Myosin heavy chain isoform expression in the failing and nonfailing human heart

Circulation Research

Volumn 86, Issue 4, 2000, Pages 386-390

  Miyata, Setsuya ^a   Minobe, Wayne ^b   Bristow, Michael R ^b   Leinwand, Leslie A ^a  

^a UNIVERSITY OF COLORADO   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

Heart failure; Isoforms; Myosin

Indexed keywords

MESSENGER RNA; MYOSIN HEAVY CHAIN;

ADULT; ARTICLE; CONTROLLED STUDY; ELECTROPHORESIS; FEMALE; GENE EXPRESSION; HEART FAILURE; HEART FUNCTION; HEART LEFT VENTRICLE; HEART MUSCLE CONTRACTILITY; HUMAN; HUMAN TISSUE; MALE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; QUANTITATIVE ASSAY; TRANSLATION REGULATION;

EID: 0034599128     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.86.4.386     Document Type: Article

References (37)

1. Pope B, Hoh JFY, Weeds A. The ATPase activities of rat cardiac myosin isozymes. FEBS Lett. 1980;118:205-208.
2. Alpert NR, Mulieri LA. Increased myothermal economy of isometric force generation in compensated cardiac hypertrophy induced by pulmonary artery constriction in the rabbit. Circ Res. 1982;50: 491-500.
3. Holubarsch CH, Goulette RP, Litten RZ, Martin BJ, Mulieri LA, Alpert NR. The economy force development, myosin isozyme pattern and myofibrillar ATPase activity in normal and hyperthyroid rat myocardium. Circ Res. 1985;56:78-86.
4. Lompre AM, Schwanz K, d'Albis A, Lacombe G, Thiem NV, Swynghedauw B. Myosin isozyme re-distribution in chronic heart over-load. Nature. 1979;282:105-107.
5. Mercardier JJ, Lompre AM, Winewsky C, Samuel JL, Bercovici J, Swynghedauw B, Schwartz K. Myosin isozyme changes in several model of rat cardiac hypertrophy. Circ Res. 1981;49:525-532.
6. Peng HB, Wolosewick JJ, Cheng P-C. The development of myofibrils in cultured muscle cells: a whole mount and thin-section electron microscopic study. Dev Biol. 1981;88:121-136.
7. Schier JJ, Adelstein R. Structural and enzymatic comparison of human cardiac muscle myosins isolated from infants, adult, and patients with hypertrophic cardiomyopathy. J Clin Invest. 1982;69:816-825.
8. Gorza L, Mercadier JJ, Schwartz K, Thornell LE, Sartore S, Schiaffino S. Myosin types in the human heart: an immunofluorescence study of normal and hypertrophied atrial and ventricular myocardium. Circ Res. 1984;54:694-702.
9. Mercadier JJ, Bouveret P, Gorza L, Schiaffino S, Clark WA, Zak R, Swynghedauw B, Schwartz K. Myosin isozymes in normal and hypertrophied human ventricle myocardium. Circ Res. 1983;53:52-62.
10. Hirtel HO, Tuchschmid CR, Schneider J, Krayenbuehl HP, Schaub MC. Relationship between myosin isozyme composition, hemodynamics, and myocardial structure in various forms of human cardiac hypertrophy. Circ Res. 1985;57:729-740.
11. Schiaffino S, Gorza L, Saggin L, Valfre C, Sartore S. Myosin changes in hypertrophied human atrial and ventricular myocardium: a correlated immunofluorescence and quantitative immunochemical study on serial cryosections. Eur Heart J. 1984;5:95-102.
12. Bouvagnet P, Marirhofer H, Leger JO, Puech P, Leger JJ. Distribution pattern of α and β myosin in normal and diseased human ventricular myocardium. Basic Res Cardiol. 1989;84:91-102.
13. Tsuchimochi H, Sugi M, Kuro-o S, Ueda F, Takaku F, Furuta S, Shirai T, Yazaki Y. Isozymic change in myosin of human atrial myocardium induced by overload: immunohistochemical study using monoclonal antibodies. J Clin Invest. 1984;74:662-665.
14. Swynghedauw B. Developmental and functional adaptation of contractile proteins in cardiac and skeletal muscles. Physiol Rev. 1986; 66:710-730.
15. Dechesne C, Leger J, Bouvagnet P, Claviez M, Leger JJ. Fractionation and characterization of two molecular variants of myosin from adult human atrium. J Mol Cell Cardiol. 1985;17:753-756.
16. Leger J, Bouvagnet P, Pau B, Roncucci R, Leger JJ. Levels of ventricular myosin fragments in human sera after myocardial infarction, determined with monoclonal antibodies to myosin heavy chain. Eur J Clin Invest. 1985;15:422-429.
