata H, Gukovskaya AS, Gukovsky I, Pizzo DP, VandenBerg S, Tarin D, Atay C, Arkan MC, Deerinck TJ, Moscat J, Diaz-Meco M, Dawson D, Erkan M, Kleeff J, et al (2013) Loss of acinar cell IKKalpha triggers spontaneous pancreatitis in mice. J Clin Invest 123: 2231-2243
-
(2013)
J Clin Invest
, vol.123
, pp. 2231-2243
-
-
Li, N.1
Wu, X.2
Holzer, R.G.3
Lee, J.H.4
Todoric, J.5
Park, E.J.6
Ogata, H.7
Gukovskaya, A.S.8
Gukovsky, I.9
Pizzo, D.P.10
VandenBerg, S.11
Tarin, D.12
Atay, C.13
Arkan, M.C.14
Deerinck, T.J.15
Moscat, J.16
Diaz-Meco, M.17
Dawson, D.18
Erkan, M.19
Kleeff, J.20
more..
-
116
-
-
84875476574
-
I kappa b kinase alpha (ikkalpha) activity is required for functional maturation of dendritic cells and acquired immunity to infection
-
Mancino A, Habbeddine M, Johnson E, Luron L, Bebien M, Memet S, Fong C, Bajenoff M, Wu X, Karin M, Caamano J, Chi H, Seed M, Lawrence T (2013) I kappa B kinase alpha (IKKalpha) activity is required for functional maturation of dendritic cells and acquired immunity to infection. EMBO J 32: 816-828
-
(2013)
EMBO J
, vol.32
, pp. 816-828
-
-
Mancino, A.1
Habbeddine, M.2
Johnson, E.3
Luron, L.4
Bebien, M.5
Memet, S.6
Fong, C.7
Bajenoff, M.8
Wu, X.9
Karin, M.10
Caamano, J.11
Chi, H.12
Seed, M.13
Lawrence, T.14
-
117
-
-
84858722471
-
Dna damage-dependent nf-kappab activation: Nemo turns nuclear signaling inside out
-
McCool KW, Miyamoto S (2012) DNA damage-dependent NF-kappaB activation: NEMO turns nuclear signaling inside out. Immunol Rev 246: 311-326
-
(2012)
Immunol Rev
, vol.246
, pp. 311-326
-
-
McCool, K.W.1
Miyamoto, S.2
-
118
-
-
17844386319
-
Ikkalpha limits macrophage nf-kappab activation and contributes to the resolution of inflammation
-
Lawrence T, Bebien M, Liu GY, Nizet V, Karin M (2005) IKKalpha limits macrophage NF-kappaB activation and contributes to the resolution of inflammation. Nature 434: 1138-1143
-
(2005)
Nature
, vol.434
, pp. 1138-1143
-
-
Lawrence, T.1
Bebien, M.2
Liu, G.Y.3
Nizet, V.4
Karin, M.5
-
119
-
-
0032589462
-
Ikappab kinases phosphorylate nf-kappab p65 subunit on serine 536 in the transactivation domain
-
Sakurai H, Chiba H, Miyoshi H, Sugita T, Toriumi W (1999) IkappaB kinases phosphorylate NF-kappaB p65 subunit on serine 536 in the transactivation domain. J Biol Chem 274: 30353-30356
-
(1999)
J Biol Chem
, vol.274
, pp. 30353-30356
-
-
Sakurai, H.1
Chiba, H.2
Miyoshi, H.3
Sugita, T.4
Toriumi, W.5
-
120
-
-
68749103771
-
The nf-kappab-independent functions of ikk subunits in immunity and cancer
-
Chariot A (2009) The NF-kappaB-independent functions of IKK subunits in immunity and cancer. Trends Cell Biol 19: 404-413
-
(2009)
Trends Cell Biol
, vol.19
, pp. 404-413
-
-
Chariot, A.1
-
121
-
-
0037329233
-
Ikkalpha regulates mitogenic signaling through transcriptional induction of cyclin d1 via tcf
-
Albanese C, Wu K, D'Amico M, Jarrett C, Joyce D, Hughes J, Hulit J, Sakamaki T, Fu M, Ben-Ze'ev A, Bromberg JF, Lamberti C, Verma U, Gaynor RB, Byers SW, Pestell RG (2003) IKKalpha regulates mitogenic signaling through transcriptional induction of cyclin D1 via Tcf. Mol Biol Cell 14: 585-599
-
(2003)
Mol Biol Cell
, vol.14
, pp. 585-599
-
-
Albanese, C.1
Wu, K.2
D'Amico, M.3
Jarrett, C.4
Joyce, D.5
Hughes, J.6
Hulit, J.7
Sakamaki, T.8
Fu, M.9
Ben-Ze'ev, A.10
Bromberg, J.F.11
Lamberti, C.12
Verma, U.13
Gaynor, R.B.14
