메뉴 건너뛰기




Volumn 113, Issue 21, 2009, Pages 5228-5236

Biologic sequelae of IκB kinase (IKK) inhibition in multiple myeloma: Therapeutic implications

Author keywords

[No Author keywords available]

Indexed keywords

6 CHLORO 8 NICOTINAMIDO BETA CARBOLINE; AURORA A KINASE; BETA CATENIN; I KAPPA B KINASE; I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; I KAPPA B KINASE INHIBITOR; MLN 120B; TANESPIMYCIN; UNCLASSIFIED DRUG; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN SUBUNIT;

EID: 67149089043     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2008-06-161505     Document Type: Article
Times cited : (69)

References (49)
  • 2
    • 34547106018 scopus 로고    scopus 로고
    • Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets
    • Hideshima T, Mitsiades C, Tonon G, Richardson PG, Anderson KC. Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets. Nat Rev Cancer. 2007;7:585-598.
    • (2007) Nat Rev Cancer , vol.7 , pp. 585-598
    • Hideshima, T.1    Mitsiades, C.2    Tonon, G.3    Richardson, P.G.4    Anderson, K.C.5
  • 3
    • 0029874138 scopus 로고    scopus 로고
    • The NF-κB and IκB proteins: New discoveries and insights
    • DOI 10.1146/annurev.immunol.14.1.649
    • Baldwin AS Jr. The NF-κB and IκB proteins: new discoveries and insights. Annu Rev Immunol. 1996;14:649-683. (Pubitemid 26130197)
    • (1996) Annual Review of Immunology , vol.14 , pp. 649-683
    • Baldwin Jr., A.S.1
  • 8
    • 0030613551 scopus 로고    scopus 로고
    • The IκB kinase complex (IKK) contains two kinase subunits, IKKα and IKKβ, necessary for Iκb phosphorylation and NF-κB activation
    • DOI 10.1016/S0092-8674(00)80406-7
    • Zandi E, Rothwarf DM, Delhase M, Hayakawa M, Karin M. The IκB kinase complex (IKK) contains two kinase subunits, IKKα and IKKβ, necessary for IκB phosphorylation and NF-κB activation. Cell. 1997;91:243-252. (Pubitemid 27456391)
    • (1997) Cell , vol.91 , Issue.2 , pp. 243-252
    • Zandi, E.1    Rothwarf, D.M.2    Delhase, M.3    Hayakawa, M.4    Karin, M.5
  • 9
    • 25844459154 scopus 로고    scopus 로고
    • NF-κB: Linking inflammation and immunity to cancer development and progression
    • DOI 10.1038/nri1703
    • Karin M, Greten FR. NF-κB: linking inflammation and immunity to cancer development and progression. Nat Rev Immunol. 2005;5:749-759. (Pubitemid 41400849)
    • (2005) Nature Reviews Immunology , vol.5 , Issue.10 , pp. 749-759
    • Karin, M.1    Greten, F.R.2
  • 16
    • 33947586159 scopus 로고    scopus 로고
    • Aberrant NF-κB signaling in lymphoma: Mechanisms, consequences, and therapeutic implications
    • DOI 10.1182/blood-2006-07-025809
    • Jost PJ, Ruland J. Aberrant NF-κB signaling in lymphoma: mechanisms, consequences, and therapeutic implications. Blood. 2007;109:2700-2707. (Pubitemid 46482061)
    • (2007) Blood , vol.109 , Issue.7 , pp. 2700-2707
    • Jost, P.J.1    Ruland, J.2
  • 17
    • 33845768987 scopus 로고    scopus 로고
    • Integrating cell-signalling pathways with NF-κB and IKK function
    • DOI 10.1038/nrm2083, PII NRM2083
    • Perkins ND. Integrating cell-signalling pathways with NF-κB and IKK function. Nat Rev Mol Cell Biol. 2007;8:49-62. (Pubitemid 46012014)
    • (2007) Nature Reviews Molecular Cell Biology , vol.8 , Issue.1 , pp. 49-62
    • Perkins, N.D.1
  • 23
    • 33751200630 scopus 로고    scopus 로고
    • IKKα regulates the mitotic phase of the cell cycle by modulating Aurora a phosphorylation
    • Prajapati S, Tu Z, Yamamoto Y, Gaynor RB. IKKα regulates the mitotic phase of the cell cycle by modulating Aurora A phosphorylation. Cell Cycle. 2006;5:2371-2380. (Pubitemid 44785847)
    • (2006) Cell Cycle , vol.5 , Issue.20 , pp. 2371-2380
    • Prajapati, S.1    Tu, Z.2    Yamamoto, Y.3    Gaynor, R.B.4
  • 26
    • 0036009115 scopus 로고    scopus 로고
    • NF-κB at the crossroads of life and death
    • Karin M, Lin A. NF-κB at the crossroads of life and death. Nat Immunol. 2002;3:221-227.
    • (2002) Nat Immunol , vol.3 , pp. 221-227
    • Karin, M.1    Lin, A.2
  • 27
    • 33645999706 scopus 로고    scopus 로고
    • NF-κB and IKK as therapeutic targets in cancer
    • Kim HJ, Hawke N, Baldwin AS. NF-κB and IKK as therapeutic targets in cancer. Cell Death Differ. 2006;13:738-747.
