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Volumn 2, Issue 6, 2011, Pages 449-465

NF-κB in aging and disease

Author keywords

Aging; Inflammation; NF B; Senescence

Indexed keywords

MAMMALIA;

EID: 84863544685     PISSN: None     EISSN: 21525250     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (299)

References (147)
  • 1
    • 33750729203 scopus 로고    scopus 로고
    • Theories of biological aging: genes, proteins, and free radicals
    • Rattan SI (2006). Theories of biological aging: genes, proteins, and free radicals. Free Radic Res, 40:1230-8.
    • (2006) Free Radic Res , vol.40 , pp. 1230-1238
    • Rattan, S.I.1
  • 2
    • 13944262937 scopus 로고    scopus 로고
    • Understanding the odd science of aging
    • Kirkwood TB (2005). Understanding the odd science of aging. Cell, 120:437-47.
    • (2005) Cell , vol.120 , pp. 437-447
    • Kirkwood, T.B.1
  • 4
    • 0022481133 scopus 로고
    • Multiple nuclear factors interact with the immunoglobulin enhancer sequences
    • Sen R and Baltimore D (1986). Multiple nuclear factors interact with the immunoglobulin enhancer sequences. Cell, 46:705-16.
    • (1986) Cell , vol.46 , pp. 705-716
    • Sen, R.1    Baltimore, D.2
  • 5
    • 0022930702 scopus 로고
    • Inducibility of kappa immunoglobulin enhancer-binding protein Nf-kappa B by a posttranslational mechanism
    • Sen R and Baltimore D (1986). Inducibility of kappa immunoglobulin enhancer-binding protein Nf-kappa B by a posttranslational mechanism. Cell, 47:921-8.
    • (1986) Cell , vol.47 , pp. 921-928
    • Sen, R.1    Baltimore, D.2
  • 6
    • 7044262742 scopus 로고    scopus 로고
    • Nuclear factor (NF)-kappaB proteins: therapeutic targets
    • Verma IM (2004). Nuclear factor (NF)-kappaB proteins: therapeutic targets. Ann Rheum Dis, 63 Suppl 2:ii57-ii61.
    • (2004) Ann Rheum Dis , vol.63 , pp. ii57-ii61
    • Verma, I.M.1
  • 7
    • 84917713550 scopus 로고    scopus 로고
    • Rel/NF-kB Transcription Factors
    • Gilmore T (2009). Rel/NF-kB Transcription Factors. www.nf-kb.org.
    • (2009)
    • Gilmore, T.1
  • 8
    • 38849199203 scopus 로고    scopus 로고
    • Shared principles in NF-kappaB signaling
    • Hayden MS and Ghosh S (2008). Shared principles in NF-kappaB signaling. Cell, 132:344-62.
    • (2008) Cell , vol.132 , pp. 344-362
    • Hayden, M.S.1    Ghosh, S.2
  • 10
    • 0033574415 scopus 로고    scopus 로고
    • Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction
    • Chow JC, Young DW, Golenbock DT, Christ WJ, and Gusovsky F (1999). Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction. J Biol Chem, 274:10689-92.
    • (1999) J Biol Chem , vol.274 , pp. 10689-10692
    • Chow, J.C.1    Young, D.W.2    Golenbock, D.T.3    Christ, W.J.4    Gusovsky, F.5
  • 11
    • 0141704267 scopus 로고    scopus 로고
    • Ras participates in CpG oligodeoxynucleotide signaling through association with toll-like receptor 9 and promotion of interleukin-1 receptor-associated kinase/tumor necrosis factor receptor-associated factor 6 complex formation in macrophages
    • Xu H, An H, Yu Y, Zhang M, Qi R, and Cao X (2003). Ras participates in CpG oligodeoxynucleotide signaling through association with toll-like receptor 9 and promotion of interleukin-1 receptor-associated kinase/tumor necrosis factor receptor-associated factor 6 complex formation in macrophages. J Biol Chem, 278:36334-40.
    • (2003) J Biol Chem , vol.278 , pp. 36334-36340
    • Xu, H.1    An, H.2    Yu, Y.3    Zhang, M.4    Qi, R.5    Cao, X.6
  • 13
    • 0035895992 scopus 로고    scopus 로고
    • Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB
    • Ogura Y, Inohara N, Benito A, Chen FF, Yamaoka S, and Nunez G (2001). Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB. J Biol Chem, 276:4812-8.
    • (2001) J Biol Chem , vol.276 , pp. 4812-4818
    • Ogura, Y.1    Inohara, N.2    Benito, A.3    Chen, F.F.4    Yamaoka, S.5    Nunez, G.6
  • 14
    • 0344305376 scopus 로고    scopus 로고
    • Sequential modification of NEMO/IKKgamma by SUMO-1 and ubiquitin mediates NF-kappaB activation by genotoxic stress
    • Huang TT, Wuerzberger-Davis SM, Wu ZH, and Miyamoto S (2003). Sequential modification of NEMO/IKKgamma by SUMO-1 and ubiquitin mediates NF-kappaB activation by genotoxic stress. Cell, 115:565-76.
    • (2003) Cell , vol.115 , pp. 565-576
    • Huang, T.T.1    Wuerzberger-Davis, S.M.2    Wu, Z.H.3    Miyamoto, S.4
  • 15
    • 33644538632 scopus 로고    scopus 로고
    • Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuli
    • Wu ZH, Shi Y, Tibbetts RS, and Miyamoto S (2006). Molecular linkage between the kinase ATM and NF-kappaB signaling in response to genotoxic stimuli. Science, 311:1141-6.
    • (2006) Science , vol.311 , pp. 1141-1146
    • Wu, Z.H.1    Shi, Y.2    Tibbetts, R.S.3    Miyamoto, S.4
  • 16
    • 33750471197 scopus 로고    scopus 로고
    • Mutual cross-talk between reactive oxygen species and nuclear factor-kappa B: molecular basis and biological significance
    • Bubici C, Papa S, Dean K, and Franzoso G (2006). Mutual cross-talk between reactive oxygen species and nuclear factor-kappa B: molecular basis and biological significance. Oncogene, 25:6731-48.
    • (2006) Oncogene , vol.25 , pp. 6731-6748
    • Bubici, C.1    Papa, S.2    Dean, K.3    Franzoso, G.4
  • 17
    • 0034284715 scopus 로고    scopus 로고
    • Selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex
    • May MJ, D'Acquisto F, Madge LA, Glockner J, Pober JS, and Ghosh S (2000). Selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex. Science, 289:1550-4.
