Influence of genetic background on ex vivo and in vivo cardiac function in several commonly used inbred mouse strains

Physiological Genomics

Volumn 42 A, Issue 2, 2010, Pages 103-113

  Barnabei, Matthew S ^a   Palpant, Nathan J ^a   Metzger, Joseph M ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

blockade; Hypoxia; Ischemia reperfusion; Quantitative trait locus

Indexed keywords

ESMOLOL;

ADRENERGIC SYSTEM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; EX VIVO STUDY; GENETIC VARIABILITY; HEART FAILURE; HEART FUNCTION; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEMODYNAMIC PARAMETERS; IN VIVO STUDY; INBRED STRAIN; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ADRENERGIC BETA-ANTAGONISTS; ANIMALS; ANOXIA; EMBRYONIC STEM CELLS; HEART; HEART FUNCTION TESTS; HEMODYNAMICS; MICE; MICE, INBRED STRAINS; MICE, TRANSGENIC; MYOCARDIAL ISCHEMIA;

ANIMALIA; MUS;

EID: 77958066967     PISSN: 10948341     EISSN: 15312267     Source Type: Journal    
DOI: 10.1152/physiolgenomics.00071.2010     Document Type: Article

References (57)

1. Barbosa ME, Alenina N, Bader M. Induction and analysis of cardiac hypertrophy in transgenic animal models. Meth Mol Med 112: 339-352, 2005.
2. Bauman LE, Sinsheimer JS, Sobel EM, Lange K. Mixed effects models for quantitative trait loci mapping with inbred strains. Genetics 180: 1743-1761, 2008.
3. Beck JA, Lloyd S, Hafezparast M, Lennon-Pierce M, Eppig JT, Festing MF, Fisher EM. Genealogies of mouse inbred strains. Nat Genet 24: 23-25, 2000.
4. Bendall JK, Heymes C, Wright TJ, Wheatcroft S, Grieve DJ, Shah AM, Cave AC. Strain-dependent variation in vascular responses to nitric oxide in the isolated murine heart. J Mol Cell Cardiol 34: 1325-1333, 2002.
5. Bittner RE, Anderson LV, Burkhardt E, Bashir R, Vafiadaki E, Ivanova S, Raffelsberger T, Maerk I, Hoger H, Jung M, Karbasiyan M, Storch M, Lassmann H, Moss JA, Davison K, Harrison R, Bushby KM, Reis A. Dysferlin deletion in SJL mice (SJL-Dysf) defines a natural model for limb girdle muscular dystrophy 2B. Nat Genet 23: 141-142, 1999.
6. Blizard DA, Lionikas A, Vandenbergh DJ, Vasilopoulos T, Gerhard GS, Griffith JW, Klein LC, Stout JT, Mack HA, Lakoski JM, Larsson L, Spicer JM, Vogler GP, McClearn GE. Blood pressure and heart rate QTL in mice of the B6/D2 lineage: sex differences and environmental influences. Physiol Genomics 36: 158-166, 2009.
7. Blizard DA, Welty R. Cardiac activity in the mouse: strain differences. J Comp Physiol 77: 337-344, 1971.
8. Boban M, Stowe DF, Buljubasic N, Kampine JP, Bosnjak ZJ. Direct comparative effects of isoflurane and desflurane in isolated guinea pig hearts. Anesthesiology 76: 775-780, 1992.
9. Dalal PG, Corner A, Chin C, Wood C, Razavi R. Comparison of the cardiovascular effects of isoflurane and sevoflurane as measured by magnetic resonance imaging in children with congenital heart disease. J Clin Anesth 20: 40-44, 2008.
10. Day SM, Westfall MV, Fomicheva EV, Hoyer K, Yasuda S, La Cross NC, D'Alecy LG, Ingwall JS, Metzger JM. Histidine button engineered into cardiac troponin I protects the ischemic and failing heart. Nat Med 12: 181-189, 2006. (Pubitemid 43214744)
11. Dhein S, Mohr FW, Delmar M. Practical Methods in Cardiovascular Research. Springer, 2005, p. 1010.
12. Dillmann WH. Calcium regulatory proteins and their alteration by transgenic approaches. Am J Cardiol 83: 89H-91H, 1999.
13. Doorenbos C, Tsaih SW, Sheehan S, Ishimori N, Navis G, Churchill G, Dipetrillo K, Korstanje R. Quantitative trait loci for urinary albumin in crosses between C57BL/6J and A/J inbred mice in the presence and absence of Apoe. Genetics 179: 693-699, 2008.
