NADPH oxidase-dependent reactive oxygen species mediate amplified TLR4 signaling and sepsis-induced mortality in Nrf2-deficient mice

Journal of Immunology

Volumn 185, Issue 1, 2010, Pages 569-577

  Kong, Xiaoni ^a   Thimmulappa, Rajesh ^a   Kombairaju, Ponvijay ^a   Biswal, Shyam ^a,b  

^a The Johns Hopkins University   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTATHIONE; I KAPPA B; INTERFERON REGULATORY FACTOR 3; LIPOPOLYSACCHARIDE; MYELOID DIFFERENTIATION FACTOR 88; PROTEIN KINASE C; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR ADAPTOR MOLECULE 1; TRANSCRIPTION FACTOR NRF2; AUTACOID; CYBB PROTEIN, MOUSE; MEMBRANE PROTEIN; NFE2L2 PROTEIN, MOUSE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; TLR4 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CYTOKINE PRODUCTION; INFLAMMATORY DISEASE; INNATE IMMUNITY; KNOCKOUT MOUSE; LUNG INJURY; MACROPHAGE; MORTALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SEPSIS; SIGNAL TRANSDUCTION; SURVIVAL; ANIMAL; C57BL MOUSE; DRUG ANTAGONISM; GENETICS; IMMUNOLOGY; LUNG; LUNG ALVEOLUS MACROPHAGE; METABOLISM; MOUSE MUTANT; PATHOLOGY; PERITONEUM MACROPHAGE; PHYSIOLOGY;

ANIMALS; INFLAMMATION MEDIATORS; LIPOPOLYSACCHARIDES; LUNG; MACROPHAGES, ALVEOLAR; MACROPHAGES, PERITONEAL; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NADPH OXIDASE; NF-E2-RELATED FACTOR 2; REACTIVE OXYGEN SPECIES; SEPSIS; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4;

EID: 77956193657     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0902315     Document Type: Article

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