Phosphorylation of SNAP-23 by IκB Kinase 2 Regulates Mast Cell Degranulation

Cell

Volumn 134, Issue 3, 2008, Pages 485-495

  Suzuki, Kotaro ^a   Verma, Inder M ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

Author keywords

CELLBIO; CELLIMMUNO; MOLIMMUNO

Indexed keywords

I KAPPA B KINASE; I KAPPA B KINASE 2; IMMUNOGLOBULIN E; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MUTANT PROTEIN; SNARE PROTEIN; SYNAPTOSOMAL ASSOCIATED PROTEIN 23;

ALLERGIC REACTION; ANAPHYLAXIS; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; MAST CELL DEGRANULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM;

EID: 48449094278     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cell.2008.05.050     Document Type: Article

References (40)

1. Bischoff S.C. Role of mast cells in allergic and non-allergic responses: comparison of human and murine data. Nat. Rev. Immunol. 7 (2007) 93-104
2. Chamberlain L.H., and Roche P.A. SNARE proteins are highly enriched in lipid rafts in PC12 cells: implications for the spatial control of exocytosis. Proc. Natl. Acad. Sci. USA 98 (2001) 5619-5624
3. Correa R.G., Matsui T., Tergaonkar V., Rodriguez-Esteban C., Izpisua-Belmonte J.C., and Verma I.M. Zebrafish IkB kinase 1 negatively regulates NF-kB activity. Curr. Biol. 15 (2005) 1291-1295
4. Demo S.D., Masuda E., Rossi A.B., Throndset B.T., Gerald A.L., Chan E.H., Armstrong R.J., Fox B.P., Lorens J.B., Payan D.G., et al. Quantitative measurement of mast cell degranulation using a novel flow cytometric annexin-V binding assay. Cytometry 36 (1999) 340-348
5. Galli S.J., Nakase S., and Tsai M. Mast cells in the development of adaptive immune responses. Nat. Immunol. 6 (2005) 135-142
6. Galli S.J., Kalesnikoff J., Grimbaldeston M.A., Piliponsky A.M., Williams C.M., and Tsai M. Mast cells as "tunable" effector and immunoregulatory cells: recent advances. Annu. Rev. Immunol. 23 (2005) 749-786
7. Gringhuis S.I., Garcia-Vallejo J.J., van het Hof B., and van Dijk W. Convergent actions of IkB kinase β and protein kinase Cδ modulate mRNA stability through phosphorylation of 14-3-3β complexed with tristetraprolin. Mol. Cell. Biol. 25 (2005) 6454-6463
8. Guo Z., Turner C., and Castle D. Relocation of the t-SNARE SNAP-23 from lamellipodia-like cell surface projections regulates compound exocytosis in mast cells. Cell 94 (1998) 537-548
9. Hayden M.S., and Ghosh S. Signaling to NF-kB. Genes Dev. 18 (2004) 2195-2224
10. Hepp R., Puri N., Hohenstein A.C., Crawford G.L., Whiteheart S.W., and Roche P.A. Phosphorylation of SNAP-23 regulates exocytosis from mast cells. J. Biol. Chem. 280 (2005) 6610-6620
11. Hu M.C.-T., Lee D.F.-F., Xia W., Golfman L.S., Ou-Yang F., Yang J.-Y., Zou Y., Bao S., Hanada N., Saso H., et al. IkB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a. Cell 117 (2004) 225-237
12. Jahn R., and Sudhof T.C. Membrane fusion and exocytosis. Annu. Rev. Biochem. 68 (1999) 863-911
13. Karin M., and Ben-Neriah Y. Phosphorylation meets ubiquitination: the control of NF-kB activity. Annu. Rev. Immunol. 18 (2000) 621-663
14. Kay J.G., Murray R.Z., Pagan J.K., and Stow J.L. Cytokine secretion via cholesterol-rich lipid raft-associated SNAREs at the phagocytic cup. J. Biol. Chem. 281 (2006) 11949-11954
15. Klemm S., Gutermuth J., Hultner L., Sparwasser T., Behrendt H., Peschel C., Mak T.W., Jakob T., and Ruland J. The Bcl10-Malt1 complex segregates FcεRI-mediated nuclear factor κB activation and cytokine production from mast cell degranulation. J. Exp. Med. 203 (2006) 337-347
16. Lawrence T., Bebien M., Liu G.Y., Nizet V., and Karin M. IKKα limits macrophage NF-kB activation and contributes to the resolution of inflammation. Nature 434 (2005) 1138-1143
17. Lee S., Andrieu C., Saltel F., Destaing O., Auclair J., Pouchkine V., Michelon J., Salaun B., Kobayashi R., Jurdic P., et al. IkB kinase β phosphorylates Dok1 serines in response to TNF, IL-1, or γ radiation. Proc. Natl. Acad. Sci. USA 101 (2004) 17416-17421
18. Li Q., and Verma I.M. NF-kB regulation in the immune system. Nat. Rev. Immunol. 2 (2002) 725-734