    • (2000) Science , vol.289 , pp. 1550-1554
    • May, M.J.1    D'Acquisto, F.2    Madge, L.A.3    Glockner, J.4    Pober, J.S.5    Ghosh, S.6
  • 18
    • 0034746919 scopus 로고    scopus 로고
    • NF-kappaB: a key role in inflammatory diseases
    • Tak PP and Firestein GS (2001). NF-kappaB: a key role in inflammatory diseases. J Clin Invest, 107:7-11.
    • (2001) J Clin Invest , vol.107 , pp. 7-11
    • Tak, P.P.1    Firestein, G.S.2
  • 19
    • 33750466230 scopus 로고    scopus 로고
    • Introduction to NF-kappaB: players, pathways, perspectives
    • Gilmore TD (2006). Introduction to NF-kappaB: players, pathways, perspectives. Oncogene, 25:6680-4.
    • (2006) Oncogene , vol.25 , pp. 6680-6684
    • Gilmore, T.D.1
  • 20
    • 1942484963 scopus 로고    scopus 로고
    • IkappaB kinase-alpha acts in the epidermis to control skeletal and craniofacial morphogenesis
    • Sil AK, Maeda S, Sano Y, Roop DR, and Karin M (2004). IkappaB kinase-alpha acts in the epidermis to control skeletal and craniofacial morphogenesis. Nature, 428:660-4.
    • (2004) Nature , vol.428 , pp. 660-664
    • Sil, A.K.1    Maeda, S.2    Sano, Y.3    Roop, D.R.4    Karin, M.5
  • 21
    • 33750433585 scopus 로고    scopus 로고
    • Manipulation of the nuclear factor-kappaB pathway and the innate immune response by viruses
    • Hiscott J, Nguyen TL, Arguello M, Nakhaei P, and Paz S (2006). Manipulation of the nuclear factor-kappaB pathway and the innate immune response by viruses. Oncogene, 25:6844-67.
    • (2006) Oncogene , vol.25 , pp. 6844-6867
    • Hiscott, J.1    Nguyen, T.L.2    Arguello, M.3    Nakhaei, P.4    Paz, S.5
  • 22
    • 4444376712 scopus 로고    scopus 로고
    • Signaling to NF-kappaB
    • Hayden MS and Ghosh S (2004). Signaling to NF-kappaB. Genes Dev, 18:2195-224.
    • (2004) Genes Dev , vol.18 , pp. 2195-2224
    • Hayden, M.S.1    Ghosh, S.2
  • 23
    • 34247874508 scopus 로고    scopus 로고
    • Interleukin-1-induced NF-kappaB activation is NEMO-dependent but does not require IKKbeta
    • Solt LA, Madge LA, Orange JS, and May MJ (2007). Interleukin-1-induced NF-kappaB activation is NEMO-dependent but does not require IKKbeta. J Biol Chem, 282:8724-33.
    • (2007) J Biol Chem , vol.282 , pp. 8724-8733
    • Solt, L.A.1    Madge, L.A.2    Orange, J.S.3    May, M.J.4
  • 24
    • 34547815755 scopus 로고    scopus 로고
    • Negative regulation of toll-like receptor signaling by NF-kappaB p50 ubiquitination blockade
    • Carmody RJ, Ruan Q, Palmer S, Hilliard B, and Chen YH (2007). Negative regulation of toll-like receptor signaling by NF-kappaB p50 ubiquitination blockade. Science, 317:675-8.
    • (2007) Science , vol.317 , pp. 675-678
    • Carmody, R.J.1    Ruan, Q.2    Palmer, S.3    Hilliard, B.4    Chen, Y.H.5
  • 25
    • 64049086206 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1 alpha activates and is inhibited by unoccupied estrogen receptor beta
    • Lim W, Cho J, Kwon HY, Park Y, Rhyu MR, and Lee Y (2009). Hypoxia-inducible factor 1 alpha activates and is inhibited by unoccupied estrogen receptor beta. FEBS Lett, 583:1314-8.
    • (2009) FEBS Lett , vol.583 , pp. 1314-1318
    • Lim, W.1    Cho, J.2    Kwon, H.Y.3    Park, Y.4    Rhyu, M.R.5    Lee, Y.6
  • 27
    • 34547135737 scopus 로고    scopus 로고
    • Regulation of FOXO3a/beta-catenin/GSK-3beta signaling by 3,3'-diindolylmethane contributes to inhibition of cell proliferation and induction of apoptosis in prostate cancer cells
    • Li Y, Wang Z, Kong D, Murthy S, Dou QP, Sheng S, Reddy GP, and Sarkar FH (2007). Regulation of FOXO3a/beta-catenin/GSK-3beta signaling by 3,3'-diindolylmethane contributes to inhibition of cell proliferation and induction of apoptosis in prostate cancer cells. J Biol Chem, 282:21542-50.
    • (2007) J Biol Chem , vol.282 , pp. 21542-21550
    • Li, Y.1    Wang, Z.2    Kong, D.3    Murthy, S.4    Dou, Q.P.5    Sheng, S.6    Reddy, G.P.7    Sarkar, F.H.8
  • 28
    • 33750443289 scopus 로고    scopus 로고
    • IkappaB kinase complexes: gateways to NF-kappaB activation and transcription
    • Scheidereit C (2006). IkappaB kinase complexes: gateways to NF-kappaB activation and transcription. Oncogene, 25:6685-705.
    • (2006) Oncogene , vol.25 , pp. 6685-6705
    • Scheidereit, C.1
  • 29
    • 36248956174 scopus 로고    scopus 로고
    • Signaling mechanisms involved in the response to genotoxic stress and regulating lifespan
    • Niedernhofer LJ and Robbins PD (2008). Signaling mechanisms involved in the response to genotoxic stress and regulating lifespan. Int J Biochem Cell Biol, 40:176-80.
    • (2008) Int J Biochem Cell Biol , vol.40 , pp. 176-180
    • Niedernhofer, L.J.1    Robbins, P.D.2
  • 31
    • 0035866797 scopus 로고    scopus 로고
    • Antiproliferative and antiapoptotic effects of crel may occur within the same cells via the up-regulation of manganese superoxide dismutase
    • Bernard D, Quatannens B, Begue A, Vandenbunder B, and Abbadie C (2001). Antiproliferative and antiapoptotic effects of crel may occur within the same cells via the up-regulation of manganese superoxide dismutase. Cancer Res, 61:2656-64.
    • (2001) Cancer Res , vol.61 , pp. 2656-2664
    • Bernard, D.1    Quatannens, B.2    Begue, A.3    Vandenbunder, B.4    Abbadie, C.5
  • 33
    • 0033624673 scopus 로고    scopus 로고
    • Nuclear factor kappaB subunits induce epithelial cell growth arrest
    • Seitz CS, Deng H, Hinata K, Lin Q, and Khavari PA (2000). Nuclear factor kappaB subunits induce epithelial cell growth arrest. Cancer Res, 60:4085-92.