Byers, S.W.15
Pestell, R.G.16
-
122
-
-
33749263685
-
Ikkalpha stabilizes cytosolic beta-catenin by inhibiting both canonical and non-canonical degradation pathways
-
Carayol N, Wang CY (2006) IKKalpha stabilizes cytosolic beta-catenin by inhibiting both canonical and non-canonical degradation pathways. Cell Signal 18: 1941-1946
-
(2006)
Cell Signal
, vol.18
, pp. 1941-1946
-
-
Carayol, N.1
Wang, C.Y.2
-
123
-
-
0035834717
-
Regulation of beta-catenin function by the ikappab kinases
-
Lamberti C, Lin KM, Yamamoto Y, Verma U, Verma IM, Byers S, Gaynor RB (2001) Regulation of beta-catenin function by the IkappaB kinases. J Biol Chem 276: 42276-42286
-
(2001)
J Biol Chem
, vol.276
, pp. 42276-42286
-
-
Lamberti, C.1
Lin, K.M.2
Yamamoto, Y.3
Verma, U.4
Verma, I.M.5
Byers, S.6
Gaynor, R.B.7
-
124
-
-
67149089043
-
Biologic sequelae of i-kappa}b kinase (ikk) inhibition in multiple myeloma: Therapeutic implications
-
Hideshima T, Chauhan D, Kiziltepe T, Ikeda H, Okawa Y, Podar K, Raje N, Protopopov A, Munshi NC, Richardson PG, Carrasco RD, Anderson KC (2009) Biologic sequelae of I-kappa}B kinase (IKK) inhibition in multiple myeloma: therapeutic implications. Blood 113: 5228-5236
-
(2009)
Blood
, vol.113
, pp. 5228-5236
-
-
Hideshima, T.1
Chauhan, D.2
Kiziltepe, T.3
Ikeda, H.4
Okawa, Y.5
Podar, K.6
Raje, N.7
Protopopov, A.8
Munshi, N.C.9
Richardson, P.G.10
Carrasco, R.D.11
Anderson, K.C.12
-
125
-
-
0032588186
-
Nf-kappab controls cell growth and differentiation through transcriptional regulation of cyclin d1
-
Guttridge DC, Albanese C, Reuther JY, Pestell RG, Baldwin AS Jr (1999) NF-kappaB controls cell growth and differentiation through transcriptional regulation of cyclin D1. Mol Cell Biol 19: 5785-5799
-
(1999)
Mol Cell Biol
, vol.19
, pp. 5785-5799
-
-
Guttridge, D.C.1
Albanese, C.2
Reuther, J.Y.3
Pestell, R.G.4
Baldwin Jr., A.S.5
-
126
-
-
0032588170
-
Nf-kappab function in growth control: Regulation of cyclin d1 expression and g0/g1-to-s-phase transition
-
Hinz M, Krappmann D, Eichten A, Heder A, Scheidereit C, Strauss M (1999) NF-kappaB function in growth control: regulation of cyclin D1 expression and G0/G1-to-S-phase transition. Mol Cell Biol 19: 2690-2698
-
(1999)
Mol Cell Biol
, vol.19
, pp. 2690-2698
-
-
Hinz, M.1
Krappmann, D.2
Eichten, A.3
Heder, A.4
Scheidereit, C.5
Strauss, M.6
-
127
-
-
26644457201
-
Ikappab kinase alpha regulates subcellular distribution and turnover of cyclin d1 by phosphorylation
-
Kwak YT, Li R, Becerra CR, Tripathy D, Frenkel EP, Verma UN (2005) IkappaB kinase alpha regulates subcellular distribution and turnover of cyclin D1 by phosphorylation. J Biol Chem 280: 33945-33952
-
(2005)
J Biol Chem
, vol.280
, pp. 33945-33952
-
-
Kwak, Y.T.1
Li, R.2
Becerra, C.R.3
Tripathy, D.4
Frenkel, E.P.5
Verma, U.N.6
-
128
-
-
84872587266
-
Inactivation of bad by ikk inhibits tnfalpha-induced apoptosis independently of nf-kappab activation
-
Yan J, Xiang J, Lin Y, Ma J, Zhang J, Zhang H, Sun J, Danial NN, Liu J, Lin A (2013) Inactivation of BAD by IKK inhibits TNFalpha-induced apoptosis independently of NF-kappaB activation. Cell 152: 304-315
-
(2013)
Cell
, vol.152
, pp. 304-315
-
-
Yan, J.1
Xiang, J.2
Lin, Y.3
Ma, J.4
Zhang, J.5
Zhang, H.6
Sun, J.7
Danial, N.N.8
Liu, J.9
Lin, A.10
-
129
-
-
84872280035
-
Ikk-beta mediates hydrogen peroxide induced cell death through p85 s6k1
