Regulation of IκB kinase (IKK) complex by IKKγ-dependent phosphorylation of the T-loop and C terminus of IKKβ

Journal of Biological Chemistry

Volumn 281, Issue 22, 2006, Pages 15268-15276

  Schomer Miller, Beth ^a   Higashimoto, Tomoyasu ^a   Lee, Yung Kang ^b   Zandi, Ebrahim ^a,c  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; COMPLEXATION; ENZYME KINETICS; YEAST;

ACTIVATION DOMAIN; AUTOPHOSPHORYLATION; PHOSPHORYLATION; RECONSTITUTION SYSTEMS;

ENZYMES;

I KAPPA B ALPHA; I KAPPA B KINASE; I KAPPA B KINASE GAMMA; MULTIPROTEIN COMPLEX; RECOMBINANT PROTEIN; SERINE;

ANIMAL CELL; ARTICLE; AUTOPHOSPHORYLATION; CARBOXY TERMINAL SEQUENCE; DOWN REGULATION; FIBROBLAST; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; AMINO ACID SUBSTITUTION; ANIMAL; BINDING SITE; BIOLOGICAL MODEL; CELL CULTURE; CHEMISTRY; ENZYMOLOGY; GENETICS; HUMAN; IN VITRO STUDY; METABOLISM; PHOSPHORYLATION; PROTEIN TERTIARY STRUCTURE; SACCHAROMYCES CEREVISIAE; SITE DIRECTED MUTAGENESIS;

AMINO ACID SUBSTITUTION; ANIMALS; BINDING SITES; CELLS, CULTURED; DOWN-REGULATION; HUMANS; I-KAPPA B KINASE; MICE; MODELS, BIOLOGICAL; MULTIPROTEIN COMPLEXES; MUTAGENESIS, SITE-DIRECTED; PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SACCHAROMYCES CEREVISIAE; SERINE;

EID: 33744948611     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M513793200     Document Type: Article

References (36)