    • (2000) Cancer Res , vol.60 , pp. 4085-4092
    • Seitz, C.S.1    Deng, H.2    Hinata, K.3    Lin, Q.4    Khavari, P.A.5
  • 35
    • 48549099463 scopus 로고    scopus 로고
    • Cell autonomous expression of inflammatory genes in biologically aged fibroblasts associated with elevated NF-kappaB activity
    • Kriete A, Mayo KL, Yalamanchili N, Beggs W, Bender P, Kari C, and Rodeck U (2008). Cell autonomous expression of inflammatory genes in biologically aged fibroblasts associated with elevated NF-kappaB activity. Immun Ageing, 5:5.
    • (2008) Immun Ageing , vol.5 , pp. 5
    • Kriete, A.1    Mayo, K.L.2    Yalamanchili, N.3    Beggs, W.4    Bender, P.5    Kari, C.6    Rodeck, U.7
  • 36
    • 0029834145 scopus 로고    scopus 로고
    • Changes associated with aging and replicative senescence in the regulation of transcription factor nuclear factor-kappa B
    • Helenius M, Hanninen M, Lehtinen SK, and Salminen A (1996). Changes associated with aging and replicative senescence in the regulation of transcription factor nuclear factor-kappa B. Biochem J, 318 (Pt 2):603-8.
    • (1996) Biochem J , vol.318 , pp. 603-608
    • Helenius, M.1    Hanninen, M.2    Lehtinen, S.K.3    Salminen, A.4
  • 37
    • 0030960606 scopus 로고    scopus 로고
    • Age-related changes in the regulation of transcription factor NF-kappa B in rat brain
    • Korhonen P, Helenius M, and Salminen A (1997). Age-related changes in the regulation of transcription factor NF-kappa B in rat brain. Neurosci Lett, 225:61-4.
    • (1997) Neurosci Lett , vol.225 , pp. 61-64
    • Korhonen, P.1    Helenius, M.2    Salminen, A.3
  • 38
    • 31344434396 scopus 로고    scopus 로고
    • The ubiquitin-proteasome system at the crossroads of stress-response and ageing pathways: a handle for skin care?
    • Bregegere F, Milner Y, and Friguet B (2006). The ubiquitin-proteasome system at the crossroads of stress-response and ageing pathways: a handle for skin care? Ageing Res Rev, 5:60-90.
    • (2006) Ageing Res Rev , vol.5 , pp. 60-90
    • Bregegere, F.1    Milner, Y.2    Friguet, B.3
  • 40
    • 0033921321 scopus 로고    scopus 로고
    • Induction of transcriptional activity of AP-1 and NF-kappaB in the gastric mucosa during aging
    • Xiao ZQ and Majumdar AP (2000). Induction of transcriptional activity of AP-1 and NF-kappaB in the gastric mucosa during aging. Am J Physiol Gastrointest Liver Physiol, 278:G855-65.
    • (2000) Am J Physiol Gastrointest Liver Physiol , vol.278 , pp. G855-G865
    • Xiao, Z.Q.1    Majumdar, A.P.2
  • 41
    • 0029670391 scopus 로고    scopus 로고
    • Aging-induced up-regulation of nuclear binding activities of oxidative stress responsive NF-kB transcription factor in mouse cardiac muscle
    • Helenius M, Hanninen M, Lehtinen SK, and Salminen A (1996). Aging-induced up-regulation of nuclear binding activities of oxidative stress responsive NF-kB transcription factor in mouse cardiac muscle. J Mol Cell Cardiol, 28:487-98.
    • (1996) J Mol Cell Cardiol , vol.28 , pp. 487-498
    • Helenius, M.1    Hanninen, M.2    Lehtinen, S.K.3    Salminen, A.4
  • 43
    • 58149086403 scopus 로고    scopus 로고
    • When sirtuins and NF-kappaB collide
    • Natoli G (2009). When sirtuins and NF-kappaB collide. Cell, 136:19-21.
    • (2009) Cell , vol.136 , pp. 19-21
    • Natoli, G.1
  • 45
    • 0035500487 scopus 로고    scopus 로고
    • Cellular senescence as a tumor-suppressor mechanism
    • Campisi J (2001). Cellular senescence as a tumor-suppressor mechanism. Trends in Cell Biology, 11:S27-S31.
    • (2001) Trends in Cell Biology , vol.11 , pp. S27-S31
    • Campisi, J.1
  • 46
    • 0348047392 scopus 로고    scopus 로고
    • Involvement of Rel/NF-kappa B transcription factors in senescence
    • Gosselin K and Abbadie C (2003). Involvement of Rel/NF-kappa B transcription factors in senescence. Exp Gerontol, 38:1271-83.
    • (2003) Exp Gerontol , vol.38 , pp. 1271-1283
    • Gosselin, K.1    Abbadie, C.2
  • 47
    • 0024656069 scopus 로고
    • The effect of retarded grwoth upon the length of life span and upon the ultimate body size
    • McCay CM, Crowell, M.F., and Maynard, L.A. (1935). The effect of retarded grwoth upon the length of life span and upon the ultimate body size. Nutritions, 5:155-71.
    • (1935) Nutritions , vol.5 , pp. 155-171
    • McCay, C.M.1    Crowell, M.F.2    Maynard, L.A.3
  • 48
    • 62749196605 scopus 로고    scopus 로고
    • Caloric restriction and aging: studies in mice and monkeys
    • Anderson RM, Shanmuganayagam D, and Weindruch R (2009). Caloric restriction and aging: studies in mice and monkeys. Toxicol Pathol, 37:47-51.
    • (2009) Toxicol Pathol , vol.37 , pp. 47-51
    • Anderson, R.M.1    Shanmuganayagam, D.2    Weindruch, R.3
  • 50
    • 0036860192 scopus 로고    scopus 로고
    • Modulation of redox-sensitive transcription factors by calorie restriction during aging
    • Kim HJ, Jung KJ, Yu BP, Cho CG, Choi JS, and Chung HY (2002). Modulation of redox-sensitive transcription factors by calorie restriction during aging. Mech Ageing Dev, 123:1589-95.
    • (2002) Mech Ageing Dev , vol.123 , pp. 1589-1595
    • Kim, H.J.1    Jung, K.J.2    Yu, B.P.3    Cho, C.G.4    Choi, J.S.5    Chung, H.Y.6
  • 51
    • 32444440814 scopus 로고    scopus 로고
    • Energy restriction lowers the expression of genes linked to inflammation, the cytoskeleton, the extracellular matrix, and angiogenesis in mouse adipose tissue
    • Higami Y, Barger JL, Page GP, Allison DB, Smith SR, Prolla TA, and Weindruch R (2006). Energy restriction lowers the expression of genes linked to inflammation, the cytoskeleton, the extracellular matrix, and angiogenesis in mouse adipose tissue. J Nutr, 136:343-52.