-
Jia CH, Li M, Liu J, Zhao L, Lin J, Lai PL, Zhou X, Zhang Y, Chen ZG, Li HY, Liu AL, Yang CL, Gao TM, Jiang Y, Bai XC (2013) IKK-beta mediates hydrogen peroxide induced cell death through p85 S6K1. Cell Death Differ 20: 248-258
-
(2013)
Cell Death Differ
, vol.20
, pp. 248-258
-
-
Jia, C.H.1
Li, M.2
Liu, J.3
Zhao, L.4
Lin, J.5
Lai, P.L.6
Zhou, X.7
Zhang, Y.8
Chen, Z.G.9
Li, H.Y.10
Liu, A.L.11
Yang, C.L.12
Gao, T.M.13
Jiang, Y.14
Bai, X.C.15
-
130
-
-
79953773106
-
Ikk-dependent, nf-kappab-independent control of autophagic gene expression
-
Comb WC, Cogswell P, Sitcheran R, Baldwin AS (2011) IKK-dependent, NF-kappaB-independent control of autophagic gene expression. Oncogene 30: 1727-1732
-
(2011)
Oncogene
, vol.30
, pp. 1727-1732
-
-
Comb, W.C.1
Cogswell, P.2
Sitcheran, R.3
Baldwin, A.S.4
-
131
-
-
76349090912
-
The ikk complex contributes to the induction of autophagy
-
Criollo A, Senovilla L, Authier H, Maiuri MC, Morselli E, Vitale I, Kepp O, Tasdemir E, Galluzzi L, Shen S, Tailler M, Delahaye N, Tesniere A, De Stefano D, Younes AB, Harper F, Pierron G, Lavandero S, Zitvogel L, Israel A, et al (2010) The IKK complex contributes to the induction of autophagy. EMBO J 29: 619-631
-
(2010)
EMBO J
, vol.29
, pp. 619-631
-
-
Criollo, A.1
Senovilla, L.2
Authier, H.3
Maiuri, M.C.4
Morselli, E.5
Vitale, I.6
Kepp, O.7
Tasdemir, E.8
Galluzzi, L.9
Shen, S.10
Tailler, M.11
Delahaye, N.12
Tesniere, A.13
De Stefano, D.14
Younes, A.B.15
Harper, F.16
Pierron, G.17
Lavandero, S.18
Zitvogel, L.19
Israel, A.20
more..
-
132
-
-
84859023600
-
P85alpha sh2 domain phosphorylation by ikk promotes feedback inhibition of pi3k and akt in response to cellular starvation
-
Comb WC, Hutti JE, Cogswell P, Cantley LC, Baldwin AS (2012) p85alpha SH2 domain phosphorylation by IKK promotes feedback inhibition of PI3K and Akt in response to cellular starvation. Mol Cell 45: 719-730
-
(2012)
Mol Cell
, vol.45
, pp. 719-730
-
-
Comb, W.C.1
Hutti, J.E.2
Cogswell, P.3
Cantley, L.C.4
Baldwin, A.S.5
-
133
-
-
34447131534
-
Regulation of mammalian target of rapamycin activity in pten-inactive prostate cancer cells by i kappa b kinase alpha
-
Dan HC, Adli M, Baldwin AS (2007) Regulation of mammalian target of rapamycin activity in PTEN-inactive prostate cancer cells by I kappa B kinase alpha. Cancer Res 67: 6263-6269
-
(2007)
Cancer Res
, vol.67
, pp. 6263-6269
-
-
Dan, H.C.1
Adli, M.2
Baldwin, A.S.3
-
134
-
-
34247274248
-
Nuclear cytokine-activated ikkalpha controls prostate cancer metastasis by repressing maspin
-
Luo JL, Tan W, Ricono JM, Korchynskyi O, Zhang M, Gonias SL, Cheresh DA, Karin M (2007) Nuclear cytokine-activated IKKalpha controls prostate cancer metastasis by repressing Maspin. Nature 446: 690-694
-
(2007)
Nature
, vol.446
, pp. 690-694
-
-
Luo, J.L.1
Tan, W.2
Ricono, J.M.3
Korchynskyi, O.4
Zhang, M.5
Gonias, S.L.6
Cheresh, D.A.7
Karin, M.8
-
135
-
-
35648970074
-
Ikappab kinase alpha kinase activity is required for self-renewal of erbb2/her2-transformed mammary tumorinitiating cells
-
Cao Y, Luo JL, Karin M (2007) IkappaB kinase alpha kinase activity is required for self-renewal of ErbB2/Her2-transformed mammary tumorinitiating cells. Proc Natl Acad Sci U S A 104: 15852-15857
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 15852-15857
-
-
Cao, Y.1
Luo, J.L.2
Karin, M.3
-
136
-
-
84877840834
