Myelopoietin, an engineered chimeric IL-3 and G-CSF receptor agonist, stimulates multilineage hematopoietic recovery in a nonhuman primate model of radiation-induced myelosuppression

Blood

Volumn 95, Issue 3, 2000, Pages 837-845

  MacVittie, Thomas J ^a   Farese, Ann M ^b   Smith, Walter G ^b   Baum, Charles M ^b   Burton, Earl ^b   McKearn, John P ^b  

^a UNIVERSITY OF MARYLAND   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CHIMERIC PROTEIN; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE COLONY STIMULATING FACTOR RECEPTOR; HUMAN SERUM ALBUMIN; INTERLEUKIN 3; MYELOPOIETIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW SUPPRESSION; CLONOGENESIS; CONTROLLED STUDY; GENETIC ENGINEERING; HEMATOPOIESIS; NEUTROPENIA; NONHUMAN; PRIORITY JOURNAL; RADIATION DOSE; RECEPTOR BINDING; RHESUS MONKEY;

EID: 0034141809     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v95.3.837.003k08_837_845     Document Type: Article

References (62)

1. Morstyn G, Campbell L, Souza LM, et al. Effect of granulocyte colony stimulating factor on neutropenia induced by cytotoxic chemotherapy. Lancet. 1988;1:668.
2. Sheridan WP, Morstyn G, Wolf M, et al. Granulocyte colony-stimulating factor and neutrophil recovery after high-dose chemotherapy and autologous bone marrow transplantation. Lancet. 1989; 2:891.
3. Antman KS, Griffin JD, Elias A, et al. Effect of recombinant human granulocyte-macrophage colony-stimulating factor on chemotherapy-induced myelosuppression. N Engl J Med. 1988; 319:593.
4. Vadhan-Raj S, Keating M, LeMaistre PL, et al. Effects of recombinant human granulocyte-macrophage colony-stimulating factor in patients with myelodysplastic syndrome. N Engl J Med. 1987; 317:1545.
5. Moore JO, Dodge RK, Amrein PC, et al. Granulocyte-colony stimulating factor (Filgrastim) accelerates granulocyte recovery after intensive post-remission chemotherapy for acute myeloid leukemia with aziridinyl benzoquinone and mitoxantrone: Cancer and Leukemia Group B Study 9022. Blood. 1997;89:780.
6. Crawford J, Ozer H, Stoller R, et al. Reduction by granulocyte-colony stimulating factor of fever and neutropenia induced by chemotherapy in patients with small-cell lung cancer. N Engl J Med. 1991; 325:164.
7. Rowe JM, Anderson JW. Mazza JJ, et al. A randomized placebo-controlled phase III study of granulocyte-macrophage colony-stimulating factor in adult patients (>55 to 70 years of age) with acute myelogenous leukemia: a study of the Eastern Cooperative Oncology Group (E1490). Blood. 1995;86:457.
8. Akahori H, Shibuya A, Obuchi M, et al. Effect of recombinant human thrombopoietin in nonhuman primates with chemotherapy-induced thrombocytopenia. Br J Haematol. 1996;94:722.
9. Grossman A, Lenox J, Ren HP, et al. Thrombopoietin accelerates platelet, red blood cell, and neutrophilic recovery in myelosuppressed mice. Exp Hematol. 1996;24:1238.
10. Shibuya K, Akahori H, Takahashi K, Tahara E, Kato T, Miyazaki H. Multilineage hematopoietic recovery by a single injection of pegylated recombinant human megakaryocyte growth and development factor in myelosuppressed mice. Blood. 1998;91:37.
11. Farese AM, Hunt P, Grab LB, MacVittie TJ. Combined administration of recombinant human megakaryocyte growth and development factor and granulocyte colony-stimulating factor enhances multilineage hematopoietic reconstitution in nonhuman primates after radiation-induced marrow aplasia. J Clin Invest. 1996;97:2145.