    • (2006) J Nutr , vol.136 , pp. 343-352
    • Higami, Y.1    Barger, J.L.2    Page, G.P.3    Allison, D.B.4    Smith, S.R.5    Prolla, T.A.6    Weindruch, R.7
  • 53
    • 77950200010 scopus 로고    scopus 로고
    • The genetics of ageing
    • Kenyon CJ (2010). The genetics of ageing. Nature, 464:504-12.
    • (2010) Nature , vol.464 , pp. 504-512
    • Kenyon, C.J.1
  • 54
    • 42449142360 scopus 로고    scopus 로고
    • Interaction of aging-associated signaling cascades: inhibition of NF-kappaB signaling by longevity factors FoxOs and SIRT1
    • Salminen A, Ojala J, Huuskonen J, Kauppinen A, Suuronen T, and Kaarniranta K (2008). Interaction of aging-associated signaling cascades: inhibition of NF-kappaB signaling by longevity factors FoxOs and SIRT1. Cell Mol Life Sci, 65:1049-58.
    • (2008) Cell Mol Life Sci , vol.65 , pp. 1049-1058
    • Salminen, A.1    Ojala, J.2    Huuskonen, J.3    Kauppinen, A.4    Suuronen, T.5    Kaarniranta, K.6
  • 55
    • 74449090245 scopus 로고    scopus 로고
    • Insulin/IGF-1 paradox of aging: regulation via AKT/IKK/NF-kappaB signaling
    • Salminen A and Kaarniranta K (2010). Insulin/IGF-1 paradox of aging: regulation via AKT/IKK/NF-kappaB signaling. Cell Signal, 22:573-7.
    • (2010) Cell Signal , vol.22 , pp. 573-577
    • Salminen, A.1    Kaarniranta, K.2
  • 56
    • 12344335482 scopus 로고    scopus 로고
    • Long-lived growth hormone receptor knockout mice: interaction of reduced insulin-like growth factor i/insulin signaling and caloric restriction
    • Al-Regaiey KA, Masternak MM, Bonkowski M, Sun L, and Bartke A (2005). Long-lived growth hormone receptor knockout mice: interaction of reduced insulin-like growth factor i/insulin signaling and caloric restriction. Endocrinology, 146:851-60.
    • (2005) Endocrinology , vol.146 , pp. 851-860
    • Al-Regaiey, K.A.1    Masternak, M.M.2    Bonkowski, M.3    Sun, L.4    Bartke, A.5
  • 57
    • 0033961280 scopus 로고    scopus 로고
    • Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-kappaB
    • Madrid LV, Wang CY, Guttridge DC, Schottelius AJ, Baldwin AS, Jr., and Mayo MW (2000). Akt suppresses apoptosis by stimulating the transactivation potential of the RelA/p65 subunit of NF-kappaB. Mol Cell Biol, 20:1626-38.
    • (2000) Mol Cell Biol , vol.20 , pp. 1626-1638
    • Madrid, L.V.1    Wang, C.Y.2    Guttridge, D.C.3    Schottelius, A.J.4    Baldwin Jr., A.S.5    Mayo, M.W.6
  • 58
    • 0035379555 scopus 로고    scopus 로고
    • Akt stimulates the transactivation potential of the RelA/p65 Subunit of NF-kappa B through utilization of the Ikappa B kinase and activation of the mitogen-activated protein kinase p38
    • Madrid LV, Mayo MW, Reuther JY, and Baldwin AS, Jr. (2001). Akt stimulates the transactivation potential of the RelA/p65 Subunit of NF-kappa B through utilization of the Ikappa B kinase and activation of the mitogen-activated protein kinase p38. J Biol Chem, 276:18934-40.
    • (2001) J Biol Chem , vol.276 , pp. 18934-18940
    • Madrid, L.V.1    Mayo, M.W.2    Reuther, J.Y.3    Baldwin Jr., A.S.4
  • 59
    • 0032698132 scopus 로고    scopus 로고
    • Insulin antiapoptotic signaling involves insulin activation of the nuclear factor kappaB-dependent survival genes encoding tumor necrosis factor receptor-associated factor 2 and manganese-superoxide dismutase
    • Bertrand F, Desbois-Mouthon C, Cadoret A, Prunier C, Robin H, Capeau J, AtfiA, and Cherqui G (1999). Insulin antiapoptotic signaling involves insulin activation of the nuclear factor kappaB-dependent survival genes encoding tumor necrosis factor receptor-associated factor 2 and manganese-superoxide dismutase. J Biol Chem, 274:30596-602.
    • (1999) J Biol Chem , vol.274 , pp. 30596-30602
    • Bertrand, F.1    Desbois-Mouthon, C.2    Cadoret, A.3    Prunier, C.4    Robin, H.5    Capeau, J.6    Atfi, A.7    Cherqui, G.8
  • 61
    • 0032928925 scopus 로고    scopus 로고
    • Insulin like growth factor-1 activates nuclear factor-kappaB and increases transcription of the intercellular adhesion molecule-1 gene in endothelial cells
    • Balaram SK, Agrawal DK, and Edwards JD (1999). Insulin like growth factor-1 activates nuclear factor-kappaB and increases transcription of the intercellular adhesion molecule-1 gene in endothelial cells. Cardiovasc Surg, 7:91-7.
    • (1999) Cardiovasc Surg , vol.7 , pp. 91-97
    • Balaram, S.K.1    Agrawal, D.K.2    Edwards, J.D.3
  • 62
    • 0037076787 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 enhances inflammatory responses in endothelial cells: role of Gab1 and MEKK3 in TNF-alpha-induced c-Jun and NF-kappaB activation and adhesion molecule expression
    • Che W, Lerner-Marmarosh N, Huang Q, Osawa M, Ohta S, Yoshizumi M, Glassman M, Lee JD, Yan C, Berk BC, and Abe J (2002). Insulin-like growth factor-1 enhances inflammatory responses in endothelial cells: role of Gab1 and MEKK3 in TNF-alpha-induced c-Jun and NF-kappaB activation and adhesion molecule expression. Circ Res, 90:1222-30.
    • (2002) Circ Res , vol.90 , pp. 1222-1230
    • Che, W.1    Lerner-Marmarosh, N.2    Huang, Q.3    Osawa, M.4    Ohta, S.5    Yoshizumi, M.6    Glassman, M.7    Lee, J.D.8    Yan, C.9    Berk, B.C.10    Abe, J.11
  • 63
    • 36248956174 scopus 로고    scopus 로고
    • Signaling mechanisms involved in the response to genotoxic stress and regulating lifespan
    • Niedernhofer LJ and Robbins PD (2008). Signaling mechanisms involved in the response to genotoxic stress and regulating lifespan. Int J Biochem Cell Biol, 40:176-80.
