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Volumn 60, Issue 6, 2012, Pages 544-552

Vascular remodeling-associated hypertension leads to left ventricular hypertrophy and contractile dysfunction in profilin-1 transgenic mice

Author keywords

calcium; contraction; isoproterenol; left ventricular hypertrophy; papillary muscles; profilin 1

Indexed keywords

ACTIN RELATED PROTEIN; CALCIUM ION; PROFILIN I; UNCLASSIFIED DRUG;

EID: 84871608364     PISSN: 01602446     EISSN: 15334023     Source Type: Journal    
DOI: 10.1097/FJC.0b013e318271225d     Document Type: Article
Times cited : (20)

References (54)
  • 1
    • 0036484242 scopus 로고    scopus 로고
    • Small artery remodeling in hypertension
    • Mulvany MJ. Small artery remodeling in hypertension. Curr Hypertens Rep. 2002;4:49-55.
    • (2002) Curr Hypertens Rep , vol.4 , pp. 49-55
    • Mulvany, M.J.1
  • 2
    • 0035003137 scopus 로고    scopus 로고
    • Small artery remodeling is the most prevalent (earliest?) form of target organ damage in mild essential hypertension
    • Park JB, Schiffrin EL. Small artery remodeling is the most prevalent (earliest?) form of target organ damage in mild essential hypertension. J Hypertens. 2001;19:921-930.
    • (2001) J Hypertens , vol.19 , pp. 921-930
    • Park, J.B.1    Schiffrin, E.L.2
  • 3
    • 0742304959 scopus 로고    scopus 로고
    • Cardiac remodeling in systemic hypertension
    • Kenchaiah S, Pfeffer MA. Cardiac remodeling in systemic hypertension. Med Clin North Am. 2004;88:115-130.
    • (2004) Med Clin North Am , vol.88 , pp. 115-130
    • Kenchaiah, S.1    Pfeffer, M.A.2
  • 4
  • 5
    • 33847124544 scopus 로고    scopus 로고
    • Decompensation of cardiac hypertrophy: Cellular mechanisms and novel therapeutic targets
    • Diwan A, Dorn GW II. Decompensation of cardiac hypertrophy: cellular mechanisms and novel therapeutic targets. Physiology. 2007;22:56-64.
    • (2007) Physiology , vol.22 , pp. 56-64
    • Diwan, A.1    Dorn, G.W.I.I.2
  • 6
    • 34547665415 scopus 로고    scopus 로고
    • Small-molecule therapies for cardiac hypertrophy: Moving beneath the cell surface
    • McKinsey TA, Kass DA. Small-molecule therapies for cardiac hypertrophy: moving beneath the cell surface. Nat Rev Drug Discov. 2007;6: 617-635.
    • (2007) Nat Rev Drug Discov , vol.6 , pp. 617-635
    • McKinsey, T.A.1    Kass, D.A.2
  • 7
    • 84871611204 scopus 로고    scopus 로고
    • Profilin and vascular diseases
    • Ekinci D, ed Rijeka Croatia: InTech Accessed August 20, 2012
    • Elnakish MT, Hassanain HH. Profilin, and vascular diseases. In: Ekinci D, ed. Biochemistry. Rijeka, Croatia: InTech, 2012:65-106. Available at: http://www.intechopen.com/books/biochemistry/profilinand-vascular-diseases. Accessed August 20, 2012.
    • (2012) Biochemistry , pp. 65-106
    • Elnakish, M.T.1    Hassanain, H.H.2
  • 8
    • 38049181369 scopus 로고    scopus 로고
    • Vascular hypertrophy and hypertension caused by transgenic overexpression of profilin 1
    • Moustafa-Bayoumi M, Alhaj MA, El-Sayed O, et al. Vascular hypertrophy and hypertension caused by transgenic overexpression of profilin 1. J Biol Chem. 2007;282:37632-37639.
    • (2007) J Biol Chem , vol.282 , pp. 37632-37639
    • Moustafa-Bayoumi, M.1    Alhaj, M.A.2    El-Sayed, O.3
  • 9
    • 77952599107 scopus 로고    scopus 로고
    • Vascular hypertrophy-associated hypertension of profilin 1 transgenic mouse model leads to functional remodeling of peripheral arteries
    • Hassona MD, Abouelnaga ZA, Elnakish MT, et al. Vascular hypertrophy-associated hypertension of profilin 1 transgenic mouse model leads to functional remodeling of peripheral arteries. Am J Physiol Heart Circ Physiol. 2010;298:H2112-H2120.