17. Nakao K, Minobe W, Roden R, Bristow MR, Leinwand LA. Myosin heavy chain gene expression in human heart failure. J Clin Invest. 1997;100:2362-2370.
18. Lowes BD, Minobe W, Abraham WT, Rizeq MN, Bohlmeyer TJ, Quaife RA, Roden RL, Ducher DL, Robertson AD, Voelkel NF, Badesch DB, Groves BM, Gilbert EM, Bristow MR. Changes in gene expression in the intact human heart: downregulation of a myosin heavy chain in hypertrophed, failing ventricular myocardium. J Clin Invest. 1997;100:2315-2324.
19. Reiser PJ, Kline WO. Electrophoretic separation and quantitation of cardiac myosin heavy chain isoform in eight mammalian species. Am J Physiol. 1998;274(3 pt 2):H1048-H1058.
20. Caforio AL, Grazzini M, Mann JM, Keeling PJ, Bottazzo GF, McKenna WJ, Schiaffino S. Identification of α- and β-cardiac myosin heavy chain isoforms as major autoantigens in dilated cardiomyopathy. Circulation. 1992;85:1734-1742.
21. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 1970;237:680-685.
22. Blough ER, Rennie ER, Zhang F, Reiser PJ. Enhanced electrophoretic separation and resolution of myosin heavy chain in mammalian and avian skeletal muscles. Anal Biochem. 1996;233:31-35.
23. Miller JB, Teal SB, Stockdale FE. Evolutionarily conserved sequences of striated muscle myosin heavy chain isoforms: epitope mapping by cDNA expression. J Biol Chem. 1989;264:13122-13130.
24. Bouvagnet P, Leger J, Pons F, Dechesne C, Leger J. Fiber types and myosin types in human atrial and ventricular myocardium. Circ Res. 1984;55:794-804.
25. Delcayre C, Klug D, Nguyen VT, Mouas C, Swynghedauw B. Aortic perfusion pressure as early determinant of β-isomyosin expression in perfused hearts. Am J Physiol. 1992;263:H1537-H1545.
26. Ivester CT, Tuxworth WJ, Cooper G VI, McDermont PJ. Contraction accelerates myosin heavy chain synthesis rate in adult cardiocytes by an increases in the rate of translational initiation. J Biol Chem. 1995;270:21950-21957.
27. Weisner RJ, Ehmke H, Faulhaber J, Zak R, Rvegg JC. Dissociation of left ventricular hypertrophy, β myosin heavy chain gene expression and myosin isoform switch in rats after ascending aortic construction. Circulation. 1997;95:1253-1259.
28. Samarel A, Spagia M, Maloney V, Kamal S, Engelmann GL. Contractile arrest accelerates myosin heavy chain degradation in neonatal rat heart cells. Am J Physiol. 1992;263:C642-C652.
29. +2)i and contractile activity. Am J Physiol. 1996;271:1447-1456.
30. Morgan HE, Gordon EE, Kira Y, Chura BHL, Russo LA, Peterson CJ, McDermont PJ, Watson PA. Biochemical mechanisms of cardiac hypertrophy. Annu Rev Physiol. 1987;49:533-543.
31. Nagai R, Low RB, Stirewalt WS, Alpert NR, Litten RZ. Efficiency and capacity of protein synthesis are increased in pressure overload cardiac hypertrophy. Ann Physiol. 1988;255:H325-H328.
32. Tardiff JC, Hewett TE, Factor SM, Vikstrom KL, Robbins J, Leinwand LA. Expression of the β(slow) isoform of the MHC in the adult mouse heart causes dominant-negative functional effects. Am J Physiol. In press.
33. Harris DE, Work SS, Wright RK, Alpert NR, Warshaw DM. Smooth, cardiac and skeletal muscle myosin force and motor generation is assessed by cross-bridge mechanical interactions in vitro. J Muscle Res Cell Motil. 1994;15:11-19.
34. Bonne G, Carrier L, Richard P, Hainque B, Schwartz K. Familial hypertrophic cardiomyopathy: from mutations to functional defects. Circ Res. 1998;83:580-593.
35. Cuda G, Fananapazir L, Epstein ND, Sellers JR. The in vitro motility activity of β-cardiac myosin heavy chain depends on the nature of the β myosin heavy chain gene mutation in hypertrophic cardiomyopathy. J Muscle Res Cell Motil. 1997;18:275-283.
36. Sata M, Ikebe M. Functional analysis of the mutations in the human β-cardiac myosin that are responsible for familial hypertrophic cardiomyopathy. J Clin Invest. 1996;98:2866-2873.
37. Roopnarine O, Leinwand L. Functional analysis of myosin mutations that cause familial hypertrophic cardiomyopathy. Biophys J. 1998;75: 3023-3030.