14. Du XJ. Gender modulates cardiac phenotype development in genetically modified mice. Cardiovasc Res 63: 510-519, 2004.
15. Eckhart AD, Koch WJ. Transgenic studies of cardiac adrenergic receptor regulation. J Pharmacol Exp Therapeut 299: 1-5, 2001.
16. Engelhardt S. Beta-adrenergic receptors in heart failure. Heart Fail Clin 1: 183-191, 2005.
17. Ferrier GR, Guyette CM. Ventricular tachycardia in an isolated guinea pig ventricular free wall model of ischemia and reperfusion. J Cardiovasc Pharmacol 17: 228-238, 1991.
18. Gros D, Dupays L, Alcolea S, Meysen S, Miquerol L, Theveniau- Ruissy M. Genetically modified mice: tools to decode the functions of connexins in the heart-new models for cardiovascular research. Cardiovasc Res 62: 299-308, 2004.
19. Hewett TE, Grupp IL, Grupp G, Robbins J. Alpha-skeletal actin is associated with increased contractility in the mouse heart. Circ Res 74: 740-746, 1994.
20. Heydemann A, Ceco E, Lim JE, Hadhazy M, Ryder P, Moran JL, Beier DR, Palmer AA, McNally EM. Latent TGF-beta-binding protein 4 modifies muscular dystrophy in mice. J Clin Invest 119: 3703-3712, 2009.
21. Heydemann A, Huber JM, Demonbreun A, Hadhazy M, McNally EM. Genetic background influences muscular dystrophy. Neuromuscul Disord 15: 601-609, 2005.
22. Ho M, Post CM, Donahue LR, Lidov HG, Bronson RT, Goolsby H, Watkins SC, Cox GA, Brown RH Jr. Disruption of muscle membrane and phenotype divergence in two novel mouse models of dysferlin deficiency. Hum Mol Genet 13: 1999-2010, 2004.
23. Hoit BD, Kiatchoosakun S, Restivo J, Kirkpatrick D, Olszens K, Shao H, Pao YH, Nadeau JH. Naturally occurring variation in cardiovascular traits among inbred mouse strains. Genomics 79: 679-685, 2002.
24. Insel PA, Hammond HK. Beta-adrenergic receptors in heart failure. J Clin Invest 92: 2564, 1993.
25. Landoni G, Bignami E, Oliviero F, Zangrillo A. Halogenated anaesthetics and cardiac protection in cardiac and non-cardiac anaesthesia. Ann Card Anaesth 12: 4-9, 2009.
26. Langendorff O. Untersuchungen am überlebenden Säugetierherzen. Pflügers Arch 61: 291-332, 1895.
27. Lloyd-Jones D, Adams RJ, Brown TM, Carnethon M, Dai S, De Simone G, Ferguson TB, Ford E, Furie K, Gillespie C, Go A, Greenlund K, Haase N, Hailpern S, Ho PM, Howard V, Kissela B, Kittner S, Lackland D, Lisabeth L, Marelli A, McDermott MM, Meigs J, Mozaffarian D, Mussolino M, Nichol G, Roger V, Rosamond W, Sacco R, Sorlie P, Stafford R, Thom T, Wasserthiel-Smoller S, Wong ND, Wylie-Rosett J; American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics-2010 Update: a report from the American Heart Association. Circulation 121: 948-954, 2010.
28. Merin RG, Bernard JM, Doursout MF, Cohen M, Chelly JE. Comparison of the effects of isoflurane and desflurane on cardiovascular dynamics and regional blood flow in the chronically instrumented dog. Anesthesiology 74: 568-574, 1991.
29. Michele DE, Gomez CA, Hong KE, Westfall MV, Metzger JM. Cardiac dysfunction in hypertrophic cardiomyopathy mutant tropomyosin mice is transgene-dependent, hypertrophy-independent, and improved by beta-blockade. Circ Res 91: 255-262, 2002.
30. Mogil JS, Smith SB, O'Reilly MK, Plourde G. Influence of nociception and stress-induced antinociception on genetic variation in isoflurane anesthetic potency among mouse strains. Anesthesiology 103: 751-758, 2005.
31. Nabeshima T, Ho IK. Pharmacological responses to pentobarbital in different strains of mice. J Pharmacol Exp Therapeut 216: 198-204, 1981.
32. Nilles KM, London B. Knockin animal models of inherited arrhythmogenic diseases: what have we learned from them? J Cardiovasc Electrophysiol 18: 1117-1125, 2007.