    • (2010) Am J Physiol Heart Circ Physiol , vol.298
    • Hassona, M.D.1    Abouelnaga, Z.A.2    Elnakish, M.T.3
  • 10
    • 79957716492 scopus 로고    scopus 로고
    • The effect of selective antihypertensive drugs on the vascular remodeling-associated hypertension: Insights from a profilin 1 transgenic mouse model
    • Hassona MD, Elnakish MT, Abouelnaga ZA, et al. The effect of selective antihypertensive drugs on the vascular remodeling-associated hypertension: insights from a profilin 1 transgenic mouse model. J Cardiovasc Pharmacol. 2011;57:550-558.
    • (2011) J Cardiovasc Pharmacol , vol.57 , pp. 550-558
    • Hassona, M.D.1    Elnakish, M.T.2    Abouelnaga, Z.A.3
  • 11
    • 80052334760 scopus 로고    scopus 로고
    • Cardiac remodeling caused by transgenic over-expression of a corn Rac gene
    • Elnakish MT, Awad MM, Hassona MD, et al. Cardiac remodeling caused by transgenic over-expression of a corn Rac gene. Am J Physiol Heart Circ Physiol. 2011;301:H868-H880.
    • (2011) Am J Physiol Heart Circ Physiol , vol.301
    • Elnakish, M.T.1    Awad, M.M.2    Hassona, M.D.3
  • 12
    • 0028855563 scopus 로고
    • Force, not sarcomere length, correlates with prolongation of isosarcometric contraction
    • Janssen PML, Hunter WC. Force, not sarcomere length, correlates with prolongation of isosarcometric contraction. Am J Physiol Heart Circ Physiol. 1995;269(2 pt 2):H676-H685.
    • (1995) Am J Physiol Heart Circ Physiol , vol.269 , Issue.2 PART 2
    • Pml, J.1    Hunter, W.C.2
  • 13
    • 27844451982 scopus 로고    scopus 로고
    • Utrophin deficiency worsens cardiac contractile dysfunction present in dystrophin-deficient mdx mice
    • Janssen PM, Hiranandani N, Mays TA, et al. Utrophin deficiency worsens cardiac contractile dysfunction present in dystrophin-deficient mdx mice. Am J Physiol Heart Circ Physiol. 2005;289:H2373-H2378.
    • (2005) Am J Physiol Heart Circ Physiol , vol.289
    • Janssen, P.M.1    Hiranandani, N.2    Mays, T.A.3
  • 14
    • 0026665940 scopus 로고
    • A method to reconstruct myocardial sarcomere lengths and orientations at transmural sites in beating canine hearts
    • Rodriguez EK, Hunter WC, Royce MJ, et al. A method to reconstruct myocardial sarcomere lengths and orientations at transmural sites in beating canine hearts. Am J Physiol Heart Circ Physiol. 1992;263(1 pt 2): H293-H306.
    • (1992) Am J Physiol Heart Circ Physiol , vol.263 , Issue.1 PART 2
    • Rodriguez, E.K.1    Hunter, W.C.2    Royce, M.J.3
  • 15
    • 0033525750 scopus 로고    scopus 로고
    • Cellular mechanisms of altered contractility in the hypertrophied heart Big heart, big sparks
    • Shorofsky SR, Aggarwal R, Corretti M, et al. Cellular mechanisms of altered contractility in the hypertrophied heart. Big heart, big sparks. Circ Res. 1999;84:424-434.
    • (1999) Circ Res , vol.84 , pp. 424-434
    • Shorofsky, S.R.1    Aggarwal, R.2    Corretti, M.3
  • 16
    • 0001001033 scopus 로고
    • Zur dynamik des Herzmuskels
    • Frank O. Zur dynamik des Herzmuskels. Z Biol. 1895;32:370-447.
    • (1895) Z Biol , vol.32 , pp. 370-447
    • Frank, O.1
  • 18
    • 0000515140 scopus 로고
    • Ueber die eigenthuemlichkeiten der reizbarkeit welche die muskelfasern des herzens zeigen
    • Bowditch HP. Ueber die eigenthuemlichkeiten der reizbarkeit, welche die muskelfasern des herzens zeigen. Ber Sachs Ges (Akad) Wiss. 1871;23:652-689.