    • (2008) Int J Biochem Cell Biol , vol.40 , pp. 176-180
    • Niedernhofer, L.J.1    Robbins, P.D.2
  • 66
    • 18144380684 scopus 로고    scopus 로고
    • Effects of trans-resveratrol from Polygonum cuspidatum on bone loss using the ovariectomized rat model
    • Liu ZP, Li WX, Yu B, Huang J, Sun J, Huo JS, and Liu CX (2005). Effects of trans-resveratrol from Polygonum cuspidatum on bone loss using the ovariectomized rat model. J Med Food, 8:14-9.
    • (2005) J Med Food , vol.8 , pp. 14-19
    • Liu, Z.P.1    Li, W.X.2    Yu, B.3    Huang, J.4    Sun, J.5    Huo, J.S.6    Liu, C.X.7
  • 68
    • 53249121556 scopus 로고    scopus 로고
    • Sirtuins--novel therapeutic targets to treat age-associated diseases
    • Lavu S, Boss O, Elliott PJ, and Lambert PD (2008). Sirtuins--novel therapeutic targets to treat age-associated diseases. Nat Rev Drug Discov, 7:841-53.
    • (2008) Nat Rev Drug Discov , vol.7 , pp. 841-853
    • Lavu, S.1    Boss, O.2    Elliott, P.J.3    Lambert, P.D.4
  • 69
    • 3242719545 scopus 로고    scopus 로고
    • Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase
    • Yeung F, Hoberg JE, Ramsey CS, Keller MD, Jones DR, Frye RA, and Mayo MW (2004). Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. Embo J, 23:2369-80.
    • (2004) Embo J , vol.23 , pp. 2369-2380
    • Yeung, F.1    Hoberg, J.E.2    Ramsey, C.S.3    Keller, M.D.4    Jones, D.R.5    Frye, R.A.6    Mayo, M.W.7
  • 70
    • 36248935670 scopus 로고    scopus 로고
    • Sirt1 interacts with transducin-like enhancer of split-1 to inhibit nuclear factor kappaB-mediated transcription
    • Ghosh HS, Spencer JV, Ng B, McBurney MW, and Robbins PD (2007). Sirt1 interacts with transducin-like enhancer of split-1 to inhibit nuclear factor kappaB-mediated transcription. Biochem J, 408:105-11.
    • (2007) Biochem J , vol.408 , pp. 105-111
    • Ghosh, H.S.1    Spencer, J.V.2    Ng, B.3    McBurney, M.W.4    Robbins, P.D.5
  • 72
    • 0034193776 scopus 로고    scopus 로고
    • Sir2 links chromatin silencing, metabolism, and aging
    • Guarente L (2000). Sir2 links chromatin silencing, metabolism, and aging. Genes Dev, 14:1021-6.
    • (2000) Genes Dev , vol.14 , pp. 1021-1026
    • Guarente, L.1
  • 73
    • 34548313701 scopus 로고    scopus 로고
    • Immune regulation by Foxo transcription factors
    • Peng SL (2007). Immune regulation by Foxo transcription factors. Autoimmunity, 40:462-9.
    • (2007) Autoimmunity , vol.40 , pp. 462-469
    • Peng, S.L.1
  • 74
    • 4143129696 scopus 로고    scopus 로고
    • Regulation of NF-kappaB, Th activation, and autoinflammation by the forkhead transcription factor Foxo3a
    • Lin L, Hron JD, and Peng SL (2004). Regulation of NF-kappaB, Th activation, and autoinflammation by the forkhead transcription factor Foxo3a. Immunity, 21:203-13.
    • (2004) Immunity , vol.21 , pp. 203-213
    • Lin, L.1    Hron, J.D.2    Peng, S.L.3
  • 78
    • 3042648746 scopus 로고    scopus 로고
    • Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway
    • Kapahi P, Zid BM, Harper T, Koslover D, Sapin V, and Benzer S (2004). Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. Curr Biol, 14:885-90.
    • (2004) Curr Biol , vol.14 , pp. 885-890
    • Kapahi, P.1    Zid, B.M.2    Harper, T.3    Koslover, D.4    Sapin, V.5    Benzer, S.6
  • 79
    • 33847199335 scopus 로고    scopus 로고
    • eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans
    • Syntichaki P, Troulinaki K, and Tavernarakis N (2007). eIF4E function in somatic cells modulates ageing in Caenorhabditis elegans. Nature, 445:922-6.
    • (2007) Nature , vol.445 , pp. 922-926
    • Syntichaki, P.1    Troulinaki, K.2    Tavernarakis, N.3
  • 80
    • 44849117768 scopus 로고    scopus 로고
    • Akt-dependent regulation of NF-{kappa}B is controlled by mTOR and Raptor in association with IKK
    • Dan HC, Cooper MJ, Cogswell PC, Duncan JA, Ting JP, and Baldwin AS (2008). Akt-dependent regulation of NF-{kappa}B is controlled by mTOR and Raptor in association with IKK. Genes Dev, 22:1490-500.
    • (2008) Genes Dev , vol.22 , pp. 1490-1500
    • Dan, H.C.1    Cooper, M.J.2    Cogswell, P.C.3    Duncan, J.A.4    Ting, J.P.5    Baldwin, A.S.6
  • 81
    • 67651207793 scopus 로고    scopus 로고
    • NF-kappaB signaling in the aging process
    • Salminen A and Kaarniranta K (2009). NF-kappaB signaling in the aging process. J Clin Immunol, 29:397-405.
    • (2009) J Clin Immunol , vol.29 , pp. 397-405
    • Salminen, A.1    Kaarniranta, K.2
  • 82
    • 47249125723 scopus 로고    scopus 로고
    • Differential involvement of IkappaB kinases alpha and beta in cytokine- and insulin-induced mammalian target of rapamycin activation determined by Akt
    • Dan HC and Baldwin AS (2008). Differential involvement of IkappaB kinases alpha and beta in cytokine- and insulin-induced mammalian target of rapamycin activation determined by Akt. J Immunol, 180:7582-9.
    • (2008) J Immunol , vol.180 , pp. 7582-7589
    • Dan, H.C.1    Baldwin, A.S.2
  • 86
    • 79451475153 scopus 로고    scopus 로고
    • Persistence of unrepaired DNA double strand breaks caused by inhibition of ATM does not lead to radio-sensitisation in the absence of NF-kappaB activation
    • Veuger SJ and Durkacz BW (2011). Persistence of unrepaired DNA double strand breaks caused by inhibition of ATM does not lead to radio-sensitisation in the absence of NF-kappaB activation. DNA repair, 10:235-44.