12. Harker LA, Marzec UM, Kelly AB, et al. Prevention of thrombocytopenia and neutropenia in a nonhuman primate model of marrow suppressive chemotherapy by combining pegylated recombinant human megakaryocyte growth and development factor and recombinant human granulocyte colony-stimulating factor. Blood. 1997;89:155.
13. Du XX, Keller D, Goldman S, Williams DA. Functional effects of interleukin-11 treatment in vivo following bone marrow transplantation (BMT) and combined modality therapy in mice [abstract]. Exp Hematol. 1992;20:768a.
14. Du XX, Neben T, Goldman S, Williams DA. Effects of recombinant interleukin-11 on hematopoietic reconstitution in transplant mice: acceleration of recovery of peripheral blood neutrophils and platelets. Blood. 1993;81:27.
15. Leonard JP, Quinto CM, Goldman SJ, Kozitza MK, Neben TY. Recombinant human interleukin-11(rhIL-11) multilineage hematopoietic recovery in mice after a myelosuppressive regimen of sublethal irradiation and carboplatin. Blood. 1994;83: 1499.
16. Isaacs C, Robert NJ, Bailey FA, et al. Randomized placebo-controlled study of recombinant human interleukin-11 to prevent chemotherapy-induced thrombocytopenia in patients with breast cancer receiving dose-intensive cyclophosphamide and doxorubicin. J Clin Oncol. 1997;15:3368.
17. Neelis KJ, Dubbelman YD, Qingliang L, Thomas GR, Eaton DL. Wagemaker G. Simultaneous administration of TPO and G-CSF after cytoreductive treatment of rhesus monkeys prevents thrombocytopenia, accelerates platelet and red cell reconstitution, alleviates neutropenia, and promotes the recovery of immature bone marrow cells. Exp Hematol. 1997;25:1084.
18. Farese A, MacVittie TJ, Lind LB, Smith WG, McKearn JP. The combined administration of daniplestim and MpL ligand augments the hematopoietic reconstitution observed with single cytokine administration in a nonhuman primate model of myelosuppression. In: Murphy MJ, Kutner DJ, eds. Thrombopoietin: From Molecule to Medicine. Miamisburg: AlphaMed Press; 1998:143.
19. Monahan JB, Hood WF, Joy WD, et at. Functional characterization of SC 68420 - a multifunctional agonist which activates both IL3 and G-CSF receptors. Blood. 1995;86:154a (abstract).
20. McKearn JP, Hood WF, Monahan JB, et al. Myelopoietin - a multifunctional agonist of human IL-3 and G-CSF receptors. Blood. 1995; 86:259a (abstract).
21. Kahn LE, Staten NR, Wood DC, et al. Development of engineered hematopoietic growth factors for multilineage expansion and maturation of CD34+ progenitors. Exp Hematol. 1996;24:1072 (abstract).
22. Kahn LE, Blystone LW, Villani-Price D, et al. In vitro and in vivo biology of an engineered novel factor for expansion and development of platelet producing cells. Blood. 1996;88: 351a (abstract).
23. Giri JG, Kahn LE, Staten NR, et al. An engineered novel factor for expansion and development of platelet producing cells. Exp Hematol. 1996;24:1072 (abstract).
24. Giri JG, Kahn LE, Doshi PD, et al. Promegapoietin, an engineered chimeric growth factor for platelet producing cells. Blood. 1996;88:351a (abstract).
25. McNiece IK, McGrath HE. Granulocyte colony-stimulating factor augments in vitro megakaryocyte colony formation by interleukin-3. Exp Hematol. 1988;16:807.
26. Paquette RL, Zhou JY, Yang YC, Clark SC, Koeffler HP. Recombinant gibbon interleukin-3 acts synergistically with recombinant human G-CSF and GM-CSF in vitro. Blood. 1988;71:1596.
27. McNiece IK, Andrews R, Stewart M, Clark S, Boone T, Quesenberry P. Action of interleukin-3, G-CSF, and GM-CSF on highly enriched human hematopoietic progenitor cells: Synergistic interaction of GM-CSF plus G-CSF. Blood. 1989;74: 110.