    • (1871) Ber Sachs Ges (Akad) Wiss , vol.23 , pp. 652-689
    • Bowditch, H.P.1
  • 19
    • 0018635932 scopus 로고
    • Hemodynamic consequences of left ventricular hypertrophy in spontaneously hypertensive rats
    • Hallbäck-Nordlander M, Noresson E, Thorén P. Hemodynamic consequences of left ventricular hypertrophy in spontaneously hypertensive rats. Am J Cardiol. 1979;44:986-993.
    • (1979) Am J Cardiol , vol.44 , pp. 986-993
    • Hallbäck-Nordlander, M.1    Noresson, E.2    Thorén, P.3
  • 20
    • 0017196706 scopus 로고
    • Pumping ability of the hypertrophying left ventricle of the spontaneously hypertensive rat
    • Pfeffer MA, Pfeffer JM, Frohlich ED. Pumping ability of the hypertrophying left ventricle of the spontaneously hypertensive rat. Circ Res. 1976;38:423-429.
    • (1976) Circ Res , vol.38 , pp. 423-429
    • Pfeffer, M.A.1    Pfeffer, J.M.2    Frohlich, E.D.3
  • 21
    • 0019190926 scopus 로고
    • Cardiac pumping ability following reversal of hypertrophy and hypertension in spontaneously hypertensive rats
    • Spech MM, Ferrario CM, Tarazi RC. Cardiac pumping ability following reversal of hypertrophy and hypertension in spontaneously hypertensive rats. Hypertension. 1980;2:75-82.
    • (1980) Hypertension , vol.2 , pp. 75-82
    • Spech, M.M.1    Ferrario, C.M.2    Tarazi, R.C.3
  • 22
    • 0017295423 scopus 로고
    • Cardiac performance in rats with renal hypertension
    • Averill DB, Ferrario CM, Tarazi RC, et al. Cardiac performance in rats with renal hypertension. Circ Res. 1976;38:280-288.
    • (1976) Circ Res , vol.38 , pp. 280-288
    • Averill, D.B.1    Ferrario, C.M.2    Tarazi, R.C.3
  • 23
    • 0018630077 scopus 로고
    • Ventricular function and coronary hemodynamics in hypertensive heart disease
    • Strauer BE. Ventricular function and coronary hemodynamics in hypertensive heart disease. Am J Cardiol. 1979;44:999-1006.
    • (1979) Am J Cardiol , vol.44 , pp. 999-1006
    • Strauer, B.E.1
  • 24
    • 18144453515 scopus 로고
    • Adaptation of left ventricle to chronic pressure overload: Response to inotropic drugs
    • Newman WH, Webb JG. Adaptation of left ventricle to chronic pressure overload: response to inotropic drugs. Am J Physiol. 1980;238:H134-H143.
    • (1980) Am J Physiol , vol.238
    • Newman, W.H.1    Webb, J.G.2
  • 25
    • 0015693837 scopus 로고
    • Mechanisms for the abnormal energetics of pressure-induced hypertrophy of cat myocardium
    • Cooper G 4th, Satava RM Jr, Harrison CE, et al. Mechanisms for the abnormal energetics of pressure-induced hypertrophy of cat myocardium. Circ Res. 1973;33:213-223.
    • (1973) Circ Res , vol.33 , pp. 213-223
    • Cooper, I.V.G.1    Satava Jr., R.M.2    Harrison, C.E.3
  • 26
    • 0014132503 scopus 로고
    • Contractile state of cardiac muscle obtained from cats with experimentally produced ventricular hypertrophy and heart failure
    • Spann JF Jr, Buccino RA, Sonnenblick EH, et al. Contractile state of cardiac muscle obtained from cats with experimentally produced ventricular hypertrophy and heart failure. Circ Res. 1967;21:341-354.
    • (1967) Circ Res , vol.21 , pp. 341-354
    • Spann Jr., J.F.1    Buccino, R.A.2    Sonnenblick, E.H.3
  • 27
    • 0015582658 scopus 로고
    • Myocardial oxygen consumption during experimental hypertrophy and congestive heart failure
    • Gunning JF, Coleman HN 3rd. Myocardial oxygen consumption during experimental hypertrophy and congestive heart failure. J Mol Cell Cardiol. 1973;5:25-38.
    • (1973) J Mol Cell Cardiol , vol.5 , pp. 25-38
    • Gunning, J.F.1    Coleman Iii., H.N.2
  • 28
    • 0017978216 scopus 로고
    • Recovery of myosin ATPase after relief of pressure-overload hypertrophy and failure
    • Carey RA, Bove AA, Coulson RL, et al. Recovery of myosin ATPase after relief of pressure-overload hypertrophy and failure. Am J Physiol. 1978;234(6):H711-H717.
