Regulation of the deubiquitinating enzyme CYLD by IκB kinase gamma-dependent phosphorylation

Molecular and Cellular Biology

Volumn 25, Issue 10, 2005, Pages 3886-3895

  Reiley, William ^a   Zhang, Minying ^a   Wu, Xuefeng ^a   Granger, Erica ^a   Sun, Shao Cong ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

I KAPPA B KINASE; PROTEIN CYLD; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 2; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CARCINOMA CELL; CELL LINE; CELL STIMULATION; EMBRYO CELL; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME PHOSPHORYLATION; ENZYME REGULATION; ENZYME REPRESSION; GENE EXPRESSION; HELA CELL; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN TARGETING; SIGNAL TRANSDUCTION; UBIQUITINATION;

AMINO ACID SEQUENCE; CATALYTIC DOMAIN; CELL LINE; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; HUMANS; I-KAPPA B KINASE; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MITOGENS; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PROTEIN SUBUNITS; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; TNF RECEPTOR-ASSOCIATED FACTOR 2; TUMOR SUPPRESSOR PROTEINS; UBIQUITIN;

EID: 18144368948     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.25.10.3886-3895.2005     Document Type: Article

References (45)

1. Aderem, A., and R. J. Ulevitch. 2000. Toll-like receptors in the induction of the innate immune response. Nature 406:782-787.
2. Aggarwal, B. B. 2003. Signalling pathways of the TNF superfamily: a double-edged sword. Nat. Rev. Immunol. 3:745-756.
3. Anest, V., J. L. Hanson, P. C. Cogswell, K. A. Steinbrecher, B. D. Strahl, and A. S. Baldwin. 2003. Nucleosomal function for IkappaB kinase-alpha in NF-kappaB-dependent gene expression. Nature 423:659-663.
4. Bignell, G. R., W. Warren, S. Seal, M. Takahashi, E. Rapley, R. Barfoot, H. Green, C. Brown, P. J. Biggs, S. R. Lakhani, C. Jones, J. Hansen, E. Blair, B. Hofmann, R. Siebert, G. Turner, D. G. Evans, C. Schrander-Stumpel, F. A. Beemer, A. van Den Ouweland, D. Halley, B. Delpech, M. G. Cleveland, I. Leigh, J. Leisti, and S. Rasmussen. 2000. Identification of the familial cylindromatosis tumour-suppressor gene. Nat. Genet. 25:160-165.
5. Brooke, H. G. 1892. Epithelioma adenoides cysticum. Br. J. Dermatol. 4:269-287.
6. Brummelkamp, T. R., S. M. Nijman, A. M. Dirac, and R. Bernards. 2003. Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB. Nature 424:797-801.
7. Cao, Z., J. Xiong, M. Takeuchi, T. Kurama, and D. V. Goeddel. 1996 TRAF6 is a signal transducer for interleukin-1. Nature 383:443-446.
8. Cvijic, M. E., G. Xiao, and S. C. Sun. 2003. Study of T-cell signaling by somatic cell mutagenesis and complementation cloning. J. Immunol. Methods 278:293-304.
9. Davis, R. J. 2000. Signal transduction by the JNK group of MAP kinases. Cell 103:239-252.
10. Deng, L., C. Wang, E. Spencer, L. Yang, A. Braun, J. You, C. Slaughter, C. Pickart, and Z. J. Chen. 2000. Activation of the IkB kinase complex by TRAF6 requires a dimeric ubiqutitin-conjugating enzyme complex and a unique polyubiquitin chain. Cell 103:351-361.