28. Ikebuchi K, Wong GG, Clark SC, Ihle JN, Hirai T, Ogawa M. Interleukin-6 enhancement of interteukin 3-dependent proliferation of multipotential hemopoietic progenitors. Proc Natl Acad Sci U S A. 1987;84:9035.
29. Krumwieh D, Weinmann E, Seiler FR. Different effects of interteukin-3 (IL-3) on the hematopoiesis of subhuman primates due to various combinations with granulocyte-macrophage colony-stimulating factor (GM-CSF) and granulocyte colony stimulating factor (G-CSF). Int J Cell Cloning. 1990;8:229.
30. Ulich TR, Del Castillo J, McNiece IK, et al. Acute and subacute hematologic effects of multi-colony stimulating factor in combination with granulocyte colony-stimulating factor in vivo. Blood. 1990; 75:48.
31. Farese AM, Herodin F, Grab LB, et al. Acceleration of hematopoietic reconstitution with a synthetic cytokine (SC-55494) after radiation-induced marrow aplasia. Blood. 1996;87:581.
32. Aglietta M, Sanavio F, Stacchini A, et al. Interleukin-3 in vivo: kinetic of response of target cells. Blood. 1993;82:2054.
33. MacVittie TJ, Farese AM, Herodin F, Grab LB, Baum CM, McKearn JP. Combination therapy of radiation-induced bone marrow aplasia in nonhuman primates using synthokine SC-55494 and recombinant human granulocyte colony-stimulating factor. Blood. 1996;87:4129.
34. Winton EF, Srinivasiah J, Kim BK, et al. Effect of recombinant human interteukin-6 and rhIL-3 on hematopoietic regeneration as demonstrated in a nonhuman primate chemotherapy model. Blood. 1994;84:65.
35. The Institute of Laboratory Animal Resources, National Research Council. Guide for the Care and Use of Laboratory Animals. Washington, DC: National Institutes of Health; 1996:86-23.
36. van Gils F, Budel L, Burger H, van Leen R, Lowenberg B, Wagemaker G. Interleukin-3 (IL-3) receptors on rhesus monkey cells: species specificity of human IL-3, binding characteristics, and lack of competition with GM-CSF. Exp Hematol. 1994;22:248.
37. Klein B, Thomas J, Klover J, et al. Comparison of daniptestim and human interleukin-3: impact of structure on functional activity. Blood. 1998;92: 174b (abstract).
38. Donahue RE, Seehra J, Metzger M, et al. Human IL-3 and GM-CSF act synergistically in stimulating hematopoiesis in primates. Science. 1988; 241:1820.
39. Winton EF, Hillyer CD, Srinivasiah J, et al. A nonhuman primate model for the study of effects of cytokines on hematopoietic reconstitution following chemotherapy-induced marrow damage. In: MacVittie TJ, Weiss JF, Browne D, eds. Advances in the Treatment of Radiation Injuries: Advances in the Biosciences. Great Britain: Pergamon; 1994:75.
40. Wagemaker G, van Gils FCJM, Burger H, et al. Highly increased production of bone marrow derived blood cells by administration of homologous interleukin-3 to rhesus monkeys. Blood. 1990;76: 2235.
41. Collins MK, Marvel J, Malde P, Lopez-Rivas A. Interleukin-3 protects murine bone marrow cells from apoptosis induced by DNA damaging agents. J Exp Med. 1992;176:1043.
42. Collins MKL, Perkins GR, Rodriguez-Tarduchy G, Nieto MA, Lopez-Rivas A. Growth factors as survival factors: regulation of apoptosis. Bioessays. 1994;16:133.
43. Bodine D, Crosier P, Clark SC. Effects of hematopoietic growth factors on the survival of primitive stem cells in liquid suspension culture. Blood. 1991;78:914.
44. Brandt JE, Bhalla K, Hoffman R. Effects of interleukin-3 and c-kit ligand on the survival of various classes of human hematopoietic progenitor cells. Blood. 1994;83:1507.