    • (1978) Am J Physiol , vol.234 , Issue.6
    • Carey, R.A.1    Bove, A.A.2    Coulson, R.L.3
  • 29
    • 0017332234 scopus 로고
    • Recuperative potential of cardiac muscle following relief of pressure overload hypertrophy and right ventricular failure in the cat
    • Coulson RL, Yazdanfar S, Rubio E, et al. Recuperative potential of cardiac muscle following relief of pressure overload hypertrophy and right ventricular failure in the cat. Circ Res. 1977;40:41-49.
    • (1977) Circ Res , vol.40 , pp. 41-49
    • Coulson, R.L.1    Yazdanfar, S.2    Rubio, E.3
  • 30
    • 0015011243 scopus 로고
    • Mechanical properties of rat cardiac muscle during experimental hypertrophy
    • Bing OH, Matsushita S, Fanburg BL, et al. Mechanical properties of rat cardiac muscle during experimental hypertrophy. Circ Res. 1971;28:234-245.
    • (1971) Circ Res , vol.28 , pp. 234-245
    • Bing, O.H.1    Matsushita, S.2    Fanburg, B.L.3
  • 31
    • 0037214686 scopus 로고    scopus 로고
    • Chronic inhibition of Rho kinase blunts the process of left ventricular hypertrophy leading to cardiac contractile dysfunction in hypertension-induced heart failure
    • Satoh S, Ueda Y, Koyanagi M, et al. Chronic inhibition of Rho kinase blunts the process of left ventricular hypertrophy leading to cardiac contractile dysfunction in hypertension-induced heart failure. J Mol Cell Cardiol. 2003;35:59-70.
    • (2003) J Mol Cell Cardiol , vol.35 , pp. 59-70
    • Satoh, S.1    Ueda, Y.2    Koyanagi, M.3
  • 32
    • 0030320790 scopus 로고    scopus 로고
    • Contractility changes of the right and ventricular muscle after chronic myocardial infarction
    • Novaes MA, Stefanon I, Mill JG, et al. Contractility changes of the right and ventricular muscle after chronic myocardial infarction. Braz J Med Biol Res. 1996;29:1683-1690.
    • (1996) Braz J Med Biol Res , vol.29 , pp. 1683-1690
    • Novaes, M.A.1    Stefanon, I.2    Mill, J.G.3
  • 33
    • 0037372210 scopus 로고    scopus 로고
    • Selective contractile dysfunction of left, not right, ventricular myocardium in the SHHF rat
    • Janssen PM, Stull LB, Leppo MK, et al. Selective contractile dysfunction of left, not right, ventricular myocardium in the SHHF rat. Am J Physiol Heart Circ Physiol. 2003;284:H772-H778.
    • (2003) Am J Physiol Heart Circ Physiol , vol.284
    • Janssen, P.M.1    Stull, L.B.2    Leppo, M.K.3
  • 34
    • 0031839441 scopus 로고    scopus 로고
    • Unchanged sarcoplasmic reticulum Ca2+-ATPase activity, reduced Ca2+ sensitivity, and negative force-frequency relationship in transgenic rats overexpressing the mouse renin gene
    • Zobel C, Brixius K, Pietsch M, et al. Unchanged sarcoplasmic reticulum Ca2+-ATPase activity, reduced Ca2+ sensitivity, and negative force-frequency relationship in transgenic rats overexpressing the mouse renin gene. J Mol Med (Berl). 1998;76:533-544.
    • (1998) J Mol Med (Berl) , vol.76 , pp. 533-544
    • Zobel, C.1    Brixius, K.2    Pietsch, M.3
  • 35
    • 0015260118 scopus 로고
    • Comparative force-frequency relationships in human and other mammalian ventricular myocardium
    • Buckley NM, Penefsky ZJ, Litwak RS.Comparative force-frequency relationships in human and other mammalian ventricular myocardium. Pflugers Arch. 1972;332(4):259-270.
    • (1972) Pflugers Arch , vol.332 , Issue.4 , pp. 259-270
    • Buckley, N.M.1    Penefsky, Z.J.2    Litwak, R.S.3
  • 36
    • 0035878625 scopus 로고    scopus 로고
    • Minimal force-frequency modulation of inotropy and relaxation of in situ murine heart
    • Georgakopoulos D, Kass D. Minimal force-frequency modulation of inotropy and relaxation of in situ murine heart. J Physiol. 2001;534(Pt. 2):535-545.
