Enhancing Nrf2 pathway by disruption of Keap1 in myeloid leukocytes protects against sepsis

American Journal of Respiratory and Critical Care Medicine

Volumn 184, Issue 8, 2011, Pages 928-938

  Kong, Xiaoni ^a   Thimmulappa, Rajesh ^a   Craciun, Florin ^c   Harvey, Christopher ^a   Singh, Anju ^a   Kombairaju, Ponvijay ^a   Reddy, Sekhar P ^a   Remick, Daniel ^c   Biswal, Shyam ^a,b  

^a The Johns Hopkins University   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Antioxidants; Inflammation; Keap1; Nrf2; Sepsis

Indexed keywords

KELCH LIKE ECH ASSOCIATED PROTEIN 1; LIPOPOLYSACCHARIDE; REACTIVE OXYGEN METABOLITE; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR NRF2;

ANIMAL EXPERIMENT; ARTICLE; BACTEREMIA; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME ACTIVITY; FEMALE; INFLAMMATION; LEUKOCYTE; MACROPHAGE; MORTALITY; MOUSE; NONHUMAN; ORGAN INJURY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SEPSIS; SIGNAL TRANSDUCTION; SURVIVAL; TRANS GOLGI NETWORK;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CYTOSKELETAL PROTEINS; DISEASE MODELS, ANIMAL; IMMUNITY, INNATE; IMMUNOBLOTTING; INFLAMMATION MEDIATORS; MACROPHAGES; MICE; MICE, INBRED C57BL; MYELOID CELLS; NEUTROPHILS; NF-E2-RELATED FACTOR 2; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REACTIVE OXYGEN SPECIES; REAL-TIME POLYMERASE CHAIN REACTION; SEPSIS; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4;

EID: 80054713581     PISSN: 1073449X     EISSN: 15354970     Source Type: Journal    
DOI: 10.1164/rccm.201102-0271OC     Document Type: Article

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