-
A nik-ikkalpha module expands erbb2-induced tumor-initiating cells by stimulating nuclear export of p27/kip1
-
Zhang W, Tan W, Wu X, Poustovoitov M, Strasner A, Li W, Borcherding N, Ghassemian M, Karin M (2013) A NIK-IKKalpha module expands ErbB2-induced tumor-initiating cells by stimulating nuclear export of p27/Kip1. Cancer Cell 23: 647-659
-
(2013)
Cancer Cell
, vol.23
, pp. 647-659
-
-
Zhang, W.1
Tan, W.2
Wu, X.3
Poustovoitov, M.4
Strasner, A.5
Li, W.6
Borcherding, N.7
Ghassemian, M.8
Karin, M.9
-
137
-
-
33846091089
-
Nuclear ikk activity leads to dysregulated notch-dependent gene expression in colorectal cancer
-
Fernandez-Majada V, Aguilera C, Villanueva A, Vilardell F, Robert-Moreno A, Aytes A, Real FX, Capella G, Mayo MW, Espinosa L, Bigas A (2007) Nuclear IKK activity leads to dysregulated notch-dependent gene expression in colorectal cancer. Proc Natl Acad Sci U S A 104: 276-281
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 276-281
-
-
Fernandez-Majada, V.1
Aguilera, C.2
Villanueva, A.3
Vilardell, F.4
Robert-Moreno, A.5
Aytes, A.6
Real, F.X.7
Capella, G.8
Mayo, M.W.9
Espinosa, L.10
Bigas, A.11
-
138
-
-
6344241039
-
Smrt derepression by the ikappab kinase alpha: A prerequisite to nf-kappab transcription and survival
-
Hoberg JE, Yeung F, Mayo MW (2004) SMRT derepression by the IkappaB kinase alpha: a prerequisite to NF-kappaB transcription and survival. Mol Cell 16: 245-255
-
(2004)
Mol Cell
, vol.16
, pp. 245-255
-
-
Hoberg, J.E.1
Yeung, F.2
Mayo, M.W.3
-
139
-
-
30744458869
-
Ikappab kinase alpha-mediated derepression of smrt potentiates acetylation of rela/p65 by p300
-
Hoberg JE, Popko AE, Ramsey CS, Mayo MW (2006) IkappaB kinase alpha-mediated derepression of SMRT potentiates acetylation of RelA/p65 by p300. Mol Cell Biol 26: 457-471
-
(2006)
Mol Cell Biol
, vol.26
, pp. 457-471
-
-
Hoberg, J.E.1
Popko, A.E.2
Ramsey, C.S.3
Mayo, M.W.4
-
140
-
-
84868133482
-
A truncated form of ikkalpha is responsible for specific nuclear ikk activity in colorectal cancer
-
Margalef P, Fernandez-Majada V, Villanueva A, Garcia-Carbonell R, Iglesias M, Lopez L, Martinez-Iniesta M, Villa-Freixa J, Mulero MC, Andreu M, Torres F, Mayo MW, Bigas A, Espinosa L (2012) A truncated form of IKKalpha is responsible for specific nuclear IKK activity in colorectal cancer. Cell Rep 2: 840-854
-
(2012)
Cell Rep
, vol.2
, pp. 840-854
-
-
Margalef, P.1
Fernandez-Majada, V.2
Villanueva, A.3
Garcia-Carbonell, R.4
Iglesias, M.5
Lopez, L.6
Martinez-Iniesta, M.7
Villa-Freixa, J.8
Mulero, M.C.9
Andreu, M.10
Torres, F.11
Mayo, M.W.12
Bigas, A.13
Espinosa, L.14
-
141
-
-
84876355029
-
The pivotal role of ikkalpha in the development of spontaneous lung squamous cell carcinomas
-
Xiao Z, Jiang Q, Willette-Brown J, Xi S, Zhu F, Burkett S, Back T, Song NY, Datla M, Sun Z, Goldszmid R, Lin F, Cohoon T, Pike K, Wu X, Schrump DS, Wong KK, Young HA, Trinchieri G, Wiltrout RH, et al (2013) The pivotal role of IKKalpha in the development of spontaneous lung squamous cell carcinomas. Cancer Cell 23: 527-540
-
(2013)
Cancer Cell
, vol.23
, pp. 527-540
-
-
Xiao, Z.1
Jiang, Q.2
Willette-Brown, J.3
Xi, S.4
Zhu, F.5
Burkett, S.6
Back, T.7
Song, N.Y.8
Datla, M.9
Sun, Z.10
Goldszmid, R.11
Lin, F.12
Cohoon, T.13
Pike, K.14
Wu, X.15
Schrump, D.S.16
Wong, K.K.17
Young, H.A.18
Trinchieri, G.19
Wiltrout, R.H.20
more..