33. Pacher P, Nagayama T, Mukhopadhyay P, Batkai S, Kass DA. Measurement of cardiac function using pressure-volume conductance catheter technique in mice and rats. Nat Protocols 3: 1422-1434, 2008.
34. Palpant NJ, D'Alecy LG, Metzger JM. Single histidine button in cardiac troponin I sustains heart performance in response to severe hypercapnic respiratory acidosis in vivo. FASEB J 23: 1529-1540, 2009.
35. Palpant NJ, Szatkowski ML, Wang W, Townsend D, Bedada FB, Koch LG, Britton SL, Metzger JM. Artificial selection for whole animal low intrinsic aerobic capacity co-segregates with hypoxia-induced cardiac pump failure. PloS one 4: e6117, 2009.
36. Prabhakar R, Boivin GP, Grupp IL, Hoit B, Arteaga G, Solaro JR, Wieczorek DF. A familial hypertrophic cardiomyopathy alpha-tropomyosin mutation causes severe cardiac hypertrophy and death in mice. J Mol Cell Cardiol 33: 1815-1828, 2001.
37. Reichelt ME, Willems L, Hack BA, Peart JN, Headrick JP. Cardiac and coronary function in the Langendorff-perfused mouse heart model. Exp Physiol 94: 54-70, 2009.
38. Ryder-Cook AS, Sicinski P, Thomas K, Davies KE, Worton RG, Barnard EA, Darlison MG, Barnard PJ. Localization of the mdx mutation within the mouse dystrophin gene. EMBO J 7: 3017-3021, 1988.
39. Saha DC, Saha AC, Malik G, Astiz ME, Rackow EC. Comparison of cardiovascular effects of tiletamine-zolazepam, pentobarbital, and ketamine-xylazine in male rats. J Am Assoc Lab Anim Sci 46: 74-80, 2007. (Pubitemid 47065768)
40. Schlager G. Systolic blood pressure in eight inbred strains of mice. Nature 212: 519-520, 1966.
41. Seong E, Saunders TL, Stewart CL, Burmeister M. To knockout in 129 or in C57BL/6: that is the question. Trends Genet 20: 59-62, 2004.
42. Shah AP, Siedlecka U, Gandhi A, Navaratnarajah M, Al-Saud SA, Yacoub MH, Terracciano CM. Genetic background affects function and intracellular calcium regulation of mouse hearts. Cardiovas Res. In press.
43. Sicinski P, Geng Y, Ryder-Cook AS, Barnard EA, Darlison MG, Barnard PJ. The molecular basis of muscular dystrophy in the mdx mouse: a point mutation. Science 244: 1578-1580, 1989.
44. Skolleborg KC, Gronbech JE, Grong K, Abyholm FE, Lekven J. Distribution of cardiac output during pentobarbital versus midazolam/fentanyl/fluanisone anaesthesia in the rat. Lab Anim 24: 221-227, 1990. (Pubitemid 20296987)
45. Skrzypiec-Spring M, Grotthus B, Szelag A, Schulz R. Isolated heart perfusion according to Langendorff - still viable in the new millennium. J Pharmacol Toxicol Meth 55: 113-126, 2007. (Pubitemid 46227990)
46. Sonner JM, Gong D, Eger EI, 2nd. Naturally occurring variability in anesthetic potency among inbred mouse strains. Anesth Analg 91: 720-726, 2000.
47. Stull LB, Hiranandani N, Kelley MA, Leppo MK, Marban E, Janssen PM. Murine strain differences in contractile function are temperature- and frequency-dependent. Pflügers Arch 452: 140-145, 2006.
48. Stylianou IM, Langley SR, Walsh K, Chen Y, Revenu C, Paigen B. Differences in DBA/1J and DBA/2J reveal lipid QTL genes. J Lipid Res 49: 2402-2413, 2008.
49. Sugiyama F, Churchill GA, Li R, Libby LJ, Carver T, Yagami K, John SW, Paigen B. QTL associated with blood pressure, heart rate, and heart weight in CBA/CaJ and BALB/cJ mice. Physiol Genomics 10: 5-12, 2002.
50. Suzuki M, Carlson KM, Marchuk DA, Rockman HA. Genetic modifier loci affecting survival and cardiac function in murine dilated cardiomyopathy. Circulation 105: 1824-1829, 2002.
51. Taketo M, Schroeder AC, Mobraaten LE, Gunning KB, Hanten G, Fox RR, Roderick TH, Stewart CL, Lilly F, Hansen CT, and et al. FVB/N: an inbred mouse strain preferable for transgenic analyses. Proc Natl Acad Sci USA 88: 2065-2069, 1991.