    • (2011) DNA repair , vol.10 , pp. 235-244
    • Veuger, S.J.1    Durkacz, B.W.2
  • 88
    • 4344688814 scopus 로고    scopus 로고
    • Signaling transduction: target in osteoarthritis
    • Berenbaum F (2004). Signaling transduction: target in osteoarthritis. Curr Opin Rheumatol, 16:616-22.
    • (2004) Curr Opin Rheumatol , vol.16 , pp. 616-622
    • Berenbaum, F.1
  • 89
    • 0035411587 scopus 로고    scopus 로고
    • Role of the NF-kappaB pathway in the pathogenesis of human disease states
    • Yamamoto Y and Gaynor RB (2001). Role of the NF-kappaB pathway in the pathogenesis of human disease states. Curr Mol Med, 1:287-96.
    • (2001) Curr Mol Med , vol.1 , pp. 287-296
    • Yamamoto, Y.1    Gaynor, R.B.2
  • 90
    • 33646044648 scopus 로고    scopus 로고
    • Antioxidant alpha-lipoic acid inhibits osteoclast differentiation by reducing nuclear factor-kappaB DNA binding and prevents in vivo bone resorption induced by receptor activator of nuclear factor-kappaB ligand and tumor necrosis factor-alpha
    • Kim HJ, Chang EJ, Kim HM, Lee SB, Kim HD, Su Kim G, and Kim HH (2006). Antioxidant alpha-lipoic acid inhibits osteoclast differentiation by reducing nuclear factor-kappaB DNA binding and prevents in vivo bone resorption induced by receptor activator of nuclear factor-kappaB ligand and tumor necrosis factor-alpha. Free Radic Biol Med, 40:1483-93.
    • (2006) Free Radic Biol Med , vol.40 , pp. 1483-1493
    • Kim, H.J.1    Chang, E.J.2    Kim, H.M.3    Lee, S.B.4    Kim, H.D.5    Su Kim, G.6    Kim, H.H.7
  • 91
    • 0345737283 scopus 로고    scopus 로고
    • Signal transduction through nuclear factor kappa B in ischemia-reperfusion and heart failure
    • Valen G (2004). Signal transduction through nuclear factor kappa B in ischemia-reperfusion and heart failure. Basic Res Cardiol, 99:1-7.
    • (2004) Basic Res Cardiol , vol.99 , pp. 1-7
    • Valen, G.1
  • 92
    • 55849122679 scopus 로고    scopus 로고
    • Nuanced roles of cytokines in three major human brain disorders
    • Steinman L (2008). Nuanced roles of cytokines in three major human brain disorders. J Clin Invest, 118:3557-63.
    • (2008) J Clin Invest , vol.118 , pp. 3557-3563
    • Steinman, L.1
  • 94
    • 27344444438 scopus 로고    scopus 로고
    • High cholesterol diet results in increased expression of interleukin-6 and caspase-1 in the brain of apolipoprotein E knockout and wild type mice
    • Rahman SM, Van Dam AM, Schultzberg M, and Crisby M (2005). High cholesterol diet results in increased expression of interleukin-6 and caspase-1 in the brain of apolipoprotein E knockout and wild type mice. J Neuroimmunol, 169:59-67.
    • (2005) J Neuroimmunol , vol.169 , pp. 59-67
    • Rahman, S.M.1    Van Dam, A.M.2    Schultzberg, M.3    Crisby, M.4
  • 95
    • 0007692414 scopus 로고    scopus 로고
    • In vivo and in vitro evidence supporting a role for the inflammatory cytokine interleukin-1 as a driving force in Alzheimer pathogenesis
    • Sheng JG, Ito K, Skinner RD, Mrak RE, Rovnaghi CR, Van Eldik LJ, and Griffin WS (1996). In vivo and in vitro evidence supporting a role for the inflammatory cytokine interleukin-1 as a driving force in Alzheimer pathogenesis. Neurobiol Aging, 17:761-6.
    • (1996) Neurobiol Aging , vol.17 , pp. 761-766
    • Sheng, J.G.1    Ito, K.2    Skinner, R.D.3    Mrak, R.E.4    Rovnaghi, C.R.5    Van Eldik, L.J.6    Griffin, W.S.7
  • 96
    • 0035866060 scopus 로고    scopus 로고
    • beta-Amyloid stimulation of microglia and monocytes results in TNFalpha-dependent expression of inducible nitric oxide synthase and neuronal apoptosis
    • Combs CK, Karlo JC, Kao SC, and Landreth GE (2001). beta-Amyloid stimulation of microglia and monocytes results in TNFalpha-dependent expression of inducible nitric oxide synthase and neuronal apoptosis. J Neurosci, 21:1179-88.
    • (2001) J Neurosci , vol.21 , pp. 1179-1188
    • Combs, C.K.1    Karlo, J.C.2    Kao, S.C.3    Landreth, G.E.4
  • 97
    • 28844474597 scopus 로고    scopus 로고
    • SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling
    • Chen J, Zhou Y, Mueller-Steiner S, Chen LF, Kwon H, Yi S, Mucke L, and Gan L (2005). SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling. J Biol Chem, 280:40364-74.
    • (2005) J Biol Chem , vol.280 , pp. 40364-40374
    • Chen, J.1    Zhou, Y.2    Mueller-Steiner, S.3    Chen, L.F.4    Kwon, H.5    Yi, S.6    Mucke, L.7    Gan, L.8
  • 98
    • 0029666276 scopus 로고    scopus 로고
    • Interleukin-1beta and glutamate activate the NF-kappaB/Rel binding site from the regulatory region of the amyloid precursor protein gene in primary neuronal cultures
    • Grilli M, GoffiF, Memo M, and Spano P (1996). Interleukin-1beta and glutamate activate the NF-kappaB/Rel binding site from the regulatory region of the amyloid precursor protein gene in primary neuronal cultures. J Biol Chem, 271:15002-7.
    • (1996) J Biol Chem , vol.271 , pp. 15002-15007
    • Grilli, M.1    Goffi, F.2    Memo, M.3    Spano, P.4
  • 100
    • 33748471099 scopus 로고    scopus 로고
    • Inflammation in Alzheimer disease: driving force, bystander or beneficial response?
    • Wyss-Coray T (2006). Inflammation in Alzheimer disease: driving force, bystander or beneficial response? Nat Med, 12:1005-15.
    • (2006) Nat Med , vol.12 , pp. 1005-1015
    • Wyss-Coray, T.1
  • 102
    • 58149466868 scopus 로고    scopus 로고
    • Oxidative and inflammatory pathways in Parkinson's disease
    • Miller RL, James-Kracke M, Sun GY, and Sun AY (2009). Oxidative and inflammatory pathways in Parkinson's disease. Neurochem Res, 34:55-65.