11. DiDonato, J. A., M. Hayakawa, D. M. Rothwarf, E. Zandi, and M. Karin. 1997. A cytokine-responsive IκB kinase that activates the transcription factor NF-κB. Nature 388:548-554.
12. Fischer, J. A. 2003. Deubiquitinating enzymes: their roles in development, differentiation, and disease. Int. Rev. Cytol. 229:43-72.
13. Habelhah, H., S. Takahashi, S. G. Cho, T. Kadoya, T. Watanabe, and Z. Ronai. 2003. Ubiquitination and translocation of TRAF2 is required for activation of JNK but not of p38 or NF-kappaB. EMBO J. 23:322-332.
14. Harhaj, E. W., L. Good, G.-T. Xiao, M. Uhlik, M. E. Cvijic, I. Rivera, and S.-C. Sun. 2000. Somatic mutagenesis studies of NF-kappa B signaling in human T cells: evidence for an essential role of IKK gamma in NF-kappa B activation by T-cell costimulatory signals and HTLV-I Tax protein. Oncogene 19:1386-1391.
15. Harhaj, E. W., and S.-C. Sun. 1999. Regulation of RelA subcellular localization by a putative nuclear export signal and p50. Mol. Cell. Biol. 19:7088-7095.
16. Hershko, A., and A. Ciechanover. 1998. The ubiquitin system. Annu. Rev. Biochem. 67:425-479.
17. Ip, Y. T., and R. J. Davis. 1998. Signal transduction by the c-Jun N-terminal kinase (JNK) - from inflammation to development. Curr. Opin. Cell Biol. 10:205-219.
18. Jensen, L. E., and A. S. Whitehead. 2003. Ubiquitin activated tumor necrosis factor receptor associated factor-6 (TRAF6) is recycled via deubiquitination. FEBS Lett. 553:190-194.
19. Karin, M., and Y. Ben-Neriah. 2000. Phosphorylation meets ubiquitination: the control of NF-κB activity. Annu. Rev. Immunol. 18:621-663.
20. Karin, M., and M. Delhase. 2000. The I kappa B kinase (IKK) and NF-kappa B: key elements of proinflammatory signalling. Semin. Immunol. 12:85-98.
21. Kim, J. H., K. C. Park, S. S. Chung, O. Bang, and C. H. Chung. 2003. Deubiquitinating enzymes as cellular regulators. J. Biochem. 134:9-18.
22. Kovalenko, A., C. Chable-Bessia, G. Cantarella, A. Israel, D. Wallach, and G. Courtois. 2003. The tumour suppressor CYLD negatively regulates NF-kappaB signalling by deubiquitination. Nature 424:801-805.
23. Lin, A., and B. Dibling. 2002. The true face of JNK activation in apoptosis. Aging Cell 1:112-116.
24. Lorick, K. L., J. P. Jensen, S. Fang, A. M. Ong, S. Hatakeyama, and A. M. Weissman. 1999. RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination. Proc. Natl. Acad. Sci. USA 96:11364-11369.
25. Manning, A. M., and R. J. Davis. 2003. Targeting JNK for therapeutic benefit: from junk to gold? Nat. Rev. Drug Discov. 2:554-565.
26. Naviaux, R. K., E. Costanzi, M. Haas, and I. M. Verma. 1996. The pCL vector system: rapid production of helper-free, high-liter, recombinant retroviruses. J. Virol. 70:5701-5705.
27. Ness, T. L., K. J. Carpenter, J. L. Ewing, C. J. Gerard, C. M. Hogaboam, and S. L. Kunkel. 2004. CCR1 and CC chemokine ligand 5 interactions exacerbate innate immune responses during sepsis. J. Immunol. 173:6938-6948.
28. Regamey, A., D. Hohl, J. W. Liu, T. Roger, P. Kogerman, R. Toftgard, and M. Huber. 2003. The tumor suppressor CYLD interacts with TRIP and regulates negatively nuclear factor kappaB activation by tumor necrosis factor. J. Exp. Med. 198:1959-1964.