    • (2001) J Physiol , vol.534 , Issue.PART 2 , pp. 535-545
    • Georgakopoulos, D.1    Kass, D.2
  • 37
    • 35348995458 scopus 로고    scopus 로고
    • Determinants of frequency-dependent contraction and relaxation of mammalian myocardium
    • Janssen PM, Periasamy M. Determinants of frequency-dependent contraction and relaxation of mammalian myocardium. J Mol Cell Cardiol. 2007;43:523-531.
    • (2007) J Mol Cell Cardiol , vol.43 , pp. 523-531
    • Janssen, P.M.1    Periasamy, M.2
  • 39
    • 0036448412 scopus 로고    scopus 로고
    • Mechanical activity and force-frequency relationship of isolated mouse papillary muscle: Effects of extracellular calcium concentration, temperature and contraction type
    • Redel A, Baumgartner W, Golenhofen K, et al. Mechanical activity and force-frequency relationship of isolated mouse papillary muscle: effects of extracellular calcium concentration, temperature and contraction type. Pflugers Arch. 2002;445(2):297-304.
    • (2002) Pflugers Arch , vol.445 , Issue.2 , pp. 297-304
    • Redel, A.1    Baumgartner, W.2    Golenhofen, K.3
  • 40
    • 0032520057 scopus 로고    scopus 로고
    • Calcium cycling and contractile activation in intact mouse cardiac muscle
    • Gao WD, Perez NG, Marban E. Calcium cycling and contractile activation in intact mouse cardiac muscle. J Physiol (Lond). 1998;507(pt 1): 175-184.
    • (1998) J Physiol (Lond) , vol.507 , Issue.PART 1 , pp. 175-184
    • Gao, W.D.1    Perez, N.G.2    Marban, E.3
  • 41
    • 0036772442 scopus 로고    scopus 로고
    • Physiological determinants of contractile force generation and calcium handling in mouse myocardium
    • Stull LB, Leppo M, Marban E, et al. Physiological determinants of contractile force generation and calcium handling in mouse myocardium. J Mol Cell Cardiol. 2002;34:1367-1376.
    • (2002) J Mol Cell Cardiol , vol.34 , pp. 1367-1376
    • Stull, L.B.1    Leppo, M.2    Marban, E.3
  • 42
    • 0030219715 scopus 로고    scopus 로고
    • Effect of treppe on isovolumic function in the isolated blood-perfused mouse heart
    • Brooks WW, Apstein CS. Effect of treppe on isovolumic function in the isolated blood-perfused mouse heart. J Mol Cell Cardiol. 1996;28: 1817-1822.
    • (1996) J Mol Cell Cardiol , vol.28 , pp. 1817-1822
    • Brooks, W.W.1    Apstein, C.S.2
  • 43
    • 0033969489 scopus 로고    scopus 로고
    • Phospholamban: A major determinant of the cardiac force-frequency relationship
    • Bluhm WF, Kranias EG, Dillmann WH, et al. Phospholamban: a major determinant of the cardiac force-frequency relationship. Am J Physiol. 2000;278(1):H245-H255.
    • (2000) Am J Physiol , vol.278 , Issue.1
    • Bluhm, W.F.1    Kranias, E.G.2    Dillmann, W.H.3
  • 44
    • 0032953974 scopus 로고    scopus 로고
    • Phospholamban-to-SERCA2 ratio controls the force-frequency relationship
    • Meyer M, Bluhm WF, He H, et al. Phospholamban-to-SERCA2 ratio controls the force-frequency relationship. Am J Physiol. 1999;276(3 pt 2):H779-H785.
    • (1999) Am J Physiol , vol.276 , Issue.3 PART 2
    • Meyer, M.1    Bluhm, W.F.2    He, H.3
  • 45
    • 33750692762 scopus 로고    scopus 로고
    • Method for isolation of adult mouse cardiac myocytes for studies of contraction and microfluorimetry
    • Wolska BM, Solaro RJ. Method for isolation of adult mouse cardiac myocytes for studies of contraction and microfluorimetry. Am J Physiol. 1996;271(3 pt 2):H1250-H1255.
    • (1996) Am J Physiol , vol.271 , Issue.3 PART 2
    • Wolska, B.M.1    Solaro, R.J.2
  • 46
    • 29944433957 scopus 로고    scopus 로고
    • Effect of muscle dimensions on trabecular contractile performance under physiological conditions
    • Raman S, Kelley MA, Janssen PM. Effect of muscle dimensions on trabecular contractile performance under physiological conditions. Pflugers Arch. 2006;451(5):625-630.
