Small and large animal models in cardiac contraction research: Advantages and disadvantages

Pharmacology and Therapeutics

Volumn 141, Issue 3, 2014, Pages 235-249

  Milani Nejad, Nima ^a   Janssen, Paul M L ^a  

^a OHIO STATE UNIVERSITY   (United States)

Author keywords

Cardiac contractility; Cardiac kinetics; Heart failure; Heart rate; Species

Indexed keywords

ANIMAL MODEL; CANINE MODEL; CARDIOVASCULAR PARAMETERS; HEART CONTRACTION; HEART MUSCLE RELAXATION; HEART SIZE; HEART VENTRICLE CONTRACTION; HUMAN TISSUE; HUMAN VERSUS ANIMAL COMPARISON; MOUSE MODEL; NONHUMAN; OVINE MODEL; PORCINE MODEL; PRIORITY JOURNAL; RABBIT MODEL; RAT MODEL; REVIEW; TREATMENT OUTCOME;

(DF/DT(MAX))/F; (DF/DT(MIN))/F; AAV; ACTION POTENTIAL DURATION; ADENO-ASSOCIATED VIRUS; APD; CARDIAC CONTRACTILITY; CARDIAC KINETICS; DF/DT(MAX); DF/DT(MIN); HEART FAILURE; HEART RATE; LEFT VENTRICULAR ISOVOLUMIC RELAXATION TIME CONSTANT; LEFT VENTRICULAR MAXIMAL RATE OF PRESSURE DECLINE; LEFT VENTRICULAR MAXIMAL RATE OF PRESSURE RISE; LEFT VENTRICULAR SYSTOLIC PRESSURE; LV DP/DT(MAX); LV DP/DT(MIN); LV Τ; LVSP; MAXIMAL VELOCITY OF CONTRACTION DIVIDED BY DEVELOPED FORCE IN CARDIAC TRABECULAE; MAXIMAL VELOCITY OF CONTRACTION IN CARDIAC TRABECULAE; MAXIMAL VELOCITY OF RELAXATION DIVIDED BY DEVELOPED FORCE IN CARDIAC TRABECULAE; MAXIMAL VELOCITY OF RELAXATION IN CARDIAC TRABECULAE; MHC; MYOSIN HEAVY CHAIN; NCX; RELAXATION TIME 50%: TIME FROM PEAK FORCE TO 50% RELAXATION IN CARDIAC TRABECULAE; RT(50); SARCOPLASMIC-RETICULUM CALCIUM ATPASE; SERCA; SODIUM CALCIUM EXCHANGER; SPECIES; TIME TO PEAK: TIME FROM STIMULATION TO PEAK FORCE IN CARDIAC TRABECULAE; TTP;

ANIMALS; DISEASE MODELS, ANIMAL; HEART DISEASES; HEART VENTRICLES; HUMANS; MODELS, ANIMAL; MYOCARDIAL CONTRACTION; SPECIES SPECIFICITY; VENTRICULAR FUNCTION;

EID: 84892369440     PISSN: 01637258     EISSN: 1879016X     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2013.10.007     Document Type: Review

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