29. Reiley, W., M. Zhang, and S.-C. Sun. 2004. Tumor suppressor negatively regulates JNK signaling pathway downstream of TNFR members. J. Biol. Chem. 279:55161-55167.
30. Rivera-Walsh, I., M. E. Cvijic, G. Xiao, and S. C. Sun. 2000. The NF-kappa B signaling pathway is not required for Fas ligand gene induction but mediates protection from activation-induced cell death. J. Biol. Chem. 275:25222-25230.
31. Rivera-Walsh, I., M. Waterfield, G. Xiao, A. Fong, and S.-C. Sun. 2001. NF-κB signaling pathway governs TRAIL gene expression and HTLV-I Tax-induced T-cell death. J. Biol. Chem. 276:40385-40388. (First published 11 September 2001; doi:10.1074/jbc.C100501200.)
32. Schwabe, R. F., R. Bataller, and D. A. Brenner. 2003. Human hepatic stellate cells express CCR5 and RANTES to induce proliferation and migration. Am. J. Physiol. Gastrointest. Liver Physiol. 285:G948-G95S.
33. Senftleben, U., Y. Cao, G. Xiao, G. Kraehn, F. Greten, Y. Chen, Y. Hu, A. Fong, S.-C. Sun, and M. Karin. 2001. Activation of IKKα of a second, evolutionary conserved, NF-κB signaling pathway. Science 293:1495-1499.
34. Shi, C. S., and J. H. Kehrl. 2003. TNF-induced GCKR and SAPK activation depends upon the E2/E3 complex Ubc13-Uev1A/TRAF2. J. Biol. Chem. 278:15429-15434.
35. Sil, A. K., S. Maeda, Y. Sano, D. R. Roop, and M. Karin. 2004. IkappaB kinase-alpha acts in the epidermis to control skeletal and craniofacial morphogenesis. Nature 428:660-664.
36. Silverman, N., and T. Maniatis. 2001. NF-κ signaling pathways in mammalian and insect innate immunity. Genes Dev. 15:2321-2342.
37. Spiegler, E. 1899. Ueber endotheliome der haut. Arch. Dermatol. Syphilol. 50:163-176.
38. Sun, L., L. Deng, C.-K. Ea, Z.-P. Xia, and Z. J. Chen. 2004. The TRAF6 ubiquitin ligase and TAK1 kinase mediate IKK activation by BCL10 and MALT1 in T lymphocytes. Mol. Cell 14:289-301.
39. Trompouki, E., E. Hatzivassiliou, T. Tsichritzis, H. Farmer, A. Ashworth, and G. Mosialos. 2003. CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members. Nature 424:793-796.
40. Uhlik, M., L. Good, G. Xiao, E. W. Harhaj, E. Zandi, M. Karin, and S.-C. Sun. 1998. NF-kappaB-inducing kinase and IkappaB kinase participate in human T-cell leukemia virus I Tax-mediated NF-kappaB activation. J. Biol. Chem. 273:21132-21136.
41. Wang, C., L. Deng, M. Hong, G. R. Akkaraju, J.-I. Inoue, and Z. J. Chen. 2001. TAK1 is a ubiquitin-dependent kinase of MKK and IKK. Nature 412:346-351.
42. Xiao, G., M. E. Cvijic, A. Fong, E. W. Harhaj, M. T. Uhlik, M. Waterfield, and S. C. Sun. 2001. Retroviral oncoprotein Tax induces processing of NF-kappaB2/p100 in T cells: evidence for the involvement of IKKalpha. EMBO J. 20:6805-6815.
43. Xiao, G., E. W. Harhaj, and S. C. Sun. 2001. NF-kappaB-inducing kinase regulates the processing of NF-kappaB2 p100. Mol. Cell 7:401-409.
44. Yamamoto, Y., and R. B. Gaynor. 2004. IkappaB kinases: key regulators of the NF-kappaB pathway. Trends Biochem. Sci. 29:72-79.
45. Yamamoto, Y., U. N. Verma, S. Prajapati, Y. T. Kwak, and R. B. Gaynor. 2003. Histone H3 phosphorylation by IKK-alpha is critical for cytokine-induced gene expression. Nature 423:655-659.