-
142
-
-
34047248402
-
Phosphorylation of cbp by ikkalpha promotes cell growth by switching the binding preference of cbp from p53 to nf-kappab
-
Huang WC, Ju TK, Hung MC, Chen CC (2007) Phosphorylation of CBP by IKKalpha promotes cell growth by switching the binding preference of CBP from p53 to NF-kappaB. Mol Cell 26: 75-87
-
(2007)
Mol Cell
, vol.26
, pp. 75-87
-
-
Huang, W.C.1
Ju, T.K.2
Hung, M.C.3
Chen, C.C.4
-
143
-
-
43049139541
-
P53 regulates glucose metabolism through an ikk-nf-kappab pathway and inhibits cell transformation
-
Kawauchi K, Araki K, Tobiume K, Tanaka N (2008) p53 regulates glucose metabolism through an IKK-NF-kappaB pathway and inhibits cell transformation. Nat Cell Biol 10: 611-618
-
(2008)
Nat Cell Biol
, vol.10
, pp. 611-618
-
-
Kawauchi, K.1
Araki, K.2
Tobiume, K.3
Tanaka, N.4
-
144
-
-
62549161375
-
Loss of p53 enhances catalytic activity of ikkbeta through o-linked beta-n-acetyl glucosamine modification
-
Kawauchi K, Araki K, Tobiume K, Tanaka N (2009) Loss of p53 enhances catalytic activity of IKKbeta through O-linked beta-N-acetyl glucosamine modification. Proc Natl Acad Sci U S A 106: 3431-3436
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 3431-3436
-
-
Kawauchi, K.1
Araki, K.2
Tobiume, K.3
Tanaka, N.4
-
145
-
-
62449257012
-
Phosphorylation of p53 by ikappab kinase 2 promotes its degradation by beta-trcp
-
Xia Y, Padre RC, De Mendoza TH, Bottero V, Tergaonkar VB, Verma IM (2009) Phosphorylation of p53 by IkappaB kinase 2 promotes its degradation by beta-TrCP. Proc Natl Acad Sci U S A 106: 2629-2634
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 2629-2634
-
-
Xia, Y.1
Padre, R.C.2
De Mendoza, T.H.3
Bottero, V.4
Tergaonkar, V.B.5
Verma, I.M.6
-
146
-
-
34547605613
-
Ikk beta suppression of tsc1 links inflammation and tumor angiogenesis via the mtor pathway
-
Lee DF, Kuo HP, Chen CT, Hsu JM, Chou CK, Wei Y, Sun HL, Li LY, Ping B, Huang WC, He X, Hung JY, Lai CC, Ding Q, Su JL, Yang JY, Sahin AA, Hortobagyi GN, Tsai FJ, Tsai CH, et al (2007) IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway. Cell 130: 440-455
-
(2007)
Cell
, vol.130
, pp. 440-455
-
-
Lee, D.F.1
Kuo, H.P.2
Chen, C.T.3
Hsu, J.M.4
Chou, C.K.5
Wei, Y.6
Sun, H.L.7
Li, L.Y.8
Ping, B.9
Huang, W.C.10
He, X.11
Hung, J.Y.12
Lai, C.C.13
Ding, Q.14
Su, J.L.15
Yang, J.Y.16
Sahin, A.A.17
Hortobagyi, G.N.18
Tsai, F.J.19
Tsai, C.H.20
more..
-
147
-
-
11144357466
-
Ikappab kinase promotes tumorigenesis through inhibition of forkhead foxo3a
-
Hu MC, Lee DF, Xia W, Golfman LS, Ou-Yang F, Yang JY, Zou Y, Bao S, Hanada N, Saso H, Kobayashi R, Hung MC (2004) IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a. Cell 117: 225-237
-
(2004)
Cell
, vol.117
, pp. 225-237
-
-
Hu, M.C.1
Lee, D.F.2
Xia, W.3
Golfman, L.S.4
Ou-Yang, F.5
Yang, J.Y.6
Zou, Y.7
Bao, S.8
Hanada, N.9
Saso, H.10
Kobayashi, R.11
Hung, M.C.12
-
148
-
-
84863808495
-
Activity of the selective ikappab kinase inhibitor bms-345541 against t-cell acute lymphoblastic leukemia: Involvement of foxo3a
-
Buontempo F, Chiarini F, Bressanin D, Tabellini G, Melchionda F, Pession A, Fini M, Neri LM, McCubrey JA, Martelli AM (2012) Activity of the selective IkappaB kinase inhibitor BMS-345541 against T-cell acute lymphoblastic leukemia: involvement of FOXO3a. Cell Cycle 11: 2467-2475
-
(2012)
Cell Cycle
, vol.11
, pp. 2467-2475
-
-
Buontempo, F.1
Chiarini, F.2
Bressanin, D.3
Tabellini, G.4
Melchionda, F.5
Pession, A.6
Fini, M.7
Neri, L.M.8
McCubrey, J.A.9
Martelli, A.M.10