45. Yee NS, Paek I, Besmer P. Role of kit-ligand in proliferation and suppression of apoptosis in mast cells: basis for radiosensitivity of white spotting and steel mutant mice. J Exp Med. 1994;179:1777.
46. Williams GT, Smith CA, Spooncer E, Dexter TM, Taylor DR. Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosis. Nature. 1990;343:76.
47. Lin Y, Benchimol S. Cytokines inhibit p53-mediated apoptosis but not G1 arrest. Mol Cell Biol. 1995;15:6045.
48. Silva A, Wyllie A, Collins MKL. p53 is not required for regulation of apoptosis or radioprotection by interleukin-3. Blood. 1997;89:2717.
49. Farese AM, Williams DE, Seiler FR, MacVittie TJ. Combination protocols of cytokine therapy with interleukin-3 and granulocyte-macrophage colony-stimulating factor in a primate model of radiation-induced marrow aplasia. Blood. 1993; 82:3012.
50. MacVittie TJ, Farese AM, Patchen ML, Myers LA. Therapeutic efficacy of recombinant interleukin-6 alone and combined with recombinant human IL-3 in a nonhuman primate model of high-dose, sublethal radiation-induced marrow aplasia. Blood. 1994;84:2515.
51. Gonter PW, Hillyer CD, Strobert EA, et al. Enhanced post-chemotherapy platelet and neutrophil recovery using IL-6 and rhGM-CSF in a nonhuman primate model. Blood. 1993;82:365a (abstract).
52. Gonter PW, Hillyer CD, Strobert EA, et al. The effect of varying ratios of administered rhIL-3 and rhGM-CSF on post-chemotherapy marrow regeneration in a nonhuman primate model. Blood. 1993;82:365a (abstract).
53. Farese AM, Myers LA, MacVittie TJ. Therapeutic efficacy of the combined administration of either recombinant human interleukin-6 and rh-granulocyte colony stimulating factor or rh-granulocyte-macrophage colony stimulating factor in a primate model of radiation-induced marrow aplasia. Exp Hematol. 1994;22:684a (abstract).
54. Williams DE, Dunn JT, Park LS, et al. AGM-CSF/ IL-3 fusion protein promotes neutrophil and platelet recovery in sublethally irradiated rhesus monkeys. Biotechnol Ther. 1993;4:17.
55. Monahan JB, Hood WF, Joy WD, et al. Receptor binding and signalling characteristics of MPO-1 (SC-68420) - a multifunctional IL-3 and G-CSF receptor agonist. Exp Hematol. 1996;24:1154 (abstract).
56. McKearn J, Monahan J, Hood W, et al. Myelopoietin - a multifunctional chimeric protein family. Exp Hematol. 1996;24:1154 (abstract).
57. Sato N, Caux C, Kitamura T, et al. Expression and factor-dependent modulation of interleukin-3 receptor subunits on human hematopoietic cells. Blood. 1993;82:752.
58. Wognum AW, Visser TP, de Jong MO, Egeland T, Wagemaker G. Differential expression of receptors for interleukin-3 on subsets of CD34-expressing hematopoietic cells for rhesus monkeys. Blood. 1995:86:581.
59. McKinstry WJ, Li CL, Rasko JEJ, Nicola NA, Johnson GR, Metcalf D. Cytokine receptor expression on hematopoietic stem and progenitor cells. Blood. 1997;89:65.
60. Jiang S, Levine JD, Fu Y, et al. Cytokine production by primary bone marrow megakaryocytes. Blood. 1994;84:4151.
61. Wickenhauser C, Lorenzen J, Thiele J, et al. Secretion of cytokines (Interleukins-1 , -3, and -6 and granulocyte macrophage colony-stimulating factor) by normal human bone marrow megakaryocytes. Blood. 1995;85:685.
62. Navarro S, Debili N, Le Couedic J-P, et al. Interleukin-6 and its receptor are expressed by human megakaryocytes: In vitro effects on proliferation and endoreplication. Blood. 1991;77:461.