19. Li Q., Van Antwerp D., Mercurio F., Lee K.-F., and Verma I.M. Severe liver degeneration in mice lacking the IkB kinase 2 gene. Science 284 (1999) 321-325
20. Li Q., Lu Q., Hwang J.Y., Buscher D., Lee K.-F., Izpisua-Belmonte J.C., and Verma I.M. IKK1-deficient mice exhibit abnormal development of skin and skeleton. Genes Dev. 13 (1999) 1322-1328
21. Li Q., Lu Q., Bottero V., Estepa G., Morrison L., Mercurio F., and Verma I.M. Enhanced NF-kB activation and cellular function in macrophages lacking IkB kinase 1 (IKK1). Proc. Natl. Acad. Sci. USA 102 (2005) 12425-12430
22. Li Q., Estepa G., Memet S., Israel A., and Verma I.M. Complete lack of NF-kB activity in IKK1 and IKK2 double-deficient mice: additional defect in neurulation. Genes Dev. 14 (2000) 1729-1733
23. Lin R.C., and Scheller R.H. Mechanisms of synaptic vesicle exocytosis. Annu. Rev. Cell Dev. Biol. 16 (2000) 19-49
24. Martin-Verdeaux S., Pombo I., Iannascoli B., Roa M., Varin-Blank N., Rivera J., and Blank U. Evidence of a role for Munc18-2 and microtubules in mast cell granule exocytosis. J. Cell Sci. 116 (2003) 325-334
25. Marash M., and Gerst J.E. t-SNARE dephosphorylation promotes SNARE assembly and exocytosis in yeast. EMBO J. 20 (2001) 411-421
26. Mercurio F., Zhu H., Murray B.W., Shevchenko A., Benenett B.L., Wu Li J., Young D.B., Barbosa M., Mann M., Manning A., et al. IKK-1 and IKK-2: cytokine-activated IkB kinases essential for NF-kB activation. Science 278 (1997) 860-866
27. Miesenbock G., De Angelis D.A., and Rothman J.E. Visualizing secretion and synaptic transmission with pH-sensitive green fluorescent proteins. Nature 394 (1998) 192-195
28. Paumet F., Mao J.L., Martin S., Galli T., David B., Blank U., and Roa M. Soluble NSF attachment protein receptors (SNAREs) in RBL-2H3 mast cells: functional role of syntaxin 4 in exocytosis and identification of vesicle-associated membrane protein 8-containing secretory compartment. J. Immunol. 164 (2000) 5850-5857
29. Peng Y., Power M.R., Li B., and Lin T.-J. Inhibition of IKK down-regulates antigen + IgE-induced TNF production by mast cells: a role for IKK-IκB-NF-κB pathway in IgE-dependent mast cell activation. J. Leukoc. Biol. 77 (2005) 975-983
30. Perkins N.D. Integrating cell-signaling pathways with NF-kB and IKK function. Nat. Rev. Mol. Cell Biol. 8 (2007) 49-62
31. Puri N., and Roche P.A. Ternary SNARE complexes are enriched in lipid rafts during mast cell exocytosis. Traffic 7 (2006) 1482-1494
32. Salaun C., Gould G.W., and Chamberlain L.H. Lipid raft association of SNARE proteins regulates exocytosis in PC12 cells. J. Biol. Chem. 280 (2005) 19449-19453
33. Scheidereit C. IkB kinase complexes: gateways to NF-kB activation and transcription. Oncogene 25 (2006) 6685-6705
34. Shambharkar P.B., Blonska M., Pappu B.P., Li H., You Y., Sakurai H., Darnay B.G., Hara H., Penninger J., and Lin X. Phosphorylation and ubiquitination of the IκB kinase complex by two distinct signaling pathways. EMBO J. 26 (2007) 1794-1805
35. Shen J., Tareste D.C., Paumet F., Rothman J.E., and Melia T.J. Selective activation of cognate SNAREpins by Sec1/Munc18 proteins. Cell 128 (2007) 183-195
36. Thome M., and Tschopp J. TCR-induced NF-kB activation: a crucial role for Carma1, Bcl10 and MALT1. Trends Immunol. 24 (2003) 419-424
37. Thome M. CARMA1, BCL-10 and MALT1 in lymphocyte development and activation. Nat. Rev. Immunol. 4 (2004) 348-359
38. Vicogne J., Vollenweider D., Smith J.R., Huang P., Frohman M.A., and Pessin J.E. Asymmetric phospholipid distribution drives in vitro reconstituted SNARE-dependent membrane fusion. Proc. Natl. Acad. Sci. USA 103 (2006) 14761-14766
39. Weber T., Zemelman B.V., McNew J.A., Westermann B., Gmachl M., Parlati F., Sollner T.H., and Rothman J.E. SNAREpins: minimal machinery for membrane fusion. Cell 92 (1998) 759-772
40. Wegener E., Oeckinghaus A., Papadopoulou N., Lavitas L., Schmidt-Supprian M., Ferch U., Mak T.W., Ruland J., Heissmeyer V., and Krappmann D. Essential role for IkB kinase β in remodeling Carma1-Bcl10-Malt1 complexes upon T cell activation. Mol. Cell 23 (2006) 13-23