-
149
-
-
78549243034
-
Ikappab kinase overcomes pi3k/akt and erk/mapk to control foxo3a activity in acute myeloid leukemia
-
Chapuis N, Park S, Leotoing L, Tamburini J, Verdier F, Bardet V, Green AS, Willems L, Agou F, Ifrah N, Dreyfus F, Bismuth G, Baud V, Lacombe C, Mayeux P, Bouscary D (2010) IkappaB kinase overcomes PI3K/Akt and ERK/MAPK to control FOXO3a activity in acute myeloid leukemia. Blood 116: 4240-4250
-
(2010)
Blood
, vol.116
, pp. 4240-4250
-
-
Chapuis, N.1
Park, S.2
Leotoing, L.3
Tamburini, J.4
Verdier, F.5
Bardet, V.6
Green, A.S.7
Willems, L.8
Agou, F.9
Ifrah, N.10
Dreyfus, F.11
Bismuth, G.12
Baud, V.13
Lacombe, C.14
Mayeux, P.15
Bouscary, D.16
-
151
-
-
84877734347
-
Hypothalamic programming of systemic ageing involving ikkbeta
-
Zhang G, Li J, Purkayastha S, Tang Y, Zhang H, Yin Y, Li B, Liu G, Cai D (2013) Hypothalamic programming of systemic ageing involving IKKbeta, NF-kappaB and GnRH. Nature 497: 211-216
-
(2013)
NF-kappaB and GnRH. Nature
, vol.497
, pp. 211-216
-
-
Zhang, G.1
Li, J.2
Purkayastha, S.3
Tang, Y.4
Zhang, H.5
Yin, Y.6
Li, B.7
Liu, G.8
Cai, D.9
-
152
-
-
0041706156
-
A proteomics approach to understanding protein ubiquitination
-
Peng J, Schwartz D, Elias JE, Thoreen CC, Cheng D, Marsischky G, Roelofs J, Finley D, Gygi SP (2003) A proteomics approach to understanding protein ubiquitination. Nat Biotechnol 21: 921-926
-
(2003)
Nat Biotechnol
, vol.21
, pp. 921-926
-
-
Peng, J.1
Schwartz, D.2
Elias, J.E.3
Thoreen, C.C.4
Cheng, D.5
Marsischky, G.6
Roelofs, J.7
Finley, D.8
Gygi, S.P.9
-
153
-
-
84878832998
-
Otu deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis
-
Mevissen TE, Hospenthal MK, Geurink PP, Elliott PR, Akutsu M, Arnaudo N, Ekkebus R, Kulathu Y, Wauer T, El Oualid F, Freund SM, Ovaa H, Komander D (2013) OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis. Cell 154: 169-184
-
(2013)
Cell
, vol.154
, pp. 169-184
-
-
Mevissen, T.E.1
Hospenthal, M.K.2
Geurink, P.P.3
Elliott, P.R.4
Akutsu, M.5
Arnaudo, N.6
Ekkebus, R.7
Kulathu, Y.8
Wauer, T.9
El Oualid, F.10
Freund, S.M.11
Ovaa, H.12
Komander, D.13
-
154
-
-
63049125531
-
Quantitative proteomics reveals the function of unconventional ubiquitin chains in proteasomal degradation
-
Xu P, Duong DM, Seyfried NT, Cheng D, Xie Y, Robert J, Rush J, Hochstrasser M, Finley D, Peng J (2009) Quantitative proteomics reveals the function of unconventional ubiquitin chains in proteasomal degradation. Cell 137: 133-145
-
(2009)
Cell
, vol.137
, pp. 133-145
-
-
Xu, P.1
Duong, D.M.2
Seyfried, N.T.3
Cheng, D.4
Xie, Y.5
Robert, J.6
Rush, J.7
-
155
-
-
15944379896
-
Formation of an ikkalpha-dependent transcription complex is required for estrogen receptor-mediated gene activation
-
Park KJ, Krishnan V, O'Malley BW, Yamamoto Y, Gaynor RB (2005) Formation of an IKKalpha-dependent transcription complex is required for estrogen receptor-mediated gene activation. Mol Cell 18: 71-82
-
(2005)
Mol Cell
, vol.18
, pp. 71-82
-
-
Park, K.J.1
Krishnan, V.2
O'Malley, B.W.3
Yamamoto, Y.4
Gaynor, R.B.5
-
156
-
-
70349987565
-
Ikkalpha negatively regulates irf-5 function in a myd88-traf6 pathway
-
Balkhi MY, Fitzgerald KA, Pitha PM (2010) IKKalpha negatively regulates IRF-5 function in a MyD88-TRAF6 pathway. Cell Signal 22: 117-127
-
(2010)
Cell Signal
, vol.22
, pp. 117-127
-
-
Balkhi, M.Y.1
Fitzgerald, K.A.2
Pitha, P.M.3
-
157
-
-
33645841633
-
Ikappab kinase-alpha is critical for interferon-alpha production induced by toll-like receptors 7 and 9
-