    • (2009) Neurochem Res , vol.34 , pp. 55-65
    • Miller, R.L.1    James-Kracke, M.2    Sun, G.Y.3    Sun, A.Y.4
  • 103
    • 0028178281 scopus 로고
    • Tumor necrosis factor-alpha (TNF-alpha) increases both in the brain and in the cerebrospinal fluid from parkinsonian patients
    • Mogi M, Harada M, Riederer P, Narabayashi H, Fujita K, and Nagatsu T (1994). Tumor necrosis factor-alpha (TNF-alpha) increases both in the brain and in the cerebrospinal fluid from parkinsonian patients. Neurosci Lett, 165:208-10.
    • (1994) Neurosci Lett , vol.165 , pp. 208-210
    • Mogi, M.1    Harada, M.2    Riederer, P.3    Narabayashi, H.4    Fujita, K.5    Nagatsu, T.6
  • 104
    • 0030582991 scopus 로고    scopus 로고
    • Interleukin (IL)-1 beta, IL-2, IL-4, IL-6 and transforming growth factor-alpha levels are elevated in ventricular cerebrospinal fluid in juvenile parkinsonism and Parkinson's disease
    • Mogi M, Harada M, Narabayashi H, Inagaki H, Minami M, and Nagatsu T (1996). Interleukin (IL)-1 beta, IL-2, IL-4, IL-6 and transforming growth factor-alpha levels are elevated in ventricular cerebrospinal fluid in juvenile parkinsonism and Parkinson's disease. Neurosci Lett, 211:13-6.
    • (1996) Neurosci Lett , vol.211 , pp. 13-16
    • Mogi, M.1    Harada, M.2    Narabayashi, H.3    Inagaki, H.4    Minami, M.5    Nagatsu, T.6
  • 105
    • 0038322494 scopus 로고    scopus 로고
    • Neuroprotective effect of vasoactive intestinal peptide (VIP) in a mouse model of Parkinson's disease by blocking microglial activation
    • Delgado M and Ganea D (2003). Neuroprotective effect of vasoactive intestinal peptide (VIP) in a mouse model of Parkinson's disease by blocking microglial activation. FASEB J, 17:944-6.
    • (2003) FASEB J , vol.17 , pp. 944-946
    • Delgado, M.1    Ganea, D.2
  • 106
    • 0023789193 scopus 로고
    • Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains
    • McGeer PL, Itagaki S, Boyes BE, and McGeer EG (1988). Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains. Neurology, 38:1285-91.
    • (1988) Neurology , vol.38 , pp. 1285-1291
    • McGeer, P.L.1    Itagaki, S.2    Boyes, B.E.3    McGeer, E.G.4
  • 109
    • 27344438938 scopus 로고    scopus 로고
    • Microglial inflammation in the parkinsonian substantia nigra: relationship to alpha-synuclein deposition
    • Croisier E, Moran LB, Dexter DT, Pearce RK, and Graeber MB (2005). Microglial inflammation in the parkinsonian substantia nigra: relationship to alpha-synuclein deposition. J Neuroinflammation, 2:14.
    • (2005) J Neuroinflammation , vol.2 , pp. 14
    • Croisier, E.1    Moran, L.B.2    Dexter, D.T.3    Pearce, R.K.4    Graeber, M.B.5
  • 110
    • 84863116750 scopus 로고    scopus 로고
    • Critical role of microglial NADPH oxidase-derived free radicals in the in vitro MPTP model of Parkinson's disease
    • Gao HM, Liu B, Zhang W, and Hong JS (2003). Critical role of microglial NADPH oxidase-derived free radicals in the in vitro MPTP model of Parkinson's disease. FASEB J, 17:1954-6.
    • (2003) FASEB J , vol.17 , pp. 1954-1956
    • Gao, H.M.1    Liu, B.2    Zhang, W.3    Hong, J.S.4
  • 113
    • 34548125007 scopus 로고    scopus 로고
    • Cytotoxicity of paraquat in microglial cells: Involvement of PKCd- and ERK1/2-dependent NADPH oxidase
    • Miller RL, Sun GY, and Sun AY (2007). Cytotoxicity of paraquat in microglial cells: Involvement of PKCd- and ERK1/2-dependent NADPH oxidase. Brain Res, 1167:129-139.
    • (2007) Brain Res , vol.1167 , pp. 129-139
    • Miller, R.L.1    Sun, G.Y.2    Sun, A.Y.3
  • 114
    • 0036470165 scopus 로고    scopus 로고
    • Distinct role for microglia in rotenone-induced degeneration of dopaminergic neurons
    • Gao HM, Hong JS, Zhang W, and Liu B (2002). Distinct role for microglia in rotenone-induced degeneration of dopaminergic neurons. J Neurosci, 22:782-90.
    • (2002) J Neurosci , vol.22 , pp. 782-790
    • Gao, H.M.1    Hong, J.S.2    Zhang, W.3    Liu, B.4
  • 116
    • 16344374513 scopus 로고    scopus 로고
    • Femtomolar concentrations of dextromethorphan protect mesencephalic dopaminergic neurons from inflammatory damage
    • Li G, Cui G, Tzeng N-S, Wei S-J, Wang T, Block ML, and Hong J-S (2005). Femtomolar concentrations of dextromethorphan protect mesencephalic dopaminergic neurons from inflammatory damage. The FASEB Journal, 19:489-496.
    • (2005) The FASEB Journal , vol.19 , pp. 489-496
    • Li, G.1    Cui, G.2    Tzeng, N-S.3    Wei, S-J.4    Wang, T.5    Block, M.L.6    Hong, J-S.7
  • 119
    • 0035044196 scopus 로고    scopus 로고
    • Activation of nuclear transcription factor kappa B (NF-kappaB) is essential for dopamine-induced apoptosis in PC12 cells
    • Panet H, Barzilai A, Daily D, Melamed E, and Offen D (2001). Activation of nuclear transcription factor kappa B (NF-kappaB) is essential for dopamine-induced apoptosis in PC12 cells. J Neurochem, 77:391-8.
    • (2001) J Neurochem , vol.77 , pp. 391-398
    • Panet, H.1    Barzilai, A.2    Daily, D.3    Melamed, E.4    Offen, D.5
  • 120
    • 33846585119 scopus 로고    scopus 로고
    • Systemic infections and inflammation affect chronic neurodegeneration
    • Perry VH, Cunningham C, and Holmes C (2007). Systemic infections and inflammation affect chronic neurodegeneration. Nat Rev Immunol, 7:161-7.
    • (2007) Nat Rev Immunol , vol.7 , pp. 161-167
    • Perry, V.H.1    Cunningham, C.2    Holmes, C.3
  • 121
    • 0043162103 scopus 로고    scopus 로고
    • Novel anti-inflammatory therapy for Parkinson's disease
    • Gao HM, Liu B, Zhang W, and Hong JS (2003). Novel anti-inflammatory therapy for Parkinson's disease. Trends Pharmacol Sci, 24:395-401.