    • (2006) Pflugers Arch , vol.451 , Issue.5 , pp. 625-630
    • Raman, S.1    Kelley, M.A.2    Janssen, P.M.3
  • 47
    • 0022137180 scopus 로고
    • Renal hypertension impairs inotropic isoproterenol effect without beta-receptor changes
    • Gende OA, Mattiazzi A, Camilion MC, et al. Renal hypertension impairs inotropic isoproterenol effect without beta-receptor changes. Am J Physiol. 1985;249(4 pt 2):H814-H819.
    • (1985) Am J Physiol , vol.249 , Issue.4 PART 2
    • Gende, O.A.1    Mattiazzi, A.2    Camilion, M.C.3
  • 48
    • 0019796398 scopus 로고
    • Impaired cardiac contractile response to isoproterenol in the spontaneously hypertensive rat
    • Saragoca MA, Tarazi RC. Impaired cardiac contractile response to isoproterenol in the spontaneously hypertensive rat. Hypertension. 1981;3:380-385.
    • (1981) Hypertension , vol.3 , pp. 380-385
    • Saragoca, M.A.1    Tarazi, R.C.2
  • 49
    • 0011914967 scopus 로고
    • Beta adrenergic receptor response coupling in hypertrophied hearts
    • Kumano K, Upsher ME, Khairallah PA. Beta adrenergic receptor response coupling in hypertrophied hearts. Hypertension. 1983;5(2 pt 2): 175-183.
    • (1983) Hypertension , vol.5 , Issue.2 PART 2 , pp. 175-183
    • Kumano, K.1    Upsher, M.E.2    Khairallah, P.A.3
  • 50
    • 0018096893 scopus 로고
    • Reduced number of b-adrenergic receptors in the myocardium of spontaneously rats
    • Limas C, Limas CJ. Reduced number of b-adrenergic receptors in the myocardium of spontaneously rats. Biochem Biophys Res Commun. 1987;83:710-716.
    • (1987) Biochem Biophys Res Commun , vol.83 , pp. 710-716
    • Limas, C.1    Limas, C.J.2
  • 51
    • 0034045758 scopus 로고    scopus 로고
    • Altered inotropic responsiveness and gene expression of hypertrophied myocardium with captopril
    • Brooks WW, Bing OH, Boluyt MO, et al. Altered inotropic responsiveness and gene expression of hypertrophied myocardium with captopril. Hypertension. 2000;35:1203-1209.
    • (2000) Hypertension , vol.35 , pp. 1203-1209
    • Brooks, W.W.1    Bing, O.H.2    Boluyt, M.O.3
  • 52
    • 80051780569 scopus 로고    scopus 로고
    • Involvement of profilin-1 in angiotensin II-induced vascular smooth muscle cell proliferation
    • Cheng JF, Ni GH, Chen MF, et al. Involvement of profilin-1 in angiotensin II-induced vascular smooth muscle cell proliferation. Vascul Pharmacol. 2011;55:34-41.
    • (2011) Vascul Pharmacol , vol.55 , pp. 34-41
    • Cheng, J.F.1    Ni, G.H.2    Chen, M.F.3
  • 53
    • 78650170861 scopus 로고    scopus 로고
    • Telmisartan attenuates aortic hypertrophy in hypertensive rats by the modulation of ACE2 and profilin-1 expression
    • Zhong JC, Ye JY, Jin HY, et al. Telmisartan attenuates aortic hypertrophy in hypertensive rats by the modulation of ACE2 and profilin-1 expression. Regul Pept. 2011;166:90-97.
    • (2011) Regul Pept , vol.166 , pp. 90-97
    • Zhong, J.C.1    Ye, J.Y.2    Jin, H.Y.3
  • 54
    • 78149423199 scopus 로고    scopus 로고
    • Profilin-1 is expressed in human atherosclerotic plaques and induces atherogenic effects on vascular smooth muscle cells
    • Caglayan E, Romeo GR, Kappert K, et al. Profilin-1 is expressed in human atherosclerotic plaques and induces atherogenic effects on vascular smooth muscle cells. PLoS One. 2010;5(10):e13608.
    • (2010) PLoS One , vol.5 , Issue.10
    • Caglayan, E.1    Romeo, G.R.2    Kappert, K.3


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