Inhibition of elevated Ca2+/calmodulin-dependent protein kinase II improves contractility in human failing myocardium

Circulation Research

Volumn 107, Issue 9, 2010, Pages 1150-1161

  Sossalla, Samuel ^a   Fluschnik, Nina ^a   Schotola, Hanna ^b   Ort, Katharina R ^a   Neef, Stefan ^a   Schulte, Timo ^a   Wittköpper, Katrin ^a   Renner, André ^c   Schmitto, Jan D ^d   Gummert, Jan ^c   El Armouche, Ali ^a   Hasenfuss, Gerd ^a   Maier, Lars S ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b Department of Anesthesiology ^*  (Germany)

^c RUHR UNIVERSITY BOCHUM   (Germany)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Ca2+ calmodulin dependent kinase II; calcium; contractility; heart failure; ryanodine receptor; sarcoplasmic reticulum Ca2+ leak

Indexed keywords

CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; N [2 [[N [3 (4 CHLOROPHENYL) 2 PROPENYL] N METHYLAMINO]METHYL]PHENYL] N (2 HYDROXYETHYL) 4 METHOXYBENZENESULFONAMIDE; RYANODINE RECEPTOR 2; PROTEIN KINASE INHIBITOR;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIOMYOPATHY; CELL ISOLATION; CLINICAL ARTICLE; CONGESTIVE CARDIOMYOPATHY; CONTROLLED STUDY; CYTOSOL; ENZYME INHIBITION; FEMALE; HEART FAILURE; HEART MUSCLE CONTRACTILITY; HUMAN; HUMAN CELL; HUMAN TISSUE; ISCHEMIC CARDIOMYOPATHY; MALE; MUSCLE ISOMETRIC CONTRACTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RNA SPLICING; SHEEP; ANIMAL; BIOSYNTHESIS; CELL CULTURE; COMPARATIVE STUDY; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; HEART CONTRACTION; HEART MUSCLE; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANIMALS; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; CELLS, CULTURED; HEART FAILURE; HUMANS; MYOCARDIAL CONTRACTION; MYOCARDIUM; PROTEIN KINASE INHIBITORS; SHEEP;

EID: 78349303787     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.110.220418     Document Type: Article

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