    • (2003) Trends Pharmacol Sci , vol.24 , pp. 395-401
    • Gao, H.M.1    Liu, B.2    Zhang, W.3    Hong, J.S.4
  • 123
    • 0035979775 scopus 로고    scopus 로고
    • Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta
    • Yuan M, Konstantopoulos N, Lee J, Hansen L, Li ZW, Karin M, and Shoelson SE (2001). Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta. Science, 293:1673-7.
    • (2001) Science , vol.293 , pp. 1673-1677
    • Yuan, M.1    Konstantopoulos, N.2    Lee, J.3    Hansen, L.4    Li, Z.W.5    Karin, M.6    Shoelson, S.E.7
  • 124
    • 14644427890 scopus 로고    scopus 로고
    • Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB
    • Cai D, Yuan M, Frantz DF, Melendez PA, Hansen L, Lee J, and Shoelson SE (2005). Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB. Nat Med, 11:183-90.
    • (2005) Nat Med , vol.11 , pp. 183-190
    • Cai, D.1    Yuan, M.2    Frantz, D.F.3    Melendez, P.A.4    Hansen, L.5    Lee, J.6    Shoelson, S.E.7
  • 127
    • 0032830997 scopus 로고    scopus 로고
    • Adenoviral gene transfer of the interleukin-1 receptor antagonist protein to human islets prevents IL-1beta-induced beta-cell impairment and activation of islet cell apoptosis in vitro
    • Giannoukakis N, Rudert WA, Ghivizzani SC, Gambotto A, Ricordi C, Trucco M, and Robbins PD (1999). Adenoviral gene transfer of the interleukin-1 receptor antagonist protein to human islets prevents IL-1beta-induced beta-cell impairment and activation of islet cell apoptosis in vitro. Diabetes, 48:1730-6.
    • (1999) Diabetes , vol.48 , pp. 1730-1736
    • Giannoukakis, N.1    Rudert, W.A.2    Ghivizzani, S.C.3    Gambotto, A.4    Ricordi, C.5    Trucco, M.6    Robbins, P.D.7
  • 128
    • 0030756346 scopus 로고    scopus 로고
    • Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function
    • Uysal KT, Wiesbrock SM, Marino MW, and Hotamisligil GS (1997). Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Nature, 389:610-4.
    • (1997) Nature , vol.389 , pp. 610-614
    • Uysal, K.T.1    Wiesbrock, S.M.2    Marino, M.W.3    Hotamisligil, G.S.4
  • 131
    • 48749110858 scopus 로고    scopus 로고
    • Cytokines and atherosclerosis: a comprehensive review of studies in mice
    • Kleemann R, Zadelaar S, and Kooistra T (2008). Cytokines and atherosclerosis: a comprehensive review of studies in mice. Cardiovasc Res, 79:360-76.
    • (2008) Cardiovasc Res , vol.79 , pp. 360-376
    • Kleemann, R.1    Zadelaar, S.2    Kooistra, T.3
  • 132
    • 33847032609 scopus 로고    scopus 로고
    • Vasculoprotective effects of anti-tumor necrosis factor-alpha treatment in aging
    • Csiszar A, Labinskyy N, Smith K, Rivera A, Orosz Z, and Ungvari Z (2007). Vasculoprotective effects of anti-tumor necrosis factor-alpha treatment in aging. Am J Pathol, 170:388-98.
    • (2007) Am J Pathol , vol.170 , pp. 388-398
    • Csiszar, A.1    Labinskyy, N.2    Smith, K.3    Rivera, A.4    Orosz, Z.5    Ungvari, Z.6
  • 133
    • 0017568848 scopus 로고
    • Effect of muscle mass decrease on age-related BMR changes
    • TzankoffSP and Norris AH (1977). Effect of muscle mass decrease on age-related BMR changes. J Appl Physiol, 43:1001-6.
    • (1977) J Appl Physiol , vol.43 , pp. 1001-1006
    • Tzankoff, S.P.1    Norris, A.H.2
  • 134
    • 18244384047 scopus 로고    scopus 로고
    • Circulating acute phase mediators and skeletal muscle performance in hospitalized geriatric patients
    • Bautmans I, Njemini R, Lambert M, Demanet C, and Mets T (2005). Circulating acute phase mediators and skeletal muscle performance in hospitalized geriatric patients. J Gerontol A Biol Sci Med Sci, 60:361-7.
    • (2005) J Gerontol A Biol Sci Med Sci , vol.60 , pp. 361-367
    • Bautmans, I.1    Njemini, R.2    Lambert, M.3    Demanet, C.4    Mets, T.5
  • 138
    • 32144457727 scopus 로고    scopus 로고
    • Intracellular signaling during skeletal muscle atrophy
    • Kandarian SC and Jackman RW (2006). Intracellular signaling during skeletal muscle atrophy. Muscle Nerve, 33:155-65.
    • (2006) Muscle Nerve , vol.33 , pp. 155-165
    • Kandarian, S.C.1    Jackman, R.W.2
  • 139
    • 11144317940 scopus 로고    scopus 로고
    • Disruption of either the Nfkb1 or the Bcl3 gene inhibits skeletal muscle atrophy
    • Hunter RB and Kandarian SC (2004). Disruption of either the Nfkb1 or the Bcl3 gene inhibits skeletal muscle atrophy. The Journal of Clinical Investigation, 114:1504-1511.
    • (2004) The Journal of Clinical Investigation , vol.114 , pp. 1504-1511
    • Hunter, R.B.1    Kandarian, S.C.2
  • 141
    • 3342957361 scopus 로고    scopus 로고
    • Maldaptation of the link between inflammation and bone turnover may be a key determinant of osteoporosis
    • Yun AJ and Lee PY (2004). Maldaptation of the link between inflammation and bone turnover may be a key determinant of osteoporosis. Med Hypotheses, 63:532-7.
    • (2004) Med Hypotheses , vol.63 , pp. 532-537
    • Yun, A.J.1    Lee, P.Y.2
  • 143
    • 43249118596 scopus 로고    scopus 로고
    • Circulating levels of inflammatory markers predict change in bone mineral density and resorption in older adults: a longitudinal study
    • Ding C, Parameswaran V, Udayan R, Burgess J, and Jones G (2008). Circulating levels of inflammatory markers predict change in bone mineral density and resorption in older adults: a longitudinal study. J Clin Endocrinol Metab, 93:1952-8.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 1952-1958
    • Ding, C.1    Parameswaran, V.2    Udayan, R.3    Burgess, J.4    Jones, G.5
  • 147
    • 84917713548 scopus 로고    scopus 로고
    • NF-kB Signaling, in jpeg
    • www.proteinlounge.com, NF-kB Signaling, in jpeg. 2005.
    • (2005)


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