    • (2006) Cell Death Differ , vol.13 , pp. 738-747
    • Kim, H.J.1    Hawke, N.2    Baldwin, A.S.3
  • 28
    • 33947202249 scopus 로고    scopus 로고
    • Nuclear factor-κB in development, prevention, and therapy of cancer
    • DOI 10.1158/1078-0432.CCR-06-2221
    • Van Waes C. Nuclear factor-κB in development, prevention, and therapy of cancer. Clin Cancer Res. 2007;13:1076-1082. (Pubitemid 46424045)
    • (2007) Clinical Cancer Research , vol.13 , Issue.4 , pp. 1076-1082
    • Van Waes, C.1
  • 32
  • 35
    • 0035933772 scopus 로고    scopus 로고
    • Inhibition of NF-κB Activity by Thalidomide through Suppression of IκB Kinase Activity
    • DOI 10.1074/jbc.M100938200
    • Keifer JA, Guttridge DC, Ashburner BP, Baldwin AS Jr. Inhibition of NF-κB activity by thalidomide through suppression of IκB kinase activity. J Biol Chem. 2001;276:22382-22387. (Pubitemid 37410912)
    • (2001) Journal of Biological Chemistry , vol.276 , Issue.25 , pp. 22382-22387
    • Keifer, J.A.1    Guttridge, D.C.2    Ashburner, B.P.3    Baldwin Jr., A.S.4
  • 40
    • 20144363221 scopus 로고    scopus 로고
    • 1′-acetoxychavicol acetate is a novel nuclear factor κB inhibitor with significant activity against multiple myeloma in vitro and in vivo
    • DOI 10.1158/0008-5472.CAN-05-0072
    • Ito K, Nakazato T, Xian MJ, et al. 1′-acetoxychavicol acetate is a novel nuclear factor κB inhibitor with significant activity against multiple myeloma in vitro and in vivo. Cancer Res. 2005;65:4417-4424. (Pubitemid 40775681)
    • (2005) Cancer Research , vol.65 , Issue.10 , pp. 4417-4424
    • Ito, K.1    Nakazato, T.2    Xian, M.J.3    Yamada, T.4    Hozumi, N.5    Murakami, A.6    Ohigashi, H.7    Ikeda, Y.8    Kizaki, M.9
  • 43
    • 0033624920 scopus 로고    scopus 로고
    • IκB kinase α (IKKα) regulation of IKKβ kinase activity
    • Yamamoto Y, Yin MJ, Gaynor RB. IκB kinase α (IKKα) regulation of IKKβ kinase activity. Mol Cell Biol. 2000;20:3655-3666.
    • (2000) Mol Cell Biol , vol.20 , pp. 3655-3666
    • Yamamoto, Y.1    Yin, M.J.2    Gaynor, R.B.3
  • 44
    • 0442307969 scopus 로고    scopus 로고
    • IκB kinases: Key regulators of the NF-κB pathway
    • DOI 10.1016/j.tibs.2003.12.003
    • Yamamoto Y, Gaynor RB. IκB kinases: key regulators of the NF-κB pathway. Trends Biochem Sci. 2004;29:72-79. (Pubitemid 38186577)
    • (2004) Trends in Biochemical Sciences , vol.29 , Issue.2 , pp. 72-79
    • Yamamoto, Y.1    Gaynor, R.B.2
  • 47
    • 3142719113 scopus 로고    scopus 로고
    • Requirement of Hsp90 activity for IκB kinase (IKK) biosynthesis and for constitutive and inducible IKK and NF-κB activation
    • DOI 10.1038/sj.onc.1207705
    • Broemer M, Krappmann D, Scheidereit C. Requirement of Hsp90 activity for IκB kinase (IKK) biosynthesis and for constitutive and inducible IKK and NF-κB activation. Oncogene. 2004;23:5378-5386. (Pubitemid 39005813)
    • (2004) Oncogene , vol.23 , Issue.31 , pp. 5378-5386
    • Broemer, M.1    Krappmann, D.2    Scheidereit, C.3
  • 48
    • 0030041147 scopus 로고    scopus 로고
    • Multiple myeloma cell adhesion-induced interleukin-6 expression in bone marrow stromal cells involves activation of NF-κB
    • Chauhan D, Uchiyama H, Akbarali Y, et al. Multiple myeloma cell adhesion-induced interleukin-6 expression in bone marrow stromal cells involves activation of NF-κB. Blood. 1996;87:1104-1112. (Pubitemid 26043538)
    • (1996) Blood , vol.87 , Issue.3 , pp. 1104-1112
    • Chauhan, D.1    Uchiyama, H.2    Akbarali, Y.3    Urashima, M.4    Yamamoto, K.-I.5    Libermann, T.A.6    Anderson, K.C.7
  • 49
    • 0038369758 scopus 로고    scopus 로고
    • Cell adhesion-mediated drug resistance (CAM-DR) is associated with activation of NF-κB (RelB/p50) in myeloma cells
    • DOI 10.1038/sj.onc.1206315
    • Landowski TH, Olashaw NE, Agrawal D, Dalton WS. Cell adhesion-mediated drug resistance (CAM-DR) is associated with activation of NF-κB (RelB/p50) in myeloma cells. Oncogene. 2003;22:2417-2421. (Pubitemid 36560725)
    • (2003) Oncogene , vol.22 , Issue.16 , pp. 2417-2421
    • Landowski, T.H.1    Olashaw, N.E.2    Agrawal, D.3    Dalton, W.S.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.