Hoshino K, Sugiyama T, Matsumoto M, Tanaka T, Saito M, Hemmi H, Ohara O, Akira S, Kaisho T (2006) IkappaB kinase-alpha is critical for interferon-alpha production induced by Toll-like receptors 7 and 9. Nature 440: 949-953
-
(2006)
Nature
, vol.440
, pp. 949-953
-
-
Hoshino, K.1
Sugiyama, T.2
Matsumoto, M.3
Tanaka, T.4
Saito, M.5
Hemmi, H.6
Ohara, O.7
Akira, S.8
Kaisho, T.9
-
158
-
-
34249039031
-
Proinflammatory stimuli induce ikkalpha-mediated phosphorylation of pias1 to restrict inflammation and immunity
-
Liu B, Yang Y, Chernishof V, Loo RR, Jang H, Tahk S, Yang R, Mink S, Shultz D, Bellone CJ, Loo JA, Shuai K (2007) Proinflammatory stimuli induce IKKalpha-mediated phosphorylation of PIAS1 to restrict inflammation and immunity. Cell 129: 903-914
-
(2007)
Cell
, vol.129
, pp. 903-914
-
-
Liu, B.1
Yang, Y.2
Chernishof, V.3
Loo, R.R.4
Jang, H.5
Tahk, S.6
Yang, R.7
Mink, S.8
Shultz, D.9
Bellone, C.J.10
Loo, J.A.11
Shuai, K.12
-
159
-
-
3843135237
-
Ikappab kinase alpha and p65/rela contribute to optimal epidermal growth factor-induced c-fos gene expression independent of ikappabalpha degradation
-
Anest V, Cogswell PC, Baldwin AS Jr (2004) IkappaB kinase alpha and p65/RelA contribute to optimal epidermal growth factor-induced c-fos gene expression independent of IkappaBalpha degradation. J Biol Chem 279: 31183-31189
-
(2004)
J Biol Chem
, vol.279
, pp. 31183-31189
-
-
Anest, V.1
Cogswell, P.C.2
Baldwin Jr., A.S.3
-
160
-
-
0037497184
-
A nucleosomal function for ikappab kinase-alpha in nf-kappab-dependent gene expression
-
Anest V, Hanson JL, Cogswell PC, Steinbrecher KA, Strahl BD, Baldwin AS (2003) A nucleosomal function for IkappaB kinase-alpha in NF-kappaB-dependent gene expression. Nature 423: 659-663
-
(2003)
Nature
, vol.423
, pp. 659-663
-
-
Anest, V.1
Hanson, J.L.2
Cogswell, P.C.3
Steinbrecher, K.A.4
Strahl, B.D.5
Baldwin, A.S.6
-
161
-
-
0038511129
-
Histone h3 phosphorylation by ikk-alpha is critical for cytokine-induced gene expression
-
Yamamoto Y, Verma UN, Prajapati S, Kwak YT, Gaynor RB (2003) Histone H3 phosphorylation by IKK-alpha is critical for cytokine-induced gene expression. Nature 423: 655-659
-
(2003)
Nature
, vol.423
, pp. 655-659
-
-
Yamamoto, Y.1
Verma, U.N.2
Prajapati, S.3
Kwak, Y.T.4
Gaynor, R.B.5
-
162
-
-
0036242554
-
Regulation of src-3 (pcip/actr/aib-1/rac-3/tram-1) coactivator activity by i kappa b kinase
-
Wu RC, Qin J, Hashimoto Y, Wong J, Xu J, Tsai SY, Tsai MJ, O'Malley BW (2002) Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator activity by I kappa B kinase. Mol Cell Biol 22: 3549-3561
-
(2002)
Mol Cell Biol
, vol.22
, pp. 3549-3561
-
-
Wu, R.C.1
Qin, J.2
Hashimoto, Y.3
Wong, J.4
Xu, J.5
Tsai, S.Y.6
Tsai, M.J.7
O'Malley, B.W.8
-
163
-
-
6344264987
-
Lipopolysaccharide activation of the tpl-2/mek/extracellular signal-regulated kinase mitogen-activated protein kinase cascade is regulated by ikappab kinase-induced proteolysis of nf-kappab1 p105
-
Beinke S, Robinson MJ, Hugunin M, Ley SC (2004) Lipopolysaccharide activation of the TPL-2/MEK/extracellular signal-regulated kinase mitogen-activated protein kinase cascade is regulated by IkappaB kinase-induced proteolysis of NF-kappaB1 p105. Mol Cell Biol 24: 9658-9667
-
(2004)
Mol Cell Biol
, vol.24
, pp. 9658-9667
-
-
Beinke, S.1
Robinson, M.J.2
Hugunin, M.3
Ley, S.C.4
-
164
-
-
2942707765
-
Ikappab kinase is an essential component of the tpl2 signaling pathway
-
