The crystal structure of the catalytic domain of the NF-κB inducing kinase reveals a narrow but flexible active site

Structure

Volumn 20, Issue 10, 2012, Pages 1704-1714

  De Leon Boenig, Gladys ^a   Bowman, Krista K ^a   Feng, Jianwen A ^a   Crawford, Terry ^a   Everett, Christine ^a   Franke, Yvonne ^a   Oh, Angela ^a   Stanley, Mark ^a   Staben, Steven T ^a   Starovasnik, Melissa A ^a   Wallweber, Heidi J A ^a   Wu, Jiansheng ^a   Wu, Lawren C ^a   Johnson, Adam R ^a   Hymowitz, Sarah G ^a  

^a GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NF KAPPA B INDUCING KINASE; PROTEIN KINASE; UNCLASSIFIED DRUG;

ARTICLE; AUTOIMMUNE DISEASE; BINDING AFFINITY; CHEMICAL STRUCTURE; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME STRUCTURE; HEMATOLOGIC MALIGNANCY; HUMAN; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; CATALYTIC DOMAIN; CONSERVED SEQUENCE; CRYSTALLOGRAPHY, X-RAY; HUMANS; HYDROGEN BONDING; KINETICS; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, SECONDARY; PROTEIN-SERINE-THREONINE KINASES; STRUCTURAL HOMOLOGY, PROTEIN;

MURINAE; PYRONIA TITHONUS;

EID: 84867339398     PISSN: 09692126     EISSN: 18784186     Source Type: Journal    
DOI: 10.1016/j.str.2012.07.013     Document Type: Article

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