1. Delhase, M., Hayakawa, M., Chen, Y., and Karin, M. (1999) Science 284, 309-313
2. DiDonato, J. A., Hayakawa, M., Rothwarf, D. M., Zandi, E., and Karin, M. (1997) Nature 388, 548-554
3. Mercurio, F., Zhu, H., Murray, B. W., Shevchenko, A., Bennett, B. L., Li, J., Young, D. B., Barbosa, M., Mann, M., Manning, A., and Rao, A. (1997) Science 278, 860-866
4. Zandi, E., Rothwarf, D. M., Delhase, M., Hayakawa, M., and Karin, M. (1997) Cell 91, 243-252
5. Rothwarf, D. M., Zandi, E., Natoli, G., and Karin, M. (1998) Nature 395, 297-300
6. Yamaoka, S., Courtois, G., Bessia, C., Whiteside, S. T., Weil, R., Agou, F., Kirk, H. E., Kay, R. J., and Israel, A. (1998) Cell 93, 1231-1240
7. Ghosh, S., and Karin, M. (2002) Cell 109, (suppl.) S81-S96
8. Siebenlist, U., Franzoso, G., and Brown, K. (1994) Annu. Rev. Cell Biol. 10, 405-455
9. Yaron, A., Hatzubai, A., Davis, M., Lavon, I., Amit, S., Manning, A. M., Andersen, J. S., Mann, M., Mercurio, F., and Ben-Neriah, Y. (1998) Nature 396, 590-594
10. Strack, P., Caligiuri, M., Pelletier, M., Boisclair, M., Theodoras, A., Beer-Romero, P., Glass, S., Parsons, T., Copeland, R. A., Auger, K. R., Benfield, P., Brizuela, L., and Rolfe, M. (2000) Oncogene 19, 3529-3536
11. Miller, B. S., and Zandi, E. (2001) J. Biol. Chem. 276, 36320-36326
12. Zandi, E., Chen, Y., and Karin, M. (1998) Science 281, 1360-1363
13. May, M. J., D'Acquisto, F., Madge, L. A., Glockner, J., Pober, J. S., and Ghosh, S. (2000) Science 289, 1550-1554
14. Takeda, K., Takeuchi, O., Tsujimura, T., Itami, S., Adachi, O., Kawai, T., Sanjo, H., Yoshikawa, K., Terada, N., and Akira, S. (1999) Science 284, 313-316
15. Hu, Y., Baud, V., Delhase, M., Zhang, P., Deerinck, T., Ellisman, M., Johnson, R., and Karin, M. (1999) Science 284, 316-320
16. Li, Q., Van Antwerp, D., Mercurio, F., Lee, K. F., and Verma, I. M. (1999) Science 284, 321-325
17. Dejardin, E., Droin, N. M., Delhase, M., Haas, E., Cao, Y., Makris, C., Li, Z. W., Karin, M., Ware, C. F., and Green, D. R. (2002) Immunity 17, 525-535
18. Claudio, E., Brown, K., Park, S., Wang, H., and Siebenlist, U. (2002) Nat. Immunol. 3, 958-965
19. Senftleben, U., Cao, Y., Xiao, G., Greten, F. R., Krahn, G., Bonizzi, G., Chen, Y., Hu, Y., Fong, A., Sun, S. C., and Karin, M. (2001) Science 293, 1495-1499
20. Huynh, Q. K., Boddupalli, H., Rouw, S. A., Koboldt, C. M., Hall, T., Sommers, C., Hauser, S. D., Pierce, J. L., Combs, R. G., Reitz, B. A., Diaz-Collier, J. A., Weinberg, R. A., Hood, B. L., Kilpatrick, B. F., and Tripp, C. S. (2000) J. Biol. Chem. 275, 25883-25891
21. May, M. J., Larsen, S. E., Shim, J. H., Madge, L. A., and Ghosh, S. (2004) J. Biol. Chem. 279, 45528-45539
22. Lomaga, M. A., Yeh, W. C., Sarosi, I., Duncan, G. S., Furlonger, C., Ho, A., Morony, S., Capparelli, C., Van, G., Kaufman, S., van der Heiden, A., Itie, A., Wakeham, A., Khoo, W., Sasaki, T., Cao, Z., Penninger, J. M., Paige, C. J., Lacey, D. L., Dunstan, C. R., Boyle, W. J., Goeddel, D. V., and Mak, T. W. (1999) Genes Dev. 13, 1015-1024
23. Krappmann, D., and Scheidereit, C. (2005) EMBO Rep. 6, 321-326
24. Wang, C., Deng, L., Hong, M., Akkaraju, G. R., Inoue, J., and Chen, Z. J. (2001) Nature 412, 346-351
25. Sun, L., Deng, L., Ea, C. K., Xia, Z. P., and Chen, Z. J. (2004) Mol. Cell 14, 289-301
26. Deng, L., Wang, C., Spencer, E., Yang, L., Braun, A., You, J., Slaughter, C., Pickart, C., and Chen, Z. J. (2000) Cell 103, 351-361
27. Abbott, D. W., Wilkins, A., Asara, J. M., and Cantley, L. C. (2004) Curr. Biol. 14, 2217-2227
28. Huang, T. T., Wuerzberger-Davis, S. M., Wu, Z. H., and Miyamoto, S. (2003) Cell 115, 565-576
29. Brummelkamp, T. R., Nijman, S. M., Dirac, A. M., and Bernards, R. (2003) Nature 424, 797-801
30. Kovalenko, A., Chable-Bessia, C., Cantarella, G., Israel, A., Wallach, D., and Courtois, G. (2003) Nature 424, 801-805
31. Trompouki, E., Hatzivassiliou, E., Tsichritzis, T., Farmer, H., Ashworth, A., and Mosialos, G. (2003) Nature 424, 793-796
32. Prajapati, S., Verma, U., Yamamoto, Y., Kwak, Y. T., and Gaynor, R. B. (2004) J. Biol. Chem. 279, 1739-1746
33. May, M. J., Marienfeld, R. B., and Ghosh, S. (2002) J. Biol. Chem. 277, 45992-46000
34. Li, Z. W., Chu, W., Hu, Y., Delhase, M., Deerinck, T., Ellisman, M., Johnson, R., and Karin, M. (1999) J. Exp. Med. 189, 1839-1845
35. Li, Q., Estepa, G., Memet, S., Israel, A., and Verma, I. M. (2000) Genes Dev. 14, 1729-1733
36. Brunet, A., Pages, G., and Pouyssegur, J. (1994) Oncogene 9, 3379-3387