Waterfield M, Jin W, Reiley W, Zhang M, Sun SC (2004) IkappaB kinase is an essential component of the Tpl2 signaling pathway. Mol Cell Biol 24: 6040-6048
-
(2004)
Mol Cell Biol
, vol.24
, pp. 6040-6048
-
-
Waterfield, M.1
Jin, W.2
Reiley, W.3
Zhang, M.4
Sun, S.C.5
-
165
-
-
22544461297
-
Convergent actions of i kappa b kinase beta and protein kinase c delta modulate mrna stability through phosphorylation of 14-3-3 beta complexed with tristetraprolin
-
Gringhuis SI, Garcia-Vallejo JJ, van Het Hof B, van Dijk W (2005) Convergent actions of I kappa B kinase beta and protein kinase C delta modulate mRNA stability through phosphorylation of 14-3-3 beta complexed with tristetraprolin. Mol Cell Biol 25: 6454-6463
-
(2005)
Mol Cell Biol
, vol.25
, pp. 6454-6463
-
-
Gringhuis, S.I.1
Garcia-Vallejo, J.J.2
Van Het Hof, B.3
Van Dijk, W.4
-
166
-
-
36749009085
-
A role for ikappab kinase 2 in bipolar spindle assembly
-
Irelan JT, Murphy TJ, DeJesus PD, Teo H, Xu D, Gomez-Ferreria MA, Zhou Y, Miraglia LJ, Rines DR, Verma IM, Sharp DJ, Tergaonkar V, Chanda SK (2007) A role for IkappaB kinase 2 in bipolar spindle assembly. Proc Natl Acad Sci U S A 104: 16940-16945
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 16940-16945
-
-
Irelan, J.T.1
Murphy, T.J.2
DeJesus, P.D.3
Teo, H.4
Xu, D.5
Gomez-Ferreria, M.A.6
Zhou, Y.7
Miraglia, L.J.8
Rines, D.R.9
Verma, I.M.10
Sharp, D.J.11
Tergaonkar, V.12
Chanda, S.K.13
-
167
-
-
37549011707
-
Ikappab kinase beta-induced phosphorylation of carma1 contributes to carma1 bcl10 malt1 complex formation in b cells
-
Shinohara H, Maeda S, Watarai H, Kurosaki T (2007) IkappaB kinase beta-induced phosphorylation of CARMA1 contributes to CARMA1 Bcl10 MALT1 complex formation in B cells. J Exp Med 204: 3285-3293
-
(2007)
J Exp Med
, vol.204
, pp. 3285-3293
-
-
Shinohara, H.1
Maeda, S.2
Watarai, H.3
Kurosaki, T.4
-
168
-
-
18144368948
-
Regulation of the deubiquitinating enzyme cyld by ikappab kinase gamma-dependent phosphorylation
-
Reiley W, Zhang M, Wu X, Granger E, Sun SC (2005) Regulation of the deubiquitinating enzyme CYLD by IkappaB kinase gamma-dependent phosphorylation. Mol Cell Biol 25: 3886-3895
-
(2005)
Mol Cell Biol
, vol.25
, pp. 3886-3895
-
-
Reiley, W.1
Zhang, M.2
Wu, X.3
Granger, E.4
Sun, S.C.5
-
169
-
-
10644252695
-
Ikappab kinase beta phosphorylates dok1 serines in response to tnf, il-1, or gamma radiation
-
Lee S, Andrieu C, Saltel F, Destaing O, Auclair J, Pouchkine V, Michelon J, Salaun B, Kobayashi R, Jurdic P, Kieff ED, Sylla BS (2004) IkappaB kinase beta phosphorylates Dok1 serines in response to TNF, IL-1, or gamma radiation. Proc Natl Acad Sci U S A 101: 17416-17421
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 17416-17421
-
-
Lee, S.1
Andrieu, C.2
Saltel, F.3
Destaing, O.4
Auclair, J.5
Pouchkine, V.6
Michelon, J.7
Salaun, B.8
Kobayashi, R.9
Jurdic, P.10
Kieff, E.D.11
Sylla, B.S.12
-
170
-
-
0037073679
-
Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa b kinase complex
-
Gao Z, Hwang D, Bataille F, Lefevre M, York D, Quon MJ, Ye J (2002) Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex. J Biol Chem 277: 48115-48121
-
(2002)
J Biol Chem
, vol.277
, pp. 48115-48121
-
-
Gao, Z.1
Hwang, D.2
Bataille, F.3
Lefevre, M.4
York, D.5
Quon, M.J.6
Ye, J.7
-
171
-
-
48449094278
-
Phosphorylation of snap-23 by ikappab kinase 2 regulates mast cell degranulation
-
Suzuki K, Verma IM (2008) Phosphorylation of SNAP-23 by IkappaB kinase 2 regulates mast cell degranulation. Cell 134: 485-495
-
(2008)
Cell
, vol.134
, pp. 485-495
-
-
Suzuki, K.1
Verma, I.M.2
|