52. Tamargo J, Caballero R, Nunez L, Gomez R, Vaquero M, Delpon E. Genetically engineered mice as a model for studying cardiac arrhythmias. Front Biosci 12: 22-38, 2007.
53. Townsend D, Blankinship MJ, Allen JM, Gregorevic P, Chamberlain JS, Metzger JM. Systemic administration of micro-dystrophin restores cardiac geometry and prevents dobutamine-induced cardiac pump failure. Mol Ther 15: 1086-1092, 2007.
54. Townsend D, Yasuda S, Li S, Chamberlain JS, Metzger JM. Emergent dilated cardiomyopathy caused by targeted repair of dystrophic skeletal muscle. Mol Ther 16: 832-835, 2008. (Pubitemid 351587091)
55. Waldeyer C, Fabritz L, Fortmueller L, Gerss J, Damke D, Blana A, Laakmann S, Kreienkamp N, Volkery D, Breithardt G, Kirchhof P. Regional, age-dependent, and genotype-dependent differences in ventricular action potential duration and activation time in 410 Langendorff-perfused mouse hearts. Basic Res Cardiol 104: 523-533, 2009.
56. Ware CB, Siverts LA, Nelson AM, Morton JF, Ladiges WC. Utility of a C57BL/6 ES line versus 129 ES lines for targeted mutations in mice. Transgen Res 12: 743-746, 2003.
57. Waterston RH, Lindblad-Toh K, Birney E, Rogers J, Abril JF, Agarwal P, Agarwala R, Ainscough R, Alexandersson M, An P, Antonarakis SE, Attwood J, Baertsch R, Bailey J, Barlow K, Beck S, Berry E, Birren B, Bloom T, Bork P, Botcherby M, Bray N, Brent MR, Brown DG, Brown SD, Bult C, Burton J, Butler J, Campbell RD, Carninci P, Cawley S, Chiaromonte F, Chinwalla AT, Church DM, Clamp M, Clee C, Collins FS, Cook LL, Copley RR, Coulson A, Couronne O, Cuff J, Curwen V, Cutts T, Daly M, David R, Davies J, Delehaunty KD, Deri J, Dermitzakis ET, Dewey C, Dickens NJ, Diekhans M, Dodge S, Dubchak I, Dunn DM, Eddy SR, Elnitski L, Emes RD, Eswara P, Eyras E, Felsenfeld A, Fewell GA, Flicek P, Foley K, Frankel WN, Fulton LA, Fulton RS, Furey TS, Gage D, Gibbs RA, Glusman G, Gnerre S, Goldman N, Goodstadt L, Grafham D, Graves TA, Green ED, Gregory S, Guigo R, Guyer M, Hardison RC, Haussler D, Hayashizaki Y, Hillier LW, Hinrichs A, Hlavina W, Holzer T, Hsu F, Hua A, Hubbard T, Hunt A, Jackson I, Jaffe DB, Johnson LS, Jones M, Jones TA, Joy A, Kamal M, Karlsson EK, Karolchik D, Kasprzyk A, Kawai J, Keibler E, Kells C, Kent WJ, Kirby A, Kolbe DL, Korf I, Kucherlapati RS, Kulbokas EJ, Kulp D, Landers T, Leger JP, Leonard S, Letunic I, Levine R, Li J, Li M, Lloyd C, Lucas S, Ma B, Maglott DR, Mardis ER, Matthews L, Mauceli E, Mayer JH, McCarthy M, McCombie WR, McLaren S, McLay K, McPherson JD, Meldrim J, Meredith B, Mesirov JP, Miller W, Miner TL, Mongin E, Montgomery KT, Morgan M, Mott R, Mullikin JC, Muzny DM, Nash WE, Nelson JO, Nhan MN, Nicol R, Ning Z, Nusbaum C, O'Connor MJ, Okazaki Y, Oliver K, Overton-Larty E, Pachter L, Parra G, Pepin KH, Peterson J, Pevzner P, Plumb R, Pohl CS, Poliakov A, Ponce TC, Ponting CP, Potter S, Quail M, Reymond A, Roe BA, Roskin KM, Rubin EM, Rust AG, Santos R, Sapojnikov V, Schultz B, Schultz J, Schwartz MS, Schwartz S, Scott C, Seaman S, Searle S, Sharpe T, Sheridan A, Shownkeen R, Sims S, Singer JB, Slater G, Smit A, Smith DR, Spencer B, Stabenau A, Stange-Thomann N, Sugnet C, Suyama M, Tesler G, Thompson J, Torrents D, Trevaskis E, Tromp J, Ucla C, Ureta-Vidal A, Vinson JP, Von Niederhausern AC, Wade CM, Wall M, Weber RJ, Weiss RB, Wendl MC, West AP, Wetterstrand K, Wheeler R, Whelan S, Wierzbowski J, Willey D, Williams S, Wilson RK, Winter E, Worley KC, Wyman D, Yang S, Yang SP, Zdobnov EM, Zody MC, Lander ES. Initial sequencing and comparative analysis of the mouse genome. Nature 420: 520-562, 2002.